The document discusses a novel stem cell therapy developed by the National Children's Leukemia Foundation (NCLF) for treating leukemia and cancer. Called the "Stem Cell Cocktail", it involves targeting multiple molecular pathways that regulate cancer cell growth using a combination of stem cell compounds. In vitro and in vivo studies show the therapy is effective at inhibiting leukemia cell growth and increasing survival in animal models. The NCLF aims to further test additional combinations and expand the approach to other cancer types with the goal of bringing this potential cure to clinical trials.
IED Summit 2011 - Middle School Rural Students, STEM Subjects, and Virtual ...Kansas State University
This slide show describes the year-long Virtual World Builders Academy, developed by Rich White Greenbush Educational Service Center for rural middle school students of leadership potential. These students learned STEM subjects through inworld collaborative activities in OpenCobalt, OpenSim, EduSim and also used Scratch, MyAvatar and other communication, building and drawing tools, as well. Some guidelines are presented for doing inworld STEM with middle school students, based on teacher and student feedback and focus groups.
Stem cells under the microscope a picture galleryPriya-Menon
This document provides a picture gallery of stem cells from various sources and research. It includes images of neural stem cells in rat brains, human embryonic stem cells forming colonies in vitro and for transplantation, germ line stem cells in niches, human hematopoietic stem cells, and spontaneous embryonic stem cell differentiation. Key milestones are noted such as the discovery of stem cells in human cord blood in 1981 and the first embryonic stem cell line developed from mice in 1988.
This document provides an overview of stem cell research including different types of stem cells, their potential medical applications, and the processes of embryonic stem cell derivation and therapeutic cloning. It discusses embryonic stem cells' ability to differentiate into any cell type compared to adult stem cells' more limited potential. Current research aims to develop stem cell therapies for conditions like diabetes, spinal cord injury, and heart disease. However, significant challenges remain regarding controlling stem cell behavior and ensuring therapies are long-lasting without tumor formation.
This document summarizes key topics related to cancer stem cells. It discusses how cancers contain and arise from stem cells, known as cancer stem cells. Traditional cancer therapies target transit amplifying cells but not cancer stem cells. The document outlines several mechanisms of targeting cancer stem cells, including targeting surface markers, inducing apoptosis, and modulating signaling pathways like mTOR, SHH, and WNT/β-catenin. Radiation therapy is also described as damaging cancer cell DNA to kill cells or slow growth. The conclusion emphasizes that identifying therapies targeting cancer stem cells could help prevent cancer recurrence when combined with standard chemotherapy.
Dissertation topics on cellular basics of cancer and therapeutics - PubricaPubrica
• Researching cancer and its therapeutics is an important tool for cancer studies and medical writing services.
• The important topics to be covered while writing a thesis for cancer and its therapeutics are discussed in scientific medical writing.
• Pubrica is here to help with the easy scientific medical writingabout cancer research and its therapeutics.
Full Information: https://bit.ly/3llZgmV
Reference: https://pubrica.com/services/physician-writing-services/
Why Pubrica?
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Contact us :
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44- 74248 10299
Intracellular Events in Antigen Processing.pptxDr.Kanury Rao
Intracellular signaling or events are caused on the surfaces of the cells. Dr. Kanury Rao, the greatest immunologist of all time, has conducted an in-depth analysis of intracellular events to develop a tool for early detection of cancer.
Tumour markers can play a crucial role in detecting cancer and assessing response to therapy. They are substances produced either by tumour cells or by the body in response to cancer. Oncoproteins are proteins encoded by oncogenes which normally maintain a fine balance between cell proliferation and differentiation but become permanently activated in cancer, stimulating cell growth. Elevated levels of various oncoproteins and other tumour markers can be detected in blood and other body fluids, serving as biomarkers for early cancer detection and prediction of prognosis. Common tumour markers discussed include AFP, CEA, CA19-9, CA15-3, CA125, and proteins associated with growth factors, receptors, and cellular signalling pathways.
IED Summit 2011 - Middle School Rural Students, STEM Subjects, and Virtual ...Kansas State University
This slide show describes the year-long Virtual World Builders Academy, developed by Rich White Greenbush Educational Service Center for rural middle school students of leadership potential. These students learned STEM subjects through inworld collaborative activities in OpenCobalt, OpenSim, EduSim and also used Scratch, MyAvatar and other communication, building and drawing tools, as well. Some guidelines are presented for doing inworld STEM with middle school students, based on teacher and student feedback and focus groups.
Stem cells under the microscope a picture galleryPriya-Menon
This document provides a picture gallery of stem cells from various sources and research. It includes images of neural stem cells in rat brains, human embryonic stem cells forming colonies in vitro and for transplantation, germ line stem cells in niches, human hematopoietic stem cells, and spontaneous embryonic stem cell differentiation. Key milestones are noted such as the discovery of stem cells in human cord blood in 1981 and the first embryonic stem cell line developed from mice in 1988.
This document provides an overview of stem cell research including different types of stem cells, their potential medical applications, and the processes of embryonic stem cell derivation and therapeutic cloning. It discusses embryonic stem cells' ability to differentiate into any cell type compared to adult stem cells' more limited potential. Current research aims to develop stem cell therapies for conditions like diabetes, spinal cord injury, and heart disease. However, significant challenges remain regarding controlling stem cell behavior and ensuring therapies are long-lasting without tumor formation.
This document summarizes key topics related to cancer stem cells. It discusses how cancers contain and arise from stem cells, known as cancer stem cells. Traditional cancer therapies target transit amplifying cells but not cancer stem cells. The document outlines several mechanisms of targeting cancer stem cells, including targeting surface markers, inducing apoptosis, and modulating signaling pathways like mTOR, SHH, and WNT/β-catenin. Radiation therapy is also described as damaging cancer cell DNA to kill cells or slow growth. The conclusion emphasizes that identifying therapies targeting cancer stem cells could help prevent cancer recurrence when combined with standard chemotherapy.
Dissertation topics on cellular basics of cancer and therapeutics - PubricaPubrica
• Researching cancer and its therapeutics is an important tool for cancer studies and medical writing services.
• The important topics to be covered while writing a thesis for cancer and its therapeutics are discussed in scientific medical writing.
• Pubrica is here to help with the easy scientific medical writingabout cancer research and its therapeutics.
Full Information: https://bit.ly/3llZgmV
Reference: https://pubrica.com/services/physician-writing-services/
Why Pubrica?
When you order our services, we promise you the following – Plagiarism free, always on Time, outstanding customer support, written to Standard, Unlimited Revisions support and High-quality Subject Matter Experts.
Contact us :
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44- 74248 10299
Intracellular Events in Antigen Processing.pptxDr.Kanury Rao
Intracellular signaling or events are caused on the surfaces of the cells. Dr. Kanury Rao, the greatest immunologist of all time, has conducted an in-depth analysis of intracellular events to develop a tool for early detection of cancer.
Tumour markers can play a crucial role in detecting cancer and assessing response to therapy. They are substances produced either by tumour cells or by the body in response to cancer. Oncoproteins are proteins encoded by oncogenes which normally maintain a fine balance between cell proliferation and differentiation but become permanently activated in cancer, stimulating cell growth. Elevated levels of various oncoproteins and other tumour markers can be detected in blood and other body fluids, serving as biomarkers for early cancer detection and prediction of prognosis. Common tumour markers discussed include AFP, CEA, CA19-9, CA15-3, CA125, and proteins associated with growth factors, receptors, and cellular signalling pathways.
The document provides information about oncology nursing including objectives, cancer pathophysiology, risk factors, prevention, screening, detection methods, grading and staging of cancer, common cancer types, and nursing interventions. Key points include identifying risk factors from a patient's history, formulating nursing diagnoses, utilizing interventions to maintain health, providing spiritual care, and displaying caring behavior in the delivery of cancer nursing care.
National Foundation for Cancer Research Progress Report 2013Lance Cassell
From day one, NFCR has stood apart from larger cancer charities and government science funding institutions because we support the cutting edge research that those other groups can't and won't fund. NFCR is dedicated to supporting "high risk/high reward" cancer research and public education relating to prevention, early diagnosis, better treatments and, ultimately, a cure for cancer.
With the help of 4.5 million individual donors over the last 40 years, NFCR has delivered more than $320 million in funding to cancer research leading to numerous breakthroughs, including prevention strategies, earlier diagnostic techniques, and new anticancer drugs and therapies.
Cancer Stem Cells (CSCs) have become a vital target for biologists and researchers.
The following presentation focuses on the treatment of cancer through targeting CSCs and its advantages.
UCLA CTSI Director, Steven Dubinett, MD, participated in the 11th Annual American Association for Cancer Research (AACR) Frontiers in Cancer Prevention Research International Conference and discussed the advantages of the CTSI during his educational session on “The Clinical and Translational Science Award Program: Transdisciplinary Teams in Cancer Prevention Research” on Tuesday, October 16th.
Cancer arises due to genetic aberrations that accumulate in somatic cells and alter gene expression. There are several types of genomic changes including mutations, chromosome defects, and changes to oncogenes and tumor suppressor genes. Genetic testing can identify inherited cancer risk genes and guide diagnosis and treatment, while gene therapy holds promise for directly treating cancer at the genetic level.
This document reviews tumor markers that can aid in the diagnosis and assessment of oral cancer. It discusses how tumor markers are substances produced by tumors or the body in response to cancer. Several markers are described including cytokeratins and desmoplakin that indicate epithelial differentiation, and desmin, actin, and myoglobin that serve as mesenchymal markers. It also reviews proliferation markers like AgNORs and p53 mutations. The implications are that tumor markers can serve as an important diagnostic tool but cannot be used alone for diagnosis and are best used along with other tests. They may reflect disease extent and progression and help differentiate cancer types.
Dan Dixon and Nancy Roach present Cancer Biology - understanding the basics. This webinar was presented to our RATS team in order to get better understanding of cell biology, research language and getting comfortable with the jargon.
The document summarizes the state of cancer research in 2010 according to the Campbell Family Cancer Research Institute. Key points include:
- Significant advances have been made in understanding the genetic and epigenetic basis of cancer and tumor behavior. However, cures require strategies to destroy both bulk tumor cells and tumor-initiating cells.
- The immune system plays an important role in preventing tumors, but tumors evade immunity; immunotherapies aim to reactivate anti-tumor immune responses.
- Early detection through improved imaging techniques can increase cure rates for cancers caught at smaller sizes.
The document discusses the hallmarks of cancer as proposed by Hanahan and Weinberg. It identifies the eight hallmarks as sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, deregulating cellular energetics, and avoiding immune destruction. It also discusses two enabling characteristics - genome instability and mutation, and tumor-promoting inflammation. Finally, it summarizes how several of these hallmarks, including sustaining proliferative signaling, activating invasion and metastasis, resisting cell death, and genome instability and mutation have been identified in breast cancer and contribute to its heterogeneity and treatment resistance.
This document summarizes a presentation on using social media tools and metrics to raise awareness of clinical trials and recruit participants. It discusses engaging audiences on social platforms by using interesting, relevant, and motivating messages. The presentation also describes focus groups that identified effective messaging around clinical trials, including normalizing them, emphasizing options and hope, and presenting action steps. Additionally, it summarizes a case study partnering with organizations to increase African Americans' awareness of and participation in a multiple myeloma clinical trial through targeted social media outreach.
4th International Conference on Biomarkers & Clinical Research, will be organized around the theme "Impact of Biomarker Developments in Health Diagnostics and Clinical Research."
Neoplasia refers to abnormal growths or tumors. Cancer is a genetic disease caused by DNA mutations that cause uncontrolled cell growth. Tumors can be benign or malignant, with malignant tumors able to spread to other parts of the body and be life-threatening. The development of cancer is influenced by oncogenes, tumor suppressor genes, DNA changes, infiltration of surrounding tissue, metastasis, and failure of immune surveillance mechanisms. A variety of environmental and viral agents can also cause cancer by inducing DNA mutations.
This document discusses biochemistry of carcinogens and cancer. It begins with definitions of cancer and carcinogens. It then compares the characteristics of normal cells versus cancer cells. Cancer cells do not die, stop reproducing, or specialize like normal cells. Statistics on common cancers in the US and Saudi Arabia are provided. Tumors are abnormal cell growths that can be benign or malignant. Malignant tumors are cancerous. The document discusses topics like anaplasia, tumorigenesis, cell differentiation, and apoptosis in relation to cancer development.
This document discusses biochemistry of carcinogens and cancer. It begins with definitions of cancer and carcinogens. It then covers topics such as normal vs cancer cells, common cancers in the US and their rates, cancer rates in Saudi Arabia and worldwide. It also discusses tumors, tumor markers, anaplasia, apoptosis, cell differentiation, tumorigenesis and occupational cancers. In summary, it provides an overview of cancer at the biochemical level, including causes, characteristics of cancer cells, common cancer types and rates, and occupational factors that can contribute to cancer development.
Dino Masic traveled to Cincinnati Children's Hospital from March to September 2014 to collaborate on developing a disease model for IGH-CEBPD B-cell precursor acute lymphoblastic leukemia. The project aims to recreate the genetic insults that initiate leukemia by transducing cord blood with a retroviral vector containing the IGH-CEBPD fusion partner. This mimics the patient phenotype and may help answer questions about cell lineage commitment. While there, Masic learned new techniques for developing disease models, including transducing cord blood and engrafting cells in animals. He is now integrating these techniques into his research group in Newcastle to further investigate the developmental mechanisms behind this leukemia subtype.
Global cancer stem cell therapy market outlook 2020KuicK Research
“Global Cancer Stem Cell Therapy Market Outlook 2020” Report Highlight:
Introduction & Classification of Stem Cells
Stem Cell Transplants Classification
Cancer Stem Cell Therapy Mechanism of Action
Global Cancer Stem Cell Market Analysis
Global Cancer Stem Cell Clinical Pipeline by Company & Phase
Global Cancer Stem Cell Clinical Pipeline: 32 Therapies
Global Cancer Stem Cell Market Dynamics: Challenges & Favorable Parameters
Global Cancer Stem Cell Market Future Outlook
Daniel Catchpoole describes institutional experience with Biobanking in Australia.
This talk was sponsored by the NIH Data Science Special Interest Group and part of a webinar panel on June 23, 2017 on Global Biobanking and Access to Specimens.
ROJoson PEP Talk: Cancer Awareness & Myths on Treatment Reynaldo Joson
There are several common myths about cancer treatment and prognosis. Some myths include that cancer is a modern disease, that cancer is always a death sentence, and that there is no effective treatment or cure for cancer. In reality, cancer has been known for thousands of years, while early detection and treatment can lead to remission and even cure for some cancer patients. The likelihood of recurrence depends on factors like cancer type and stage of detection and treatment. Finding a cure is challenging due to the complexity of cancer biology.
The document provides information about oncology nursing including objectives, cancer pathophysiology, risk factors, prevention, screening, detection methods, grading and staging of cancer, common cancer types, and nursing interventions. Key points include identifying risk factors from a patient's history, formulating nursing diagnoses, utilizing interventions to maintain health, providing spiritual care, and displaying caring behavior in the delivery of cancer nursing care.
National Foundation for Cancer Research Progress Report 2013Lance Cassell
From day one, NFCR has stood apart from larger cancer charities and government science funding institutions because we support the cutting edge research that those other groups can't and won't fund. NFCR is dedicated to supporting "high risk/high reward" cancer research and public education relating to prevention, early diagnosis, better treatments and, ultimately, a cure for cancer.
With the help of 4.5 million individual donors over the last 40 years, NFCR has delivered more than $320 million in funding to cancer research leading to numerous breakthroughs, including prevention strategies, earlier diagnostic techniques, and new anticancer drugs and therapies.
Cancer Stem Cells (CSCs) have become a vital target for biologists and researchers.
The following presentation focuses on the treatment of cancer through targeting CSCs and its advantages.
UCLA CTSI Director, Steven Dubinett, MD, participated in the 11th Annual American Association for Cancer Research (AACR) Frontiers in Cancer Prevention Research International Conference and discussed the advantages of the CTSI during his educational session on “The Clinical and Translational Science Award Program: Transdisciplinary Teams in Cancer Prevention Research” on Tuesday, October 16th.
Cancer arises due to genetic aberrations that accumulate in somatic cells and alter gene expression. There are several types of genomic changes including mutations, chromosome defects, and changes to oncogenes and tumor suppressor genes. Genetic testing can identify inherited cancer risk genes and guide diagnosis and treatment, while gene therapy holds promise for directly treating cancer at the genetic level.
This document reviews tumor markers that can aid in the diagnosis and assessment of oral cancer. It discusses how tumor markers are substances produced by tumors or the body in response to cancer. Several markers are described including cytokeratins and desmoplakin that indicate epithelial differentiation, and desmin, actin, and myoglobin that serve as mesenchymal markers. It also reviews proliferation markers like AgNORs and p53 mutations. The implications are that tumor markers can serve as an important diagnostic tool but cannot be used alone for diagnosis and are best used along with other tests. They may reflect disease extent and progression and help differentiate cancer types.
Dan Dixon and Nancy Roach present Cancer Biology - understanding the basics. This webinar was presented to our RATS team in order to get better understanding of cell biology, research language and getting comfortable with the jargon.
The document summarizes the state of cancer research in 2010 according to the Campbell Family Cancer Research Institute. Key points include:
- Significant advances have been made in understanding the genetic and epigenetic basis of cancer and tumor behavior. However, cures require strategies to destroy both bulk tumor cells and tumor-initiating cells.
- The immune system plays an important role in preventing tumors, but tumors evade immunity; immunotherapies aim to reactivate anti-tumor immune responses.
- Early detection through improved imaging techniques can increase cure rates for cancers caught at smaller sizes.
The document discusses the hallmarks of cancer as proposed by Hanahan and Weinberg. It identifies the eight hallmarks as sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, deregulating cellular energetics, and avoiding immune destruction. It also discusses two enabling characteristics - genome instability and mutation, and tumor-promoting inflammation. Finally, it summarizes how several of these hallmarks, including sustaining proliferative signaling, activating invasion and metastasis, resisting cell death, and genome instability and mutation have been identified in breast cancer and contribute to its heterogeneity and treatment resistance.
This document summarizes a presentation on using social media tools and metrics to raise awareness of clinical trials and recruit participants. It discusses engaging audiences on social platforms by using interesting, relevant, and motivating messages. The presentation also describes focus groups that identified effective messaging around clinical trials, including normalizing them, emphasizing options and hope, and presenting action steps. Additionally, it summarizes a case study partnering with organizations to increase African Americans' awareness of and participation in a multiple myeloma clinical trial through targeted social media outreach.
4th International Conference on Biomarkers & Clinical Research, will be organized around the theme "Impact of Biomarker Developments in Health Diagnostics and Clinical Research."
Neoplasia refers to abnormal growths or tumors. Cancer is a genetic disease caused by DNA mutations that cause uncontrolled cell growth. Tumors can be benign or malignant, with malignant tumors able to spread to other parts of the body and be life-threatening. The development of cancer is influenced by oncogenes, tumor suppressor genes, DNA changes, infiltration of surrounding tissue, metastasis, and failure of immune surveillance mechanisms. A variety of environmental and viral agents can also cause cancer by inducing DNA mutations.
This document discusses biochemistry of carcinogens and cancer. It begins with definitions of cancer and carcinogens. It then compares the characteristics of normal cells versus cancer cells. Cancer cells do not die, stop reproducing, or specialize like normal cells. Statistics on common cancers in the US and Saudi Arabia are provided. Tumors are abnormal cell growths that can be benign or malignant. Malignant tumors are cancerous. The document discusses topics like anaplasia, tumorigenesis, cell differentiation, and apoptosis in relation to cancer development.
This document discusses biochemistry of carcinogens and cancer. It begins with definitions of cancer and carcinogens. It then covers topics such as normal vs cancer cells, common cancers in the US and their rates, cancer rates in Saudi Arabia and worldwide. It also discusses tumors, tumor markers, anaplasia, apoptosis, cell differentiation, tumorigenesis and occupational cancers. In summary, it provides an overview of cancer at the biochemical level, including causes, characteristics of cancer cells, common cancer types and rates, and occupational factors that can contribute to cancer development.
Dino Masic traveled to Cincinnati Children's Hospital from March to September 2014 to collaborate on developing a disease model for IGH-CEBPD B-cell precursor acute lymphoblastic leukemia. The project aims to recreate the genetic insults that initiate leukemia by transducing cord blood with a retroviral vector containing the IGH-CEBPD fusion partner. This mimics the patient phenotype and may help answer questions about cell lineage commitment. While there, Masic learned new techniques for developing disease models, including transducing cord blood and engrafting cells in animals. He is now integrating these techniques into his research group in Newcastle to further investigate the developmental mechanisms behind this leukemia subtype.
Global cancer stem cell therapy market outlook 2020KuicK Research
“Global Cancer Stem Cell Therapy Market Outlook 2020” Report Highlight:
Introduction & Classification of Stem Cells
Stem Cell Transplants Classification
Cancer Stem Cell Therapy Mechanism of Action
Global Cancer Stem Cell Market Analysis
Global Cancer Stem Cell Clinical Pipeline by Company & Phase
Global Cancer Stem Cell Clinical Pipeline: 32 Therapies
Global Cancer Stem Cell Market Dynamics: Challenges & Favorable Parameters
Global Cancer Stem Cell Market Future Outlook
Daniel Catchpoole describes institutional experience with Biobanking in Australia.
This talk was sponsored by the NIH Data Science Special Interest Group and part of a webinar panel on June 23, 2017 on Global Biobanking and Access to Specimens.
ROJoson PEP Talk: Cancer Awareness & Myths on Treatment Reynaldo Joson
There are several common myths about cancer treatment and prognosis. Some myths include that cancer is a modern disease, that cancer is always a death sentence, and that there is no effective treatment or cure for cancer. In reality, cancer has been known for thousands of years, while early detection and treatment can lead to remission and even cure for some cancer patients. The likelihood of recurrence depends on factors like cancer type and stage of detection and treatment. Finding a cure is challenging due to the complexity of cancer biology.
ROJoson PEP Talk: Cancer Awareness & Myths on Treatment
Gil 2012 Stem Cell Cocktail
1. Providing the Cure
GIL 2012: RUSSIA
The Global Community of Growth, Innovation and Leadership
A Novel Therapy for the Treatment of
Leukemia and Cancer
“The Stem-Cell Cocktail”
Steve Shor Brian Denker
Founder & Executive Director Vice President & Global Head
NCLF Cancer Research Center Growth, Innovation and Leadership
Frost & Sullivan
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
2. Providing the Cure
Why is cancer so challenging?
Cancer is dynamic & adaptive.
Cancer is strong & resilient.
Cancer is complex & innovative.
Cancer is opportunistic.
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
3. Providing the Cure
The Typical Question: The BIG Question…
In what ways does the The NCLF Question
typical cancer cell differ
• What are the mechanisms that
from the normal cell?
foster growth in cancer cells?
• Are there multiple pathways of
growth?
• How does the cancer cell
harness the energy of the human
body to facilitate growth?
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
4. Providing the Cure
NCLF Bio Medical Research Center
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
5. Cancer/Leukemia cells Providing the Cure
The Stem Cell & Cancer
Interaction Paradigm
Molecular pathways analysis
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te
Adult Stem Cells
6. Providing the Cure
Unleashing the Potential of Stem Cells
in Cancer Therapy
Cancer -Stem cell Interaction Paradigm
Identify target molecular pathways
regulating cancer cell growth & development
Design of interventions using
multiple target molecular pathways
Addressing the complexity of
cancer development and diversity
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
7. Providing the Cure
Combination Therapy Approach
Pathway
#1
Pathway
#3
Pathway #2
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
8. Providing the Cure
Stem Cells
• Multiple Pathways
Compound
#2
• Multiple Targets
• Multiple Compounds
Compound
#3
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
9. Providing the Cure
Growth Inhibition of Leukemia Cells using
“Stem Cell Cocktail” Therapy
Growth inhibition of Leukemia cells after 72h of culture
Viable cell number (OD)
1.8
1.75
1.7
(in vitro results)
1.65
1.6
1.55
1.5
1.45
1.4
1.35
1.3
A
B
C
)
l
ro
+C
d
d
d
nt
un
un
un
+B
Co
po
po
po
(A
m
m
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Co
Co
Co
ai
kt
oc
"C
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
10. Providing the Cure
“Stem Cell Cocktail”
A Therapy to Treat Cancer
(in vivo results)
Survival of Leukemia harboring animals treated with Adult stem cells
1.1
1.0 control
0.9 SC treated
Fraction survival
0.8
0.7 P<0.0001
0.6
0.5
0.4
0.3
0.2
0.1
0.0
0 10 20 30 40 50 60 70
In S t rate gi c P art n e rs h i p wi th :
Days
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
11. Providing the Cure
A Cure IS POSSIBLE in our Generation
National Children’s Leukemia Foundation
Use of Mesenchymal Stem Cells
for the Treatment of Leukemia
United States Provisional Patent Application #61/564,317
November 29, 2011
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
12. Providing the Cure
Trajectory of Progress
Clinical Trials
Pre-Clinical Trials
*Testing Additional Combinations
*Creating additional “Cocktails”
*Expanding the paradigm to
other cancer types.
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
13. Providing the Cure
The Cure IS Within Our Reach
• Explore these advancements in cancer
research further, be apart of it.
• Determine how you too can help
NCLF to contribute to these
advancements.
• Make a Difference – Find your
visionary innovation, support each
other, members of the GIL
Community and it’s global partners
contributing and changing the world.
In S t rate gi c P art n e rs h i p wi th :
F ro s t & S u lli v an In s ti tu te www.leukemiafoundation.org
14. GIL 2012: Beyond the Journey to Visionary Innovation
Next Steps
Share, Engage and Inspire 24x365 Schedule a one-on-one Develop Your Visionary and Innovative Skills
via the online GIL Community Growth Strategic Dialogue Growth Partnership Service
Leverage the GTL in your monthly Envision Your Future and Succeed Get Your Entire Team Innovating to Zero
GIL Community Newsletter (GCN) with Growth Workshops with an on-site Mega Trends Workshop