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Genomics & Precision Medicine
Pelatihan Genomic Researcher
IMERI FK UI
Dr. Muhammad Taufiq Rahman
GENOMIC & PRECISION MEDICINE
• PENGGUNAAN PROFIL GENETIK UNTUK MEMANDU KEPUTUSAN
DALAM TATALAKSANA, PREVENSI,DIAGNOSIS DAN TERAPI PENYAKIT
ONE TREATMENT
FITS ALL
ERA LAMA
PERSONALIZED
MEDICINE
ERA BARU
Precision Medicine
genomic
personalized
precision
GENOM
• KESELURUHAN INFORMASI GENETIK DI DALAM TUBUH (THE BOOK OF
LIFE)
• INTI SEL  MATERI GENETIK  KROMOSOM (46)
• KROSOM  GULUNGAN RANTAI PANJANG DNA
• DI DALAM DNA TSB  BERISI INSTRUKSI UNTUK MEMBUAT PROTEIN
GENOMIC TEST
PREDIKSI
RESIKO
DIAGNOSIS
RESPON
PENGOBATAN
APA YANG MEMBUAT KITA BERBEDA
99,9 % DNA MANUSIA
SAMA
0,1 %
WARNA RAMBUT,
WARNA KULIT DSB
KETIKA DNA DISALIN  KETURUNAN
BERIKUTNYA  NUKLEOTIDA DAPAT BERTAMBAH
MAUPUN HILANG  PERBEDAAN
FARMAKOGENOMIK
• PENGGUNAAN PROFIL GENETIK SESEORANG DALAM
MEMETABOLISME OBAT
FARMAKOGENOMIK
• MEMILIH KOMBINASI OBAT YANG TEPAT
• MENCEGAH TERJADINYA RESISTENSI OBAT
• BIG DATA
FARMAKOGENETIK
• CYP2C9  METABOLISME SIMVASTATIN
• BEBERAPA PERLU PENYESUAIAN DOSIS
• CYP2D6  METABOLISME TAMOXIFEN
ALEXIS DAN NOAH BEERY, MISDIAGNOSED CEREBRAL PALSY SELAMA 14 TAHUN, PADA TAHUN 2010 ORANG
TUA MEREKA MELAKUKAN GENETIC SEQUENCING  DRD (DOPA- RESPONSIVE DYSTONIA  DIOBATI DENGAN
L DOPA  SEMBUH
FASILITAS LAB GENOMIC IMERI UI
Lab karyotyping
FASILITAS LAB GENOMIC IMERI UI
LAB PCR
LAB IMUNOLOGY & INFECTIOUS DISEASE
LAB GENOMIC SEQUENCE
PRODUCT RISET UI
PENGEMBANGAN PCR PORTABLE UNTUK
RISET GENOMIC
GELATO ELECTROPHORESIS. TIDAK
MENGGUNAKAN ETHIDIUM BROMIDE, DAN
MENGGUNAKAN TEKNOLOGI BLUE LIGHT
HARGA 50 JT
MASUKAN UNTUK INSTITUSI
• BAHWA RESEARCH GENOMIC MELIBATKAN BANYAK DISIPLIN ILMU,
KEDOKTERAN BERSAMA DENGAN PRODI ATLM, FARMASI DAN GIZI
AKAN AKTIF BERKOLABORASI  PRODUCT
NUTRIGENOMICS
PHARMACOGENOMICS
PENTINGNYA MENGAPLIKASIKAN ARTIFICIAL INTELEGENCE DALAM
PROSES PEMBELAJARAN
3 PILAR PENGEMBANGAN KEDOKTERAN
UNIVERSITY BASED
HOSPITALITY
BASED
RESEARCH
CENTER

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GENOMIC & PRECISION MEDICINE (1).pptx