Genetic Profiling is the basis for Personalised Medicine. The world is moving towards precision medicine, India is slowly warming up to the concept.

1. A comprehensive health
analysis for longer and
healthier life
By K&H personalized Medicine

2. FOUNDERS
Dr. Kalyan Uppaluri MD
FACP
MD in Internal Medicine, USA
Professional Degree in Medical
Genomics,
Stanford University
Cancer research at Wayne State
University
Associate Professor, Internal
Medicine
Campbell University
Dr. Hima Challa MD FACP
MD in Internal Medicine, USA
Professional Degree in Medical
Genomics,
Harvard Medical School
Masters in Nutrition
science,
Texas Women University
Founding member of
Pharmacogenomics Research Network
Program Director, Internal Medicine
residency program, Campbell University
2

3. PERSONALIZED MEDICINE-
FUTURE IS HERE
Related terms- Integrative Medicine, Precision Medicine

4. Why Personalized Medicine?
• Current medical guidelines group all individuals with
similar diseases into one category and dictate the exact
same management for every individual.
• Result? Treatment failures.
• Initial response to medical management only, is as low
as 50% for most chronic conditions.

5. The traditional approach
Current medical practices group all individuals with similar
diseases into one category
Dictate the exact same management for every individual
4
Result?
Treatment
failures
Multiple testing
regimens
Powerful
medications
Invasive
treatment
Effectiveness of drugs
Hypertension Drugs
ACE Inhibitors 10-30
%
Heart Failure Drugs
Beta Blockers 15-25
%
Anti Depressants 20-50
%
Cholesterol Drugs
Statins 30-70
%
Asthma Drugs
Beta-2-agonists 40-70
%
6.7% of patients in hospitals experience
serious drug reactions

6. “One size fits all”
Approach is clearly not working

7. RESULT
Emergence of multiple diets like Atkins, Paleo, ketosis diet,
hcg weight loss designed by less qualified individuals.
Focusing on a single nutritional culprit as a solution.
Serious medical complications arising from the above.

8. THE FUTURE…

9. 4 P’s of Medicine
• Personalized
• Predictive
• Preventative
• Participatory

10. •Major organizations across the globe, including
American Heart Association, American College of
Physicians are embracing personalized and
integrative care as a major approach in patient care.
•AHA in November 2013 advised an integrative
approach which combines---Fitness, Mental health
and Diet.

11. 6
Genomics in
Personalized
Medicine
What is Genomics? Human
Genome Project
Genome Wide
Association Studies
(GWAS)

12. Genomics in
Personalized
Medicine
Everyone has
unique genes
GENES PLAY AN IMPORTANT ROLE
Your predisposition
to diseases
How you react to various
foods and medicines
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Personalized medicine uses your genetic information,
along with other factors such as your environment and
history, in order to make more precise, personalized,
and safer medical choices.

13. Scope of Genomics- Helps in Longevity
Genetics can be used along with medical information in the following
areas-
 Heart disease risk
 Know your medications
 Diabetes , high BP, Thyroid, Obesity Risk and management
 Nutrition
 Fitness

14. • Comprehensive Genomic Analysis.
• Nutrition and Fitness Genomics.
• Metabolic Genomic Analysis- Includes Hormonal
health, Gut health, Obesity risk and management,
Thyroid management, Musculoskeletal Health.

15. Increase your Longevity and Healthy Years
of Life
A comprehensive program that combines the power of DNA sequencing
data to your health plan to provide accurate plan designed for you.
• This is an advanced genomic clinical interpretation technology. It looks at
over 20,000 genes unique to you and provides health insights.
• It uses the latest DNA sequencing technology to help you prevent cancer,
heart diseases, diabetes, obesity and other lifestyle disorders.
• Based on your unique gene information and blood tests, it provides the
risk of certain diseases you carry and gives a clear plan on how to prevent
them.

16. BENEFITS
• Provides chances of diseases, complications and
Management plans, based on your genes for-
Diabetes, High BP, Heart disease, Parkinson’s
disease, Gastro conditions, kidney disorders.
Also provides, detailed plans on how to avoid
them.
• Pharmacogenomics- Provides an exhaustive list
of all the medications which are FDA approved,
you will respond well to and have low chances
of side effects. Covers medications for the
conditions listed above.

17. NUTRITION AND FITNESS
• Includes Carbohydrate metabolism, Lipid metabolism,
Proteins, Vitamins and Minerals Metabolism.
• What kind of foods will suit you. Eating according to genes.
• If keto diets and fasting is good for your body.
• Diet plans to maintain optimum health.
• Know the right amount and type of workout to suit your
body.

18. • Analysis and reporting of over 40 blood biomarkers including testing
for anaemia and iron status, liver and kidney function, insulin and
glucose markers, cholesterol panel with particle size, inflammatory
markers, hormones, certain vitamin nutrient levels.
• Imaging studies if needed.

19. How is it done?
• Initial consultation by a doctor to go over your current conditions, physical
exam and blood work.
• 10 ml blood draw, for your labs and DNA to be extracted and analyzed.
• Final output- Your current health profile along with your lifestyle habits, and
your gene analysis is put together, to give a complete report and detailed
health plan.

20. Flow chart of the process
DNA Quality &
Quantity
Nanodrop & QUBIT
DNA fragments
Quantity &
Quantity –
Bioanalyzer/ Tape
station
• Data Trimming
• Alignment of
Reads to
Reference
Genome
• QC Post
Alignment
• File
Conversions
• Duplicate
Markup File
• Variant
Detections
• Validations
Data Cleaning,
Demultiplexing
Raw Data
Annotation of
detected genetic
variants
Report Generation
FDA Approved
pharmacogenomic
analysis

21. Suit#2B Plot No.240,Nirvana, Road
No. 36, Jawahar Nagar, Jubilee Hills,
Hyderabad, Telangana 500033, India
+91 950-222-2300
info@khdreamlife.com
https://genepowerx.com/