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Frailty and Its Impact on
Treatment Outcomes
ROHAN PHILIP (FY1)
Introduction
What is Frailty?
 Physiological reserve to withstand and survive acute ‘stressor events’
 Manifestations of frailty/frailty syndromes:
 Falls
 Immobility
 Delirium
 Incontinence
 Susceptibility to medications
Why Is it Important?
 Proportion of frail people are increasing (1)
NICE Guidelines in COVID-19(1)
Clinical Frailty Score (CFS)
Does Frailty Affect Treatment
Outcomes
 Frailty could be helpful in predicting short-term adverse outcomes in
patients admitted with COVID-19 (3)
 In this study, odds for 7-day mortality increased, by CFS group in
observational data from the UK (3)
 Frailty in critical care is associated with increased mortality and higher
likelihood of discharge to another institution (4)
Limitations and Caveats (1)
 Pre-COVID, those with frailty (by CFS standards) were frequently offered
critical care treatments
 Canadian Metanalysis: 30%(4)
 Retrospective ANZ Study – 39.7(5)
 Good Outcomes?: (5)
 88% survived to hospital discharge
 55% were discharged to their own homes and a further
 24% were discharged to a rehabilitation facility
Limitations and Caveats (2)
 Significant Limitation: incongruence between assessors(6)
Is It Appropriate to Ration Care Based
on Frailty?
 Frailty is distributed across socioeconomic gradients(7)
 Environmental factors and social determinants shape health in old age
Conclusion
 If used appropriately, the use of CFS will contribute to shared decision-
making based on the likelihood of short-term survival
 One major limitation of the CFS, as applied in the current NICE guideline,
is that it has the potential to reinforce established patterns of inequality
 More informative and less discriminatory than chronological age alone
Suggestions for Future Projects
 Potential audit of compliance in Nervecentre Rockwood Score entries/TEP
form completion
References
1. COVID-19 rapid guideline: Managing COVID-19 - The National Institute for Health and Care
Excellence (NICE)
2. Rockwood K, Song X, MacKnight C et al. ‘A global clinical measure of fitness and frailty in elderly
people’ CMAJ 2005 (173) pg: 489-95
3. Hewitt J, Carter B, Vilches-Moraga A et al. ‘The effect of frailty on survival in patients with COVID-
19 (COPE): a multicentre, European, observational cohort study Lancet Public Health 2020; 1–8
4. Muscedere, J., Waters, B., Varambally, A., Bagshaw, S.M., Boyd, J.G., Maslove, D., Sibley, S. and
Rockwood, K., 2017. The impact of frailty on intensive care unit outcomes: a systematic review and
meta-analysis. Intensive care medicine, 43(8), pp.1105-1122.
5. Darvall, J.N., Bellomo, R., Paul, E., Subramaniam, A., Santamaria, J.D., Bagshaw, S.M., Rai, S., Hubbard,
R.E. and Pilcher, D., 2019. Frailty in very old critically ill patients in Australia and New Zealand: a
population‐based cohort study. Medical Journal of Australia, 211(7), pp.318-323.
6. Pugh, R.J., Battle, C.E., Thorpe, C., Lynch, C., Williams, J.P., Campbell, A., Subbe, C.P., Whitaker, R.,
Szakmany, T., Clegg, A.P. and Lone, N.I., 2019. Reliability of frailty assessment in the critically ill: a
multicentre prospective observational study. Anaesthesia, 74(6), pp.758-764.
7. Lang, I.A., Hubbard, R.E., Andrew, M.K., Llewellyn, D.J., Melzer, D. and Rockwood, K., 2009.
Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. Journal of
the American Geriatrics Society, 57(10), pp.1776-1780.

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Frailty Presentation.pptx

  • 1. Frailty and Its Impact on Treatment Outcomes ROHAN PHILIP (FY1)
  • 3. What is Frailty?  Physiological reserve to withstand and survive acute ‘stressor events’  Manifestations of frailty/frailty syndromes:  Falls  Immobility  Delirium  Incontinence  Susceptibility to medications
  • 4. Why Is it Important?  Proportion of frail people are increasing (1)
  • 5. NICE Guidelines in COVID-19(1)
  • 7. Does Frailty Affect Treatment Outcomes  Frailty could be helpful in predicting short-term adverse outcomes in patients admitted with COVID-19 (3)  In this study, odds for 7-day mortality increased, by CFS group in observational data from the UK (3)  Frailty in critical care is associated with increased mortality and higher likelihood of discharge to another institution (4)
  • 8. Limitations and Caveats (1)  Pre-COVID, those with frailty (by CFS standards) were frequently offered critical care treatments  Canadian Metanalysis: 30%(4)  Retrospective ANZ Study – 39.7(5)  Good Outcomes?: (5)  88% survived to hospital discharge  55% were discharged to their own homes and a further  24% were discharged to a rehabilitation facility
  • 9. Limitations and Caveats (2)  Significant Limitation: incongruence between assessors(6)
  • 10. Is It Appropriate to Ration Care Based on Frailty?  Frailty is distributed across socioeconomic gradients(7)  Environmental factors and social determinants shape health in old age
  • 11. Conclusion  If used appropriately, the use of CFS will contribute to shared decision- making based on the likelihood of short-term survival  One major limitation of the CFS, as applied in the current NICE guideline, is that it has the potential to reinforce established patterns of inequality  More informative and less discriminatory than chronological age alone
  • 12. Suggestions for Future Projects  Potential audit of compliance in Nervecentre Rockwood Score entries/TEP form completion
  • 13. References 1. COVID-19 rapid guideline: Managing COVID-19 - The National Institute for Health and Care Excellence (NICE) 2. Rockwood K, Song X, MacKnight C et al. ‘A global clinical measure of fitness and frailty in elderly people’ CMAJ 2005 (173) pg: 489-95 3. Hewitt J, Carter B, Vilches-Moraga A et al. ‘The effect of frailty on survival in patients with COVID- 19 (COPE): a multicentre, European, observational cohort study Lancet Public Health 2020; 1–8 4. Muscedere, J., Waters, B., Varambally, A., Bagshaw, S.M., Boyd, J.G., Maslove, D., Sibley, S. and Rockwood, K., 2017. The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis. Intensive care medicine, 43(8), pp.1105-1122. 5. Darvall, J.N., Bellomo, R., Paul, E., Subramaniam, A., Santamaria, J.D., Bagshaw, S.M., Rai, S., Hubbard, R.E. and Pilcher, D., 2019. Frailty in very old critically ill patients in Australia and New Zealand: a population‐based cohort study. Medical Journal of Australia, 211(7), pp.318-323. 6. Pugh, R.J., Battle, C.E., Thorpe, C., Lynch, C., Williams, J.P., Campbell, A., Subbe, C.P., Whitaker, R., Szakmany, T., Clegg, A.P. and Lone, N.I., 2019. Reliability of frailty assessment in the critically ill: a multicentre prospective observational study. Anaesthesia, 74(6), pp.758-764. 7. Lang, I.A., Hubbard, R.E., Andrew, M.K., Llewellyn, D.J., Melzer, D. and Rockwood, K., 2009. Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. Journal of the American Geriatrics Society, 57(10), pp.1776-1780.