Formula N = n1= n2 = (Zα/2+ zβ)2 x2σ2
( µ2-µ1 )2
Where Zα/2 = normal distribution value at α/2 level of significance
Zβ = normal distribution value at (1- β )power of test
σ2 = population variance of outcome variable under study which can be assumed from the
studies or as( max-min)/6.in case from any previous studies µ2-µ1=MID (minimum
important difference ) is available, the same can be used

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  • 1.
    Formula N =n1= n2 = (Zα/2+ zβ)2 x2σ2 ( µ2-µ1 )2 Where Zα/2 = normal distribution value at α/2 level of significance Zβ = normal distribution value at (1- β )power of test σ2 = population variance of outcome variable under study which can be assumed from the studies or as( max-min)/6.in case from any previous studies µ2-µ1=MID (minimum important difference ) is available, the same can be used