Speaker Presentation from U.S. News Healthcare of Tomorrow leadership summit, November 2-4, 2016 in Washington, DC. Find out more about this forum at www.usnewshot.com.

1. Focus Factories: The Advantages of the
Specialized Approach - City of Hope
Harlan Levine
Chief Execu2ve, City of Hope Medical Founda2on

2. Focus Factory Case Study:
COH Hematopoie?c Cell Transplant (HCT) Program
• Flagship program founded 41 years ago
• Performed more than 13,000 marrow and
blood stem cell transplants
– Second largest HCT program in United States (650/
year)
• Volume and focus lead to:
– Rapid integraLon of phase I clinical trial and novel
therapeuLcs into transplant regimens
– Data-driven, mulL-stakeholder quality program
drives conLnuous process improvement
– Only HCT program in the United States to achieve
survival outcomes above risk-adjusted expected
survival for 11 consecu?ve years

3. CIBMTR Analysis of 1-year Survival for Allogeneic Transplanta<on
1: -1 indicates under-performing; 1 indicates over-performing; 0 indicates performing as predicted.
2: 2012 includes unrelated and related HCTs performed in 2008-2010; 2013 includes unrelated and related HCTs performed 2009-2011;
2014 includes unrelated and related HCTs performed 2010-2012.
In the U.S., only
City of Hope has
performed above
expecta?on for
11 consecu?ve
repor?ng years
• Center for InternaLonal Blood & Marrow Research released data showing hematopoieLc
stem cell transplant survival outcomes (most recent results published 12/15)
• Our rates for one-year survival were among the best
– Predicted one-year survival: 67.7% (95%CI: 64.6-71.0)/Actual one-year survival: 75.2
Performance by Report Year1,2
Center Center Name 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
60 Shands HealthCare & University of Florida 1 0 0 0 0 0 -1 0 0 1 1
61 University of Iowa Hospital & Clinics 0 -1 0 0 0 0 -1 0 0 1 1
63 Johns Hopkins Oncology Center 0 0 0 0 0 1 1 1 0 0
65 Cleveland Clinic 0 0 0 0 0 0 0 0 0 -1 0
68 University of PiVsburgh Medical Center 0 0 0 0 0 -1 0 0 0 0 0
69 University of Wisconsin Hospital & Clinics -1 0 0 1 1 0 0 0 0 0 0
70 Froedert & Medical College of Wisconsin 0 -1 -1 -1 -1 0 0 0 0 1 1
73 Wayne State University Hospital (Karmanos) 0 -1 -1 0 0 0 1 1 1 0 0
74 All Children's Hospital 0 0 0 -1 -1 -1 0 0 0 0 0
76 Children's Hospital of Los Angeles 0 0 0 0 0 0 0 -1 -1 0 0
78 Dana Farber Cancer Ins<tute-Adults 1 0 1 1 1 1 0 0 0 1 1
79 University of California-San Francisco-Pediatrics 0 0 0 0 0 0 1 1 0 0 0
80 Vanderbilt University 0 0 0 0 0 0 0 1 1 1
81 City of Hope Na<onal Medical Center 1 1 1 1 1 1 1 1 1 1 1