Filoviridae are filamentous viruses with single-stranded RNA genomes that cause severe hemorrhagic fevers in humans. There are two main genera: Marburgvirus which includes Marburg virus, and Ebolavirus which includes four species of Ebola virus. Filovirus infections produce diseases like Marburg hemorrhagic fever and Ebola hemorrhagic fever, characterized by uncontrolled bleeding, vomiting, and high mortality rates. Filoviruses are enveloped, sensitive to ether, replicate cytoplasmically, and can cause lethal infections transmitted through contact with bodily fluids.

1. Filoviridae
Filovirus only virus having reservoir host unknown

2. Properties
Pleomorphic, long filamentus, some time
branched form or 6 shape or Circular form
Single stranded RNA (Reo, Birna)
Negative, Non segmented
Enveloped- (Picorna,Calci,Astro,Reo,Birna- NE)
Sensitive to ether
Largest virus of all negative sense virus

3. Helical symmetry (Picorna, Calci, Astro, Reo,
Birna, Togo, Flavi, Retro)
Replication - cytoplasmic, (Borna, Orthromyxo)

4. Classification
1. Marburg like virus
2. Ebola virus
-Zaire
-Sudan
-Cote ivoire
- Reston

5. Marburg & Ebola Haemorrhagic fever
Cause by Filovirus
Produce disease in Human
Petechiae echymoses haemorrhagic pharyngitis
Uncontrolled bleeding from melena
Vomiting
Biosefty leval 4 pathogen

7. Properties
Size 90 nm
Single stranded RNA (Reo, Birna)
Negative, Non segmented
Enveloped- (Picorna,Calci,Astro,Reo,Birna- NE)
Sensitive to ether

8. Helical symmetry (Picorna, Calci, Astro, Reo,
Birna, Togo, Flavi, Retro)
Replication - Nucleus, (Borna, Orthromyxo)

9. Neurological disease of Horse
Borna disease in horse and sheep
Menigoencephalitis
Rodent and wild birda act as reservoir host
Staggering disease
Intra nuclear inclusion bodies in brain