This document summarizes a presentation made by Fibrocell Science at the UBS Global Life Sciences Conference on September 20, 2011. The presentation outlines Fibrocell Science's vision to be a unique autologous cellular therapeutic company focused on aesthetics and dermatology. Specifically, it discusses laViv, an innovative autologous fibroblast technology to treat wrinkles and folds, as well as potential applications for restrictive burn scars, vocal cord scarring, and other indications. The presentation highlights the growing aesthetics market, laViv's patient and physician value propositions, clinical trial results demonstrating improvement in skin quality characteristics, and photos showcasing laViv's effects on nasolabial folds.
Fibrocell Science, Inc. (OTCBB: FCSC) is a cell therapy company focused on the development of a line of autologous tissue regeneration products for aesthetic, medical, and scientific applications. Using Fibrocell Science's patented process, a patient’s own fibroblast cells are harvested using a minimally invasive skin procedure, then processed, multiplied, purified, cryopreserved and re-injected as personalized therapy. Fibroblasts are cells that contribute to the production of collagen essential in the formation of connective tissue fibers. These matrix fibers are critical to the strength and elasticity of the skin.
This paper by Dr. Patrick Treacy Medical Director Ailesbury Clinics Ltd. sought to establish the efficacy and safety profile the dermal filler, calcium hydroxylapatite filler in the treatment of atrophic acne scars. Forty two subjects with differing degrees of atrophic acne scars were treated with this filler over an eighteen month period and the results are published below
The document discusses BioTime, Inc., a biotechnology company leading the regenerative medicine revolution. It summarizes BioTime's expertise in pluripotent stem cells and its focus on advancing two clinical programs - Renevia for facial aesthetics and OpRegen for dry age-related macular degeneration. It outlines upcoming milestones for these programs in 2016-2017, and how BioTime is unlocking value from its ownership stakes in public subsidiaries Asterias and OncoCyte, which are applying BioTime's stem cell technologies to therapies for conditions with high unmet medical need.
Cytori Therapeutics presented at the Lazard Capital Markets 8th Annual Healthcare Conference. They discussed their large pipeline opportunities including EU chronic ischemia approval and US chronic ischemia pilot trial. They also highlighted the near term commercial potential of their soft tissue and translational research, growing in select emerging markets. Cytori has established partnerships that have provided over $100 million in funding and sees potential future licensing opportunities. Their patent protection extends into the mid-2020s.
The document provides an overview of MADARA Cosmetics Group, an organic cosmetics innovator. It summarizes the company's structure, research and development processes, certifications, hero products, and product range. Key points include that MADARA has a diverse product portfolio including face care, baby care, hair care and body care products. It also details the research behind their flagship anti-aging product using birch water extracts and cell repair bio-complex.
The document discusses trends in the anti-aging industry and the launch of Nu Skin's new ageLOC Me product. Key points:
1) The anti-aging market is growing rapidly and is projected to reach $346 billion by 2018 as more people seek to delay signs of aging. Skin care products specifically are also growing significantly.
2) Consumers increasingly want customized, high-tech beauty products and solutions tailored to their individual needs. They also seek expert guidance on products.
3) ageLOC Me is Nu Skin's new personalized skin care system that allows users to mix serums customized for their skin type and needs using a device. It has numerous patents and saw significant research and testing to prove its
1) The Chairman discussed Biocon's focus on developing affordable biopharmaceuticals to make healthcare more accessible globally through five growth verticals.
2) These verticals include small molecules, biosimilars, branded formulations, novel molecules, and integrated research services. Biosimilars and insulin formulations are seen as major growth opportunities.
3) Biocon is augmenting manufacturing, R&D, and marketing capabilities to pursue strong sustainable growth through a new facility in Malaysia and an R&D center in Bangalore. Clinical trials show promise for biosimilar molecules in development.
Fibrocell Science, Inc. (OTCBB: FCSC) is a cell therapy company focused on the development of a line of autologous tissue regeneration products for aesthetic, medical, and scientific applications. Using Fibrocell Science's patented process, a patient’s own fibroblast cells are harvested using a minimally invasive skin procedure, then processed, multiplied, purified, cryopreserved and re-injected as personalized therapy. Fibroblasts are cells that contribute to the production of collagen essential in the formation of connective tissue fibers. These matrix fibers are critical to the strength and elasticity of the skin.
This paper by Dr. Patrick Treacy Medical Director Ailesbury Clinics Ltd. sought to establish the efficacy and safety profile the dermal filler, calcium hydroxylapatite filler in the treatment of atrophic acne scars. Forty two subjects with differing degrees of atrophic acne scars were treated with this filler over an eighteen month period and the results are published below
The document discusses BioTime, Inc., a biotechnology company leading the regenerative medicine revolution. It summarizes BioTime's expertise in pluripotent stem cells and its focus on advancing two clinical programs - Renevia for facial aesthetics and OpRegen for dry age-related macular degeneration. It outlines upcoming milestones for these programs in 2016-2017, and how BioTime is unlocking value from its ownership stakes in public subsidiaries Asterias and OncoCyte, which are applying BioTime's stem cell technologies to therapies for conditions with high unmet medical need.
Cytori Therapeutics presented at the Lazard Capital Markets 8th Annual Healthcare Conference. They discussed their large pipeline opportunities including EU chronic ischemia approval and US chronic ischemia pilot trial. They also highlighted the near term commercial potential of their soft tissue and translational research, growing in select emerging markets. Cytori has established partnerships that have provided over $100 million in funding and sees potential future licensing opportunities. Their patent protection extends into the mid-2020s.
The document provides an overview of MADARA Cosmetics Group, an organic cosmetics innovator. It summarizes the company's structure, research and development processes, certifications, hero products, and product range. Key points include that MADARA has a diverse product portfolio including face care, baby care, hair care and body care products. It also details the research behind their flagship anti-aging product using birch water extracts and cell repair bio-complex.
The document discusses trends in the anti-aging industry and the launch of Nu Skin's new ageLOC Me product. Key points:
1) The anti-aging market is growing rapidly and is projected to reach $346 billion by 2018 as more people seek to delay signs of aging. Skin care products specifically are also growing significantly.
2) Consumers increasingly want customized, high-tech beauty products and solutions tailored to their individual needs. They also seek expert guidance on products.
3) ageLOC Me is Nu Skin's new personalized skin care system that allows users to mix serums customized for their skin type and needs using a device. It has numerous patents and saw significant research and testing to prove its
1) The Chairman discussed Biocon's focus on developing affordable biopharmaceuticals to make healthcare more accessible globally through five growth verticals.
2) These verticals include small molecules, biosimilars, branded formulations, novel molecules, and integrated research services. Biosimilars and insulin formulations are seen as major growth opportunities.
3) Biocon is augmenting manufacturing, R&D, and marketing capabilities to pursue strong sustainable growth through a new facility in Malaysia and an R&D center in Bangalore. Clinical trials show promise for biosimilar molecules in development.
Radiesse and Ellanse are considered biostimulant dermal fillers as they stimulate collagen production in addition to providing immediate volume restoration. Radiesse contains calcium hydroxylapatite microspheres suspended in a gel carrier that provide both immediate correction and induce new collagen formation over time. Ellanse contains polycaprolactone microspheres that degrade slowly and stimulate collagen production. Both fillers have been shown to effectively treat areas such as the cheeks and folds with natural results and high patient satisfaction.
This document outlines several new treatments and technologies for dry eye disease. It discusses increased expenditures on dry eye medications from 2001-2006 driven by Restasis. Six new tools to treat dry eyes are described, including anterior segment OCT, osmolarity testing, LipiFlow, Inflammadry, Ziena eyewear, and intraductal meibomian gland probes. New artificial tear formulations and the use of diquafosol and cyclosporine for dry eyes are also covered.
Vitiligo research foundation-achievements,_present,_future_trends_2017VR Foundation
The document discusses achievements and future trends in vitiligo research by the Vitiligo Research Foundation. It summarizes the Foundation's approach of understanding repigmentation through collecting clinical data and biosamples, open-source data sharing, and disseminating knowledge. It outlines current vitiligo treatments including phototherapy and experimental options. It also discusses the Foundation's work developing an electronic health record, vitiligo biobank, and data analysis to help accelerate drug development for vitiligo. Emerging trends highlighted include increased patient self-treatment options using home phototherapy and nutraceuticals.
This document summarizes a presentation on chronic wound management in primary care. It discusses identifying the etiology of chronic wounds, assessing systemic factors, executing basic treatment including wound bed preparation and dressing selection, providing patient education, and establishing long term management plans. Specific guidance is provided on managing common chronic wound types like diabetic foot ulcers, venous leg ulcers, and pressure injuries. Data on chronic wound cases in one primary care setting is also presented, showing most wounds are chronic and related to diabetes. The full presentation is accessible online for free.
Jeunesse Business Presentation www.bizjaya.comDevan Kumar
2. In BizJaya.com you will find some of the best Network Marketing product review and opportunities to choose from. We do all the due diligence of company legitimacy, product testing and such so you will not have to.
In this presentation, Joseph Campos of Children’s National Medical Center discusses healthcare and laboratory testing using Lean, and the 5 Lean principles that apply to the laboratory. He shares three case studies from his lab: microbiology lab workload and staffing data, microbiology incoming work cell and automated culture plate inoculation. Joe also discusses the difference between and traditional approach to microbiology testing versus a Lean approach.
VIVITÉ® is an advanced skin care system developed with GLX TechnologyTM to help improve the appearance of mild to moderate photodamaged skin in as few as 3 weeks. The VIVITÉ® line includes facial cleansers, serums, eye treatments, and moisturizers. Clinical trials showed VIVITÉ® helped improve fine lines and wrinkles, smoothness, and moisture. VIVITÉ® Vibrance is a natural hydroquinone-free agent that helped improve the appearance of fine lines, roughness, and hyperpigmentation after 8 weeks of treatment in a clinical trial.
This document provides information about a skin care product guide from Skin Specialists. It details a new genetic test called Vita-Genes that tests 16 genetic markers associated with skin aging. The test analyzes genes related to firmness, wrinkling, sun damage, free radicals, and inflammation. It provides customized recommendations based on the test results to help consumers make more informed skin care choices and save money on ineffective products. The genetic test costs $200 and provides personalized product recommendations to address a person's unique genetic risks and skin needs.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
Silospheres™ is the unique silicone base used in our innovative line of creams and lotions. Due to the nature of silicones, numerous aesthetic and efficacy benefits have been revealed in our topical products.
This document discusses dermal fillers for facial rejuvenation. It presents information on EVOLENCE, a collagen-based dermal filler, including its benefits, composition, and safety profile. EVOLENCE uses collagen and Glymatrix technology to provide natural, long-lasting results of at least 12 months. Clinical studies demonstrated its safety, with no reported allergic reactions among over 30,000 injections. Histological examinations on rabbits found EVOLENCE remained intact for 24 months without degradation.
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This document summarizes information about Avenova, a lid and lash cleanser produced by NovaBay Pharmaceuticals. It discusses blepharitis and meibomian gland dysfunction that Avenova treats. Avenova uses Neutrox technology, which contains pure hypochlorous acid that kills bacteria quickly without generating resistance. It is more effective than other lid cleansers and has anti-toxin and anti-biofilm properties. The document provides details on NovaBay as a company and clinical cases that demonstrate the effectiveness of Avenova in treating blepharitis and improving symptoms.
This document summarizes information about Avenova, a lid and lash cleanser produced by NovaBay Pharmaceuticals. It discusses blepharitis and meibomian gland dysfunction that Avenova treats. Avenova uses Neutrox technology, which contains pure hypochlorous acid that kills bacteria quickly without generating resistance. It is more effective than other lid cleansers and has anti-toxin and anti-biofilm properties. The document provides examples of patients whose blepharitis and dry eye symptoms improved after using Avenova.
Radiesse is a synthetic calcium hydroxylapatite dermal filler that received FDA approval in 2006 for the correction of facial wrinkles and folds as well as for correction of facial wasting from HIV-associated lipoatrophy. Clinical studies showed that Radiesse provided immediate correction and lasted longer than other fillers, with effects lasting up to 18 months. Radiesse was shown to be safe and effective for facial wrinkles and lipoatrophy, with patients reporting high levels of satisfaction and improved quality of life for over a year following treatment.
Cytori Therapeutics presented at the Meeting on the Mesa conference on October 29, 2012. The presentation highlighted Cytori's (1) scientific leadership in characterizing adipose-derived regenerative cells, (2) $106 million contract from BARDA to develop cell therapy for thermal burns, and (3) extensive patent portfolio protecting its Celution technology through the mid-2020s.
This document discusses outsourcing bioavailability and bioequivalence studies to contract research organizations (CROs). It defines key terms like bioavailability, bioequivalence, and outlines services commonly outsourced. Choosing a qualified CRO requires assessing their clinical, bioanalytical, pharmacokinetic capabilities and timelines. Proper qualification includes due diligence, and ensuring clinical, bioanalytical, and pharmacokinetic sites meet standards. Outsourcing can provide cost savings and expertise, though it also presents risks like loss of control and quality issues that require careful CRO selection and management.
Radiesse and Ellanse are considered biostimulant dermal fillers as they stimulate collagen production in addition to providing immediate volume restoration. Radiesse contains calcium hydroxylapatite microspheres suspended in a gel carrier that provide both immediate correction and induce new collagen formation over time. Ellanse contains polycaprolactone microspheres that degrade slowly and stimulate collagen production. Both fillers have been shown to effectively treat areas such as the cheeks and folds with natural results and high patient satisfaction.
This document outlines several new treatments and technologies for dry eye disease. It discusses increased expenditures on dry eye medications from 2001-2006 driven by Restasis. Six new tools to treat dry eyes are described, including anterior segment OCT, osmolarity testing, LipiFlow, Inflammadry, Ziena eyewear, and intraductal meibomian gland probes. New artificial tear formulations and the use of diquafosol and cyclosporine for dry eyes are also covered.
Vitiligo research foundation-achievements,_present,_future_trends_2017VR Foundation
The document discusses achievements and future trends in vitiligo research by the Vitiligo Research Foundation. It summarizes the Foundation's approach of understanding repigmentation through collecting clinical data and biosamples, open-source data sharing, and disseminating knowledge. It outlines current vitiligo treatments including phototherapy and experimental options. It also discusses the Foundation's work developing an electronic health record, vitiligo biobank, and data analysis to help accelerate drug development for vitiligo. Emerging trends highlighted include increased patient self-treatment options using home phototherapy and nutraceuticals.
This document summarizes a presentation on chronic wound management in primary care. It discusses identifying the etiology of chronic wounds, assessing systemic factors, executing basic treatment including wound bed preparation and dressing selection, providing patient education, and establishing long term management plans. Specific guidance is provided on managing common chronic wound types like diabetic foot ulcers, venous leg ulcers, and pressure injuries. Data on chronic wound cases in one primary care setting is also presented, showing most wounds are chronic and related to diabetes. The full presentation is accessible online for free.
Jeunesse Business Presentation www.bizjaya.comDevan Kumar
2. In BizJaya.com you will find some of the best Network Marketing product review and opportunities to choose from. We do all the due diligence of company legitimacy, product testing and such so you will not have to.
In this presentation, Joseph Campos of Children’s National Medical Center discusses healthcare and laboratory testing using Lean, and the 5 Lean principles that apply to the laboratory. He shares three case studies from his lab: microbiology lab workload and staffing data, microbiology incoming work cell and automated culture plate inoculation. Joe also discusses the difference between and traditional approach to microbiology testing versus a Lean approach.
VIVITÉ® is an advanced skin care system developed with GLX TechnologyTM to help improve the appearance of mild to moderate photodamaged skin in as few as 3 weeks. The VIVITÉ® line includes facial cleansers, serums, eye treatments, and moisturizers. Clinical trials showed VIVITÉ® helped improve fine lines and wrinkles, smoothness, and moisture. VIVITÉ® Vibrance is a natural hydroquinone-free agent that helped improve the appearance of fine lines, roughness, and hyperpigmentation after 8 weeks of treatment in a clinical trial.
This document provides information about a skin care product guide from Skin Specialists. It details a new genetic test called Vita-Genes that tests 16 genetic markers associated with skin aging. The test analyzes genes related to firmness, wrinkling, sun damage, free radicals, and inflammation. It provides customized recommendations based on the test results to help consumers make more informed skin care choices and save money on ineffective products. The genetic test costs $200 and provides personalized product recommendations to address a person's unique genetic risks and skin needs.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
- Avenova is a new prescription eye drop product containing hypochlorous acid that is being used to treat common eye conditions like blepharitis and dry eye syndrome, especially in elderly patients.
- It is described as a potent and effective new solution by Dr. Arthur Epstein for alleviating inflammation of the eyelids associated with blepharitis and dry eye symptoms.
- Hypochlorous acid is naturally produced by the body to fight microbes and Avenova contains a stabilized form of it that is well-tolerated on the ocular surface.
Silospheres™ is the unique silicone base used in our innovative line of creams and lotions. Due to the nature of silicones, numerous aesthetic and efficacy benefits have been revealed in our topical products.
This document discusses dermal fillers for facial rejuvenation. It presents information on EVOLENCE, a collagen-based dermal filler, including its benefits, composition, and safety profile. EVOLENCE uses collagen and Glymatrix technology to provide natural, long-lasting results of at least 12 months. Clinical studies demonstrated its safety, with no reported allergic reactions among over 30,000 injections. Histological examinations on rabbits found EVOLENCE remained intact for 24 months without degradation.
Best facial cosmetic surgeons
Best facial plastic surgeon
Browlift
Charlotte endoscopic brow lift
Charlotte’s top facial plastic surgeon
Facial plastic surgeons
Facial plastic surgery
Face lifts
Facial mini-tuck
Lip enhancement
Lip augmentation
Nose job
Nose job cost
Nose surgery
Rhinoplasty
Rhinoplasty Expert
Rhinoplasty and teens
Revision rhinoplasty
Teen Rhinoplasty, Charlotte
Teen Rhinoplasty, North Carolina
Teen Rhinoplasty Expert
Top rhinoplasty surgeons
Best Charlotte rhinoplasty surgeons
Most experienced rhinoplasty surgeons
This document summarizes information about Avenova, a lid and lash cleanser produced by NovaBay Pharmaceuticals. It discusses blepharitis and meibomian gland dysfunction that Avenova treats. Avenova uses Neutrox technology, which contains pure hypochlorous acid that kills bacteria quickly without generating resistance. It is more effective than other lid cleansers and has anti-toxin and anti-biofilm properties. The document provides details on NovaBay as a company and clinical cases that demonstrate the effectiveness of Avenova in treating blepharitis and improving symptoms.
This document summarizes information about Avenova, a lid and lash cleanser produced by NovaBay Pharmaceuticals. It discusses blepharitis and meibomian gland dysfunction that Avenova treats. Avenova uses Neutrox technology, which contains pure hypochlorous acid that kills bacteria quickly without generating resistance. It is more effective than other lid cleansers and has anti-toxin and anti-biofilm properties. The document provides examples of patients whose blepharitis and dry eye symptoms improved after using Avenova.
Radiesse is a synthetic calcium hydroxylapatite dermal filler that received FDA approval in 2006 for the correction of facial wrinkles and folds as well as for correction of facial wasting from HIV-associated lipoatrophy. Clinical studies showed that Radiesse provided immediate correction and lasted longer than other fillers, with effects lasting up to 18 months. Radiesse was shown to be safe and effective for facial wrinkles and lipoatrophy, with patients reporting high levels of satisfaction and improved quality of life for over a year following treatment.
Cytori Therapeutics presented at the Meeting on the Mesa conference on October 29, 2012. The presentation highlighted Cytori's (1) scientific leadership in characterizing adipose-derived regenerative cells, (2) $106 million contract from BARDA to develop cell therapy for thermal burns, and (3) extensive patent portfolio protecting its Celution technology through the mid-2020s.
This document discusses outsourcing bioavailability and bioequivalence studies to contract research organizations (CROs). It defines key terms like bioavailability, bioequivalence, and outlines services commonly outsourced. Choosing a qualified CRO requires assessing their clinical, bioanalytical, pharmacokinetic capabilities and timelines. Proper qualification includes due diligence, and ensuring clinical, bioanalytical, and pharmacokinetic sites meet standards. Outsourcing can provide cost savings and expertise, though it also presents risks like loss of control and quality issues that require careful CRO selection and management.
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
2. Safe Harbor Provision
This presentation includes statements that are “forward-looking statements.” While
management has based any forward-looking statements contained in the presentation on its
current expectations, the information on which such expectations were based may change.
These forward-looking statements rely on a number of assumptions concerning future events
and are subject to a number of risks, uncertainties, and other factors, many of which are
outside of Fibrocell Science’s control, that could cause actual results to materially differ from
such statements. Such risks, uncertainties, and other factors include, but are not necessarily
limited to, those set forth under the caption “Item 1A. Risk Factors” in Fibrocell Science’s
most recent Form 10-K filing, as updated in “Item 1A. Risk Factors” in Fibrocell Science’s
most recent Form 10-Q filing. In addition, Fibrocell Science operates in a highly competitive
and rapidly changing environment, and new risks may arise. Accordingly, you should not
place any reliance on forward-looking statements as a prediction of actual results. Fibrocell
Science disclaims any intention to, and undertakes no obligation to, update or revise any
forward-looking statement. You are also urged to carefully review and consider the various
disclosures in Fibrocell Science’s most recent annual report on Form 10-K, our most recent
10-Q as well as other public filings with the SEC since the filing of Fibrocell Science’s annual
report.
2
3. Fibrocell Vision
Fibrocell Science: A unique autologous cellular therapeutic company with near term
promising revenue and a broad platform.
1. The first area of focus is aesthetics and dermatology, with an indication in
wrinkles/folds. Other possible indications: acne scarring, an unmet need, and
other areas i.e. fine lines and wrinkles around eyes/lips, décolletage and total
facial treatment
2. We will also pursue orphan indications for restrictive burn scars and vocal
cord scarring
3. Our long term vision is to biotransform autologous dermal fibroblasts to
“factor free” IPSC cells capable of differentiation into multiple cell types for
toxicological, research use, and therapeutics
3
4. Growing Market - Aesthetics
• Over 4.2 Million injectable procedures in 2010
• Market expansion through additional indications
• Demographic expansion
Source: American Society for Aesthetic Plastic Surgery, 2010 4
5. laViv – Personalized Dermal Technology
Innovative technology to isolate, purify and regenerate a patient’s own
fibroblast cells for re-injection
Fibroblast cells are part of the structural
framework of animal tissues and play a critical role
in wound healing by synthesizing extracellular
matrix proteins such as collagens
The regenerated cells are native to the recipient
and recognized by the body’s immune system as
“self”
Potential applications extend beyond the
dermatology field
5
6. Restoring the Equilibrium
• The first autologous cell therapy for use in aesthetics filed with the FDA
• Strict release testing on each clinical lot to ensure performance and safety,
including:
– Collagen content testing results must achieve specification for each
prepped injection, indicating cells are biologically active and produce
collagen
– Cell suspension must consist of at least 98% fibroblasts prior to
release
– Cells in suspension must achieve a viability level of at least 85%
Human Fibroblast Cell
Cytoskeleton in a Human Fibroblast Cell. Actin (Red), Microtubules 6
(Green), Nucleus (Blue). Image by Jiashan Wang
10. Widespread Press Coverage
Awarded a Beauty Breakthrough of the
Year Award by Allure Magazine
July issue of Vogue
October issue of Marie Claire
10
12. Patient Value Proposition
Younger demographics Desire to maintain youthful look
Not satisfied with current options Seeking more natural, soft look
Complement to existing regiments Longer lasting effect
Attraction to organic products Early patient surveys indicate strong
satisfaction
Women 25 - 35 Women 35+ Men 35+
Source: American Society for Aesthetic Plastic Surgery, 2010 12
13. Dermatologists Value Proposition
Only approved cell-based treatment
Patient retention
More frequent patient interactions
Personalized Skincare Cream
• Premium skin cream
• Contains patient’s own natural collagen
• Provided exclusively by your physician
13
14. laViv Potential
“That’s where I see the real home run. We should be able to inject laViv in small amounts all over to
up-regulate your fibroblasts and improve pigmentation, scarring, and sagginess–and not only on the
face but on hands, the arms and legs.” – Frederic Brandt, M.D., clinical investigator
Line Filling Other Aesthetic Applications*
Back of Hands Upper Chest / Neck
Full Face
Acne Scars
Nasolabial Folds
* Indication not approved 14
15. laViv - Skin Quality Characteristics
Percent of Patients with Improvement
Improvement in Improvement in
Skin Quality Characteristic Subject Self- Evaluator
Assessment Assessment
Total Score 93% 95%
Softness 56% 65%
Suppleness 47% 65%
Smoothness 63% 65%
Firmness 77% 67%
Thickness 47% 56%
Moistness 65% 65%
Even Appearance 77% 67%
Refreshed Appearance 77% 84%
Trial IT-R-007 (n=45)
16. laViv Treatment Process
Extraction
• A small sample of cells is removed from behind the ear from a small
skin punch biopsy with the use of local anesthetic
• The location is chosen due to limited exposure to the sun and to
avoid creating a visible scar
Purification & Culturing
• A proprietary manufacturing process expands fibroblasts from the
sample into tens of millions of new cells in 90 days
• Fibroblasts are tested by quality control and released by quality
assurance prior to shipment
• Cells are frozen for use in potentially multiple treatment sessions
16
16
25. Natrillaire™ Daily Moisturizing Cremè
First and Only Natural Personalized Skin Cream:
Expected launch in early 2012
Natrillaire Daily
Moisturizing Cremè
• Premium skin cream
• Contains your own
natural collagen
Skin Creams with
animal collagen or • Exclusively from your
non-personalized skincare physician
Premium human fibroblast
Skin growth media
Creams
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26. Conventions and Scientific Association
Meetings
Association Meetings: Date/Location
American Society of Dermatologic November 3 – 6, 2011
Surgeons (ASDS) Washington, D.C.
American Society of Cosmetic December 1 – 4, 2011
Dermatology and Aesthetic Surgery Las Vegas, NV
(ASCDAS)
Orlando Dermatology Aesthetic and January 13,16, 2012
Clinical Conference Orlando, FL
American Academy of Cosmetic Surgery January 18-22, 2012
(AACS) Las Vegas, NV
American Society for Aesthetic Plastic May 3-8, 2012
Surgery (ASAPS) Vancouver, British Columbia
American Academy of Dermatology March 16-20, 2012
(AAD) San Diego, CA
27. Physician Training Programs Scheduled
In Target Markets :
• Dinner meetings in major markets beginning September through
December of 2011
• 10 – 15 attendees per meeting
• Expert moderated programs
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28. Fibrocell Pipeline & Partner Opportunities
Numerous near-term indications to pursue
FDA-approved platform has significant partnership opportunities
In addition to Acne Scars, potential new indications include Total
Face, Restrictive Burn Scars, and Vocal Cord Scars
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29. Acne Scarring Key Points
• Completed one Phase II/III study
Statistically significant efficacy results
Currently in discussions with the FDA
• Large market potential – estimated to be 3 million patients
• Opportunity to be the first medical treatment for Acne Scars
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35. laViv Therapy
Acne Scar, Actual Result
Before Treatment 6 Months Post Treatment
Courtesy of Robert Weiss, MD, Margeret Weiss, MD, Karen Beasley MD, Gillish Munavalli, MD
35
36. laViv Therapy
Acne Scar, Actual Result
Before After
Courtesy of Gilly Munavalli, MDMD
36
37. Restrictive Burn Scars
Situation Patient Treated with Fibroblasts
• 63 year-old woman • Reviewed 5 months post second treatment
• Burned 10 years previously • Improvement on both sides of neck
• Full thickness burns • Stopped all analgesics
• Originally treated with skin grafts • Discarded cervical collar
• Scar tissue progressively became hardened, • Full range of motion and pain free
contracted and inflexible
• Constant pain with severe restriction and abduction
• Wearing cervical collar, taking strong analgesics
• Plastic surgeon reluctant to intervene
Feb. 1, 2006 August 11, 2006
Before Scar tissue now very soft &
treatment flexible, no longer palpable as a
Courtesy of Mark Palmer, MD
ridge, appearance much improved
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40. laViv Therapy
Hypertrophic Burn Scar, Actual Result
Before Treatment 12 Months Post Treatment 14 Months Post Treatment
•Full range - Clench •Fine movement Fingers
Courtesy of Chris Inglefield, BsC 40
41. Vocal Cord Scars
Publication in the January edition of The Laryngoscope
“Cellular-based approaches using tissue engineering and
regenerative medicine techniques like Fibrocell’s autologous
fibroblasts are promising for the treatment of vocal scars.”
• Dinesh K. Dr. Chhetri, MD, Associate Professor, Division of Head
and Neck Surgery, David Geffen School of Medicine at UCLA
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42. Long Range Potential
Fibroblast cells are present throughout the body
Potential alternative to stem cells
Ability to use in models for studying medical conditions, particularly where
no good animal models exist
James A. Byrne, PhD
Byrne (2008). Hum. Mol. Gen. 17:R37-R41
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44. In Conclusion:
• Establish LAVIV in key U.S. markets
Recruiting/Training Physicians
Interest has been strong and encouraging
• First and only cell based therapy FDA approved
• Other possible aesthetic indications:
Total facial treatment, fine lines and wrinkles around eyes, lips, &
décolletage
• Acne Scarring offers a significant opportunity
• Restrictive Burn Scars and Vocal Cord Scarring are potential orphan
indications
Applied for Restrictive Burn Scars orphan status
Vocal Cord Scarring orphan drug application in progress
• Several important scientific publications this year
• UCLA – offers potential to be a stem cell alternative
• Launch in China expected 2012
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45. Hypothetical Market Size
If each of the estimated
1.5 million current
Aesthetics Each 5% share of woman or
1.8% share of procedures =
women were treated for •Current indication approximately $150 - $225
one of the potential new •Potential new indications million annually
areas > $3 billion
market
Acne Scars 3 million patients each received
a treatment potential market is >
$5 billion
Restrictive
Burn Scars 25,000 patients = $100 - $150
million annually
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