This document summarizes a presentation about opening up clinical performance variation and financial incentives in primary care quality of care. It discusses the Quality and Outcomes Framework (QOF), a pay-for-performance program introduced in 2004 as part of a new GP contract in the UK. The QOF rewards general practices for achieving quality targets in chronic disease care. It has expanded over time to include more indicators and domains. While initially estimated to cost £1.8 billion over 3 years, the program has cost over £9 billion after its first 9 years. The presentation examines research on the impact and effectiveness of the QOF program.