1. Blueworks – Ophthalmologic Decision Support System Coimbra, 29 January 2009 blueworks@blueworks.pt

3. In ophthalmology, this is even a bigger issue due to the inherent difficulty of self-administrating eye-drops.

4. Even when someone tries to correctly apply it, he may fail

5. In chronical diseases such as glaucoma, even if diagnosis and medication are correctly defined, patients may go irreversible blind due to poor compliance

6. Clinical trial pose the biggest challenge, due to intentional non-compliance22 April, 2009

8. Ask patients to keep compliance diary

9. In clinical trials, dislocate volunteers to study center every day to have someone apply them the eye-drops

10. In clinical trials, rent an hotel or private clinic

11. Accommodate in there all volunteers

12. Accommodate physicians, nurses and researchers.

13. Use electronical devices to get data regarding compliance22 April, 2009

15. Typically, they store data regarding:

16. Date

17. Time

18. Flask squeeze / Drop leaving flask

19. As mentioned, the big question in ophthalmology compliance is:As the drop reached the eye ? Is that eye the correct one ? 22 April, 2009

21. Device inclination sensors assess optimal angle of usage

22. Sound cues guide user to optimal angle of drop

23. Drop-use and recording synchronization mechanisms*Success - Underdevelopment * This device has a Patent Pending 22 April, 2009

25. Remote data upload to study-center via UMTS data-transmission *

26. Drop-application success evaluation trough image analysis*Failure - Underdevelopment * This device has a Patent Pending 22 April, 2009

28. Laterality assessment through iris pattern - Underdevelopment * This device has a Patent Pending 22 April, 2009

30. Portable Device able to contain a drop dispenser

31. Schedule alarms

32. Light and sound alarms

33. Remotely programmable therapeutical schedule* Current Prototype - Underdevelopment * This device has a Patent Pending 22 April, 2009

34. Blueworks – Ophthalmologic Decision Support System System Workflow 1 - Innitial Contact 2 – Patient takes EyeDropper home 3 – Patient applies drops as usual 6 – Data is downloaded and analysed 7 – Researcher reviews results 4 – Patient Returns with EyeDropper 5 – Researcher plugs device to PC 22 April, 2009

35. Blueworks – Ophthalmologic Decision Support System Alternative Workflow 1 - Innitial Contact 2 – Patient takes EyeDropper home 3 – Patient applies drops as usual 4 – Data is sent in real-time by GSM/UMTS 6 – Researcher reviews results 5 – Data is received and analyzed 22 April, 2009

36. Blueworks – Ophthalmologic Decision Support System Alternative Workflow v2 1 - Innitial Contact 2 – Patient takes EyeDropper home 3 – Patient applies drops as usual 4 – Data is sent in real-time by GSM/UMTS 6 – Researcher analyses gathered data 7 – Researcher reviews results 5 – Data is downloaded 22 April, 2009

37. Blueworks – Ophthalmologic Decision Support System Researcher Software Register / Import Patient Data Gather an Iris Sample Step 1 Innitial Contact Define Therapy Schedule 22 April, 2009

38. Blueworks – Ophthalmologic Decision Support System Researcher Software View Gathered Videos Use Algorithms Step 2 Analyze Gathered Data Manually define instillation success 22 April, 2009

39. Blueworks – Ophthalmologic Decision Support System Researcher Software Graphic Representation Monthly Schedule Step 3 Review Compliance Results Statistics Detailed event List 22 April, 2009

40. Blueworks – Ophthalmologic Decision Support System Contactus: blueworks@blueworks.pt