Excipients in Pharmaceuticals

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Excipients in Pharmaceuticals
Published on August 2011

Report Summary

REPORT HIGHLIGHTS

* The global excipients market was at $4.6 billion in 2010 and it is expected to reach at $4.9 billion in 2011. It is further anticipated
to increase to $6.7 billion by 2016 at a compound annual growth rate (CAGR) of 6.5%.
* The market for organic chemicals was at $4.3 billion approximately in 2010 and it is expected to reach at $4.5 billion in 2011. It is
further anticipated to increase to $6.3 billion by 2016 at a compound annual growth rate (CAGR) of 6.6%.
* The market for inorganic chemicals was at $248 million approximately in 2010 and it is expected to reach at $268 millions in 2011.
It is further anticipated to increase to $350 million by 2016 at a compound annual growth rate (CAGR) of 5.5%.

INTRODUCTION

REASON FOR THE STUDY

Among the significant forces that continue to affect the global excipients industry in 2011 are a crisis in the global supply chain, the
demands of Quality by Design (QbD), and worries about drug safety. Positive trends include the development of creative ideas in
response to the need for new excipients and new levels of cooperation between major players (e.g., Dow and Colorcon). These
forces are reshaping the global market for excipients.

GOALS AND OBJECTIVES

The primary goals of this technical/market report are to provide a detailed analysis of the current excipients market and a forecast of
what the market will look like in 5 years. The specific objectives are (1) identify excipients being used; (2) quantify global market
volume; (3) track important developments; (4) analyze the structure of the industry and its driving forces; (5) examine the most active
companies and describe how they respond to market demands; and (6) provide data with which the reader can further evaluate the
industry.

AUDIENCE

As a market and technology summary, this report consolidates a wide range of industrial and technical information that should aid
excipient suppliers, chemical companies, drug manufacturers, healthcare regulators, and congressional staffers to stay current with
today's market. The report should be of value to companies interested in entering or expanding their involvement in the field. The
report should provide senior marketing personnel and executive planners with insight about what materials can best satisfy customer
demands. Market projections may be of interest to venture capitalists interested in exploring commercialization opportunities, as well
as companies and personnel involved in designing and constructing chemical and excipient manufacturing plants and/or those who
service such plants. The report offers useful background to consultants in the field. The report can serve as an introductory resource
for newcomers to the business, including new employees. In addition, the report can offer background to governmental officials
examining reform.

SCOPE OF REPORT

Excipients in Pharmaceuticals (From Slideshare) Page 1/21


Excipients in Pharmaceuticals offers coverage of the most important issues surrounding excipients: technological, regulatory,
economic, and political issues, and so on.

Excluded from the study are ingredients for cosmetics, personal care, food, quasi-medical, unorthodox, alternative, home remedies,
underground and/or illegal drugs, and veterinary drugs.

This report organizes information from diverse sources into sections entitled Summary, Overview, Technology, Industry Structure, and
Company Profiles. The Summary encapsulates several key conclusions and includes a table of market findings. The Overview
provides deep background information on the most important issues of the day, including the global supply chain crisis, QbD, and
legislative prospects. The Technology section examines excipients by chemical compounds, functional uses, and delivery systems,
and as finished products. The Industry Structure section discusses the market environment, strategies, influences, market shares,
international aspects, and other related factors. The Company Profiles segment provides summaries of more than 120 companies
that supply excipients or are relevant to the industry.

METHODOLOGY AND INFORMATION SOURCES

Both primary and secondary research methodologies were used in preparing this study. The methodology used to create Excipients in
Pharmaceuticals included extensive telephone interviews with key executives of leading U.S. and European companies and
consultancies. This commentary was combined with information gleaned from websites, annual reports, the trade press, textbooks,
patents, press releases, and government documents.

The information has been used to project and forecast market size, and calculate compound annual growth rates (CAGRs) of the
overall market and many market segments. All market sizes refer to worldwide values and volumes, which are rounded to the nearest
million in dollars and pounds. Market size is estimated at the manufacturer level; that is, the level of consumption in actual drug
formulations. Where precise information was not available, a consensus was made using a formulation of reasonable assumptions
and estimates based on historical data. In this report, the market size for 2010 serves as a basis for making estimates for 2011 and
projections to 2016.

Table of Content

CHAPTER ONE: INTRODUCTION'1
REASON FOR THE STUDY 1
GOALS AND OBJECTIVES 1
AUDIENCE 1
SCOPE OF REPORT 2
METHODOLOGY AND INFORMATION SOURCES 2
ANALYST CREDENTIALS 3
RELATED BCC REPORTS 3
BCC ONLINE SERVICES 3
DISCLAIMER 4
CHAPTER TWO: SUMMARY 5
SUMMARY TABLE GLOBAL EXCIPIENTS MARKET BY MATERIAL
TYPE, THROUGH 2016 ($ MILLIONS) 5
SUMMARY FIGURE GLOBAL EXCIPIENTS MARKET, 2011 AND 2016
($ MILLIONS) 6
SUMMARY (CONTINUED) 7



CHAPTER THREE: OVERVIEW 11
WHAT IS AN EXCIPIENT' 11
WHAT IS AN EXCIPIENT (CONTINUED) 12
WHAT IS AN EXCIPIENT' (CONTINUED) 13
THE PHARMACEUTICALS INDUSTRY IN TURMOIL: 2000 TO
TODAY 13
THE KNOWLEDGE CRISIS 14
THE KNOWLEDGE CRISIS (CONTINUED) 15
THE NEED FOR NEW EXCIPIENTS 16
THE NEED FOR NEW EXCIPIENTS (CONTINUED) 17
A NOTE ABOUT DIRECT COMPRESSION 18
COPROCESSING IS SPLENDID, BUT IT IS NOT ENOUGH 19
QBD AND THE GLOBAL SUPPLY CHAIN CRISIS: TWO TIDAL
WAVES 20
HOW AND WHY THE QUALITY APPROACH CAME TO PHARMA 20
HOW AND WHY THE QUALITY '(CONTINUED) 21
THE BASICS OF QBD 23
THE BASICS OF QBD (CONTINUED) 24
THE BASICS OF QBD IN 1,000 WORDS (CONTINUED) 25
THE GLOBAL SUPPLY CHAIN CRISIS 27
THE GLOBAL SUPPLY CHAIN CRISIS (CONTINUED) 28
THE GLOBAL SUPPLY CHAIN CRISIS (CONTINUED) 29
CHRONOLOGY, PART II (CONTINUED) 30
IS THE WORKFORCE UP TO IT' 33
A NOTE ON THE RECESSION 34
CHAPTER FOUR: GLOBAL EXCIPIENT MARKET: SEVERAL BASIC
FIGURES 35
FIGURE 1 GLOBAL EXCIPIENTS MARKET SHARE BY CATEGORY
OF MATERIAL, 2011 (%) 35
FIGURE 2 GLOBAL EXCIPIENTS MARKET SHARE BY TYPE OF
ORGANIC CHEMICAL, 2011 (%) 36
INORGANIC CHEMICAL, 2011 (%) 37
FIGURE 4 GLOBAL EXCIPIENTS MARKET SHARE BY TYPE OF USP
WATER, 2011 (%) 38
FIGURE 5 GLOBAL EXCIPIENTS MARKET SHARE BY FUNCTIONAL
USE, 2011 (%) 39
DELIVERY SYSTEM, 2011 (%) 40



FIGURE 7 GLOBAL EXCIPIENTS MARKET FOR FINISHED
PRODUCTS BY TYPE (RX AND OTC), 2011 (%) 41
CHAPTER FIVE: CHEMICAL COMPOUNDS 42
CHEMICAL COMPOUNDS 42
MARKET SIZE 42
TABLE 1 GLOBAL EXCIPIENTS MARKET VALUE BY MATERIAL
TABLE 2 GLOBAL EXCIPIENTS MARKET VOLUME BY MATERIAL
TYPE, THROUGH 2016 (MILLION LBS) 43
ORGANIC CHEMICALS 44
SIZE OF THE MARKET FOR ORGANIC CHEMICALS 44
TABLE 3 GLOBAL ORGANIC CHEMICAL EXCIPIENTS MARKET
VALUE BY TYPE, THROUGH 2016 ($ MILLIONS) 44
TABLE 4 GLOBAL ORGANIC CHEMICAL EXCIPIENTS MARKET
VOLUME BY TYPE, THROUGH 2016 (MILLION LBS) 45
CARBOHYDRATES 45
Market Size 45
TABLE 5 GLOBAL CARBOHYDRATE EXCIPIENTS MARKET BY
TABLE 6 GLOBAL CARBOHYDRATES EXCIPIENTS MARKET BY
Celluloses 46
Market Size 46
TABLE 7 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE,
THROUGH 2016 ($ MILLIONS) 46
TABLE 8 GLOBAL CELLULOSE EXCIPIENT MARKET BY TYPE,
THROUGH 2016 (MILLION LBS) 47
Microcrystalline Cellulose 47
Market Size 47
TABLE 9 GLOBAL MCC EXCIPIENT MARKET, THROUGH 2016 ($
MILLIONS/MILLION LBS) 48
Cellulose Ethers 48
Market Size 48
TABLE 10 GLOBAL CELLULOSE ETHER EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/MILLION LBS) 48
Cellulose Esters 49
Market Size 49
TABLE 11 GLOBAL CELLULOSE ESTER EXCIPIENT MARKET,
Carboxymethyl Cellulose and Croscarmellose
Sodium 50
Market Size 50
TABLE 12 GLOBAL CMC AND CROSCARMELLOSE S MARKET,
Sugars 50
Market Size 50
TABLE 13 VALUE OF GLOBAL SUGAR EXCIPIENT MARKET BY



TABLE 14 VOLUME OF GLOBAL SUGAR EXCIPIENT MARKET BY
Actual Sugars 51
Market Size 52
TABLE 15 VALUE OF GLOBAL ACTUAL SUGAR EXCIPIENT
MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 52
TABLE 16 VOLUME OF GLOBAL ACTUAL SUGAR EXCIPIENT
MARKET BY TYPE, THROUGH 2016 (MILLION LBS) 52
Lactose 52
Market Size 53
TABLE 17 GLOBAL LACTOSE EXCIPIENT MARKET, THROUGH 2016
($ MILLIONS/MILLION LBS) 53
Sucrose 53
Market Size 54
TABLE 18 GLOBAL SUCROSE EXCIPIENT MARKET, THROUGH 2016
Dextrose (Glucose) 54
Market Size 54
TABLE 19 GLOBAL DEXTROSE (GLUCOSE) EXCIPIENT MARKET,
Sugar Alcohols 55
Market Size 55
TABLE 20 VALUE OF GLOBAL SUGAR ALCOHOL (POLYOL)
EXCIPIENT MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 55
TABLE 21 VOLUME OF GLOBAL SUGAR ALCOHOL (POLYOL)
EXCIPIENT MARKET BY TYPE, THROUGH 2016 (MILLION LBS) 56
Sorbitol 56
Market Size 56
TABLE 22 GLOBAL SORBITOL EXCIPIENT MARKET, THROUGH
2016 ($ MILLIONS/MILLION LBS) 56
Mannitol 57
Market Size 57
TABLE 23 GLOBAL MANNITOL EXCIPIENT MARKET, THROUGH
Other Sugar Alcohols 57
Market Size 58
TABLE 24 GLOBAL OTHER SUGAR ALCOHOL EXCIPIENT MARKET,
Maltitol 58
Xylitol 58
Erythritol 59
Isomalt 59
Tagatose 59
Trehalose 59
Artificial Sweeteners 60
Market Size 60
TABLE 25 GLOBAL ARTIFICIAL SWEETENER EXCIPIENT MARKET,



Aspartame 60
Neotame 61
Acesulfame-K 61
Saccharin 61
Sucralose 62
Starches 62
Market Size 63
TABLE 26 VALUE OF THE GLOBAL STARCHES EXCIPIENT
TABLE 27 VOLUME OF THE GLOBAL STARCHES EXCIPIENT
Dried Starch 63
Market Size 64
TABLE 28 GLOBAL DRIED STARCH EXCIPIENT MARKET,
Modified Starch 64
Market Size 65
TABLE 29 GLOBAL MODIFIED STARCH EXCIPIENT MARKET,
Converted Starch 65
Market Size 65
TABLE 30 GLOBAL CONVERTED STARCH EXCIPIENT MARKET,
PETROCHEMICALS 66
Market Size 66
TABLE 31 VALUE OF THE GLOBAL PETROCHEMICAL EXCIPIENT
TABLE 32 VOLUME OF THE GLOBAL PETROCHEMICAL EXCIPIENT
Glycols 67
Market Size 67
TABLE 33 VALUE OF THE GLOBAL GLYCOL EXCIPIENT MARKET
BY TYPE, THROUGH 2016 ($ MILLIONS) 67
TABLE 34 VOLUME OF THE GLOBAL GLYCOL EXCIPIENT MARKET
BY TYPE, THROUGH 2016 (MILLION LBS) 68
Polyethylene Glycol 68
Market Size 68
TABLE 35 GLOBAL PEG EXCIPIENT MARKET, THROUGH 2016 ($
Propylene Glycol 69
Market Size 69
TABLE 36 GLOBAL PG EXCIPIENT MARKET, THROUGH 2016 ($
Povidones 70
Market Size 70
TABLE 37 GLOBAL PVP EXCIPIENT MARKET, THROUGH 2016 ($
Mineral Hydrocarbons 70



Market Size 71
TABLE 38 DOLLAR VALUE OF THE GLOBAL MINERAL
HYDROCARBON EXCIPIENT MARKET BY TYPE, THROUGH 2016
($ MILLIONS) 71
TABLE 39 VOLUME OF THE GLOBAL MINERAL HYDROCARBON
Petrolatum 72
Market Size 72
TABLE 40 GLOBAL PETROLATUM EXCIPIENT MARKET, THROUGH
Mineral Waxes 72
Market Size 73
TABLE 41 GLOBAL MINERAL WAX EXCIPIENT MARKET, THROUGH
Mineral Oils 73
Market Size 73
TABLE 42 GLOBAL MINERAL OIL EXCIPIENT MARKET, THROUGH
Acrylic Polymers 74
Market Size 74
TABLE 43 GLOBAL ACRYLIC EXCIPIENT MARKET, THROUGH 2016
Other Petrochemical Materials 75
Market Size 75
TABLE 44 GLOBAL OTHER PETROCHEMICAL EXCIPIENT MARKET,
Antimicrobials 76
Antioxidants 76
Dyes and Lakes 76
TABLE 45 SYNTHETIC COLORANTS IN PHARMACEUTICALS 77
EDTA 77
Flavors 78
Glycine and Glycylglycine 78
Vinyl Polymers 78
Silicones 79
Miscellaneous Synthetic Petrochemicals 79
OLEOCHEMICALS 79
Market Size 80
TABLE 46 VALUE OF THE GLOBAL OLEOCHEMICAL EXCIPIENT
TABLE 47 VOLUME OF THE GLOBAL OLEOCHEMICAL EXCIPIENT
Fatty Alcohols 80
Market Size 81
TABLE 48 GLOBAL FATTY ALCOHOL EXCIPIENT MARKET,
Glycerin 81
Market Size 81



TABLE 49 GLOBAL GLYCERIN EXCIPIENT MARKET, THROUGH
Metal Stearates 82
Market Size 82
TABLE 50 GLOBAL METAL STEARATE EXCIPIENT MARKET,
Other Oleochemicals 83
Market Size 83
TABLE 51 GLOBAL OTHER OLEOCHEMICAL EXCIPIENT MARKET,
Natural Waxes 84
Beeswax 84
Candelilla Wax 84
Carnauba Wax 84
Cocoa and Shea Butters 84
Lanolin 84
Phospholipids 85
Sodium Lauryl Sulfate 85
Sorbitan 85
Synthetic Glyceryl Esters 85
Vegetable Oils 85
PROTEINS 86
Gelatin 86
Market Size 86
TABLE 52 GLOBAL PROTEINS (GELATIN) EXCIPIENT MARKET,
Albumin 87
OTHER ORGANIC CHEMICALS 87
TABLE 53 GLOBAL OTHER ORGANIC CHEMICAL EXCIPIENT
MARKET, THROUGH 2016 ($ MILLIONS/MILLION LBS) 88
Alcohols 88
Citric Acid 88
Lactic Acid 89
Polysaccharide Gums 89
Shellac 89
INORGANIC CHEMICALS 89
MARKET SIZE 89
TABLE 54 VALUE OF THE GLOBAL INORGANIC CHEMICAL
TABLE 55 VOLUME OF THE GLOBAL INORGANIC CHEMICAL
CALCIUM SALTS 90
Market Size 90
TABLE 56 VALUE OF THE GLOBAL CALCIUM SALT EXCIPIENT
TABLE 57 VOLUME OF THE GLOBAL CALCIUM SALT EXCIPIENT
Calcium Phosphate 91



Market Size 92
TABLE 58 GLOBAL CALCIUM PHOSPHATE EXCIPIENT MARKET,
Calcium Carbonate 92
Market Size 93
TABLE 59 GLOBAL CALCIUM CARBONATE EXCIPIENT MARKET,
Calcium Sulfate 93
Market Size 93
TABLE 60 GLOBAL CALCIUM SULFATE EXCIPIENT MARKET,
HALITES 94
Market Size 94
TABLE 61 GLOBAL HALITE EXCIPIENT MARKET, THROUGH 2016 ($
METAL OXIDES 95
Market Size 95
TABLE 62 VALUE OF THE GLOBAL METAL OXIDE EXCIPIENT
TABLE 63 VOLUME OF THE GLOBAL METAL OXIDE EXCIPIENT
Titanium Dioxide 96
Market Size 96
TABLE 64 GLOBAL TIO2 EXCIPIENT MARKET, THROUGH 2016 ($
Iron Oxide 96
Market Size 97
TABLE 65 GLOBAL IRON OXIDE EXCIPIENT MARKET THROUGH
SILICATES 97
Market Size 97
TABLE 66 VALUE OF THE GLOBAL SILICATES EXCIPIENT MARKET
TABLE 67 VOLUME OF THE GLOBAL SILICATES EXCIPIENT
Silicon Dioxide 98
Market Size 99
TABLE 68 GLOBAL SILICON DIOXIDE EXCIPIENT MARKET,
Talc 99
Market Size 99
TABLE 69 GLOBAL TALC EXCIPIENT MARKET, THROUGH 2016 ($
Clay 100
Market Size 100
TABLE 70 GLOBAL CLAY EXCIPIENT MARKET, THROUGH 2016 ($
OTHER INORGANIC CHEMICALS 101



Market Size 101
TABLE 71 GLOBAL OTHER INORGANIC CHEMICAL EXCIPIENT
MARKET, THROUGH 2016 ($ MILLIONS/MILLION LBS) 101
USP WATER (PHARMACEUTICAL WATER) 101
MARKET SIZE 102
TABLE 72 VALUE OF THE GLOBAL USP WATER EXCIPIENT
MARKET, THROUGH 2016 ($ MILLIONS) 102
TABLE 73 VOLUME OF THE GLOBAL USP WATER EXCIPIENT
MARKET, THROUGH 2016 (MILLION LBS) 102
WATER FOR INJECTIONS 103
Market Size 103
TABLE 74 GLOBAL USP WFI EXCIPIENT MARKET, THROUGH 2016
($ MILLIONS/LBS MILLLIONS) 103
PURIFIED WATER 103
Market Size 104
TABLE 75 GLOBAL USP PURIFIED WATER EXCIPIENT MARKET,
THROUGH 2016 ($ MILLIONS/LBS MILLLIONS) 104
FUNCTIONAL USES 104
TABLE 76 VALUE OF THE GLOBAL EXCIPIENT FUNCTIONAL USES
TABLE 77 VOLUME OF THE GLOBAL EXCIPIENT FUNCTIONAL
USES MARKET BY TYPE, THROUGH 2016 (MILLION LBS) 105
FILLERS 106
MARKET SIZE 106
TABLE 78 VALUE OF THE GLOBAL EXCIPIENT FILLER MARKET BY
TABLE 79 VOLUME OF THE GLOBAL EXCIPIENT FILLER MARKET
VOLUME BY TYPE, THROUGH 2016 (MILLION LBS) 107
EMOLLIENTS 107
MARKET SIZE 107
TABLE 80 GLOBAL EMOLLIENTS EXCIPIENT MARKET, THROUGH
VEHICLES 108
MARKET SIZE 108
TABLE 81 VALUE OF THE GLOBAL VEHICLE EXCIPIENT MARKET
TABLE 82 VOLUME OF THE GLOBAL VEHICLE EXCIPIENT
COATINGS 110
MARKET SIZE 110
TABLE 83 VALUE OF THE GLOBAL COATINGS EXCIPIENT MARKET
TABLE 84 VOLUME OF THE GLOBAL COATINGS EXCIPIENT
DISINTEGRANTS 112
MARKET SIZE 112
TABLE 85 VALUE OF THE GLOBAL SUPERDISINTEGRANT



TABLE 86 VOLUME OF THE GLOBAL SUPERDISINTEGRANT
FLAVORS 113
MARKET SIZE 113
TABLE 87 VALUE OF THE GLOBAL FLAVORS EXCIPIENT MARKET
TABLE 88 VOLUME OF THE GLOBAL FLAVORS EXCIPIENT
TABLE 89 COMPARISON OF SEVERAL SWEETENERS TO SUCROSE
(%) 115
TONICITY AGENTS 115
MARKET SIZE 115
TABLE 90 GLOBAL TONICITY AGENT EXCIPIENT MARKET VALUE,
TABLE 91 GLOBAL TONICITY AGENT EXCIPIENT MARKET
VOLUME, THROUGH 2016 (MILLION LBS) 116
COLORANTS 116
MARKET SIZE 116
TABLE 92 GLOBAL COLORANTS EXCIPIENT MARKET BY TYPE,
TABLE 93 GLOBAL COLORANTS EXCIPIENT MARKET VOLUME BY
OTHER FUNCTIONAL USES 117
MARKET SIZE 118
TABLE 94 GLOBAL MARKET FOR OTHER FUNCTIONAL USES,
PERFUMES 118
BINDERS 118
BUFFERS 119
CHELATING AGENTS 119
COMPRESSION AIDS 119
EMULSIFIERS 119
FOAM CONTROL AGENTS 120
GLIDANTS 120
HUMECTANTS 120
LUBRICANTS 120
PLASTICIZERS 121
PRESERVATIVES 121
THICKENERS 121
DELIVERY SYSTEMS 122
MARKET SIZE 122
TABLE 95 VALUE OF THE GLOBAL EXCIPIENT DELIVERY
SYSTEMS MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 122
TABLE 96 VOLUME OF THE GLOBAL EXCIPIENT DELIVERY
SYSTEMS MARKET BY TYPE, THROUGH 2016 (MILLION LBS) 123
FIGURE 8 GLOBAL EXCIPIENT DELIVERY SYSTEMS MARKET BY
TYPE, 2011 AND 2016 (%) 123
FIGURE 8 (CONTINUED) 124



INJECTIONS 124
TABLE 97 TYPICAL INJECTION COMPOSITION (%) 124
MARKET SIZE 125
TABLE 98 GLOBAL EXCIPIENTS FOR INJECTIONS, MARKET
VALUE BY FUNCTION, THROUGH 2016 ($ MILLIONS) 125
TABLE 99 GLOBAL EXCIPIENTS FOR INJECTIONS, MARKET
VOLUME BY FUNCTION, THROUGH 2016 (MILLION LBS) 125
ORAL DELIVERY SYSTEMS 126
MARKET SIZE 126
TABLE 100 VALUE OF THE GLOBAL EXCIPIENTS IN ORAL
DELIVERY SYSTEMS MARKET BY TYPE, THROUGH 2016 ($
MILLIONS) 127
TABLE 101 VOLUME OF THE GLOBAL EXCIPIENTS IN ORAL
DELIVERY SYSTEMS MARKET BY TYPE, THROUGH 2016
(MILLION LBS) 127
SOLIDS 127
MARKET SIZE 127
TABLE 102 VALUE OF THE MARKET FOR GLOBAL EXCIPIENTS IN
ORAL SOLID DELIVERY SYSTEMS, BY TYPE, THROUGH 2016 ($
MILLIONS) 128
TABLE 103 VOLUME OF THE MARKET FOR GLOBAL EXCIPIENTS
IN ORAL SOLID DELIVERY SYSTEMS, BY TYPE, THROUGH 2016
(MILLION LBS) 128
TABLETS 128
TABLE 104 TYPICAL TABLET COMPOSITION (WT/WT%) 129
MARKET SIZE 130
TABLE 105 VALUE OF THE GLOBAL EXCIPIENTS IN TABLETS
MARKET BY FUNCTION, THROUGH 2016 ($ MILLIONS) 130
TABLE 106 VOLUME OF THE GLOBAL EXCIPIENTS IN TABLETS
MARKET BY FUNCTION, THROUGH 2016 (MILLION LBS) 131
Market Size (Continued) 132
CAPSULES 133
MARKET SIZE 133
TABLE 107 VALUE OF THE GLOBAL EXCIPIENTS IN GELATIN
CAPSULES MARKET BY TYPE, THROUGH 2016 ($ MILLIONS) 133
TABLE 108 VOLUME OF THE GLOBAL EXCIPIENTS IN GELATIN
CAPSULES MARKET BY TYPE, THROUGH 2016 (MILLION LBS) 134
HARD GELATIN CAPSULES 134
TABLE 109 TYPICAL HARD GELATIN CAPSULE COMPOSITION
(WT/WT%) 134
Market Size 135
TABLE 110 GLOBAL EXCIPIENTS IN HARD GELATIN CAPSULES
MARKET VALUE BY FUNCTION, THROUGH 2016 ($ MILLIONS) 135
TABLE 111 GLOBAL EXCIPIENTS IN HARD GELATIN CAPSULES
MARKET VOLUME BY FUNCTION, THROUGH 2016 (MILLION
LBS) 135
SOFT GELATIN CAPSULES 136
TABLE 112 TYPICAL SOFT GELATIN CAPSULE COMPOSITION 136



Market Size 136
TABLE 113 VALUE OF THE GLOBAL EXCIPIENTS IN SOFT
GELATIN CAPSULES MARKET, BY FUNCTION, THROUGH 2016 ($
MILLIONS) 137
TABLE 114 VOLUME OF THE GLOBAL EXCIPIENTS IN SOFT
GELATIN CAPSULES MARKET, BY FUNCTION, THROUGH 2016
(MILLION LBS) 137
LIQUIDS 138
TABLE 115 TYPICAL LIQUID COMPOSITION (%) 138
MARKET SIZE 138
TABLE 116 GLOBAL EXCIPIENTS IN LIQUIDS MARKET VALUE BY
FUNCTION, THROUGH 2016 ($ MILLIONS) 139
TABLE 117 GLOBAL EXCIPIENTS IN LIQUIDS MARKET VOLUME
BY FUNCTION, THROUGH 2016 (MILLION LBS) 139
TOPICAL DELIVERY SYSTEMS 140
MARKET SIZE 140
TABLE 118 VALUE OF GLOBAL EXCIPIENTS IN TOPICAL
DELIVERY SYSTEMS BY TYPE, THROUGH 2016 ($ MILLIONS) 141
TABLE 119 VOLUME OF GLOBAL EXCIPIENTS IN TOPICAL
DELIVERY SYSTEMS BY TYPE, THROUGH 2016 (MILLION LBS) 141
TABLE 120 TYPICAL OINTMENT COMPOSITION (%) 142
CREAMS AND GELS 142
TABLE 121 TYPICAL CREAM COMPOSITION (%) 142
LOTIONS 143
TABLE 122 TYPICAL TOPICAL LOTION COMPOSITION (%) 143
DERMAL POWDERS 144
SOLUTIONS 144
ADVANCED DELIVERY SYSTEMS 144
MARKET SIZE 145
TABLE 123 GLOBAL EXCIPIENT ADVANCED DELIVERY SYSTEMS
VALUE BY FUNCTION, THROUGH 2016 ($ MILLIONS) 145
TABLE 124 GLOBAL EXCIPIENT ADVANCED DELIVERY SYSTEMS
VOLUME BY FUNCTION, THROUGH 2016 (MILLION LBS) 146
CYCLODEXTRINS 146
HYDROGELS 146
IMPLANTS 146
LIPOSOMES 147
MICROPARTICLES 147
MICROSPHERES 147
NANOTECHNOLOGY (NANOPARTICLES) 147
Nanotechnology (nanoparticles) (Continued) 148
OSMOTIC PUMPS 149
TRANSDERMAL 150
TRANSMUCOSAL 150
Buccal 150
Tablets 151
Capsules 152
Lozenges 152



Particles 152
Thin Strips 153
Inhalation 153
Nasal 154
Pulmonary 154
Ophthalmic 155
Otic 155
Rectal 156
Vaginal 156
FINISHED PRODUCTS 157
MARKET SIZE 157
TABLE 125 VALUE OF THE GLOBAL EXCIPIENTS MARKET IN
FINISHED PRODUCTS BY TYPE, THROUGH 2016 ($ MILLIONS) 158
TABLE 126 VALUE OF THE GLOBAL EXCIPIENTS MARKET IN
FINISHED PRODUCTS BY TYPE, THROUGH 2016 (MILLION LBS) 158
PRESCRIPTION PRODUCTS 159
MARKET SIZE 159
TABLE 127 VALUE OF THE GLOBAL EXCIPIENTS IN
PRESCRIPTION DRUGS MARKET, BY DELIVERY SYSTEM,
TABLE 128 VOLUME OF THE GLOBAL EXCIPIENTS IN
PRESCRIPTION DRUGS MARKET, BY DELIVERY SYSTEM,
THROUGH 2016 (MILLION LBS) 160
INJECTIONS 160
Market Size 160
TABLE 129 VALUE OF GLOBAL EXCIPIENTS IN INJECTED
PRESCRIPTION DRUGS BY TYPE, THROUGH 2016 ($ MILLIONS) 161
TABLE 130 VOLUME OF GLOBAL EXCIPIENTS IN INJECTED
PRESCRIPTION DRUGS BY TYPE, THROUGH 2016 (MILLION
LBS) 161
Small Molecule Drug Injections 161
TABLE 131 GLOBAL EXCIPIENTS IN INJECTED PRESCRIPTION
SMALL MOLECULE DRUGS MARKET, THROUGH 2016 ($
Biologic Drug Injections 162
TABLE 132 GLOBAL EXCIPIENTS IN INJECTED RX BIOLOGIC
DRUGS MARKET, THROUGH 2016 ($ MILLIONS/MILLION LBS) 162
Protein Drugs 163
Vaccines 164
ORAL PRESCRIPTION DRUGS 164
Market Size 164
TABLE 133 GLOBAL EXCIPIENTS IN ORAL RX DRUGS MARKET,
TOPICAL 165
TABLE 134 GLOBAL EXCIPIENTS IN TOPICAL RX DRUGS MARKET,
ADVANCED DRUG DELIVERY SYSTEMS 166
TABLE 135 GLOBAL EXCIPIENTS IN ADVANCED SYSTEMS FOR



PRESCRIPTION DRUGS MARKET, THROUGH 2016 ($
OVER-THE-COUNTER PRODUCTS 166
MARKET SIZE 167
TABLE 136 VALUE OF THE GLOBAL EXCIPIENTS IN OTC FINISHED
PRODUCTS MARKET, BY DELIVERY SYSTEM, THROUGH 2016 ($
MILLIONS) 167
TABLE 137 VOLUME OF GLOBAL EXCIPIENTS IN OTC FINISHED
PRODUCTS MARKET, BY DELIVERY SYSTEM, THROUGH 2016
(MILLION LBS) 168
FINISHED PRODUCT TRENDS 168
PHARMACOGENOMICS 168
COUNTERFEIT/STOLEN DRUGS 169
INDUSTRY STRUCTURE 169
INDUSTRY ENVIRONMENT 170
MARKET INFLUENCES 170
Pharmaceutical Industry Pressures 170
General Health Trends 170
Healthcare Industry 171
Consumer Demographics 171
IMPORTANT STRATEGIES 172
R&D SPENDING 172
CONSUMER ADVERTISING 172
LEGISLATIVE LOBBYING 172
CONSOLIDATION 172
MULTIPLICITY OF DELIVERY SYSTEMS 173
SUPPLIER LISTS 173
MATERIAL CHOICE DECISIONS 173
DRIVING FORCES 174
MARKET SHARES 174
FIGURE 9 SIMPLIFIED INDUSTRY STRUCTURE 174
RAW MATERIAL SUPPLIERS 175
Organic Chemical Suppliers 175
Carbohydrate Suppliers 175
Cellulose Suppliers 175
FIGURE 10 MARKET SHARE OF MAJOR CELLULOSE SUPPLIERS,
2011 (%) 176
Sugar Suppliers 176
Actual Sugar Suppliers 176
FIGURE 11 MARKET SHARE OF ACTUAL SUGAR EXCIPIENT
SUPPLIERS, 2011 (%) 177
Sugar Alcohols (Polyols) 178
FIGURE 12 ESTIMATED MARKET SHARE OF MAJOR SUGAR
ALCOHOL (POLYOL) EXCIPIENT SUPPLIERS, 2011 (%) 178
Artificial Sweeteners 179
Starch Suppliers 179
FIGURE 13 ESTIMATED MARKET SHARE OF MAJOR STARCH
EXCIPIENT SUPPLIERS, 2011 (%) 180



Protein Suppliers 180
FIGURE 14 ESTIMATED MARKET SHARE OF MAJOR PROTEIN
(GELATIN) EXCIPIENT SUPPLIERS, 2011 (%) 181
Petrochemical Suppliers 182
Glycol Suppliers 182
FIGURE 15 ESTIMATED MARKET SHARE OF MAJOR GLYCOL
PVP Suppliers 183
Mineral Hydrocarbon Suppliers 183
Acrylic Suppliers 183
Oleochemical Suppliers 183
FIGURE 16 ESTIMATED MARKET SHARE OF MAJOR
OLEOCHEMICAL EXCIPIENT SUPPLIERS, 2011 (%) 184
Inorganic Chemical Suppliers 185
Calcium Salts Suppliers 185
FIGURE 17 ESTIMATED MARKET SHARE OF MAJOR CALCIUMBASED
EXCIPIENTS SUPPLIERS, 2011 (%) 185
Halite Suppliers 186
FIGURE 18 ESTIMATED MARKET SHARE OF MAJOR HALITE
FIGURE 18 (CONTINUED) 187
Metal Oxide Suppliers 187
FIGURE 19 ESTIMATED MARKET SHARE OF MAJOR METAL
OXIDES EXCIPIENT SUPPLIERS, 2011 (%) 188
Silicate Suppliers 189
USP Water Suppliers 189
FIGURE 20 ESTIMATED MARKET SHARE OF MAJOR USP WATER
SUPPLIERS, 2011 (%) 189
DISTRIBUTORS/MODIFIERS 190
Distributors 190
TABLE 138 DISTRIBUTOR CATEGORIES 191
Brokers 191
Import/Export Traders 191
Chemical Stocking/Repacking 191
Modifiers 192
TABLE 139 CATEGORIES OF MODIFIERS 192
Contract Development Organizations 192
Contract Coaters 193
END USERS 193
TABLE 140 CATEGORIES OF MODIFIERS 193
Drug Companies 193
Contract Formulators 194
Retail and Hospital Pharmacies 194
Pharmacy Colleges and Other Academic Institutions 195
Other End Users 195
INTERNATIONAL ASPECTS 195
Americas 195
Europe 196



Asia/Pacific Rim 196
Others 197
CHAPTER SIX: COMPANY PROFILES 198
COMPANY PROFILES 198
COMPANY PROFILES (CONTINUED) 199
ABBOTT LABORATORIES 200
ADAMAS PHARMACEUTICALS, INC 201
ADM (ARCHER DANIELS MIDLAND CO) 201
AKZO NOBEL NV (ALSO ICI AND NATIONAL STARCH) 201
AMERICHEM PHARMACEUTICAL CORP 202
AMTEX (QUIMICA AMTEX MEXICO) 203
ARLA FOODS AMBA 203
ASAHI KASEI CORP (ASAHI KASEI PHARMA) 204
ASHLAND AQUALON FUNCTIONAL INGREDIENTS (AAFI) 205
ASSOCIATED BRITISH FOODS (ABF) 206
BANNER PHARMACAPS, INC 206
BASF AG 207
BASF AG (CONTINUED) 208
BAXTER INTERNATIONAL, INC 209
BLANVER FARMOQUIMICA, LTDA 210
BLUE REFERENCE 210
BRENNTAG GROUP 211
BUDENHEIM 211
CABOT CORP 212
CALUMET SPECIALTY PRODUCTS PARTNERS, LP (PENRECO) 212
CARGILL, INC 213
CHARLES TENNANT & CO, LTD 214
CHR HANSEN A/S 214
COGNIS DEUTSCHLAND GMBH & CO KG 215
COLORCON, INC 216
CORN PRODUCTS INTERNATIONAL, INC 217
COSMETIC SPECIALTIES, INC 218
CRISTAL GLOBAL (NATIONAL TITANIUM DIOXIDE CO, LTD) 218
CRODA INTERNATIONAL, PLC 219
CSL BEHRING, LLC 220
CSM NV 220
CTD, INC 221
CYDEX PHARMACEUTICALS, INC 221
DANISCO A/S 222
DOW CHEMICAL CO 223
DOW CHEMICAL CO (CONTINUED) 224
DUPONT (EI DU PONT DE NEMOURS & CO) 225
EASTMAN CHEMICAL CO 226
EM2 SOLUTIONS, INC 227
EURAND 227
EVONIK DEGUSSA GMBH (EVONIK INDUSTRIES AG) 227
FERRO CORP 228
FIBROGEN, INC 229



FINNBRIT CONSULTING 229
FLAVORX INC 229
FMC CORP 230
FMC CORP (CONTINUED) 231
FMC CORP (CONTINUED) 232
FONTERRA CO-OPERATIVE GROUP, LTD 233
FOREMOST FARMS USA 233
FUJI HEALTH SCIENCE, INC (FUJI CHEMICAL INDUSTRY CO,
LTD) 234
GATTEFOSSE GROUP 234
GE HEALTHCARE 235
GELITA AG 235
GENERAL CHEMICAL (GENCHEM) 236
GLATT GMBH (GLATT AIR TECHNIQUES, INC) 236
GRAIN PROCESSING CORP 237
GRIFOLS SA (LABORATORIOS GRIFOLS SA) 237
GTC BIOTHERAPEUTICS, INC 238
HILMAR CHEESE CO (HILMAR INGREDIENTS) 238
HOLLANDSE MELKSUIKERFABRIEK 239
IMERYS 239
INNOPHOS, INC 240
INTERNATIONAL SPECIALTY PRODUCTS (ISP) 240
INTERNATIONAL SPECIALTY PRODUCTS '(CONTINUED) 241
JM HUBER CORP (CP KELCO AND HUBER ENGINEERED
MATERIALS) 242
CP KELCO 242
HUBER ENGINEERED MATERIALS 242
JOST CHEMICAL CO 243
JRS PHARMA (AND J RETTENMAIER) 243
KEMIRA OYJ 244
KOSTER KEUNEN HOLLAND BV 245
KRAFT FOODS ATLANTIC GELATIN 245
KRONOS WORLDWIDE, INC 245
LANXESS AG 246
LUBRIZOL CORP 246
LYONDELLBASELL INDUSTRIES 247
MALLINCKRODT BAKER, INC (COVIDIEN) 247
MEGGLE GMBH 248
MERCK KGAA (AND EMD) 249
MICRO-MACINAZIONE SA 250
MINERALS TECHNOLOGIES, INC (SPECIALTY MINERALS, INC) 250
MINGTAI CHEMICAL CO, LTD 251
MITSUBISHI CHEMICAL PERFORMANCE POLYMERS, INC 252
MUTCHLER, INC PHARMACEUTICAL INGREDIENTS 252
NITTA GELATIN, INC 252
NORDZUCKER AG 253
NOVOZYMES A/S 253
NUSIL TECHNOLOGY 254



NUTRASWEET CO 254
OMYA AG 255
PARAYTEC, LTD 256
PERRIGO CO 256
PFIZER, INC 256
P&G CHEMICALS 257
PHARMACEUTICAL-TECHNOLOGYCOM 257
PMC GLOBAL, INC 258
PURDUE PHARMA, LP 258
QUALITY SYSTEMS DESIGN, INC 259
RHODIA SA 259
RIO TINTO, PLC 259
ROQUETTE FRERES 260
ROUSSELOT SAS 261
ROYAL FRIESLANDCAMPINA NV 262
RT VANDERBILT COMPANY, INC 263
SASOL, LTD ADR 263
SENSIENT TECHNOLOGIES CORP 264
SEPPIC SA 264
SHEFFIELD PHARMA INGREDIENTS 265
SHELL CHEMICALS (ROYAL DUTCH SHELL) 266
SHIN-ETSU CHEMICAL CO, LTD 266
SOLVAY SA 267
SPI PHARMA, INC 268
STEPAN CO 268
STERLING BIOTECH, LTD 269
TAKEHARA CHEMICAL INDUSTRIAL CO, LTD 269
TALECRIS BIOTHERAPEUTICS, INC 270
TATE & LYLE, PLC 270
TESSENDERLO GROUP (PB GELATINS) 271
TOMITA PHARMACEUTICAL CO, LTD 272
UNIVAR NV (AND UNIVAR USA) 272
USG CORP 272
VALIDATION & ENGINEERING GROUP (VEG) 273
VERTELLUS PERFORMANCE MATERIALS, INC (VPMI) 273
WACKER FINE CHEMICALS (WACKER CHEMIE) 273
WEI MING PHARMACEUTICAL MFG CO, LTD 274
WEISHARDT GROUP 275
WR GRACE & CO 275


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