The document discusses the concept of perfect health as the normal state that the human body evolved to be in based on its environment during the Stone Age. It describes signs of a perfectly healthy body as having consistent mental and physical energy, rapid recovery from illness, excellent sleep, clear skin, and pain-free movement. It states that perfect health is possible at almost any age if one adopts the right diet and lifestyle. The body is naturally capable of self-repair and strives for homeostasis. To achieve perfect health, one must provide the body with proper nourishment and avoid interfering with its natural functions.
This document discusses some of the ethical considerations related to collecting data on hand hygiene compliance, including potential biases. It notes that bias can be introduced during data collection and defines different types of biases like observer bias. It also addresses privacy concerns, staffing issues, and the use of technology to collect data. Finally, it discusses recommendations and strategies from organizations like WHO to help standardize data collection methods and ensure ethical practices.
The document outlines an individual's priorities, goals, and strategies. It lists faith, working, and love as top priorities. The goal is to glorify and enjoy God, and the strategy is to lay down one's life. Key aspects are righteousness by faith alone, trusting God's promises, speaking truth in love to family, being a fisher of men for the world, and laying down one's life to obey God's word.
This document contains 14 poems written by the author. The poems explore themes of death, the afterlife, visions of angels and demons, and reflections on truth and humanity. The poems are written in a dark, cryptic style with religious and supernatural imagery and symbolism. They provide glimpses into the author's imaginings about existence, spirituality, and humanity's relationship with divine forces.
The document discusses the concept of perfect health as the normal state that the human body evolved to be in based on its environment during the Stone Age. It describes signs of a perfectly healthy body as having consistent mental and physical energy, rapid recovery from illness, excellent sleep, clear skin, and pain-free movement. It states that perfect health is possible at almost any age if one adopts the right diet and lifestyle. The body is naturally capable of self-repair and strives for homeostasis. To achieve perfect health, one must provide the body with proper nourishment and avoid interfering with its natural functions.
This document discusses some of the ethical considerations related to collecting data on hand hygiene compliance, including potential biases. It notes that bias can be introduced during data collection and defines different types of biases like observer bias. It also addresses privacy concerns, staffing issues, and the use of technology to collect data. Finally, it discusses recommendations and strategies from organizations like WHO to help standardize data collection methods and ensure ethical practices.
The document outlines an individual's priorities, goals, and strategies. It lists faith, working, and love as top priorities. The goal is to glorify and enjoy God, and the strategy is to lay down one's life. Key aspects are righteousness by faith alone, trusting God's promises, speaking truth in love to family, being a fisher of men for the world, and laying down one's life to obey God's word.
This document contains 14 poems written by the author. The poems explore themes of death, the afterlife, visions of angels and demons, and reflections on truth and humanity. The poems are written in a dark, cryptic style with religious and supernatural imagery and symbolism. They provide glimpses into the author's imaginings about existence, spirituality, and humanity's relationship with divine forces.
Cognitive theories suggest that depressed individuals experience cognitive distortions and irrational beliefs that contribute to their mood disturbances. Beck's depression theory proposes that depressed people tend to develop negative cognitive schemas, such as overgeneralization from negative events, illogical thoughts about themselves, and dichotomous thinking. A perspective study found a possible link between certain cognitive styles and the later development of depression.
Additionally, social and cultural factors can influence depression risk. Research by Brown and Harris determined that lack of social support, unemployment, several young children, loss of a parent early in life, and a history of abuse increased vulnerability to depression. Collectivist cultures tend to have lower depression rates than individualist cultures. Women are also more likely to experience clinical
Centegra Health System is introducing revolutionary 3D breast imaging technology called tomosynthesis at the Centegra Gavers Breast Center. Tomosynthesis takes multiple images of the breast from different angles to produce thin slices that can be viewed individually or as a 3D reconstruction, allowing radiologists to view tissues without overlap and detect cancers earlier. The new technology was made possible by donations to the Centegra Foundation including a $120,000 gift. Medical Nutrition Therapy is now also offered to help with weight loss and improving health conditions like diabetes and heart disease. Screening at Centegra led to early detection of cancer for a patient after plaque was discovered in her carotid artery during a vascular screening.
Presented by: Peter Harrod
Watch as you learn how to recognize deficiencies in your equipment, identify code violations, and plan the retroactive and forward thinking changes that will attract and retain tenants, lower risk and positively position your property for resale!
Watch the webinar on-demand: http://be.buildingengines.com/StatementofConditions_1.25.11_RegforOn-DemandWebinar.html
Acest document afost elaborat în cadrul Proiectului Europen YESdigital finanțat de Comisia Europeană prin Programul Lifelong Learning, acțiunea TOI LdV și conține detalii despre obiectivele și activitățile Workshop-ului PBL & Video.
1) The document introduces four children from Korea - Kim So-Mi, Park Ju-Hyuck, and Park Bo-Hyoung, who share details about their families, interests, and goals.
2) It also briefly describes the four seasons in Korea and some attractions in Suwon, including Bulhui alcoholic drink, Suwon History Museum, and Suwon Hwaseong Fortress.
3) The children say goodbye at the end.
The document describes various non-vegetarian and vegetarian snack options. For non-vegetarian snacks, there are options including chicken tikka, mutton kebabs, fish fingers and prawns prepared in different styles. For vegetarian snacks, there are options for barbeque items like paneer and mushroom tikka as well as various fried snacks like samosas, rolls and fritters made with vegetables.
Cognitive theories suggest that depressed individuals experience cognitive distortions and irrational beliefs that contribute to their mood disturbances. Beck's depression theory proposes that depressed people tend to develop negative cognitive schemas, such as overgeneralization from negative events, illogical thoughts about themselves, and dichotomous thinking. A perspective study found a possible link between certain cognitive styles and the later development of depression.
Additionally, social and cultural factors can influence depression risk. Research by Brown and Harris determined that lack of social support, unemployment, several young children, loss of a parent early in life, and a history of abuse increased vulnerability to depression. Collectivist cultures tend to have lower depression rates than individualist cultures. Women are also more likely to experience clinical
Centegra Health System is introducing revolutionary 3D breast imaging technology called tomosynthesis at the Centegra Gavers Breast Center. Tomosynthesis takes multiple images of the breast from different angles to produce thin slices that can be viewed individually or as a 3D reconstruction, allowing radiologists to view tissues without overlap and detect cancers earlier. The new technology was made possible by donations to the Centegra Foundation including a $120,000 gift. Medical Nutrition Therapy is now also offered to help with weight loss and improving health conditions like diabetes and heart disease. Screening at Centegra led to early detection of cancer for a patient after plaque was discovered in her carotid artery during a vascular screening.
Presented by: Peter Harrod
Watch as you learn how to recognize deficiencies in your equipment, identify code violations, and plan the retroactive and forward thinking changes that will attract and retain tenants, lower risk and positively position your property for resale!
Watch the webinar on-demand: http://be.buildingengines.com/StatementofConditions_1.25.11_RegforOn-DemandWebinar.html
Acest document afost elaborat în cadrul Proiectului Europen YESdigital finanțat de Comisia Europeană prin Programul Lifelong Learning, acțiunea TOI LdV și conține detalii despre obiectivele și activitățile Workshop-ului PBL & Video.
1) The document introduces four children from Korea - Kim So-Mi, Park Ju-Hyuck, and Park Bo-Hyoung, who share details about their families, interests, and goals.
2) It also briefly describes the four seasons in Korea and some attractions in Suwon, including Bulhui alcoholic drink, Suwon History Museum, and Suwon Hwaseong Fortress.
3) The children say goodbye at the end.
The document describes various non-vegetarian and vegetarian snack options. For non-vegetarian snacks, there are options including chicken tikka, mutton kebabs, fish fingers and prawns prepared in different styles. For vegetarian snacks, there are options for barbeque items like paneer and mushroom tikka as well as various fried snacks like samosas, rolls and fritters made with vegetables.
2-3 июня 2014 года. ИЦ Сколково. http://startupvillage.ru
STARTUP VILLAGE – УНИКАЛЬНАЯ ИНТЕРАКТИВНАЯ ПЛОЩАДКА В ФОРМАТЕ OPEN AIR! ФЕСТИВАЛЬ НАУЧНО-ТЕХНИЧЕСКОГО ПРОГРЕССА, ТЕХНОЛОГИЧЕСКОГО ПРЕДПРИНИМАТЕЛЬСТВА И ХОРОШЕГО НАСТРОЕНИЯ
КОНФЕРЕНЦИЯ SUV: мастер-классы и индивидуальные тренинги от лидеров мирового инвестиционного и предпринимательского сообщества, представителей крупнейших научных центров, бизнес-гуру.
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Palmira Biopharma, company presentationSelf Employed
Palmbio is a bio-pharmaceutical company engaged in the discovery and development of a novel class of therapeutic proteins based on Soluble receptors (“traps”) for a range of serious human diseases, including cardiovascular diseases, ophthalmology and cancer. Today, the Company has seven molecules in the pipeline
нпмфу астлек приложение к заявке на грант презентация
Evrika trushina
1. Конкурс «Эврика» 2014
Микроконтейнеры для доставки лекарств в
мозг
Трушина Дарья Борисовна
МГУ им. М.В. Ломоносова, Физический факультет
Номинация: Образ жизни, здоровье и медицина, эко-инновации
2. Основная проблема доставки лекарственных
веществ в мозг – преодоление гемато-
энцефалического барьера (ГЭБ)
Решение - Интраназальный
способ введения лекарств
Обход ГЭБ
Неинвазивный метод
Быстрое действие лекарства
Пролонгированное действие
Отсутствие влияния на другие органы
Минусы: Низкая биодоступность
препаратов, очищение реснитчатого
эпителия
Решение: Использование
микроконтейнеров, загруженных
лекарственным веществом, покрытие
частиц специальным полимером
3. Контейнеры – частицы карбоната кальция
• Гибкость системы: возможность
варьировать размер частиц, пор,
полимер для покрытия;
• дешевизна, легкость получения;
• биосовместимость;
• широкая область применения;
• пористая структура обеспечивает
высокую адсорбционную
способность к широкому диапазону
соединений Размер частицы – 5 мкм,
размер пор – 2-80 нм.
4. Актуальность
Система может быть использована для создания эффективных
лекарственных форм для лечения большого количества
нейродегенеративных заболеваний мозга (болезнь Альцгеймера,
Паркинсона, Пика, эпилепсия, лечение опухолей мозга…)
Паркинсонизм Альцгеймер
• Заболеваемость:
1-2% - старше 50лет
3.4% - старше 75 лет
10% - старше 80 лет
В последнее время стал
встречаться у людей до 40
лет (около 5% людей с
диагнозом болезнь
Паркинсона моложе 40 лет).
• Всего в мире ей страдают около
14,5 миллионов человек, причем
на ее долю приходится 60% всех
случаев слабоумия
• Общемировая заболеваемость на
2006 год оценивалась в 26,6 млн
человек, а к 2050 году число
больных может вырасти вчетверо
• В США по состоянию на 2000 год:
1.6 % - 65–74 года
19 % - 75–84 года
42% - старше 84 лет
5. Подобные разработки
Конечных продуктов нет, есть лабораторные разработки за рубежом
Известна фармакологическая композиция, предназначенная для введения в мозг активного компонента с
проникновением через ГЭБ, содержащая вещество-контейнер, фармакологически активный компонент
и сурфактант (патент США № 6117454, "Drug targeting to the nervous system by nanoparticles", МПК
A61K 9/51, опубл. 12.09.2000).
Разрабатываются системы доставки
на основе других частиц:
полибутилцианоакрилат,
диоксид титана, оксид кремния,
полистирол, гидроксиапатит,
полилактид, хитозан
Другие методы введения или за счет
увеличения проницаемости
слизистой и ее разрушения
То, что предлагается:
Неинвазивный метод введения
лекарства в мозг с использованием
контейнеров на основе карбоната
кальция
Трудоемкие методы получения
Токсичные продукты разложения
Необходимость применения
дорогостоящих компонентов
Высвобождение активного компонента
за счет деструкции частиц
(ограниченное время высвобождения)
Использование органических
растворителей
Трудности с масштабированием
Преимущества:
• Гибкость системы доставки
• Низкая стоимость производства
• В мозг попадает только лекарство !!!
• Усиление эффекта от действующего вещества
• Снижение побочных эффектов
6. Коммерциализация
• Универсальность предлагаемой системы предоставляет
широкий рынок сбыта – потребителями являются
крупные современные фармакологические компании
Мировой рынок средств лечения
болезней ЦНС
2005 г. – 55.5 млрд.долл.
2011 г. - 65 млрд. долл.
К 2019 г. объем европейского рынка
лекарственных средств для лечения
болезни Альцгеймера составит 4,78
млрд долл. США (2012г -1,80 млрд
долл.). (Pharma Times)
Компании, производящие препараты для
интраназального введения: Aegis Therapeutics LLC,
Alza Corporation, AptarGroup, Inc., Archimedes
Pharma Limited., AstraZeneca Plc., MedImmune, Inc.,
Bayer Consumer Care, Bespak Plc.,
GlaxoSmithKline Plc, Ikano Therapeutics Inc., Javelin
Pharmaceuticals, Inc., Kurve Technology, Inc., Marina
Biotech, Inc., Merck & Co., Inc., Novartis AG,
OptiNose AS, Pfizer Inc., Rexam Plc, Sanofi S.A, and
Unigene Laboratories, Inc.Market data and analytics…
7. Экспериментальная база
• Лабораторные in-vitro исследования –
Институт кристаллографии
РАН
• In-vivo исследования –
Институт высшей нервной
деятельности и
нейрофизиологии РАН