Focusing on health verticle consistent with Open Knowledge Networking initiative. Also see a relevant review of: Contextualized Knowledge Graph portal: https://www.slideshare.net/ntkimvinh7/ckg-portal-a-knowledge-publishing-proposal-for-open-knowledge-network

1. Evolving Open Health Knowledge Network
Amit Sheth
LexisNexis Ohio Eminent Scholar, Wright State U
Executive Director, Kno.e.sis
Co-founder, ezDI
amit@knoesis.org
27th October, 201727th October, 2017

2. 2
Background

3. Active Healthcare Projects in Kno.e.sis
kHealth
for
Asthma
kHealth
for
Bariatrics
kHealth for
Dementia
Depression
EDrugTrends
EDarkNets
Alchemy for
Healthcare
Knowledge Graph
Development
Platform
Contextual Knowledge
Representation
3

4. HealthChallenges
(Also, Dementia,
Obesity,
Parkinson’s, Liver
Cirrhosis, ADHF )
Public Policy/
Population
Epidemiology Personalized
Health
PCS + EMR
kHealth
Asthma in Children
Bariatric Surgery
Physical(IoT)/Cyber/
Social (PCS)+ EMR
Marijuana Social
Drug Abuse Social
Mental Health
Depression (Suicide) Social + Public + EMR
Health Knowledge
Graph
Services
Social + Clinical Data
Health Related Studies at Kno.e.sis [overview]
4
...and infrastructure
technologies: Context-
aware KR (SP), KG
development, Smart
Data from PCS Big Data,
Twitris,....

5. Role of Knowledge Graph
Various distributed
knowledge sources
Update Knowledge
Graph
Core Services offered by
EKN
Personalized Health
Management
Evolving Open
Health Knowledge
Graph (EKN)
Disease Progression
Intervention
CDI and CAC
5

6. HKG & HDB enabled Services
6
Semantic
Browsing
Extraction
Data Integration and Interlinking
Entity
Complex Extraction
Aberrant
Drug-related
Behaviour
Neuro-Cognitive
Symptoms
Adverse
Drug
Reaction
Relation IntentSeverity
Context Representation Relevant Subgraph Selection
Semantic Search
Disease-specific
Chatbot
Visualization
Event
Personal Sensor Data
De-identified EMR Blog Post
Health Knowledge
Graph

7. Alchemy for Healthcare Project
Cloning and characterization of the mouse MColn1 gene
reveals an alternatively spliced transcript not seen in humans.
cloning characterization mouse MColn1 gene
alternatively spliced transcript
Raw Text Data
Markov Random
Fields
Natural Language
Processing
techniques
Compound Entities
Mucolipidosis
Type IV
Lysosomal
Homologue gene
Transmembrane
protein
Word2Vec enhanced query to
Medical Knowledge Bases for
relevant entities
Enriched Knowledge
<Cloning characterization mouse MCol1 gene> < Predicate> <alternatively spliced transcripts>
<Cloning characterization mouse MCol1 gene> < Predicate> <Mucolipidosis Type IV>
<Mucolipidosis Type IV> <Predicate> <lysosomal>
<MCol1 gene> < Predicate> <Homologue gene>
<alternatively spliced transcripts> <Predicate> <transmembrane protein>
Context Embedding technique and
Hierarchical Clustering algorithms
Contextually Related entities
Relationship validation from
Structured Knowledge Bases
Cloning characterization
mouse MCol1 gene
Alternatively spliced
transcripts
reveals
Cloning characterization
mouse MCol1 gene
Mucolipidosis Type IV
causes
Relationship present in text
identified
Additional relationships, i.e.
additional relevant knowledge
identified
7

8. Augmented Personalize Health [dHeath/mHealth]
Personal level
Signals
Risk Model
Events from
Social streams
Take Medication before
going to work
Avoid going out in the
evening due to high
pollen levels
Analysis
Personalized
Actionable
Information
Data Acquisition &
aggregation
Public level
Signals
Population
level Signals
Domain
Knowledge
Contact Doctor
Evolving Open Health
Knowledge Graph
(EKN)
http://bit.ly/k-APH
8

9. Ohio Center of Excellence in Knowledge-enabled Computing
Wright State University
Thank you
Visit us at http://knoesis.org