Breaking through that running rut - with some help from an Instagram coach! Some easy tips to train less, rest more, and get more out of your marathon training to break through your plateau and achieve new PRs and more confidence in your running ability!
Jennifer Heiner directs retail operations for a New Jersey running company, including performing the human resources function for the company’s retail stores, monitoring inventory, and overseeing customer service satisfaction levels. She also plays a major role in the firm’s sponsorship of five races in the metropolitan area. Prior to taking her current job, she worked as a client services coordinator at a northern New Jersey animal hospital. An owner of an English bulldog, Jennifer Heiner volunteers much of her time with animal rescue groups.
Running an animal rescue is hard work, though it can also be immensely rewarding. Some of the important elements of starting an animal rescue is determining the target animals, how they’ll be boarded and fed before adoption, arranging for medical attention, engaging the services of volunteers, paid staff, and board members, and navigating government regulations both for an animal rescue and a business.
Most animal rescues operate as not-for-profit organizations, a status which must be secured from the Internal Revenue Service (IRS), which means that their income isn’t taxed like other businesses. They still incur expenses that must be met. They generate income by seeking contributions from the general public and area businesses by charging adoption and surrender fees. They try to keep expenses low by recruiting volunteer labor and foster parents when appropriate and entering into partnerships with area veterinarians and animal welfare organizations.
For animal lovers with entrepreneurial inclinations, operating an animal rescue might be the ideal career path. For those not oriented to the whole business side of the equation, an alternative option is to get a job working as paid staff for an existing animal rescue.
Jennifer Heiner is a sales professional and animal lover who owns an English bulldog. Scientific studies have shown that owning a dog can boost both physical and emotional health. Dogs make their owners feel happier by increasing oxytocin levels. They also encourage more physical activity, as dog owners walk an average of 300 minutes per week compared to 100 minutes for non-owners. Additionally, the human-dog bond helps lower stress levels, reducing the risk of cardiovascular disease.
This year's New York City Marathon will mark the 50th running of the event. It is expected to host one of the most successful women's fields in history, following a successful Tokyo Olympics. Top runners expected to compete include Molly Seidel, who won bronze in her third ever marathon in Tokyo, and Des Linden, the 2018 Boston Marathon winner who will have a quick turnaround after also running the rescheduled 2021 Boston Marathon several weeks prior.
Choosing the right running shoe is important to prevent injury and maximize comfort and performance. Runners should consider their foot type, running gait, and terrain when selecting a shoe with the proper support and cushioning. A knowledgeable salesperson can help analyze a runner's needs to pick the best shoe for their body and running routine.
Jennifer Heiner graduated from Lehigh University with degrees in marketing and economics. Since 2019, she has served as the retail director of a New Jersey running company. To choose the optimal running shoes, select shoes specifically designed for running to prevent injury, and make sure the shoes fit comfortably with half an inch of space at the toe and your foot centered without pinching or sliding.
Trail runners should choose shoes with good grip if they run on trails frequently. Road runners are often better suited to lightweight shoes that can also be used for sprints and races. Runners should replace their shoes every 400-500 miles and purchase new shoes in person from a store that can properly analyze their gait, arch type, and foot width to find shoes tailored to their individual needs in order to reduce injury and improve performance.
Breaking through that running rut - with some help from an Instagram coach! Some easy tips to train less, rest more, and get more out of your marathon training to break through your plateau and achieve new PRs and more confidence in your running ability!
Jennifer Heiner directs retail operations for a New Jersey running company, including performing the human resources function for the company’s retail stores, monitoring inventory, and overseeing customer service satisfaction levels. She also plays a major role in the firm’s sponsorship of five races in the metropolitan area. Prior to taking her current job, she worked as a client services coordinator at a northern New Jersey animal hospital. An owner of an English bulldog, Jennifer Heiner volunteers much of her time with animal rescue groups.
Running an animal rescue is hard work, though it can also be immensely rewarding. Some of the important elements of starting an animal rescue is determining the target animals, how they’ll be boarded and fed before adoption, arranging for medical attention, engaging the services of volunteers, paid staff, and board members, and navigating government regulations both for an animal rescue and a business.
Most animal rescues operate as not-for-profit organizations, a status which must be secured from the Internal Revenue Service (IRS), which means that their income isn’t taxed like other businesses. They still incur expenses that must be met. They generate income by seeking contributions from the general public and area businesses by charging adoption and surrender fees. They try to keep expenses low by recruiting volunteer labor and foster parents when appropriate and entering into partnerships with area veterinarians and animal welfare organizations.
For animal lovers with entrepreneurial inclinations, operating an animal rescue might be the ideal career path. For those not oriented to the whole business side of the equation, an alternative option is to get a job working as paid staff for an existing animal rescue.
Jennifer Heiner is a sales professional and animal lover who owns an English bulldog. Scientific studies have shown that owning a dog can boost both physical and emotional health. Dogs make their owners feel happier by increasing oxytocin levels. They also encourage more physical activity, as dog owners walk an average of 300 minutes per week compared to 100 minutes for non-owners. Additionally, the human-dog bond helps lower stress levels, reducing the risk of cardiovascular disease.
This year's New York City Marathon will mark the 50th running of the event. It is expected to host one of the most successful women's fields in history, following a successful Tokyo Olympics. Top runners expected to compete include Molly Seidel, who won bronze in her third ever marathon in Tokyo, and Des Linden, the 2018 Boston Marathon winner who will have a quick turnaround after also running the rescheduled 2021 Boston Marathon several weeks prior.
Choosing the right running shoe is important to prevent injury and maximize comfort and performance. Runners should consider their foot type, running gait, and terrain when selecting a shoe with the proper support and cushioning. A knowledgeable salesperson can help analyze a runner's needs to pick the best shoe for their body and running routine.
Jennifer Heiner graduated from Lehigh University with degrees in marketing and economics. Since 2019, she has served as the retail director of a New Jersey running company. To choose the optimal running shoes, select shoes specifically designed for running to prevent injury, and make sure the shoes fit comfortably with half an inch of space at the toe and your foot centered without pinching or sliding.
Trail runners should choose shoes with good grip if they run on trails frequently. Road runners are often better suited to lightweight shoes that can also be used for sprints and races. Runners should replace their shoes every 400-500 miles and purchase new shoes in person from a store that can properly analyze their gait, arch type, and foot width to find shoes tailored to their individual needs in order to reduce injury and improve performance.
Jennifer Heiner is the retail director for an East Coast running company, managing four retail stores and helping launch their new sneaker line. In her free time, she enjoys trying new restaurants and wines, especially lighter rose wines during the summer.
English Bulldogs have a difficult time cooling themselves down due to their physical traits. As a brachycephalic breed, they have short snouts and thick wrinkly skin which makes it hard for them to pant and regulate their body temperature. Their shortened nasal passages also limit effective breathing and heat dissipation.
The Phoenix Marathon will take place in 2018. As the date approaches, the sun is increasing temperatures in Arizona, a state known for its hot climate. Runners will have to battle the heat when competing in this marathon.
The document discusses the 2018 Phoenix Marathon. It notes that the runner is still smiling early in the race and has not yet felt any pain or hit the proverbial "wall" that runners sometimes experience later in long distance races.
The Phoenix Marathon took place in 2018. The document refers to a marathon race that was more than halfway completed. It does not provide any other details about the event, participants, or results.
The document discusses a marathon race that took place in Phoenix in 2018. It notes that the author finished the race and set a new personal record (PR) with a time of 3 hours, 37 minutes and 39 seconds.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Jennifer Heiner is the retail director for an East Coast running company, managing four retail stores and helping launch their new sneaker line. In her free time, she enjoys trying new restaurants and wines, especially lighter rose wines during the summer.
English Bulldogs have a difficult time cooling themselves down due to their physical traits. As a brachycephalic breed, they have short snouts and thick wrinkly skin which makes it hard for them to pant and regulate their body temperature. Their shortened nasal passages also limit effective breathing and heat dissipation.
The Phoenix Marathon will take place in 2018. As the date approaches, the sun is increasing temperatures in Arizona, a state known for its hot climate. Runners will have to battle the heat when competing in this marathon.
The document discusses the 2018 Phoenix Marathon. It notes that the runner is still smiling early in the race and has not yet felt any pain or hit the proverbial "wall" that runners sometimes experience later in long distance races.
The Phoenix Marathon took place in 2018. The document refers to a marathon race that was more than halfway completed. It does not provide any other details about the event, participants, or results.
The document discusses a marathon race that took place in Phoenix in 2018. It notes that the author finished the race and set a new personal record (PR) with a time of 3 hours, 37 minutes and 39 seconds.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
How to Control Your Asthma Tips by gokuldas hospital.Gokuldas Hospital
Respiratory issues like asthma are the most sensitive issue that is affecting millions worldwide. It hampers the daily activities leaving the body tired and breathless.
The key to a good grip on asthma is proper knowledge and management strategies. Understanding the patient-specific symptoms and carving out an effective treatment likewise is the best way to keep asthma under control.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
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- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
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