The document discusses major themes in Hamlet including isolation, betrayal of trust, romantic love, and appearance and disguise. As Hamlet descends further into madness, he becomes increasingly isolated from those around him with the exception of Horatio. Many characters spy on one another, destroying genuine interactions. Romantic love is portrayed as failing through the Queen's actions and Ophelia's rejection of Hamlet. A key theme is the shifting of identities and disguises used by many characters, calling into question what is real versus just appearance.