This study reviewed 15 years of experience with emergency coronary artery bypass grafting (CABG) after unsuccessful percutaneous transluminal coronary angioplasty (PTCA) at a hospital in Australia. The study found that of over 4,000 PTCA procedures performed during that period, 74 patients (1.8%) required emergency CABG within 24 hours of PTCA failure. Compared to a matched group of 74 elective CABG patients, the emergency CABG patients had a higher rate of acute myocardial infarction (AMI) after the procedure (8.1% vs 2.7%) but similar low mortality rates (2 deaths vs none). With prompt and complete revascularization, outcomes for emergency CABG patients were not significantly
Reperfusion strategy in patients with ST-Segment Elevation Myocardial Infarct...Premier Publishers
Reperfusion therapy is the cornerstone in management of STEMI. This study was designed to evaluate both In-hospital and 30 days outcome in patients with STEMI treated with primary percutaneous coronary intervention (PPCI) versus fibrinolysis. This prospective, controlled, study included 140 patients with STEMI who were eligible for reperfusion therapy. In hospital and 30 days major adverse cardiovascular events (MACE) were reported and head to head comparison was done between PPCI versus fibrinolysis. All-cause mortality was reported in 5% of patients (10% versus 0% in fibrinolysis and PPCI respectively, p=0.07), recurrence of ischemic symptoms was reported in 18% of patients (30% versus 7% in fibrinolysis and PPCI respectively, P =0.02), heart failure was evident in 22% of patients (33% versus 10% in fibrinolysis and PPCI respectively, P =0.02). PPCI is safe and effective treatment option for patients with STEMI
DANISH is a major breakthrough trial published in NEJM on 29/09/2016 regarding Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure. All content of this slide is Copy right of NEJM.
Meta analysis of percutaneous ventricular restoration (pvr) therapy using the...Cardio Kinetix
This is a presentation given by Martyn R. Thomas, MD titled "Meta-Analysis of Percutaneous Ventricular Restoration (PVR) Therapy Using the Parachute Device in Patient's With Ischemic Dilated Heart Failure". The Parachute is a medical device created by Cardio Kinetix (http://www.cardiokinetix.com/) that helps to prevent heart failure in heart attack patients.
Reperfusion strategy in patients with ST-Segment Elevation Myocardial Infarct...Premier Publishers
Reperfusion therapy is the cornerstone in management of STEMI. This study was designed to evaluate both In-hospital and 30 days outcome in patients with STEMI treated with primary percutaneous coronary intervention (PPCI) versus fibrinolysis. This prospective, controlled, study included 140 patients with STEMI who were eligible for reperfusion therapy. In hospital and 30 days major adverse cardiovascular events (MACE) were reported and head to head comparison was done between PPCI versus fibrinolysis. All-cause mortality was reported in 5% of patients (10% versus 0% in fibrinolysis and PPCI respectively, p=0.07), recurrence of ischemic symptoms was reported in 18% of patients (30% versus 7% in fibrinolysis and PPCI respectively, P =0.02), heart failure was evident in 22% of patients (33% versus 10% in fibrinolysis and PPCI respectively, P =0.02). PPCI is safe and effective treatment option for patients with STEMI
DANISH is a major breakthrough trial published in NEJM on 29/09/2016 regarding Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure. All content of this slide is Copy right of NEJM.
Meta analysis of percutaneous ventricular restoration (pvr) therapy using the...Cardio Kinetix
This is a presentation given by Martyn R. Thomas, MD titled "Meta-Analysis of Percutaneous Ventricular Restoration (PVR) Therapy Using the Parachute Device in Patient's With Ischemic Dilated Heart Failure". The Parachute is a medical device created by Cardio Kinetix (http://www.cardiokinetix.com/) that helps to prevent heart failure in heart attack patients.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results.
A primary Percutaneous Coronary Intervention (PCI) Primary PCI continues to be the optimal reperfusion therapy in
patients with ST elevation myocardial infarction however, in areas where PCI centers are not readily available, a pharmaco-invasive strategy has been proposed. This study investigated the safety, efficacy and cost effective analysis of a pharmaco-invasive strategy compared with primary (PCI) strategy for ST-Segment Elevation Myocardial Infarction (STEMI) in Gaza.
Methods: We ran domized 145 patients presenting within 2 hours of symptom onset of acute ST elevation myocardial infarction to primary PCI or for pharmaco-invasive PCI 2-24 hours after streptokinase, except in the event of failed reperfusion, in which case, emergency angiography was recommended. The primary endpoint a composite of death, shock and congestive heart failure at 30 days. Secondary end points: total bleeding and failed streptokinase required emergent PCI. Tertiary end points: cost effective analysis.
Bleeding avoidance strategies, such as a transradial approach (TRA), should be considered especially for patients with high bleeding risk.3) However, PCI operators hesitate to choose conventional TRA for patients on dialysis because of the increased risk of radial artery occlusion (RAO) and general tendency to preserve possible hemodialysis access points for the future.
Terapi Endovaskuler, Standar Baru Manajemen Stroke Iskemik Akut? Ersifa Fatimah
Konon, plenary pertama International Stroke Conference (ISC) 2015 yang digelar di Nashville, Tennessee bulan Februari lalu merupakan sesi ISC terseru selama beberapa tahun terakhir. Sebagaimana diberitakan dalam Medscape (Hughes, 2015), para presenter terpaksa memberi jeda beberapa saat untuk menyambut applause dari audiens. Suatu kejadian langka dalam partemuan saintifik. Adalah MR CLEAN, ESCAPE, EXTEND-IA, dan SWIFT PRIME yang menjadi topik hangat lantaran keempat studi ini dirilis dengan hasil yang positif dramatis hingga diprediksi bakal menjadikan terapi endovascular sebagai standar baru dalam manajemen stroke iskemik akut. Sehebat apakah 4 studi yang “menyejarah” dalam tatalaksana stroke iskemik akut ini? Bagaimana bila studi-studi ini diadopsi dan diaplikasikan dalam praktik sehari-hari di sentra kita?
Note: Esai ini ditulis saat SWIFT PRIME fulltext belum published (akhir Maret-awal April 2015). Update & beberapa revisi dibuat menjelang presentasi tanggal 18 Mei 2015.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results.
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results
Right Anterior Thoracotomy Minimally Invasive Aortic Valve Replacement vs. Co...semualkaira
This research aims to compare intraoperative
and postoperative outcomes of Right Anterior Thoracotomy minimally invasive aortic valve replacement (RAT-MIAVR) surgery
with conventional aortic valve replacement (C-AVR) surgery and
analyze the results.
A primary Percutaneous Coronary Intervention (PCI) Primary PCI continues to be the optimal reperfusion therapy in
patients with ST elevation myocardial infarction however, in areas where PCI centers are not readily available, a pharmaco-invasive strategy has been proposed. This study investigated the safety, efficacy and cost effective analysis of a pharmaco-invasive strategy compared with primary (PCI) strategy for ST-Segment Elevation Myocardial Infarction (STEMI) in Gaza.
Methods: We ran domized 145 patients presenting within 2 hours of symptom onset of acute ST elevation myocardial infarction to primary PCI or for pharmaco-invasive PCI 2-24 hours after streptokinase, except in the event of failed reperfusion, in which case, emergency angiography was recommended. The primary endpoint a composite of death, shock and congestive heart failure at 30 days. Secondary end points: total bleeding and failed streptokinase required emergent PCI. Tertiary end points: cost effective analysis.
Bleeding avoidance strategies, such as a transradial approach (TRA), should be considered especially for patients with high bleeding risk.3) However, PCI operators hesitate to choose conventional TRA for patients on dialysis because of the increased risk of radial artery occlusion (RAO) and general tendency to preserve possible hemodialysis access points for the future.
Terapi Endovaskuler, Standar Baru Manajemen Stroke Iskemik Akut? Ersifa Fatimah
Konon, plenary pertama International Stroke Conference (ISC) 2015 yang digelar di Nashville, Tennessee bulan Februari lalu merupakan sesi ISC terseru selama beberapa tahun terakhir. Sebagaimana diberitakan dalam Medscape (Hughes, 2015), para presenter terpaksa memberi jeda beberapa saat untuk menyambut applause dari audiens. Suatu kejadian langka dalam partemuan saintifik. Adalah MR CLEAN, ESCAPE, EXTEND-IA, dan SWIFT PRIME yang menjadi topik hangat lantaran keempat studi ini dirilis dengan hasil yang positif dramatis hingga diprediksi bakal menjadikan terapi endovascular sebagai standar baru dalam manajemen stroke iskemik akut. Sehebat apakah 4 studi yang “menyejarah” dalam tatalaksana stroke iskemik akut ini? Bagaimana bila studi-studi ini diadopsi dan diaplikasikan dalam praktik sehari-hari di sentra kita?
Note: Esai ini ditulis saat SWIFT PRIME fulltext belum published (akhir Maret-awal April 2015). Update & beberapa revisi dibuat menjelang presentasi tanggal 18 Mei 2015.
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptxEduSkills OECD
Andreas Schleicher presents at the OECD webinar ‘Digital devices in schools: detrimental distraction or secret to success?’ on 27 May 2024. The presentation was based on findings from PISA 2022 results and the webinar helped launch the PISA in Focus ‘Managing screen time: How to protect and equip students against distraction’ https://www.oecd-ilibrary.org/education/managing-screen-time_7c225af4-en and the OECD Education Policy Perspective ‘Students, digital devices and success’ can be found here - https://oe.cd/il/5yV
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
2. records, and the surgeons’ records. Control group data
were matched to the crash group data for the year of
operation, the number of coronary systems diseased, and
number of bypass grafts performed. We then checked
that there were no statistically significant differences in
preoperative risk factors. Preoperative risk factors as-
sessed for the two study groups included left ventricular
ejection fraction, coexisting valvular heart disease, diabe-
tes mellitus, obesity, previous stroke, preexisting chronic
renal impairment, chronic obstructive pulmonary dis-
ease, peripheral vascular disease, and family history of
ischemic heart disease. Patients who had previous CABG
were excluded from both groups. Preoperative compari-
son is shown in Table 1.
Statistics
Comparison between the crash and control groups was
performed using the SPSS statistical software package
(SPSS Inc, Chicago, IL). Fisher’s exact tests were calcu-
lated for two-by-two tables. Mann-Whitney U tests were
calculated for continuous data, as appropriate.
Results
Emergency surgery was necessary in 74 patients having
PTCA (1.8%). The PTCA failure rate leading to emer-
gency CABG was 4.2% over the first half of the study
(January 1982 to June 1989) and was 1.3% over the latter
half of the study (July 1989 to December 1996 inclusive).
Comparisons of preoperative criteria studied are shown
in Table 1. Of the 74 crash CABG patients, all were
intended to have angioplasty of one system, usually a
single culprit vessel. The angiograms had been reported
before intervention, and on review of these reports it was
found that 47 of 74 patients (63.5%) had significant
stenosis of one coronary system, 19 of 74 (25.7%) had
two-system disease, and 8 of 74 (10.8%) had three-system
disease. Two patients had significant left main stem
disease. Details regarding coronary arteries diseased,
coronary systems grafted, mean cardiopulmonary bypass
(CPB) times, and number of distal anastomoses per-
formed for both study groups are shown in Table 2.
PTCA failures were due to arterial dissection with or
without complete occlusion in 40 patients (54%) and
complete occlusion without dissection in 34 patients
(46%). Vessels intended to be dilated were the left ante-
rior descending in 39 patients (52.7%), the right coronary
artery in 26 patients (35.1%), and the left circumflex in 9
patients (12.2%). Only 1 patient had two-vessel dilatation
for disease of the left anterior descending and first
diagonal arteries. GpIIbIIIa inhibitors were not available
at our institution until 1998. Intraaortic balloon pumps
(IABP) were not inserted preoperatively. A coronary
artery stent was inserted in 3 patients (4%), indicated by
arterial dissection in 2 and acute arterial closure in 1
Table 1. Comparison of Preoperative Characteristics by
Patient Group
Age (years)
Mean 59.7 61.7 NS
Range
Female sex
37.3–80.8
18 (24%)
41.6–76.8
20 (27%) NS
Duration of angina (months)
Mean
Range
Previous MI
28.3
1–240
38 (51%)
38.4
1–240
33 (45%)
<0.05
NS
Unstable angina before PTCA 53 (72%) n/a
Family history of IHD 24 (32%) 15 (20%) NS
Valvular heart disease 1 (1%) 2 (3%) NS
Diabetes 12 (16%) 7 (9%) NS
Smoking history 34 (46%) 56 (76%) <0.01
Hypertension 34 (46%) 19 (26%) <0.02
Hyperlipidemia 28 (38%) 37 (50%) NS
Obesity 30 (41%) 27 (36%) NS
Previous stroke 7 (9%) 8 (11%) NS
Creatinine >150 SI units 0 1 (1%) NS
Chronic airways limitation 1 (1%) 5 (7%) NS
Peripheral vascular disease 7 (9%) 6 (8%) NS
Venous disease 3 (4%) 7 (9%) NS
Ejection fraction
Mean 0.68 0.64 NS
Range 0.35–0.88 0.26–0.87
Variable
Crash
Group
(n = 74)
Control
Group p
(n = 74) Value
IHD = ischemic heart disease; MI = myocardial infarction; n/a =
not applicable; NS = not significant; PTCA = percutaneous trans-
luminal coronary angioplasty; SI = system international.
Table 2. Extent of Coronary Artery Disease and Operative
Data
Arteries diseased
Right coronary artery 34 29 NS
Left anterior descending artery 52 62 NS
Left circumflex artery 23 18 NS
Left main artery 2 1 NS
Coronary systems grafted
One 47 47
Two 19 19
Three 8 8
Mean systems grafted 1.5 1.5 NS
Cardiopulmonary bypass time (min)
Mean 52.2 57.2
Range 26–104 25–111 NS
Distal anastomoses
One 28 22
Two 25 29
Three 12 12
Four 5 7
Five 2 4
Six 1 0
Seven 1 0
Mean number 2.1 2.2 NS
NS = not significant.
Variable
Crash Control
Group Group p
(n = 74) (n = 74) Value
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Ann Thorac Surg
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3. patient. Of these 3, the patient with acute arterial closure
sustained an AMI but made a good recovery after emer-
gency CABG. The remaining 2 patients did well without
complication after emergency CABG. A reperfusion cath-
eter was inserted in 24 crash group patients (32%). For
details regarding outcomes after emergency CABG after
unsuccessful PTCA with and without reperfusion cathe-
ter usage see Figure 1.
Angioplasty failure was accompanied by angina in 63
patients (85%), and ECG changes of evolving myocardial
infarction in 58 patients (78%). Hemodynamic instability
occurred in 24 patients (33%) after the procedure, with
prolonged hypotension in 13 patients (18%), and unstable
ventricular arrhythmias in 8 patients (11%). Cardiopul-
monary resuscitation was required for 3 patients (4%)
with evolving AMI and shock who were transported
directly to the operating theater. These 3 patients were
massaged onto CPB, fortunately all of whom survived.
The average time from termination of the PTCA to
commencement of CPB was 3 hours 22 minutes for 59
patients (80%) in whom the decision to operate was made
in the catheterization laboratory. After emergency CABG
the AMI and mortality rates for these patients were 4 of
59 (6.8%) and 2 of 59 (3.4%) respectively. For the remain-
ing 15 patients time from termination of PTCA to com-
mencement of CPB ranged from 6 to 24 hours. These
patients had all developed intractable angina pectoris
and signs of evolving myocardial infarction that necessi-
tated emergency operative revascularization. After emer-
gency CABG the AMI rate for these patients was 2 of 15
(13.3%) with no mortality. The overall mortality rate for
the crash group was 2 of 74 (2.7%).
Crash group patients received St. Thomas II cardiople-
gic solution (crystalloid buffered with bicarbonate with-
out additives; Mayne Pharma, Melbourne, Victoria). This
was administered antegrade through the aortic root in 65
patients. Nine patients received cardioplegia through
other means: retrograde through the coronary sinus in 2,
antegrade and retrograde in 2, antegrade and retrograde
and down the grafts in 1, and antegrade and down the
grafts in 4 patients. These 9 patients were operated on
over the last 7 years of the study (1991 to 1996 inclusive)
and none of these patients suffered myocardial infarction
or died.
There was no significant difference in the CPB times of
the two groups. Although single system angioplasty was
initially intended for all patients, at operation the average
number of systems grafted was 1.5 (see Table 2). The left
internal mammary artery (LIMA) was used for bypass
grafting in 25 patients (34%) in the crash group (4
sustained AMI, with no mortality) and 51 patients (69%)
in the control group (2 sustained AMI, with no mortality).
The average number of distal anastomoses for patients in
the crash group was 2.1 (range, 1 to 7), and for the
matched control group was 2.2 (range, 1 to 5). During the
same period the average number of distal anastomoses
was 4.1 per patient for those who underwent primary
coronary revascularization at our unit.
Differences in morbidity for the crash group between
the first and second half of the study and comparison
with the control group are shown in Table 3. For the crash
group over the first half of the study there was a higher
rate of low cardiac output, postoperative hemorrhage
greater than 1.5 L, myocardial infarction, and 30-day
mortality. There were no significant differences between
the two study groups in incidences of postoperative AMI
or 30-day mortality. In the crash group AMI developed in
6 patients, 2 of whom died. In the control group 2 patients
developed AMI, with no mortality. There were no signif-
icant differences in requirement for postoperative cat-
echolamines, reoperation for hemorrhage, nor the inci-
dence of postoperative arrhythmias. There was no
significant difference between mean in-hospital length of
stay.
Comment
The reported incidence of emergency CABG after PTCA
failure ranges from 0.32% to 7% [1–5, 7]. Emergency
CABG after PTCA failure is now required infrequently,
however, owing to increased operator experience in
PTCA techniques and intracoronary stent usage [4, 7].
The consequences of PTCA failure can be serious and
include AMI and death. The international literature in-
dicates that the patient immediately enters a higher risk
group after PTCA failure, with reported mortality rates
for subsequent emergency CABG of 3.8% to 14% [1–5]. In
contrast, the 30-day mortality in this series was 2 of 74
(2.7%). The explanation for this is multifactorial and
demands a multidisciplinary approach to management
after PTCA failure. In our experience the key factors in
achieving a satisfactory outcome include simultaneous
Fig 1. Details regarding outcomes after emer-
gency coronary artery bypass graft (CABG)
surgery after unsuccessful percutaneous trans-
luminal angioplasty (PTCA) with and with-
out reperfusion catheter usage. (AMI = acute
myocardial infarction despite emergency
CABG; h = hours; LIMA = left internal
mammary artery usage at CABG; m = min-
utes; OR = operating room.)
1402 BARAKATE ET AL
EMERGENCY SURGERY AFTER UNSUCCESSFUL ANGIOPLASTY
Ann Thorac Surg
2003;75:1400–5
CARDIOVASCULAR
4. resuscitation and management in the catheterization
laboratory, minimizing the time to surgical revasculariza-
tion (with the operating rooms in the same building as
the catheterization laboratory in our hospital), and com-
plete myocardial revascularization at surgery.
In the present study the overall rate of emergency
CABG after PTCA failure was 1.8%, with a rate of 4.2% for
the first half of the study period compared with 1.3%
during the latter half. The cause of PTCA failure in the
present study was arterial dissection (54%) and acute
arterial occlusion (46%), and these are the most com-
monly reported reasons for PTCA failure necessitating
emergency CABG [1–3, 8–11]. Other reported indications
for emergency surgery include arterial spasm and arte-
rial perforation into the pericardial cavity [1, 10–12].
More recently stent complications have been reported as
the cause of PTCA failure in as many as 37% of cases [4].
When PTCA failure causes coronary artery damage,
surgical options for that artery may be difficult depend-
ing upon the extent of the injury (ie, coronary artery
dissection). As a result of the failure 33% of patients in
this series were in critical condition before surgery. That
is consistent with 25% to 38% of patients in other re-
ported series being unstable before emergency CABG
after PTCA failure [2, 5, 8], highlighting the high risk
involved in operating in these circumstances.
Our devised policy was to get the patient to the
operating room and on CPB as quickly as possible. For
the crash group the AMI rate was 6.8% for those in whom
the decision to operate was made in the catheterization
laboratory, compared with 13.3% for those patients held
until intractable angina pectoris and signs of evolving
myocardial infarction developed (see Results). The re-
ported risk of AMI and death is proportional to the
duration of myocardial ischemia [1, 4, 5] and it was our
surgical aim to minimize the time to revascularization.
Measures to decrease ischemia may be used after PTCA
failure [2]. The use of reperfusion catheters after PTCA
failure has been shown to help reverse the ECG changes
seen and reduce the incidence of AMI [7, 12–14]. In our
experience reperfusion catheter usage resulted in a
longer delay to the commencement of CPB (4 hours 6
minutes versus 3 hours 18 minutes) and subsequently
higher AMI (12.5% versus 5.3%) and mortality (4.2%
versus 2.6%) rates for those patients in whom the deci-
sion to operate was made in the catheterization labora-
tory (see Fig 1). Reperfusion catheter use after unsuccess-
ful angioplasty may delay time to operative
revascularization and lead to a false sense of security,
potentially resulting in worse outcomes. This area needs
further investigation.
Other techniques reported to successfully decrease the
rate of AMI in this setting include the use of the IABP,
intracoronary nitroglycerin, and coronary stenting. Per-
cutaneous CPB may minimize myocardial damage after
unsuccessful PTCA but only when the patient regains a
stable cardiac rhythm [15]. In the early experience IABP
use meant an open procedure under difficult nonsterile
circumstances and our view was that the risk outweighed
the benefit of urgent CABG once the patient crashed.
Since the advent of percutaneous IABP this is now
possible in the catheterization laboratory but use should
not delay transfer to the operating room and institution
of CPB. Our experience has shown that IABP use (along
with new techniques) is not critical provided there is no
delay with prompt operative revascularization after un-
successful PTCA.
Table 3. Differences in Morbidity for the Crash Group Between the First and Second Half of the Study and Comparison
Between the Whole Crash and Control Groups
Clinical Variables
Crasha
Group
January 1982
to June 1989
(n = 22)
Crasha
Group
July 1989 to
December 1996
(n = 52)
Crash Group
Totalb
(n = 74)
Control Group
Totalb
(n = 74)
Intra-aortic balloon pump use 1 (4.5%) 0 1 (1%) 1 (1%)
Low cardiac output 2 (9.1%) 3 (5.8%) 5 (7%) 1 (1%)
Prolonged ventilation (>48 hours) 1 (4.5%) 2 (3.8%) 3 (4%) 3 (4%)
Required dialysis 0 0 0 1 (1%)
Required catecholamines 2 (9.1%) 4 (7.7%) 6 (8%) 7 (9%)
Hemorrhage >1.5 L 4 (18.2%) 5 (9.6%) 9 (12%) 6 (8%)
Reoperation for hemorrhage 0 2 (3.8%) 2 (3%) 1 (1%)
Permanent neurologic injury 1 (4.5%) 0 1 (1%) 0
Wound infection 0 1 (1.9%) 1 (1%) 0
Myocardial infarction 3 (13.6%) 3 (5.8%) 6 (8%) 2 (3%)
Atrial fibrillation on discharge 1 (4.5%) 0 1 (1%) 1 (1%)
Ventricular tachycardia (requiring cardioversion) 0 1 (1.9%) 1 (1%) 1 (1%)
Thirty-day mortality 1 (4.5%) 1 (1.9%) 2 (3%) 0
In-hospital length of stay
Mean (days) 10.1 9.1 9.4 8.3
Range 4–21 3–57 3–57 4–27
a
There were no significant differences in postoperative variables between the first and second halves of the study for patients in the crash group.
were no significant differences in postoperative variables between the whole crash and control group.
b
There
1403
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EMERGENCY SURGERY AFTER UNSUCCESSFUL ANGIOPLASTY
CARDIOVASCULAR
5. Ischemic time has been defined differently in previous
reports, making comparison difficult. Parsonnet and col-
leagues [1] reported time for transit from the catheteriza-
tion room to the operating room for 59 of 67 patients (88%
of their study group) averaging 26 minutes, with 8 pa-
tients (12%) held for observation until sudden accelera-
tion of symptoms and signs. In the post-PTCA group the
rate of AMI was 28% and mortality of 12% [1]. Greene
and colleagues [2] reported the time for revascularization
from angioplasty failure to when the patient came off
bypass. This time averaged 3 hours 4 minutes for 53
patients, with an AMI rate of 51% and a mortality rate of
3.8% [2]. Borkon and colleagues [5] reported 73 of 91
patients (80%) went directly from the catheterization
room to the operating room without specifying the actual
time while the remaining 18 patients (20%) had develop-
ment of symptoms within 24 hours after PTCA that
necessitated emergency CABG. The AMI rate was 29%
with a mortality rate of 12.1% [5]. The differences in
outcomes between these studies may in part be ex-
plained by a different method of estimating ischemic
time, which may inaccurately reflect the actual duration
of myocardial ischemia. Therefore we recommend stan-
dardization of reported ischemic times. We have em-
ployed the time from the onset of ischemia (by clinical
and angiographic features) to the commencement of
CPB. The time for onset of CPB was a consistently
reported time point for all patients and represents the
point at which the myocardium was rested.
Previous reports have employed varied methods for
obtaining control groups to compare with patients un-
dergoing emergency CABG after unsuccessful PTCA [1,
2, 5, 8, 10, 12]. We chose a control group who underwent
elective CABG matched for the year of operation, the
number of coronary systems diseased, and number of
bypass grafts performed. We then checked that there
were no statistically significant differences in preopera-
tive risk factors as shown in Table 1. We were unable to
confirm the validity of the data for smoking history and
presence of hypertension because these factors were not
consistently measured over the study period. Smoking
history was not always reliably recorded in the emer-
gency situation. Year of operation was matched to ensure
that similar surgical techniques were performed. In this
way we have compared the outcomes of an emergency
procedure after unsuccessful PTCA intervention with a
similar but elective procedure. It is interesting to note
that the PTCA (crash) group had a significantly shorter
duration of symptoms before intervention was offered
(see Table 1). It is also interesting that except for 1, all
patients were intended to have single-vessel PTCA tar-
geting the culprit vessel. At surgery, however, an average
2.1 coronary grafts (range, 1 to 7) were performed after
PTCA failure (see Table 2). That compares with an
average of approximately two grafts per patient having
emergency revascularization after failed PTCA in the
international literature [1–3, 5, 8]. It is only because of
very aggressive and complete coronary artery surgery
that we have been able to achieve results that are
equivalent to planned surgery (see Table 3). We have not
addressed long-term outcomes in this paper. This study
specifically addresses the immediate results with aggres-
sive CABG. The long-term outcomes in these circum-
stances would be complex but nevertheless of great
interest.
Recent data from Reinecke and colleagues [16] ana-
lyzed significant differences between survivors and non-
survivors of emergency CABG after failed PTCA. In their
study survivors were significantly younger (58.2 versus
65.4 years, p < 0.01), had greater mean body surface area
(1.93 m2
versus 1.73 m2
, p < 0.001), had lower mean
Cleveland score (7.06 versus 8.86, p < 0.001), more fre-
quently received complete operative revascularization
(80% versus 36%, p < 0.001), and had faster mean bypass
times (56 versus 91 minutes, p < 0.001). Furthermore this
paper stated that “non survivors were more frequently
female (64% versus 24%, p < 0.01), had a moderately or
severely reduced left ventricle (29% versus 9.4%, p <
0.05), more frequently required intensive treatment (car-
diocompression, defibrillation, IABP insertion etc., 93%
versus 33%, p < 0.001), and interestingly had faster mean
time from PTCA end to start of CABG (57 versus 94
minutes, p < 0.05)” [16]. In our series 6 patients sustained
AMI after PTCA failure and of these, 2 died. Of the
remaining 68 patients, none died. Although the relatively
small number of patients in our study who died pre-
cluded further analysis of mortality risk factors, reported
data indicates that the risk of death is greatest for those
who experience ongoing myocardial ischemia and AMI
despite surgical revascularization [1, 4, 5]. Other investi-
gators have found additional risk factors for mortality
including advanced age, low left ventricular ejection
fraction, multivessel disease, female sex, PTCA of unfa-
vorable stenoses, multiple vessel PTCA, and prior CABG
[5, 8, 10, 17, 18].
In summary, this series reports a low rate of AMI
(8.1%) and death (2.7%) for patients who underwent
emergency CABG after PTCA failure, results that were
not significantly different when compared with those of a
matched group who underwent elective CABG (see Ta-
ble 3). These results compare well with reports from units
with onsite surgical backup [1, 2, 5] and certainly com-
pare favorably with those from units with offsite surgical
backup, which cite high mortality rates of 14% [4]. The
results in this series have been achieved by simultaneous
resuscitation and management in the catheterization
laboratory, minimizing the time to surgical revasculariza-
tion, and complete myocardial revascularization at sur-
gery. Our salvage rate highlights the need for a coordi-
nated effort between cardiac surgeons and invasive
cardiologists. The era of having an operating room open
with surgeons and a team “standing by” is over. Yet acute
closures and dissections do still occur. A system that
allows early admission of trouble, notification of surgeon
and operating room team, and a coordinated effort to get
the patient to the operating room and on bypass will
clearly give the best chances of survival.
1404 BARAKATE ET AL
EMERGENCY SURGERY AFTER UNSUCCESSFUL ANGIOPLASTY
Ann Thorac Surg
2003;75:1400–5
CARDIOVASCULAR
6. The authors thank the surgeons Matthew S. Bayfield, FRACS,
Bruce G. French, FRACS, Nick Hendel, FRACS, Brian C. Mc-
Caughan, FRACS, and Duncan S. Thomson, FRACS, for their
contribution to the clinical work that formed the basis for this
research.
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Ann Thorac Surg
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CARDIOVASCULAR