This document discusses spatial econometrics and issues that can arise when performing regression analysis on spatial data. Ordinary least squares (OLS) regression may produce misleading results if there is spatial autocorrelation in the data. Spatial autocorrelation occurs when the value of a variable at one location is influenced by or correlated with values at nearby locations. This can violate OLS assumptions of independent errors. The document describes techniques like Moran's I and Lagrange multiplier tests to detect spatial autocorrelation and spatial regression models like spatial lag and spatial error models that account for spatial effects.