This document provides three scientific references related to epigenetics and nutrition. The first reference is a study finding that paternal obesity is associated with hypomethylation in newborns. The second reference is a study showing that successful treatment of post-traumatic stress disorder can reverse DNA methylation marks. The third reference is a disclaimer that individual results may vary.
This study analyzed perinatal mortality trends at Kathmandu Medical College Teaching Hospital from 2002-2007. It found that the perinatal mortality rate decreased from 30.7 in 2002-2003 to 19.1 in 2003-2005 but slightly increased to 25.5 in 2007. The main causes of perinatal deaths were prematurity (33.3%), intrapartum asphyxia (25%), and congenital anomalies (8.3%). Improving antenatal care, preventing preterm births, better monitoring during delivery, and intensive care for low birth weight infants could help reduce the perinatal mortality rate further.
Neurological Complications in Obstetric Regional Anesthetic PracticeAde Wijaya
Neurological complications following regional anesthesia during delivery can occur in up to 1 in 100 women, with anesthetic complications occurring in 1 in 3900 cases. While these complications are usually transient, prompt diagnosis and treatment are important to reduce the risk of permanent neurological impairment.
Newborn Care was written for healthcare workers providing special care for newborn infants in level 2 hospitals. It covers: An essential tool in the initial and ongoing training and teaching of any healthcare worker – Miriam Adhikari, South African Journal of Child Health, Primary Newborn Care was written specifically for nurses, midwives and doctors who provide primary care for newborn infants in level 1 clinics and hospitals. It covers: Mother and Baby Friendly Care describes gentler, kinder, evidence-based ways of caring for women during pregnancy, labour and delivery. It also presents improved methods of providing infant care with an emphasis on kangaroo mother care and exclusive breastfeeding. It covers: Saving Mothers and Babies was developed in response to the high maternal and perinatal mortality rates found in most developing countries. Learning material used in this book is based on the results of the annual confidential enquiries into maternal deaths and the Saving Mothers and Saving Babies reports published in South Africa. It addresses: the basic principles of mortality audit, maternal and perinatal mortality, managing mortality meetings, ways of reducing maternal and perinatal mortality rates, This book should be used together with the Perinatal Problem Identification Programme (PPIP).
The National Foundation for Fertility Research (NFFR) is a 501(c)(3) nonprofit and publicly funded research center dedicated to reproductive research. Founded in 1987 by Dr. William Schoolcraft, NFFR conducts scientific research and education programs focused on improving fertility without medical intervention. NFFR's research team is expected to grow from 4 staff currently to 13 staff within 5 years and 22 staff within 10 years as it expands its research and education efforts.
Saving Mothers and Babies: Introduction to maternal and perinatal mortalitySaide OER Africa
Newborn Care was written for healthcare workers providing special care for newborn infants in level 2 hospitals. It covers: An essential tool in the initial and ongoing training and teaching of any healthcare worker – Miriam Adhikari, South African Journal of Child Health, Primary Newborn Care was written specifically for nurses, midwives and doctors who provide primary care for newborn infants in level 1 clinics and hospitals. It covers: Mother and Baby Friendly Care describes gentler, kinder, evidence-based ways of caring for women during pregnancy, labour and delivery. It also presents improved methods of providing infant care with an emphasis on kangaroo mother care and exclusive breastfeeding. It covers: Saving Mothers and Babies was developed in response to the high maternal and perinatal mortality rates found in most developing countries. Learning material used in this book is based on the results of the annual confidential enquiries into maternal deaths and the Saving Mothers and Saving Babies reports published in South Africa. It addresses: the basic principles of mortality audit, maternal and perinatal mortality, managing mortality meetings, ways of reducing maternal and perinatal mortality rates, This book should be used together with the Perinatal Problem Identification Programme (PPIP).
This study analyzed the Caesarean section (CS) rate in 300 women with type 1 diabetes (T1DM) who delivered at a large tertiary hospital using the Robson criteria for meaningful comparisons. The overall CS rate was 58% for women with T1DM, significantly higher than the institutional rate of 19.6%. Nulliparous women who underwent labor induction had a higher CS rate of 48.5% compared to 11.5% for multiparous women. Women with a previous CS usually required repeat CS for subsequent deliveries. High rates of labor induction, especially in nulliparous women, contributed to the high overall CS rates in women with T1DM.
This document discusses neonatal mortality measurement and summarizes recent developments. It covers:
1) Neonatal mortality rates can now be estimated annually through improved surveys, though data reliability remains a concern. Pregnancy history modules may better capture neonatal deaths.
2) Estimates of neonatal causes of death have been improved through increased country data, especially for large countries like India and China. Rates of infections and tetanus appear to be declining in some areas.
3) Surveys can be improved by modifying questions to better capture neonatal mortality and stillbirths, and through follow up verbal autopsies to obtain cause of death data for over 75% of neonatal deaths dependent on surveys.
This document provides three scientific references related to epigenetics and nutrition. The first reference is a study finding that paternal obesity is associated with hypomethylation in newborns. The second reference is a study showing that successful treatment of post-traumatic stress disorder can reverse DNA methylation marks. The third reference is a disclaimer that individual results may vary.
This study analyzed perinatal mortality trends at Kathmandu Medical College Teaching Hospital from 2002-2007. It found that the perinatal mortality rate decreased from 30.7 in 2002-2003 to 19.1 in 2003-2005 but slightly increased to 25.5 in 2007. The main causes of perinatal deaths were prematurity (33.3%), intrapartum asphyxia (25%), and congenital anomalies (8.3%). Improving antenatal care, preventing preterm births, better monitoring during delivery, and intensive care for low birth weight infants could help reduce the perinatal mortality rate further.
Neurological Complications in Obstetric Regional Anesthetic PracticeAde Wijaya
Neurological complications following regional anesthesia during delivery can occur in up to 1 in 100 women, with anesthetic complications occurring in 1 in 3900 cases. While these complications are usually transient, prompt diagnosis and treatment are important to reduce the risk of permanent neurological impairment.
Newborn Care was written for healthcare workers providing special care for newborn infants in level 2 hospitals. It covers: An essential tool in the initial and ongoing training and teaching of any healthcare worker – Miriam Adhikari, South African Journal of Child Health, Primary Newborn Care was written specifically for nurses, midwives and doctors who provide primary care for newborn infants in level 1 clinics and hospitals. It covers: Mother and Baby Friendly Care describes gentler, kinder, evidence-based ways of caring for women during pregnancy, labour and delivery. It also presents improved methods of providing infant care with an emphasis on kangaroo mother care and exclusive breastfeeding. It covers: Saving Mothers and Babies was developed in response to the high maternal and perinatal mortality rates found in most developing countries. Learning material used in this book is based on the results of the annual confidential enquiries into maternal deaths and the Saving Mothers and Saving Babies reports published in South Africa. It addresses: the basic principles of mortality audit, maternal and perinatal mortality, managing mortality meetings, ways of reducing maternal and perinatal mortality rates, This book should be used together with the Perinatal Problem Identification Programme (PPIP).
The National Foundation for Fertility Research (NFFR) is a 501(c)(3) nonprofit and publicly funded research center dedicated to reproductive research. Founded in 1987 by Dr. William Schoolcraft, NFFR conducts scientific research and education programs focused on improving fertility without medical intervention. NFFR's research team is expected to grow from 4 staff currently to 13 staff within 5 years and 22 staff within 10 years as it expands its research and education efforts.
Saving Mothers and Babies: Introduction to maternal and perinatal mortalitySaide OER Africa
Newborn Care was written for healthcare workers providing special care for newborn infants in level 2 hospitals. It covers: An essential tool in the initial and ongoing training and teaching of any healthcare worker – Miriam Adhikari, South African Journal of Child Health, Primary Newborn Care was written specifically for nurses, midwives and doctors who provide primary care for newborn infants in level 1 clinics and hospitals. It covers: Mother and Baby Friendly Care describes gentler, kinder, evidence-based ways of caring for women during pregnancy, labour and delivery. It also presents improved methods of providing infant care with an emphasis on kangaroo mother care and exclusive breastfeeding. It covers: Saving Mothers and Babies was developed in response to the high maternal and perinatal mortality rates found in most developing countries. Learning material used in this book is based on the results of the annual confidential enquiries into maternal deaths and the Saving Mothers and Saving Babies reports published in South Africa. It addresses: the basic principles of mortality audit, maternal and perinatal mortality, managing mortality meetings, ways of reducing maternal and perinatal mortality rates, This book should be used together with the Perinatal Problem Identification Programme (PPIP).
This study analyzed the Caesarean section (CS) rate in 300 women with type 1 diabetes (T1DM) who delivered at a large tertiary hospital using the Robson criteria for meaningful comparisons. The overall CS rate was 58% for women with T1DM, significantly higher than the institutional rate of 19.6%. Nulliparous women who underwent labor induction had a higher CS rate of 48.5% compared to 11.5% for multiparous women. Women with a previous CS usually required repeat CS for subsequent deliveries. High rates of labor induction, especially in nulliparous women, contributed to the high overall CS rates in women with T1DM.
This document discusses neonatal mortality measurement and summarizes recent developments. It covers:
1) Neonatal mortality rates can now be estimated annually through improved surveys, though data reliability remains a concern. Pregnancy history modules may better capture neonatal deaths.
2) Estimates of neonatal causes of death have been improved through increased country data, especially for large countries like India and China. Rates of infections and tetanus appear to be declining in some areas.
3) Surveys can be improved by modifying questions to better capture neonatal mortality and stillbirths, and through follow up verbal autopsies to obtain cause of death data for over 75% of neonatal deaths dependent on surveys.
Collaborative on Health and the Environment Webinar, 20 March 2019.
Study : https://diethylstilbestrol.co.uk/multigenerational-neurodevelopmental-deficits/
Analysis : https://diethylstilbestrol.co.uk/transgenerational-neurodevelopmental-deficits/
DES transgenerational effects studies : https://diethylstilbestrol.co.uk/studies/transgenerational-effects/
This study examined trends in maternal complications following childbirth using hospital discharge data from Florida and New York from 1992 to 2006. It found that the cesarean delivery rate initially decreased and then increased over this period, while the rate of maternal complications overall declined substantially. Specifically, the risk-adjusted rate of composite maternal complications decreased from 14.7% to 10.7% following all deliveries. These results suggest that maternal outcomes in the US have significantly improved over the last 15 years.
This document defines various mortality rates used to measure child mortality and provides statistics for Canada in 2007. It defines perinatal mortality as deaths from 22 weeks of gestation to 7 days after birth. Neonatal mortality is defined as deaths from birth to 28 days. Infant mortality is deaths under 1 year of age. The under-5 mortality rate measures the probability of a child dying before age 5.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This retrospective study analyzed 477 cases of neonatal hypoglycemia over one year and compared maternal glycemic parameters to neonatal outcomes. 33.1% of mothers had abnormal glucose challenge test (GCT) screens while there was no significant difference between those with abnormal GCTs and one or two abnormal oral glucose tolerance tests. Babies born to mothers with abnormal GCTs had lower birth weights but no differences in APGAR scores or C-section rates. The study concludes that abnormal GCTs can identify mothers at risk of having babies with hypoglycemia and higher risks of obesity, and that earlier detection of at-risk mothers could help reduce NICU admissions and long-term childhood obesity.
This document discusses the risks associated with common medical interventions during childbirth such as epidurals, inductions, and c-sections. It cites several studies that show epidurals can lead to complications for the mother and baby, inductions have risks of prematurity and death that are often preventable, and c-section rates in the US far exceed the WHO recommended rate of 10-15% despite increasing the risk of maternal mortality. In contrast, natural childbirth attended by midwife Ina May Gaskin from 1970-2000 had a very low rate of complications, interventions, and zero maternal or infant mortality.
This document discusses the risks associated with common medical interventions during childbirth such as epidurals, inductions, and c-sections. It cites several studies that show epidurals can lead to complications for the mother and baby, inductions increase the risk of c-section and issues for the baby, and c-section rates in the US far exceed the WHO recommended rate of 10-15% despite increasing maternal mortality. Natural childbirth is shown to have extremely positive outcomes with low rates of complications based on data from Ina May Gaskin's practice.
Intrauterine growth restriction (IUGR) refers to fetal growth that fails to reach the fetus's growth potential. There are two main types - symmetrical and asymmetrical IUGR. Symmetrical IUGR affects all body parts equally while asymmetrical IUGR spares the brain by preferentially shunting nutrients to the head. IUGR can be diagnosed through ultrasound measurements, history and physical exam. Management may include testing to find the cause, ongoing monitoring, and delivery depending on fetal status. Complications of IUGR include increased risk of stillbirth, asphyxia, and problems for the newborn like hypoglycemia.
Time Bomb : a Journey into Old Exposures, Gametic Glitches, and the Autism Ex...DES Daughter
This February 2017 presentation, by Jill Escher, MA, JD, via Germline Exposure, to a student-run chapter of SFN, explained the history and science behind the "Time Bomb" hypothesis of autism.
Sources : http://www.germlineexposures.org/sfn-wonder-feb-2017.html
PDF : http://www.germlineexposures.org/uploads/6/4/0/9/6409433/sfn_escher_slides.pdf
Increasing Trends in Male Reproductive Disorders, Environmental Exposures, an...DES Daughter
On this call, Dr. Skakkebaek presented his concerns about increasing trends in male reproductive disorders, including the significant global increase in incidence of germ cell tumors. He and colleagues from all over the world demonstrated that over half of all young men's semen quality does not meet the reference standard of the World Health Organization. Dr. Skakkebaek presented evidence linking testicular cancer, poor semen quality, childlessness, and rapidly decreasing fertility rates. He showed how there is little doubt that environmental factors, most likely associated with modern lifestyles, have - in a broad sense - had an adverse influence on male reproductive health. He and his group are examining a fundamental role that exposure to endocrine-disrupting chemicals may play in these trends, trends that in a few decades will result in decreasing populations in industrialized countries, and believes collaborative research is required to identify the causes of these adverse trends.
Sources: http://healthandenvironment.org/partnership_calls/18355
This document reports a case of positive maternal anti-SSA/SSB antibodies related to fetal cardiac complications without atrioventricular block. A fetal echocardiogram found right ventricular endocardial fibroelastosis (EFE) without left ventricular involvement or conduction abnormalities. The mother received intravenous immunoglobulin and dexamethasone, and follow-up echocardiograms showed improvement in right ventricular size and function. At 4 months, the infant showed resolving right ventricular EFE with normal cardiac function. This represents a rare case of isolated right ventricular EFE associated with maternal antibodies in the absence of atrioventricular block.
Breastfeeding And The Risk Of Postneonatal Death In The United StatesBiblioteca Virtual
This study examined the association between breastfeeding and postneonatal mortality in the United States using data from the 1988 National Maternal and Infant Health Survey. The study found that children who were ever breastfed had a 21% lower risk of postneonatal death compared to children who were never breastfed. Longer durations of breastfeeding were associated with even lower risk. The protective effect of breastfeeding was seen across different causes of postneonatal death, including infections, injuries, and sudden infant death syndrome.
Here are the calculations of IMR using the four different methods described in the document:
1. Conventional method:
IMR = (9835 + 9769) / 197003 + 198016 x 1000 = 49.7
2. Numerator adjustment method (f=0.3):
IMR = 0.3x9835 + 0.7x9769 / 191998 + 0.3x197003 + 0.7x198016 x 1000 = 49.7
3. Denominator adjustment method (f=0.3):
IMR = 9835 + 9769 / 0.3x191998 + 0.7x197003 + 0.3x198016 x
SOURCES
CDC Resources and Educational Tools - Educational Tools for Clinicians
DES Lecture Presentation and DES Case Studies > http://www.cdc.gov/des/hcp/resources/tools_clinicians.html
CDC Resources and Educational Tools - Educational Tools for Nurses
DES Case Studies > http://www.cdc.gov/des/hcp/resources/tools_nurses.html
CDC Resources and Educational Tools - Clinician Information
DES References > http://www.cdc.gov/des/hcp/bibliography/index.html
MORE DES DIETHYLSTILBESTROL RESOURCES
DES cases and lawsuits:
http://diethylstilbestrol.co.uk/studies/des-lawsuits/
DES studies on cancers and screening:
https://desdaughter.com/2013/09/08/diethylstilbestrol-resources-1/
DES studies on epigenetics and transgenerational effects:
https://desdaughter.com/2015/12/16/diethylstilbestrol-resources-6/
DES studies on fertility:
http://diethylstilbestrol.co.uk/studies/des-and-fertility/
DES studies on gender identity and psychological health:
https://desdaughter.com/2015/12/04/diethylstilbestrol-resources-3/
DES studies on in-utero exposure to DES and side-effects:
https://desdaughter.com/2013/12/31/diethylstilbestrol-resources-4/
DES studies on pregnancy:
http://diethylstilbestrol.co.uk/studies/des-and-pregnancy/
DES studies on the genital tract:
https://desdaughter.com/2015/12/16/diethylstilbestrol-resources-7/
DES videos:
https://www.youtube.com/playlist?list=PL3D4F4A11812DAE00
Pregnant women are at an increased risk from influenza due to physiological changes during pregnancy. The document recommends that all women who will be pregnant during flu season (October through May) receive the inactivated influenza vaccine. Studies have not found any adverse effects to the mother or baby from the inactivated flu vaccine. Vaccination provides benefits to both mother and infant by preventing flu and reducing respiratory illnesses. Despite these recommendations and safety evidence, vaccination rates among pregnant women remain low. Healthcare providers play an important role in educating pregnant women about the importance of receiving the flu vaccine.
The document discusses the pro-choice position on abortion. It notes that the 14th amendment supports the right to choose and that the Supreme Court ruled in Roe v. Wade that women have a constitutional right to abortion. It provides statistics on abortion in the US and discusses that women denied abortions face greater economic hardships. The risks of illegal abortions are outlined as well as the risks of pregnancy. Characteristics of typical women obtaining abortions are presented. Feminist ethics and theories of desire are briefly discussed in relation to abortion rights.
The document discusses how migraine is more prevalent in women than men, with peak rates occurring between ages 20-50, and how female hormonal changes and life events like menstruation, oral contraceptive use, pregnancy, and menopause can influence the occurrence and severity of migraine symptoms. It also reviews treatment considerations for migraine in women during these stages, noting challenges in balancing efficacy and safety, especially during pregnancy and lactation.
Recent top papers in pediatric infectious diseases: pediatric infections - Sl...WAidid
Slideset on:
- Zika virus and fetal/neonatal microcephaly
- Microbiota, infections and immune response to vaccines
- Antibiotic use and weight gain in childhood
Three studies found that infant mortality rates increased with decreasing gestational age and birth weight. Infants born preterm, very preterm, or with very low birth weight had substantially higher mortality rates compared to term or normal birth weight infants. Two additional studies found higher rates of neonatal mortality and morbidity for late preterm infants compared to term infants. Three studies reported higher rates of stillbirth, perinatal mortality, and infant mortality with increasing maternal obesity, including a dose-dependent relationship between higher BMI and increased mortality. One study also found higher rates of miscarriage with obesity.
PERTUSSIS PROTECTION - CURRENT SCHEDULES IN EUROPEWAidid
Slide set by Professor Susanna Esposito, president WAidid, presented at the 3rd ESCMID Conference on Vaccines, held in Lisbon (Portugal), 6- 8 March 2015. Learn more: http://goo.gl/8GUwwL
Collaborative on Health and the Environment Webinar, 20 March 2019.
Study : https://diethylstilbestrol.co.uk/multigenerational-neurodevelopmental-deficits/
Analysis : https://diethylstilbestrol.co.uk/transgenerational-neurodevelopmental-deficits/
DES transgenerational effects studies : https://diethylstilbestrol.co.uk/studies/transgenerational-effects/
This study examined trends in maternal complications following childbirth using hospital discharge data from Florida and New York from 1992 to 2006. It found that the cesarean delivery rate initially decreased and then increased over this period, while the rate of maternal complications overall declined substantially. Specifically, the risk-adjusted rate of composite maternal complications decreased from 14.7% to 10.7% following all deliveries. These results suggest that maternal outcomes in the US have significantly improved over the last 15 years.
This document defines various mortality rates used to measure child mortality and provides statistics for Canada in 2007. It defines perinatal mortality as deaths from 22 weeks of gestation to 7 days after birth. Neonatal mortality is defined as deaths from birth to 28 days. Infant mortality is deaths under 1 year of age. The under-5 mortality rate measures the probability of a child dying before age 5.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
This retrospective study analyzed 477 cases of neonatal hypoglycemia over one year and compared maternal glycemic parameters to neonatal outcomes. 33.1% of mothers had abnormal glucose challenge test (GCT) screens while there was no significant difference between those with abnormal GCTs and one or two abnormal oral glucose tolerance tests. Babies born to mothers with abnormal GCTs had lower birth weights but no differences in APGAR scores or C-section rates. The study concludes that abnormal GCTs can identify mothers at risk of having babies with hypoglycemia and higher risks of obesity, and that earlier detection of at-risk mothers could help reduce NICU admissions and long-term childhood obesity.
This document discusses the risks associated with common medical interventions during childbirth such as epidurals, inductions, and c-sections. It cites several studies that show epidurals can lead to complications for the mother and baby, inductions have risks of prematurity and death that are often preventable, and c-section rates in the US far exceed the WHO recommended rate of 10-15% despite increasing the risk of maternal mortality. In contrast, natural childbirth attended by midwife Ina May Gaskin from 1970-2000 had a very low rate of complications, interventions, and zero maternal or infant mortality.
This document discusses the risks associated with common medical interventions during childbirth such as epidurals, inductions, and c-sections. It cites several studies that show epidurals can lead to complications for the mother and baby, inductions increase the risk of c-section and issues for the baby, and c-section rates in the US far exceed the WHO recommended rate of 10-15% despite increasing maternal mortality. Natural childbirth is shown to have extremely positive outcomes with low rates of complications based on data from Ina May Gaskin's practice.
Intrauterine growth restriction (IUGR) refers to fetal growth that fails to reach the fetus's growth potential. There are two main types - symmetrical and asymmetrical IUGR. Symmetrical IUGR affects all body parts equally while asymmetrical IUGR spares the brain by preferentially shunting nutrients to the head. IUGR can be diagnosed through ultrasound measurements, history and physical exam. Management may include testing to find the cause, ongoing monitoring, and delivery depending on fetal status. Complications of IUGR include increased risk of stillbirth, asphyxia, and problems for the newborn like hypoglycemia.
Time Bomb : a Journey into Old Exposures, Gametic Glitches, and the Autism Ex...DES Daughter
This February 2017 presentation, by Jill Escher, MA, JD, via Germline Exposure, to a student-run chapter of SFN, explained the history and science behind the "Time Bomb" hypothesis of autism.
Sources : http://www.germlineexposures.org/sfn-wonder-feb-2017.html
PDF : http://www.germlineexposures.org/uploads/6/4/0/9/6409433/sfn_escher_slides.pdf
Increasing Trends in Male Reproductive Disorders, Environmental Exposures, an...DES Daughter
On this call, Dr. Skakkebaek presented his concerns about increasing trends in male reproductive disorders, including the significant global increase in incidence of germ cell tumors. He and colleagues from all over the world demonstrated that over half of all young men's semen quality does not meet the reference standard of the World Health Organization. Dr. Skakkebaek presented evidence linking testicular cancer, poor semen quality, childlessness, and rapidly decreasing fertility rates. He showed how there is little doubt that environmental factors, most likely associated with modern lifestyles, have - in a broad sense - had an adverse influence on male reproductive health. He and his group are examining a fundamental role that exposure to endocrine-disrupting chemicals may play in these trends, trends that in a few decades will result in decreasing populations in industrialized countries, and believes collaborative research is required to identify the causes of these adverse trends.
Sources: http://healthandenvironment.org/partnership_calls/18355
This document reports a case of positive maternal anti-SSA/SSB antibodies related to fetal cardiac complications without atrioventricular block. A fetal echocardiogram found right ventricular endocardial fibroelastosis (EFE) without left ventricular involvement or conduction abnormalities. The mother received intravenous immunoglobulin and dexamethasone, and follow-up echocardiograms showed improvement in right ventricular size and function. At 4 months, the infant showed resolving right ventricular EFE with normal cardiac function. This represents a rare case of isolated right ventricular EFE associated with maternal antibodies in the absence of atrioventricular block.
Breastfeeding And The Risk Of Postneonatal Death In The United StatesBiblioteca Virtual
This study examined the association between breastfeeding and postneonatal mortality in the United States using data from the 1988 National Maternal and Infant Health Survey. The study found that children who were ever breastfed had a 21% lower risk of postneonatal death compared to children who were never breastfed. Longer durations of breastfeeding were associated with even lower risk. The protective effect of breastfeeding was seen across different causes of postneonatal death, including infections, injuries, and sudden infant death syndrome.
Here are the calculations of IMR using the four different methods described in the document:
1. Conventional method:
IMR = (9835 + 9769) / 197003 + 198016 x 1000 = 49.7
2. Numerator adjustment method (f=0.3):
IMR = 0.3x9835 + 0.7x9769 / 191998 + 0.3x197003 + 0.7x198016 x 1000 = 49.7
3. Denominator adjustment method (f=0.3):
IMR = 9835 + 9769 / 0.3x191998 + 0.7x197003 + 0.3x198016 x
SOURCES
CDC Resources and Educational Tools - Educational Tools for Clinicians
DES Lecture Presentation and DES Case Studies > http://www.cdc.gov/des/hcp/resources/tools_clinicians.html
CDC Resources and Educational Tools - Educational Tools for Nurses
DES Case Studies > http://www.cdc.gov/des/hcp/resources/tools_nurses.html
CDC Resources and Educational Tools - Clinician Information
DES References > http://www.cdc.gov/des/hcp/bibliography/index.html
MORE DES DIETHYLSTILBESTROL RESOURCES
DES cases and lawsuits:
http://diethylstilbestrol.co.uk/studies/des-lawsuits/
DES studies on cancers and screening:
https://desdaughter.com/2013/09/08/diethylstilbestrol-resources-1/
DES studies on epigenetics and transgenerational effects:
https://desdaughter.com/2015/12/16/diethylstilbestrol-resources-6/
DES studies on fertility:
http://diethylstilbestrol.co.uk/studies/des-and-fertility/
DES studies on gender identity and psychological health:
https://desdaughter.com/2015/12/04/diethylstilbestrol-resources-3/
DES studies on in-utero exposure to DES and side-effects:
https://desdaughter.com/2013/12/31/diethylstilbestrol-resources-4/
DES studies on pregnancy:
http://diethylstilbestrol.co.uk/studies/des-and-pregnancy/
DES studies on the genital tract:
https://desdaughter.com/2015/12/16/diethylstilbestrol-resources-7/
DES videos:
https://www.youtube.com/playlist?list=PL3D4F4A11812DAE00
Pregnant women are at an increased risk from influenza due to physiological changes during pregnancy. The document recommends that all women who will be pregnant during flu season (October through May) receive the inactivated influenza vaccine. Studies have not found any adverse effects to the mother or baby from the inactivated flu vaccine. Vaccination provides benefits to both mother and infant by preventing flu and reducing respiratory illnesses. Despite these recommendations and safety evidence, vaccination rates among pregnant women remain low. Healthcare providers play an important role in educating pregnant women about the importance of receiving the flu vaccine.
The document discusses the pro-choice position on abortion. It notes that the 14th amendment supports the right to choose and that the Supreme Court ruled in Roe v. Wade that women have a constitutional right to abortion. It provides statistics on abortion in the US and discusses that women denied abortions face greater economic hardships. The risks of illegal abortions are outlined as well as the risks of pregnancy. Characteristics of typical women obtaining abortions are presented. Feminist ethics and theories of desire are briefly discussed in relation to abortion rights.
The document discusses how migraine is more prevalent in women than men, with peak rates occurring between ages 20-50, and how female hormonal changes and life events like menstruation, oral contraceptive use, pregnancy, and menopause can influence the occurrence and severity of migraine symptoms. It also reviews treatment considerations for migraine in women during these stages, noting challenges in balancing efficacy and safety, especially during pregnancy and lactation.
Recent top papers in pediatric infectious diseases: pediatric infections - Sl...WAidid
Slideset on:
- Zika virus and fetal/neonatal microcephaly
- Microbiota, infections and immune response to vaccines
- Antibiotic use and weight gain in childhood
Three studies found that infant mortality rates increased with decreasing gestational age and birth weight. Infants born preterm, very preterm, or with very low birth weight had substantially higher mortality rates compared to term or normal birth weight infants. Two additional studies found higher rates of neonatal mortality and morbidity for late preterm infants compared to term infants. Three studies reported higher rates of stillbirth, perinatal mortality, and infant mortality with increasing maternal obesity, including a dose-dependent relationship between higher BMI and increased mortality. One study also found higher rates of miscarriage with obesity.
PERTUSSIS PROTECTION - CURRENT SCHEDULES IN EUROPEWAidid
Slide set by Professor Susanna Esposito, president WAidid, presented at the 3rd ESCMID Conference on Vaccines, held in Lisbon (Portugal), 6- 8 March 2015. Learn more: http://goo.gl/8GUwwL
Pertussis 2024 Lecture to avoid the signs.pptxWilsonAgustin1
This document outlines pertussis (whooping cough) including its clinical characteristics, epidemiology, disease burden, impact of adolescent vaccination and cocooning, data on dTpa vaccination in adolescents and adults, and conclusions. Pertussis is highly communicable respiratory infection caused by Bordetella pertussis. It is transmitted person-to-person through respiratory droplets. While humans are the sole reservoir, as many as 80% of susceptible household contacts become infected after exposure. Pertussis has emerged as a disease affecting adolescents and adults as immunity wanes over time. Adolescent and adult cases serve as an important reservoir, putting newborns at high risk of severe complications. Vaccination of adolescents and adults is
Regionalization of Perinatal Care: US ExperienceMCH-org-ua
International conference «Actual approaches to the extremely preterm babies: International experience and Ukrainian realities» (Kyiv, Ukraine, March 5-6, 2013)
Perinatal magnesium administration and the prevention of periventricular leuk...Ross Finesmith M.D.
This study examined the effect of magnesium sulfate (MgSO4) on the development of cystic periventricular leukomalacia (cPVL) in preterm infants. The researchers conducted a retrospective case-control study of 492 preterm infants born between 1992-1994 weighing less than 1750g who survived at least 7 days. They found infants exposed to MgSO4 in utero were less likely to develop cPVL. Specifically, 2 of 18 infants with cPVL were exposed to MgSO4 compared to 14 of 36 controls, indicating MgSO4 exposure is associated with a reduced risk of cPVL. Further analysis confirmed the groups were similar in other variables and preeclampsia alone did
Anthropometry in perinatology and beyond: Of Changing Curves and Crossing Cen...NEONATRIXAIIMS
This document summarizes a presentation on anthropometry in perinatology and beyond. It discusses the history of fetal anthropometric measurements and growth charts for neonates. It outlines various fetal growth charts including the INTERGROWTH-21st study and their limitations for the Indian population. Neonatal anthropometry based charts from various Indian studies are presented showing differences from Western standards. Postnatal growth charts for preterm infants including the Fenton 2013 chart and INTERGROWTH-21st data are highlighted. Factors making the postnatal preterm growth unique are also noted.
A presentation by Maureen Samms-Vaughn as part of the Childhood Risk and Resilience panel discussion at the International Symposium on Cohort and Longitudinal Studies in Developing Contexts, UNICEF Office of Research - Innocenti, Florence, Italy 13-15 October 2014
1. Breastfeeding provides numerous health benefits for both infants and mothers. It reduces the risk of breast cancer in mothers and lowers the risk of HIV transmission from mother to child.
2. Exclusive breastfeeding for the first 3-6 months of life protects infants from common illnesses like diarrhea and pneumonia. It also supports optimal infant nutrition and development.
3. For HIV-positive mothers, exclusive breastfeeding or replacement feeding with formula can be appropriate depending on individual circumstances. Proper support is crucial to help mothers make informed choices about infant feeding.
This study aimed to develop a predictive tool for unplanned cesarean delivery (CD) in nulliparous women using prenatal maternal and fetal characteristics. Over 2,200 nulliparous women were prospectively studied across seven Irish hospitals. Multivariate analysis identified that maternal age, BMI, height, fetal abdominal circumference, and head circumference can predict CD risk. A nomogram was developed and showed good predictive ability, with an AUC of 0.69. The tool may help counsel women on their chances of a vaginal delivery versus an elective CD.
The journey of low birth weight infant Khaled Saad
Previously known as ‘failure to thrive’ (FTT), also known as weight faltering
Infant or children whose current weight or rate of weight gain is significantly below that expected of similar children of the same age, sex and ethnicity
Can occur in both infants (< 1 year of age) and in children (> 1 year of age)
Magnesium Prevents the Cerebral Palsy Precursor in Premature InfantsRoss Finesmith M.D.
To determine if magnesium sulfate has an effect on the development of cystic
periventricular leukomalacia in preterm infants, this retrospective case control study
was conducted. There were 23,382 infants born at three teaching hospitals in the metropolitan New York area from January 1992 to December 1994. Four hundred ninety-two infants met our entrance criteria. Criteria included a birth weight less than 750 g, survival to at least 7 days of life and at least one cranial ultrasound after 7 days of life.
Infants exposed to magnesium sulfate in utero were less likely to develop periventricular
leukomalacia. Two of 18 (11%) infants with periventricular leukomalacia were
exposed to magnesium sulfate in-utero compared to 14 of 36 controls (39%) (p =
0.035) (OR = 0.196, 95% Cl = 0.039-0.988). Pre-eclampsia as an independent factor
was not associated with a reduced risk (p = 0.251) (OR = 0.294, 95% Cl =
0.033-2.65). Preterm infants exposed to antenatal magnesium sulfate were found to
have a reduced risk of developing cystic periventricular leukomalacia.
The Relationship between Maternal Anemia and Birth Weight in New Borniosrjce
This study examined the relationship between maternal anemia and birth weight in newborns delivered at a hospital in Karaikal, India between January 2014 and December 2014. The study included 1182 pregnant women, of which 924 (78%) were anemic (hemoglobin <11g/dL) and 258 (22%) were not anemic. The study found no correlation between maternal anemia and low birth weight in newborns. However, operative deliveries (C-sections) tended to be higher for anemic mothers compared to non-anemic mothers. While some previous studies have found an association between maternal anemia and increased risk of low birth weight and C-sections, this study did
This document discusses normal versus abnormal modes of delivery, specifically focusing on cesarean section rates. It provides statistics on global and Lebanese cesarean section rates, noting that Lebanese rates have risen dramatically in recent decades to over 40% currently. The document explores various factors contributing to increasing cesarean rates, such as financial incentives, malpractice concerns, and lack of labor preparation. It also reviews potential adverse effects of cesarean section on infant health outcomes like respiratory issues, microbiome disturbance, and increased risk of obesity and metabolic disorders. Solutions proposed to reduce unnecessary cesarean sections include implementing national guidelines, improving prenatal education, and promoting vaginal birth after cesarean.
The Burden of Group B Streptococcus Worldwide for Pregnant Women, Stillbirths...Anjuli Borgonha
This document provides an overview of a study estimating the global burden of Group B Streptococcus (GBS) disease for pregnant women, stillbirths, and children. The study involved over 100 authors from more than 30 institutions worldwide. It used a compartmental modeling approach and extensive literature reviews and unpublished data to estimate the number of GBS cases, deaths, and disability globally. Key findings included that an estimated 21.3 million newborns are exposed to GBS through maternal colonization each year, resulting in 205,000-327,000 early-onset and 44,000-326,000 late-onset infant GBS cases annually. The study highlights major data gaps, particularly in regions with the highest burden.
This document summarizes a presentation on neonatal meningitis and sepsis survivors. The key points are:
1. Survivors of neonatal meningitis and sepsis often experience long-term neurological impairments. Studies find moderate to severe impairment in 18-23% of survivors.
2. There are significant gaps in data on the true burden of neonatal infections due to limitations in care access, clinical assessment, laboratory testing, and long-term follow up in low-resource settings. This impacts estimates of impairment rates.
3. Improving data through strengthened health systems, innovative diagnostics, expanded cohort studies, and better impairment measures is needed to close these gaps and better support survivors long-term.
Management of postterm pregnancy involves balancing risks to the fetus and mother. Postterm is defined as past 42 weeks gestation. Accurately dating the pregnancy is important to avoid false diagnosis. Risks to the fetus include stillbirth, meconium aspiration, and macrosomia. Risks to the mother include dystocia and infection. Studies show inducing labor at 41 weeks reduces stillbirths without increasing C-sections. Methods of antenatal testing after 41 weeks are debated, though monitoring is recommended. While an unfavorable cervix was viewed as a risk factor for C-section, recent evidence suggests underlying issues may be more important. Further research is needed to determine the optimal time for induction to minimize risks
The document summarizes a literature review analyzing the role of prenatal care (PNC) in racial disparities in infant mortality rates (IMRs) between Black and White populations. It finds that Black mothers are more likely to receive inadequate or no PNC compared to White mothers, and have a higher IMR. Studies examined the influence of PNC adequacy and timing of initiation on IMR outcomes. A specific PNC intervention program, the Special Supplemental Nutrition Program for Women, Infants, and Children, was found to effectively reduce the IMR racial disparity by improving outcomes for Black infants.
The Perinatal Periods of Risk (PPOR) approach is a comprehensive 6-step method used in Massachusetts to address racial and ethnic disparities in feto-infant mortality rates. PPOR involves analyzing fetal and infant death data by birth weight and age at death over four risk periods to identify gaps between racial groups. Phase I maps and analyzes this data, while Phase II further investigates causes of death in high-risk groups and periods. An application of PPOR in Worcester, MA from 2008-2012 found Black and Latino feto-infant mortality rates around 1.5-2 times higher than whites, with the largest gaps existing for deaths occurring in the Maternal Health and Prematurity period.
This document discusses pertussis (whooping cough) and outlines the following key points:
1. Pertussis is highly communicable respiratory infection caused by Bordetella pertussis that can cause severe illness, especially in infants.
2. The epidemiology of pertussis has changed with increasing cases in adolescents and adults as immunity wanes, putting vulnerable infants at risk of exposure.
3. Strategies to prevent pertussis include adolescent and adult booster vaccinations to reduce transmission to infants who are too young to be fully protected by vaccination.
Factors Associated with Growth in the First 1,000 Days CHECKLEYCORE Group
CORE Group GHPC15
October 8, 2015
Concurrent Session: Factors Associated with Growth in the First 1,000 Days: Translating Evidence into Programs for Stunting, Wasting, and the Double Burden of Malnutrition
Similar to Effect of Time and Day of Birth on the Outcome of Preterm Infants (20)
Factors Associated with Growth in the First 1,000 Days CHECKLEY
Effect of Time and Day of Birth on the Outcome of Preterm Infants
1. Effect of time and day of birth on the outcome of preterm newborn infants Rhoda Tamakloe, Marta Barker MSN, Naveed Hussain MD Farmington, CT
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10. Day of the Week of Birth vs. % Died S&A-Sunday and Saturday W-Wednesday M-Monday H-Thursday U-Tuesday F-Friday
11. Month of Birth vs. % Died * denotes a significant p-value in univariate and multivariate analyses
12. Demographic Data * denotes a significant p-value in univariate and multivariate analyses † infants born on the weekend had lower gestational age and birth weight GA*† mean+sd BW*† mean+sd Sex (%F) White % Black % Hispanic % Other % weekend 31.36 ±3.84 1764.87 ±783.01 45.75 76.96 10.79 9.45 2.79 weekday 31.95 ±3.98 1850.52 ±836.99 46.67 74.97 9.82 12.08 3.12
13. Result: Mortality and Morbidity Chart * denotes a significant p-value in univariate analysis † when adjusted for GA, value no longer significant % died IVH (%with) ROP (% with) Rate of Growth (% poor) Weekend Weekday 5.36 5.52 7.05 7.50 11.5 * † 8.94 18.90 16.90 Wknd+off On hours 5.58 5.32 7.71 7.11 10.6 8.63 18.22 16.44 off hours on hours 5.30 5.27 7.70 7.37 10.11 9.56 18.02 17.05
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Editor's Notes
Days on vent: CPAP? BEARCUB??? Stats method used????