This document discusses rethinking research and publication with a view towards impact. It argues that traditional subscription-based publishing models have downsides like restricting access and fostering behaviors that undermine trust in research. However, moving to more open models presents challenges and risks as well. The document advocates for more open preprints, open access journals with open peer review, making data and software accessible, and developing post-publication reward systems independent of journals to better incentivize quality research. Overall it examines how to realize the benefits of openness while mitigating the potential downsides of more open publishing models.