Dt56a - Femarelle - a natural serm
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The document discusses DT56a (Femarelle), a natural compound that acts as a selective estrogen receptor modulator (SERM). It activates estrogen receptors in osteoblasts, relieves menopausal symptoms, and increases bone mineral density without affecting sex hormone or endometrial thickness levels. Studies in rats and human cells found that while DT56a and estradiol-17beta (E2) both stimulate creatine kinase in skeletal and vascular tissues, only E2 did so in the uterus. When administered together at high doses, DT56a inhibited or partially inhibited E2's effects in various rat and human tissues, demonstrating that DT56a is a SERM that has tissue-specific estro
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2) EZH1, along with SUZ12 but not EED, was shown to positively regulate the expression of NF-κB target genes upon TNFα stimulation through its interaction with UXT.
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GH and IGF Research 2014 OR3-4
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Hormones .pptx
Sex hormones include estrogens, progestins, and androgens. Testosterone is the primary male sex hormone and promotes male sexual development and secondary sex characteristics. It works by binding to androgen receptors. Progesterone prepares the uterus for pregnancy and thickens cervical mucus. Estriol, estradiol, and oestrione are estrogens involved in the female menstrual cycle and pregnancy. They act by binding to estrogen receptors and are metabolized in the liver. Sex hormones have roles in sexual development and reproduction.
Male and Female Hormones.pptx
This document discusses the roles and functions of androgens and estrogens in the male and female body. It describes how androgens and estrogens contribute to sexual development and function, their clinical uses, and potential side effects of hormone therapy. The summary also outlines the menstrual cycle and the roles of various hormones like FSH, LH, estrogen, and progesterone in regulating the female reproductive cycle.
phytoestrogen
Phytoestrogens are plant compounds that have a similar structure to the hormone estrogen. While they can bind to estrogen receptors in the body, they produce both estrogenic and anti-estrogenic effects. Estrogen is an important hormone produced primarily in women's ovaries and plays a key role in sexual development, the menstrual cycle, and maintaining overall health and bone density. Long-term estrogen therapy has been used to treat menopause symptoms and prevent osteoporosis but is also associated with increased risks of certain cancers, blood clots, and heart disease. Phytoestrogens are being studied as a potentially safer alternative to conventional estrogen therapy.
Estrogen Presentation.pptx
Estrogens are sex hormones responsible for female sexual development and regulation. The main types are estradiol, estrone, and estriol, which are produced in the ovaries, adrenal glands, and fat tissue. Estrogens act by binding to estrogen receptors and regulating gene expression. They are used for hormone replacement therapy and contraception. Selective estrogen receptor modulators like tamoxifen can have estrogen-like effects in some tissues but block estrogen in breast tissue. Aromatase inhibitors prevent estrogen production and are used to treat breast cancer.
Estrogen Hormone By @Sana_Haroon
Estrogens (also called Oestrogens) are steroid hormone that are important for development and functioning of females of the species. They are named so because they play an important role in the estrous cycle. Their name comes from estrus/oistros (period of fertility for female mammals) + gen/gonos = to generate.
Estrogen carries physiological messages to body organs and systems. These messages differ for each body organ and system. Estrogen sends messages to the uterus to grow and replace the lining that is shed during the previous menses.
Estrogen receptor and its modulators
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The document discusses estrogen receptors and various drugs that modulate estrogen receptor functions. It covers:
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Androgenic Hormones Disturbances.pdf
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Basic Pharmacology of Estrogen
These slides contain the information about Estrogen, its basic pharmacology, its synthesis in human body, Functions of estrogen, role in female puberty, Agonists of estrogen and antagonists of estrogen, also contain detail of the receptors associated with the estrogen functioning.
Sex hormones
This document discusses sex hormones, including estrogens, progesterone, antiestrogens, and antiprogestins. It provides details on the natural and synthetic forms of estrogens and progesterone, their receptors, mechanisms of action, regulation, and uses. The key points are:
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The document summarizes key aspects of the endocrine system. It describes the major endocrine glands including the adrenal gland, pancreas, thyroid gland, parathyroid glands, pineal gland, thymus gland, testes and ovaries. It also discusses the hormones produced by each gland and their functions in regulating processes like stress response, metabolism, growth, and reproduction. Additionally, it provides a brief comparison of the endocrine and nervous systems, noting examples of neuroendocrine organs that have aspects of both systems.
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Dt56a - Femarelle - a natural serm
- 1. Publishes in: Journal of Steroid Biochemistry and Molecular Biology 2007; 104:252-258 "DT56a (Femarelle®): a Natural Selective Estrogen Receptor Modulator (SERM)" Dalia Somjen and Israel Yoles Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel-Aviv, Israel Abstract A selective estrogen receptor modulator (SERM) is defined as a substance with dissimilar effects on ® different tissues: agonist in some and antagonists in others. The natural compound DT56a (Femarelle ) was shown to activate estrogen receptors in human cultured female derived osteoblasts. It was also shown to relieve menopausal symptoms and to increase bone mineral density with no effect on sex steroid hormone levels and on the endometrial thickness. DT56a, similarly to estradiol-17beta (E2), stimulated the specific activity of creatine kinase (CK) in skeletal and vascular tissues of female rats, as a marker of estrogen receptor (ER) activation. However, in the uterus, CK was activated only by E2 but not by DT56a. In order to prove that DT56a is a SERM, we examined the mutual interaction between DT56a and E2, at supra physiological doses, in different tissues in both intact and ovariectomized female rats, as well as in human cultured vascular and bone cells. Administration of DT56a or E2 stimulated CK in all tissues tested, but when given simultaneously, in intact immature female rats, DT56a completely abolished E2 stimulation of CK in all organs except in the diaphyseal bone where the inhibition was partial. In ovariectomized female rats, DT56a abolished E2's stimulation of CK in diaphyseal bone, thymus, uterus and pituitary but caused a partial inhibition in aorta, left ventricle and epiphyseal cartilage. In human bone cells E2 stimulation of CK, of alkaline phosphatase (AP) activity and of DNA synthesis was completely abolished by DT56a in post-menopausal cells and partially inhibited in pre-menopausal cells. In human vascular cells, inhibition of DNA synthesis by E2 was completely abolished by DT56a and E2-induced CK was partially inhibited by DT56a. The results support the finding that DT56a is a SERM; it stimulated different parameters similar to E2, but when given simultaneously, at supra physiological doses, inhibited these E2's effects. Further investigations regarding intra and extra cellular mechanism of action of DT56a are currently performed.