The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Making meditation a part of a daily routine, even if just 10-15 minutes per day, can have mental and physical health benefits over time by helping people feel more relaxed and focused.
In this lecture, we present the main reactions of Kreb's cycle and its clinical importance.
Most of the slides are cited from Lippincott's illustrated Biochemistry and Satyrana Biochemistry.
Best Bishes,
Dr. Haroon
In this section, we describe Glycolysis and its clinical importance and most of the slides are cited from:
1- Lippincott Biochemistry 7th edition
2- Satyrana Biochemistry
3- Harper Biochemistry
In this section, we describe different types of receptors. Most of the slides are cited from Lippincott's Illustrated Review Biochemistry. Other references include:
U. Satyrana Biochemistry
Harper's Biochmeistry
In this section, we describe enzymes. Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U. Satyrana Biochemistry
3. Harper's Biochemistry
In this section, we describe digestion and absorption of Nucleic Acids and Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U. Satyran Biochemistry
Dr. Haroon
In this section, we describe Nucleic Acids (Biochemistry). Most of the slides are cited from:
1. Lippincott's Illustrated Review's Biochemistry
2. U. Satyrana Biochemistry
Dr. Haroon
In this section we describe nucleotides and most of the slides are cited from:
Lippincott's Illustrated Review Biochemistry
U. Satyrana Biochemistry
Dr. Haroon
In this section, we describe digestion and absorption of proteins.
Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U. Satyrana Biochemistry
Dr. Haroon
In this lecture, we present the main reactions of Kreb's cycle and its clinical importance.
Most of the slides are cited from Lippincott's illustrated Biochemistry and Satyrana Biochemistry.
Best Bishes,
Dr. Haroon
In this section, we describe Glycolysis and its clinical importance and most of the slides are cited from:
1- Lippincott Biochemistry 7th edition
2- Satyrana Biochemistry
3- Harper Biochemistry
In this section, we describe different types of receptors. Most of the slides are cited from Lippincott's Illustrated Review Biochemistry. Other references include:
U. Satyrana Biochemistry
Harper's Biochmeistry
In this section, we describe enzymes. Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U. Satyrana Biochemistry
3. Harper's Biochemistry
In this section, we describe digestion and absorption of Nucleic Acids and Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U. Satyran Biochemistry
Dr. Haroon
In this section, we describe Nucleic Acids (Biochemistry). Most of the slides are cited from:
1. Lippincott's Illustrated Review's Biochemistry
2. U. Satyrana Biochemistry
Dr. Haroon
In this section we describe nucleotides and most of the slides are cited from:
Lippincott's Illustrated Review Biochemistry
U. Satyrana Biochemistry
Dr. Haroon
In this section, we describe digestion and absorption of proteins.
Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U. Satyrana Biochemistry
Dr. Haroon
In this section, we describe plasma proteins. Most of the slides are cited from:
1. Lippincott's illustrated Review Biochemistry
2. Harper's Biochemistry
3. U. Satyrana Biochemistry
In this section, we describe proteins biochemistry. Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U Satyran Biochemistry
3. Harper's Biochemistry
Dr. Haroon
In this presentation, we describe drugs used for allergic rhinitis and cough and most of the slides are cited from:
1. Lippincott's Pharmacology
2. KD Triphati Pharmacology
2. Basic Pharmacology
For further slides, you can email me at: haroonstanikzai1@gmail.com
Thank you
Dr. Haroon
In this section, we describe peptides and most of the slides are cited from:
1- Lippincott's Illustrated Review Biochemistry
2- Harper's Biochemistry
3- U. Satyr Ana Biochemistry
In this section We describe drugs used in Asthma and COPD and Most of the slides are prescribed from Lippincott's Pharmacology. Other references include:
1. Kd triphati Pharmacology
2. Basic Pharmacology
In this section, we describe Compound Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Drugs used in Constipation and Diarrhea and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Digestion and Absorption of Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Compound Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe drugs used for peptic ulcer diseases.
Most of the slides are cited from:
1- Lippincott's Illustrated Pharmacology
2- KD Triphati Pharmacology
In this section, we describe Compound Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this presentation, we describe Anti-Histamine drugs along with histamine physiology.
Most slides are cited from Lippincott's Pharmacology
Other references include:
Kd Triphati Pharmacology
Thank you,
In this section, we describe Introduction to Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe:
- Digestion and Absorption of Carbohydrates
Most of the slides are cited from:
1. Lippincott's Biochemistry
2. Stayaran's Biochemistry
3. Jaypee Biochemistry
In this section, we describe Disaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
In this section, we describe Carbohydrates Biochemistry and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Important monosaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Reactions of Monosaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- U Satyrana Biochemistry
In this section, we describe structural aspects of monosaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- U Satyrana Biochemistry
In this section, we describe Carbohydrates Biochemistry and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- U Satyrana Biochemistry
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
In this section, we describe plasma proteins. Most of the slides are cited from:
1. Lippincott's illustrated Review Biochemistry
2. Harper's Biochemistry
3. U. Satyrana Biochemistry
In this section, we describe proteins biochemistry. Most of the slides are cited from:
1. Lippincott's Illustrated Review Biochemistry
2. U Satyran Biochemistry
3. Harper's Biochemistry
Dr. Haroon
In this presentation, we describe drugs used for allergic rhinitis and cough and most of the slides are cited from:
1. Lippincott's Pharmacology
2. KD Triphati Pharmacology
2. Basic Pharmacology
For further slides, you can email me at: haroonstanikzai1@gmail.com
Thank you
Dr. Haroon
In this section, we describe peptides and most of the slides are cited from:
1- Lippincott's Illustrated Review Biochemistry
2- Harper's Biochemistry
3- U. Satyr Ana Biochemistry
In this section We describe drugs used in Asthma and COPD and Most of the slides are prescribed from Lippincott's Pharmacology. Other references include:
1. Kd triphati Pharmacology
2. Basic Pharmacology
In this section, we describe Compound Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Drugs used in Constipation and Diarrhea and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Digestion and Absorption of Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Compound Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe drugs used for peptic ulcer diseases.
Most of the slides are cited from:
1- Lippincott's Illustrated Pharmacology
2- KD Triphati Pharmacology
In this section, we describe Compound Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this presentation, we describe Anti-Histamine drugs along with histamine physiology.
Most slides are cited from Lippincott's Pharmacology
Other references include:
Kd Triphati Pharmacology
Thank you,
In this section, we describe Introduction to Lipids and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe:
- Digestion and Absorption of Carbohydrates
Most of the slides are cited from:
1. Lippincott's Biochemistry
2. Stayaran's Biochemistry
3. Jaypee Biochemistry
In this section, we describe Disaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
In this section, we describe Carbohydrates Biochemistry and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Important monosaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- Cheter-jee Biochemistry
Dr Haroon
In this section, we describe Reactions of Monosaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- U Satyrana Biochemistry
In this section, we describe structural aspects of monosaccharides and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- U Satyrana Biochemistry
In this section, we describe Carbohydrates Biochemistry and most of the slides are cited from:
1- Lippincott's Illustrated Biochemistry
2- Harper's Biochemistry
3- U Satyrana Biochemistry
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
