The document discusses abnormal vaginal discharge and its classification. It notes that abnormal discharge can be a symptom of various diseases and lists classifications based on consistency, color, and smell. It then discusses the causes of abnormal discharge, including infections from various bacteria and fungi. The document provides details on the normal vaginal flora and how discharge is normally higher during times of high estrogen levels like puberty, the menstrual cycle, and pregnancy.
Rite of Ordination of Catholic Bishop. This rite of ordination is that of Most Rev. Ivan Pereira as the Bishop of the Catholic Diocese of Jammu-Srinagar in Jammu & Kashmir, India. The liturgy document includes Rite of Ordination with commentary in Hindi and Mass sequences in English and Urdu.
Nature valley farm house is providing the best Nature Valley Farms in healthy atmosphere and beautiful landscape .All our farm houses are equipped with all required necessities .
Rite of Ordination of Catholic Bishop. This rite of ordination is that of Most Rev. Ivan Pereira as the Bishop of the Catholic Diocese of Jammu-Srinagar in Jammu & Kashmir, India. The liturgy document includes Rite of Ordination with commentary in Hindi and Mass sequences in English and Urdu.
Nature valley farm house is providing the best Nature Valley Farms in healthy atmosphere and beautiful landscape .All our farm houses are equipped with all required necessities .
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
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Technology
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Age and Gender
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Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
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Drugs used in vaginal discharge, menorrhagia and pdf
1.
2. Yoni Shrava (Vaginal discharge) :-
Abnormal vaginal discharge is actually symptom of different
diseases. On the basis of consistency, colour and smell etc.
vaginal discharge can be classified under following headings :-
Purulent vaginal discharge dQ fiÙkt
Thick, foul smelling vaginal discharge dQ fiÙkt
Mucoid vaginal discharge dQt
Blood stained, pinkish or other type of vaginal discharge fiÙkt
Thin or watery white vaginal discharge or leucorrhoea dQt
Dosha –
Vata, Pitta, Kapha
3. It is a running of white substance discharge
per vagina and the term should be restricted,
to mean an excessive amount of the normal
vaginal discharge.
Normal vaginal secretions are composed of:-
1. Vulval secretions
2. Vaginal secretions
3. Cervical secretions
4. Endometrial secretions
Abnormal vaginal discharges :-
These discahrges are mostly pathological,
arising from inflammatory conditions of
genital tract.
4. The normal vaginal flora is predominantly
aerobic, with an average of six different
species of bacteria, the most common among
all is hydrogen peroxide producing lacto
bacillus.
Physiologically- high when oestrogen level
becomes high during puberty, menstrual
cycle, pregnancy.
8. Name Botanical name Family
eaft"Bk Rubia cordifolia Linn Rubiaceae
'krkojh Asparagus racemosus Willd Liliaceae
Lkkfjok Hemidesmus indicus R. Br. Asclepiadaceae
dqekjh Aloe vera Tourn. ex Linn Liliaceae
e/kq;f"V Glycyrrhiza glabra Linn Papilionaceae
Ykks/kz Symplocos racemosa Roxb. Symplocaceae
nk:gfjæk Berberis aristata DC Berberidaceae
9. Ukke Botanical name Family
v'oxU/kk Withania somnifera Linn Solanaceae
e/kwd Madhuca indica J. F. Gmel Sapotaceae
gjhrdh Terminalia chebula Retz. Combretaceae
foHkhrdh Terminalia bellirica Roxb Combretaceae
vkEkydh Emblica officinalis Gaertn Euphorbiaceae
gfjæk Curcuma longa Linn Zingiberaceae
v'oRFk Ficus religiosa Linn Moraceae
mnqEcj Ficus glomerata Roxb Moraceae
jkLuk Pluchea lanceolata C.B. Clarke Astraceae
10. Ukke Botanical name Family
eqLrd Cyperus rotundus Linn Cyperaceae
dw"ek.M Benincasa hispida Thunb Cucurbitaceae
foMax Embelia ribes Burm F. Myrsinaceae
ik"kk.kHksn Bergenia ligulata wall Saxifragaceae
Ekkspjl Salmalia malabarica schoot engl Bombacaceae
tEcw Syzygium cumini Linn Myrtaceae
vEc"Bk Quercus infectoria oliv Fagaceae
yTtkyq Mimosa pudica Linn Mimosoidae
fcYo Aegle marmelos corr. Rutaceae
18. Asrigdar / Raktpradar
‘Asrik’ means rakta/ raj
‘Dara’ means continuous or excessive flow.
Hence ‘Asrigdara means excessive flow of menstrual blood.
Menorrhagia is defined as cyclic bleeding at normal
interval; the bleeding is either excessive in amount
(> 80 ml) or duration or both.
Metrorrhagia is defined as irregular and acyclic
bleeding from uterus with variable amount.
Dosha –
Vata, Pitta,Kapha
19. Ukke Botanical name Family
fç;axq Callicarpa macrophylla Vahl Verbenaceae
HkwE;keydh Phyllanthus urinaria Linn Euphorbiaceae
vkeydh Emblica officinalis Gaertn Euphorbiaceae
Okklk Adhatoda vasica Nees Acanthaceae
xqMwph Tinospora cordifolia (Willd) Menispermaceae
dkapukj Bauhinia variegata Linn Caesalpiniaceae
'kksHkkatu Moringa oleifera Lam Moringaceae
20. uke Botanical name Family
eqLrd Cyperus rotundus Linn Cyperaceae
m'khj Vetiveria zizanioidis Linn Graminae
ikBk Cissampelos pareira Linn Menispermaceae
Ckyk Sida cordifolia Linn Malvaceae
eaft"Bk Rubia cordifolia Linn Rubiaceae
jkLuk Pluchea lanceolata C.B. Clarke Astraceae
mnqEcj Ficus glomerata Roxb Moraceae
dkdksnqEcj Ficus hispida Linn Urticaceae
Ykks/kz Symplocos racemosa Roxb. Symplocaceae
21. uke Botanical name Family
v'kksd Saraca asoca (Roxb.) Caesalpinoidae
i=kax Caesalpinia sappan Linn Caesalpinoidae
'krkojh Asparagus racemosus Willd Liliaceae
v'oxa/kk Withania somnifera Linn Solanaceae
Ukkxds'kj Mesua ferrea Linn Guttiferae
/kkrdh Woodfordia fructicosa Kurz Lytheraceae
yTtkyq Mimosa pudica Linn Mimosoidae
30. Kshaya kalpana
• Svarasa (juice) of fruit of Aamalaki (embelic myrobalan)
– 14 -28 ml. Bd.
• Leaf svarasa (juice) of Guduchi – 14 – 28 ml. Bd.
• Svarasa (juice) of kakodumbara (gular fig green)–14-28 ml. Bd.
• Svarasa (juice) of leaf of vasa – 14-28 ml. Bd.
• Powder of bark of Ashoka – 1-2 gm. Bd.
• Bhumyamalaki churna – 3-6 gm. Bd.
• Powder of bark of Lodhra - 1-3 gm. Bd.
• Powder of Nagakeshara
(stamen of Indian iron wood tree) – 1-3 gm. Bd.
• Powdered root of Kusha (sacred grass) – 1-3 gm. Bd.
• Powder of root of Bala (country mallow) – 1-3 gm. Bd.
31. Compound preparations Dose/Anupana
1. Candraprabha vati - 2 - 4 vati twice a day with water
2. Silajatvadi vati - 1 - 2 vati twice a day with water
3. Pradarari rasa - 120 – 250 mg twice a day with honey
4. Pradarantaka rasa - 120 – 250 mg twice a day with honey
5. Kamadudha rasa - 120 – 250 mg twice a day with honey
6. Candrakala rasa - 120 – 250 mg twice a day with honey
7. Vanga bhasma - 120 – 250 mg twice a day with honey
8. Trivanga bhasma - 120 - 250 mg twice a day with honey
9. Bolbabhadra rasa - 120 – 250 mg twice a day with honey
9. Kukkutanda tvak bhasma - 250 – 500 mg twice a day with honey
10. Pradarari lauha - 120 – 250 mg twice a day with honey
11. Lodhrasava - 14 – 28 ml twice a day with equal
12. Patrangasava - 14 – 28 ml twice a day quantity of
13. Ashokarishtha - 14 – 28 ml twice a day water after meal
32. Saraca asoca Roxb.
Chemical constituents
Katecol, Ketosterol, Haematoxylin, glycoside, Flavonoids,
Tannins, Saponins, Iron Calcium
Pharmacological action :-
i. Antibacterial ii. Uterotonic
iii. Spasmogenic iv. Anti Tumour
v. Anti cancer
33. Mesua ferrea Linn
Chemical Constituents –
Mesuol, Mesuone, lactone, Xanthene A and Xanthene B, Tannin
Pharmacological action –
Anti inflammatory activity - due to Xanthene A and Xanthene B
Anti bacterial activity – due to Mesuol and Mesuone against
micrococcus pyrogens, E. coli, Mycobacterium Phlei.
Caesalpinia Sappan Linn
Chemical constituents
Triterpenoids, Flavonoids, Brazilin, Brazilien, Tannin
Pharmacological action :-
i. Antibacterial ii. Anti microbial
iii. Cytotoxic iv. Astringent
v. Anti inflammatory vi. Anti cancer
34. Withania somnifera Linn
Chemical constituents –
35 different steroidal lactones, withanolids, Withaferin,
Saponin, Bidaphyrine
Pharmacological action
i. Immunomodulator ii. Free radical scavenger
iii. Anti oxidant iv. Rejuvinator
v. Anabolic vi. Anti cancerous .
Root increases the number of red and white blood cells and
platelets in the blood. The herb may also help to prevent
chemotherapy induced neutropenia and is a daily health
supplement. Bidaphyrine kills the cancer cells.
35. Asparagus racemosus Willd
Chemical Constituents –
Asparagin, 4 saponins
Pharmacological action –
Saponin produces specific block of syntocinon induced
contraction. Due to its anti oxytocic activity so it is
used in threatened abortion.
Hipopphae rhamonids
Chemical constituents –
Flavonoides, Leucoanthocyanidins, catechins, mono
and diglycosides, quercetin, kaempherol, Vit. C and E,
Carotenoids.
Pharmacological action
i. Anti mutagenic ii. Anti cancer
iii. Anti oxidant iv. Wound healing
36. Rubia cordifolia Linn
Chemical Constituents –
Cyclic hexapeptides, alizarin, Napthohydroquinones, Rubilactone.
Pharmacological action –
i. Anti neoplastic ii. Anti oxidant
iii. Anti viral
iv. Anti bacterial (against Stapylococcus aureus)
Inhibits protein synthesis due to presence of cyclic hexa peptides.
Glycyrrhiza glabra Linn
Chemical Constituents –
Rhamnoglucoside, Glycyrrhizic acid, Glycyrrhizin, Glabridine,
Glycyrrhetic acid.
Pharmacological action –
i. Anti microbial ii. Anti inflammatory
iii. Anti ulcer iv. Anti pyretic
v. Immunomodulator vi. Anabolic
37. Symplocos racemosus Roxb.
Chemical constituents –
Loturine, Colloturine, Loturidine, Glycosides
Pharmacological action
i. Anti tumour ii. Anti cancer
iii. Anti oxidant iv. Wound healing
v. Astringent vi. Haemostatic
vii. Anti inflammatory viii. Vasoconstrictor
Woodfordia fruticosa Kurz.
Chemical constituents –
Tannin, Flavonoids, Anthraquinone, Glycosides and Polyphenols
Pharmacological action
i. Astringent ii. Haemostatic
iii. Wound healing iv. Refrigerant
38. Embelia ribes Burm F.
Chemical Constituents –
Benzoquinone derivatives, embelin and vilangin.
Pharmacological action –
i. Astringent ii. Anti helminthic
iii. Anti bacterial iv. Anti fungal
Wound healing activity of embelin as it increases granulation
by increase in collagenation.
39. Callicarpa macrophylla Vahl.
Chemical Constituents –
Volatile oil and hydrocyanic acid.
Pharmacological action –
i. Astringent ii. Haemostatic
iii. Wound healing iv. Styptic
v. Refrigerant vi.Arrests excessive secretions
Cyperus rotondus Linn
Chemical constituents –
Aromatic oil, glycosidic resin, scopoletin, coumarin
Pharmacological action
i. Astringent ii. Diaphoretic
iii. Anti inflammatory iv. Anti fungal
v. Anti bacterial vi. Promotes quick healing
40. Curcuma longa Linn
Chemical Constituents –
Active curcumin compound, essential oils, terpenoids,
Vit. A, protein and fat.
Pharmacological action –
i. Astringent ii. Antiseptic
iii. Wound healing iv. Anti inflammatory
v. Anti mutagenic vi. Anti cancerous
vii. Anti bacterial viii. Anti fungal
ix. Anthelmintic x. Blood purifier
xi. Anti histaminic xii. Refrigerant and aromatic
Curcumin has shown anti inflammatory effect and
bacteriostatic action especially on staphylococci and
essential oil has shown bactericidal action.
41. Name Original Drug Substitute/adulterant
Manjistha Rubia cordifolia Linn Stem of Rubia cordifolia
Ashoka Saraca asoca (Roxb.) Polyalthia longifolia
Priyangu Callicarpa macrophylla
Vahl
Aglaia roxburghiana, Prunus mahaleb
Nagkeshar Mesua ferrea Linn Cinnamomum tamala, Mammae
longiflia, Calophyllum inophyllum
Sthonayak Taxus baccata Linn Abies webbiana
Madhuyasthi Glycyrrhiza glabra Linn Glycyrrhiza uralensis, Roots of Abrus
precatorius
Vidanga Embelia ribes Burm F. Embelia robusta, Myrsine africana
Daruharidra Berberis aristata DC Berberis lycium, Berberis asiatica,
Coscinium fenestratum
Chirayta Swertia chirayita Karst Swertia Sp., Andrographis paniculata
Akarakarabh Anacyclus pyrethrum DC Achillea millefolium, Spilanthes
acmella
Jatamamsi Nordostachys grandiflora Selinum vaginatum Hkwrds’kh
Selinum tenuifolium ewjkekalh
45. Genuine drug, Adulterants, Substitutes :-
Credibility of drug depends upon the potency of drug which is
determined by the fact that whether it is genuine or not,
because ayurvedic system of medicine predominantly use plant
based raw materials in most of their preparations and
formulations. The credibility of this system thus mainly depends
upon the use of genuine raw materials. As a result of continuing
exploitation of these plants, many of the divine drugs have come
under endangered category.
Reasons for use of Substituents /Adulterants :-
Certain species have faced eradication/shortage due to over
exploitation and ignorance of herb-collectors.
Problems of transportation.
Geographical distribution.
Lack of knowledge regarding identification of drugs.