Dr.PGA Cosmetics What is gamma-PGA - 2013

Dr.PGA - Super HydrationYENA TRADING COMPANY
Dr.PGA - What is γ-PGA
γ-Polyglutamic Acid (γ-PGA)
& γ-Polygutamate Hydrogel
What is γ-PGA?

5
Dr. PGA products are the most powerful skin care
moisturizing products every developed…
What is γ-PGA?

5
These trendy Dr.PGA Products
contain a new moisturizing
agent called: γ-PGA (gamma-
PGA).
The patented γ-PGA hydrogel
used in these products, is the
most powerful hydrating
agent ever discovered!
Most powerful moisturizing agent
What is γ-PGA?

• γ-PGA is the worlds first Auto-Hydrating Agent…..
• γ-PGA is not only Hydrating, but also Lightening……
• γ-PGA is more Hydrating than Hyaluronic Acid / more
elastic than Collagen….
• γ-PGA is the best Hydrating Agent, for skin and hair
care, ever discovered ….
• γ-PGA can also be used as an anti-aging Skin Filler…..
The most powerful moisturizing agent
6
What is γ-PGA?

γ-PGA is a wonderful and
natural agent, ideal to enhance
the effects of health care & skin
care products. γ-PGA is
integrated into the basic skin
care product formulation. It
dissolves excellently in water.
Your can feel the difference on
the soothing, refreshing &
moisturizing effect immediately!
FAST MOISTERIZING & REFRESHMENT!
7
γ-PGA IS ALL NATURAL!!
What is γ-PGA?

Originally the substance was discovered in the marine
jellyfish. Which helps the jellyfish to store water in its
fragile tissue and therefore dose not dehydrate in salty
sea water thanks to γ-PGA.
γ-PGA (Gamma-PGA)
Dr.PGA – Power Moisturizing

A new development for best moisturizing results
γ-PGA and polyglutamates are naturally occurred biopolymers
with multifunctional ties. γ-PGA is biosythesized from L-glutamic
acid with the microbe “Bacillus subtilis var natto” which has
been one of the microbes used to make „Natto“ – fermented
soybean, a traditional food and very popular in Japan for over
800 Years.
10
What is γ-PGA?

γ-PGA is edible, biodegradable, non-toxic to human
body and good blood compatible. Its characteristic
multi-carboxylic functional groups make it polyanionic
bioploymer which has been highly proposed and
recommended for use in several fields as….
1. cosmetics moisturizer improving skin care quality, reducing
wrinkle conditions and supporting natural moisturizing
factor of the skin
2. health care agent for nutrition supplements, facilitating
calcium absorption and improving osteoporosis conditions
11
What is γ-PGA?

3. thickener for the food Industry as well as texture enhancer and
as animal feed supplement facilitating mineral absorption
4. absorbent for water treatment for removing heavy metals and
radionuclides
5. hydrogel for seed coating and the production of woman
tampons due to high water absorbing character
6. hygiene product for baby diapers due to high water absorbent
capacity
7. specialty application for biochips, membrane and LCD
production due to biocompatibility
8. agriculture agent as natural biocide or inhibitor, it acts anti
pathogenic
9. others for the production of biodegradable plastics
12

Natto is the fermented soybean which
contains higher vitamin B2，B6，B12，E，K2，
-PGA and many other digestive enzymes.
The sticky material of natto is -PGA.
NATTO & γ-PGA
What is γ-PGA?

γ-PGA fills up the los of moisture in the skin and has the
ability to keep moisture longer in the skin.
What is γ-PGA?

γ-PGA salt can easily dissolve into water and becomes ionized.
(K+，Na+，NH4
+，Ca+2，Mg+2)
• Polyanions
• Polyelectrolyte
• Macroions
8
What is γ-PGA?

γ-PGA – hydrogel
γ-PGA powder
Water
After 3 to 4 minutes the
water becomes a gel
γ-PGA has the incredible
capacity to bind water. Up to
5000 times it's own molecular
weight
What is γ-PGA?

γ-PGA – hydrogel structure
Microscopic and 3D images of γ-PGA
Microscope image 3D image
What is γ-PGA?

γ-PGA is a powerful cosmetics moisturizer
improving skin care quality, reducing wrinkle
conditions and supporting natural moisturizing
factor of the skin!
A new development for best moisturizing results
What is γ-PGA?

γ-PGA Helix Structure
15
What is γ-PGA?

-PGA is a homopolypeptide made of only glutamic
acid in -peptide bond linkage with the degree of
polymerization (n) from 1000 to 12´000
16
What is γ-PGA?

Polyglutamic acid solutions have the abilities of skin
miniaturization and of melanin inhibition.
The molecular weight of polyglutamic acid can be reduced
efficiently by HCl hydrolysis. The viscosity of low molecular
weight of polyglutamic acid solutions are not affected by pH
values.
When polyglutamic acid is added to emulsion, the particle
size of emulsion is reduced and the ability of skin
moisturization of the emulsion increases. Polyglutamid acid
can be used as an excellent ingredient for skin moisturizers.
17
What is γ-PGA?

Long lasting effects of γ-PGA
The material γ-PGA Hydrogel is with unique surpassing
moisture holding capability, combining with functions of
different molecules of γ-PGA, can develop longer time
of one-way slow release action to thoroughly infiltrate
encapsulated active ingredients into deep layer of skin.
What is γ-PGA?

γ-PGA plays a role as a filler, being able to penetrate into 3 different
levels of our facial skins due to its different molecule sizes.
γ-PGA can create water channel beneath the skin:

That's why γ-PGA can quickly fill the gaps between skin
cells, diminish the pores and re-firm your facial skin
within a moment!.
10
What is γ-PGA?

γ-PGA is not only an hydrating ingredient for skin
but also a good “ carrier “ for other ingredients!
γ-PGA with abundant of negative charges is so
good for binding with positively charged trace
elements provide the optimal adhesion to the
skin which is normally negatively charged.
11
What is γ-PGA?

Dr.PGA Super Hydration for Skin & body
12
γ-PGA Hydrogel
It is a proven fact that the moistur-
izing capability of is 10 times more
than that of Hyaluronic Acid!

Fermented soybean = NATTO GUM = γ-PGA
•International Nomenclature Cosmetic Ingredient (INCI)
NATTO GUM
•EINECS No. : 310-127-6
The European Inventory of Existing Commercial Substances (EINECS)
•CAS No. : 9079-02-1
Chemical Abstracts Service Registry No.
Function : film forming
What is γ-PGA?

Polyglutamic Acid Solution
•International Nomenclature Cosmetic Ingredient (INCI)
Polyglutamic acid
•CTFA No.: 5788
The Cosmetic, Toiletry, and Fragrance Association (CTFA)
•CAS No. : 26247-79-0
Chemical Abstracts Service Registry No.
Function : film forming
•CN-Code: 39139080
EU Combined Nomenclature (CN) code
What is γ-PGA?

γ-PGA vs. Regular Peptides
γ-PGA Regular Peptides
Body Units Glutamic Acid 20 Amino Acids
Photosensitivity Both in L&D-form Mostly in L-form
Amide Linkage γ-peptide α-peptide
R-group Super Hydrophilic Hydrophilic & Hydrophobic
Bonding Molecules 10000 Less than 10000
Bio-degradable Slow Fast
Bio-synthetic germ Few Many
Essential to Body Non-essential Essential
What is γ-PGA?

Schematic representation of the cross-linked
structure of a hydrogel including
tetrafuncional (A) and multifunctional (B)
cross-links, chain ends (C.D.), entanglements
(E), loops (F) and unreacted polymer chains
(G). The distance between two consecutive
cross-links when expressed as molecular
weight. Is the molecular weight between
cross-links Mc . Upon swelling by a penetrant
(•) the space between cross-links (H) is
available for diffusion solute flow, etc…
γ-PGA – hydrogel
What is γ-PGA?

γ-PGA applied onto the skin, can enhance the
Natural Moisturizing Factors ( NMF ) from
deep inside the skin such as Pyrolidone Carboxylic
Acid (PCA), Lactic Acid and Urocanic Acid, so that
the skin will recover the natural rehydrating ability.
This effect will never happen for example on
Hyaluronic Acid (HA).
γ-PGA truly enhances NMF
Natural Moisturizing Factor

γ-PGA is known today as the most powerful moisturizer
for skin care ever discovered. After using γ-PGA for a
minimum of 28 days, it can positively influence and
regulate the Natural Moisturizing Factor of the skin.
It also has a special characteristic in supporting active
agents of cosmetic products, as a carrier, to penetrate
the skin more efficiently.
Natural Moisturizing Factor / NMF of the skin

γ-PGA 、Hyaluronic Acid (HA)、Collagen stimulating effect
on skin NMF
150
100
50
0
%
0 11 28 days
PGA
HA
Collagen
Note: Applied once daily

Moisturizing effect Test - Comparison between γ-PGA、
Hyaluronic Acid (HA) and Collagen in stratum corneum layer
of skin
Collagen
HA
γ-PGA
Moisturizing Effect

Trans-Epidermal Water Loss – Test comparison between
γ-PGA 、Hyaluronic Acid (HA) and Collagen
80
85
90
95
100
105
110
1 14 28 Days
Collagen
HA
γ-PGA
TEWL Test%

Skin Elasticity Test - comparison between γ-PGA 、
Hyaluronic Acid (HA) and Collagen
80
85
90
95
100
105
110
115
1 14 28 Days
Collagen
HA
γ-PGA
% Skin Elasticity
27

Skin Moisture comparison
Skin Moisture
An age related
definciancy state
(rough and dark)
γ-PGA replenishes the
skin‘s own moisture
balance
(Brighter, smoother, softer
)

γ-PGA Hyarulonic Acid Collagen
skin miniaturization
water loss of skin
elasticity
extension
NMF growth
Conclusion
Enhance skin
moisture by
functional film
Cover skin with
physical film
Cover skin with
physical film
Skin Care Comparison between γ-PGA, Hyarolonic Acid
and Collagen

γ-PGA Hyaluronic Acid Collagen
Origin
Vegetable
(natto germ)
Animal
(chicken crown)
Animal
(pig or sheep)
Structure Mono-peptide Bi-saccharide Tri-peptide
Germ Resistance
Elasticity
NMF Growth
Hydrophilicity strong fair weak
pH-balance excellent good good
Skin film smooth sticky sticky
Skin Water Loss
(TEWL)
Conclusion Excellent Good Good
Skin Care Comparison between γ-PGA, Hyaluronic Acid & Collagen

Test Results. Corneometry

γ-PGA applied to hair improves surface structure
Before treatment with γ-PGA After 1 week of treatment with
γ-PGA

Nucleus
contains vital
bioinformation for
intra & extra cellular
communication
Mitochondria
(cross-section)
Each cell disposes of
several of these
„power-stations“
Mitochondria
Energy Reservoir
Adenosin-
triphosphate (ATP)
ATP is a form to keep
cellular energy
Mitochondria of each skin cell is involved supporting NMF
O2
ATP
ADP
A
From the
Blood
CO2
Back to
Blood
Energy
DNA
H2O = Natural Moisterizing Factor / NMF
33

New research reveals - Our top layer of the skin, the
stratum corneum, takes its oxygen straight from the air &
surrounding. But only moist skin can efficiently absorb
oxygen to supply the skin cells. Skin moisturizing is crucial.
The skin surface gets its
oxygen from the
atmosphere, not the
blood! Insufficient
oxygen supply to the
cells reduces the natural
moisturizing ability of the
skin significantly. Visual
signs of dry and ageing
skin appear
O2
O2
O2 O2O2 O2
What is γ-PGA?

Markus Stücker of the Ruhr-University in
Bochum, Germany, and his dermatologist
colleagues have found that air supplies the
top 0.25 - 0.4 mm of the skin with oxygen.
This is almost 10 times deeper than
previous estimates. This zone includes
the entire outermost layer of living cells -
the epidermis - and some of the dermis
below, which contains sweat glands and
hair roots.
R&D Background
35
What is γ-PGA?

The finding could change skin care specialists
approach to skin conditions. Says David Harrison, who
studies the use of oxygen by the skin at the University
Hospital of North Durham, UK: "Everyone thought that
atmospheric oxygen was unimportant, but a significant
depth of the skin is supplied from the air and
environment."
This fact opens new aspects on using skin care products
containing γ-PGA!
R&D Background
36
What is γ-PGA?

The achievement on
the development of
γ-PGA received the
2003 national
Biotechnology Gold
Prize
37
R&D Background
What is γ-PGA?

2003.12 2003-423533
Biodegradable, High Water
Absorbable PGA Hydrogel BY 3-
Dimentional Cross-Linking and ITS
Preparation Method
2003.12
200410004665.6
1-2004-00210
2003.12 092136155
2003.12 03258255.3
10/740,977
γ-PGA – global patent as brand new hydrating agent
38
What is γ-PGA?

• Visible signs of dry and aging skin are mainly due to reduced
ability of the skin to produce and store moisture.
Solution - γ-PGA is the worlds first Auto-Hydrating Agent and can
support and regulate in-depth the natural moisturizing factor of
skin cells.
• Many are looking today for a natural and non-aggressive way to
lighten skin. Solution - γ-PGA is not only a great Hydrating agent
but also has excellent Skin Lightening qualities.
Skin Care research offers different interesting
aspects for the use and application of γ-PGA :
39
What is γ-PGA?

•Moist skin is able to absorb much more oxygen then dry skin.
Solution - Super hydration of skin with γ-PGA. To ensure a long
lasting hydration γ-PGA has the ability to support and store
moister in the skin
•Moist skin looks fresher and younger due to hydration and more
efficient oxygen supply from the surface.
•Solution: γ-PGA supports the skin to optimize oxygen supply to the
skins cells on the surface (the stratum corneum)
40
What is γ-PGA?

•Hyaluronic Acid and collagen as cosmetic agents are animal
based and for many cosmetic users out today.
•Solution – The patented γ-PGA is plant based and more
Hydrating than Hyaluronic Acid Hyaluronic Acid reduces, after
longer application, the cells natural moisturizing factor of the skin.
Additionally γ-PGA A provides more elasticity to the skin than
Collagen. γ-PGA can therefore also be used as an effective anti-
aging Skin Filler
41
What is γ-PGA?

γ-PGA is today’s best choice
for skin hydration.
γ-PGA is the best & most
powerful Hydrating
Agent ever discovered!
42
What is γ-PGA?

Then contact us:
FIBD GmbH
Wolleraustrasse 41a
CH-8807 Freienbach
Switzerland
Email info@fibd.biz
Web www.fibdbusiness.com
Interested in this product line?

Thank you for
your attention!

Dr.PGA Cosmetics What is gamma-PGA - 2013

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