DRDO's 2-DG drug for treatment of Covid 19 patients
•
4 likes•482 views
- 2-Deoxy-D-glucose (2DG) is a glucose analog that was developed as an oral drug for COVID-19 by India's Defense Research and Development Organization (DRDO). - Clinical trials showed 2DG is effective against COVID-19, reducing recovery time and supplemental oxygen dependence for moderate patients. - The drug works by inhibiting glycolysis and ATP production within viral cells, blocking synthesis of viral structural components and potentially directly destroying them. No significant side effects were observed during trials.
Report
Share
Report
Share
Recommended
IMC campaign for Revital (Ranbaxy)
This document provides an analysis and proposed marketing plan for expanding the Revital supplement brand into new consumer segments in India. It begins with background on the company Ranbaxy and the current performance of the Revital brand. It then proposes targeting the large and fast-growing segments of Indian women over 14 and diabetic patients by positioning Revital as a daily nutritional supplement that provides energy and is safe for those groups. The document includes analysis of the size and growth of those potential new target segments as well as a justification for the new positioning.
Kertas Soalan Subjek Sains Tahun 5 KSSR
Eksperimen ini melihat hubungan antara jumlah sel kering dan kecerahan mentol. Hasilnya menunjukkan bahwa semakin banyak sel kering yang digunakan, semakin terang mentolnya. Eksperimen ini bertujuan untuk mengetahui pengaruh jumlah sel kering terhadap kecerahan mentol. Pembolehubah yang dapat diidentifikasi adalah jumlah sel kering sebagai pembolehubah manipulasi dan kecerahan mentol sebagai pembolehubah tergantung.
Dr reddy's
Dr. Reddy's Laboratories is an Indian pharmaceutical company founded in 1984 and headquartered in Hyderabad, India. It produces active pharmaceutical ingredients, finished dosages, and biologics. Dr. Reddy's controls its entire supply chain to offer high quality, affordable medicines while maintaining quality at every stage. It has 20,000 employees worldwide and facilities in India, the US, UK, and Mexico. Dr. Reddy's goals include becoming a global, integrated mid-sized pharmaceutical company through diversifying into generics and specialty medicines across emerging markets.
Bolly Quiz 2
This document provides clues related to Bollywood movies, music, and personalities. It includes trivia questions about film titles, directors, songs, awards, and more. The multiple choice, fill-in-the-blank, and true/false style questions require identifying names, titles, years and other details to uncover the answers.
Nationalism in india
Indian nationalism refers to the many underlying forces that defined the principles of the Indian independence movement, and strongly continue to influence the politics of India, as well as being the heart of many contrasting ideologies that have caused ethnic and religious conflict in Indian society. Indian nationalism often imbibes the consciousness of Indians that prior to 1947, India embodied the broader Indian subcontinent and influenced a part of Asia, known as Greater India.
Ziska pharmaceuticals
It is my creation about the Ziska Pharma Ltd. that how the company can adopt its strategic decisions.
Finals-Bollywood Quiz
1. The document provides details about 12 trivia questions related to Bollywood movies, actors, songs, etc. It also outlines the rules for two rounds of a quiz-style game involving points for correct and incorrect answers.
2. In the first round, participants are asked to list Hindi movies directed by Priyadarshan within 10 minutes to earn points. In the second round, they must divide their total points among 8 categories and risk them on questions in those categories.
3. The document tests knowledge of famous Bollywood songs, actors, directors, movies and more through questions requiring identification of details and making connections between entities. It structures a quiz around earning and betting points in different rounds.
The rowlatt act
Rowlatt Act known as the black bills were responsible for mobilizing the Indians against the British and the launch of Non Cooperation Movement by Mahatma Gandhi
Recommended
IMC campaign for Revital (Ranbaxy)
This document provides an analysis and proposed marketing plan for expanding the Revital supplement brand into new consumer segments in India. It begins with background on the company Ranbaxy and the current performance of the Revital brand. It then proposes targeting the large and fast-growing segments of Indian women over 14 and diabetic patients by positioning Revital as a daily nutritional supplement that provides energy and is safe for those groups. The document includes analysis of the size and growth of those potential new target segments as well as a justification for the new positioning.
Kertas Soalan Subjek Sains Tahun 5 KSSR
Eksperimen ini melihat hubungan antara jumlah sel kering dan kecerahan mentol. Hasilnya menunjukkan bahwa semakin banyak sel kering yang digunakan, semakin terang mentolnya. Eksperimen ini bertujuan untuk mengetahui pengaruh jumlah sel kering terhadap kecerahan mentol. Pembolehubah yang dapat diidentifikasi adalah jumlah sel kering sebagai pembolehubah manipulasi dan kecerahan mentol sebagai pembolehubah tergantung.
Dr reddy's
Dr. Reddy's Laboratories is an Indian pharmaceutical company founded in 1984 and headquartered in Hyderabad, India. It produces active pharmaceutical ingredients, finished dosages, and biologics. Dr. Reddy's controls its entire supply chain to offer high quality, affordable medicines while maintaining quality at every stage. It has 20,000 employees worldwide and facilities in India, the US, UK, and Mexico. Dr. Reddy's goals include becoming a global, integrated mid-sized pharmaceutical company through diversifying into generics and specialty medicines across emerging markets.
Bolly Quiz 2
This document provides clues related to Bollywood movies, music, and personalities. It includes trivia questions about film titles, directors, songs, awards, and more. The multiple choice, fill-in-the-blank, and true/false style questions require identifying names, titles, years and other details to uncover the answers.
Nationalism in india
Indian nationalism refers to the many underlying forces that defined the principles of the Indian independence movement, and strongly continue to influence the politics of India, as well as being the heart of many contrasting ideologies that have caused ethnic and religious conflict in Indian society. Indian nationalism often imbibes the consciousness of Indians that prior to 1947, India embodied the broader Indian subcontinent and influenced a part of Asia, known as Greater India.
Ziska pharmaceuticals
It is my creation about the Ziska Pharma Ltd. that how the company can adopt its strategic decisions.
Finals-Bollywood Quiz
1. The document provides details about 12 trivia questions related to Bollywood movies, actors, songs, etc. It also outlines the rules for two rounds of a quiz-style game involving points for correct and incorrect answers.
2. In the first round, participants are asked to list Hindi movies directed by Priyadarshan within 10 minutes to earn points. In the second round, they must divide their total points among 8 categories and risk them on questions in those categories.
3. The document tests knowledge of famous Bollywood songs, actors, directors, movies and more through questions requiring identification of details and making connections between entities. It structures a quiz around earning and betting points in different rounds.
The rowlatt act
Rowlatt Act known as the black bills were responsible for mobilizing the Indians against the British and the launch of Non Cooperation Movement by Mahatma Gandhi
Cadila healthcare ltd
The best stock broker and share broker in India, Rudra Shares & Stock Brokers Ltd. is member of all the leading Equity & commodity exchanges in India, dealing in stocks, shares, commodity & currency serving clientele in 18 states through 225 business partners. Rudra Shares Fundamental Call Report which will brief about Fundamental coverage of CADILA Healthcare Ltd
Strategies for ensuring a Medical Device released under EUA will stay on the ...
1) Strategies for ensuring a medical device released under an Emergency Use Authorization (EUA) stays on the market after the EUA expires include pursuing a premarket submission such as a De Novo or 510(k).
2) Key considerations in preparing a premarket submission for a device released under an EUA include leveraging any clinical data collected under the EUA if possible, conducting a gap analysis against regulations and standards, and seeking funding assistance from organizations like BARDA or the CDC.
3) Recommended strategies include having pre-submission meetings with the FDA, leveraging available EUA clinical data for the premarket submission, conducting a gap analysis of applicable quality and regulatory requirements, and seeking support from
Global submission of ind, nda, anda
The document discusses Investigational New Drug Applications (INDs), New Drug Applications (NDAs), and Abbreviated New Drug Applications (ANDAs). It provides information on the purpose and requirements for submitting each type of application to regulatory agencies like the FDA.
An IND is required to get approval to conduct clinical trials of an investigational drug in humans. It must contain preclinical and manufacturing data as well as details on the proposed clinical trial protocol. An NDA is submitted to seek marketing approval for a new drug after Phase III trials. It contains extensive data from nonclinical studies, clinical trials, and information on manufacturing. An ANDA can be submitted for a generic drug to demonstrate equivalence to an approved brand name
vaccination
This document summarizes India's strategy for COVID-19 vaccination, which aims to vaccinate its entire population of over 1.3 billion people. It discusses the four main vaccines approved or undergoing clinical trials in India - Covishield, Covaxin, ZyCoV-D, and an unnamed vaccine by Biological E. Limited. The Indian government and manufacturers are working to rapidly increase vaccine production capacity to meet domestic demand and assist other countries.
Usfda generic drug user fee act a complete review
This document provides a review of the Generic Drug User Fee Act (GDUFA) implemented by the US Food and Drug Administration (USFDA). It discusses:
1) The increasing backlog of generic drug applications and inspections that GDUFA aims to address by providing additional funds to the USFDA.
2) The key goals of GDUFA are to ensure safety, efficacy, and access by prioritizing application review, increasing facility inspections, and expediting approval processes.
3) GDUFA fees are paid by generic drug manufacturers and facility owners and are split between application fees and facility fees, with the total revenue expected to be $299 million annually from 2013-
final semiar ppt
The document provides information for filing an Investigational New Drug (IND) application in electronic Common Technical Document (eCTD) format with the US FDA. It discusses the objectives of filing an IND for the drug Riociguat to treat pulmonary hypertension. It provides background on CTD and eCTD submission formats. It also includes details on the chemistry, manufacturing, and controls of Riociguat, preclinical and clinical studies, labeling, and stability data required for the IND application in eCTD format.
Posterior Segment Company Showcase - Graybug Vision
Posterior Segment Company Showcase - Graybug Vision at OIS@AAO 2016.
Presenter:
Jeffrey Cleland, PhD, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Study of the Effect of Gedunin against Protein GTP Binding Protein RAD to Tre...
Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on herbal phytochemicals are considered as the most prominent for the treatments. The computational study helps in finding the structural basis analysis of the compounds by rapid screening tools with rational drug designing. This study aims to identify the natural inhibitor of Rad GTP binding protein to treat Diabetes dysfunctionality.Therefore, by searching the natural compounds against Rad GTPase binding protein with 2DPX structure, all the important data was retrieved by using online webservers followed by computing docking score in AutoDock Vina. Out of three selected compounds, Gedunin was used to dock with the protein 2DAX protein structure, as it follows the both criteria for proceeding further, one is to follow lowest binding criteria then ADME Absorption, Distribution, Metabolism and excretion . The docking score of Gedunin compound shows that, this bioactive agent can go against the Diabetes mellitus and inhibits the expression of Rad GTPase. By result Gedunin has shown its therapeutic role with 7.9 kcal mol value. It has been concluded that in future Gedunin may act as a novel drug target. Chanchal Prajapati | Varsha Prajapati | Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "Study of the Effect of Gedunin against Protein-GTP-Binding Protein RAD to Treat Diabetes: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43888.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43888/study-of-the-effect-of-gedunin-against-proteingtpbinding-protein-rad-to-treat-diabetes-an-insilico-approach/chanchal-prajapati
My Presentation
This document outlines the requirements for registering a new drug in India. It discusses that new drugs must be registered with the Central Drugs Standard Control Organization (CDSCO) for safety, quality, and efficacy reasons. The registration process involves filing an Investigational New Drug (IND) application with preclinical data, then conducting clinical trials in three phases before filing a New Drug Application with full clinical data. The NDA requires documentation of manufacturing methods, non-clinical and clinical studies, and evidence that the drug is safe and effective for its intended use. Approval of the NDA by the Drugs Controller General of India allows the drug to be legally marketed.
Deadly Black Fungus In COVID-19 Patients In India
Mucormycosis, also known as black fungus, is a rare but serious fungal infection caused by a group of molds called mucormycetes. It has been occurring in COVID-19 patients in India treated with steroids, which can reduce immunity and increase blood sugar levels. Symptoms vary depending on the infected organ but may include sinus congestion, black lesions, fever and loss of vision. Those at highest risk include diabetics, severely immunocompromised individuals, and those with prolonged hospital stays. The fungus enters through inhalation or skin and spreads rapidly if not treated promptly with antifungal drugs and possibly surgery to remove infected tissue.
Rainbow code of biotechnology
This document outlines different categories of biotechnology including red, industrial, green, blue, yellow, grey, gold, brown, violet, and dark biotechnology. Red biotechnology involves medical applications like antibiotics, vaccines, and genetic engineering for disease treatment. Green biotechnology includes agricultural applications such as new crops, biofertilizers, and biopesticides. Dark biotechnology involves harmful applications like biological warfare and bioterrorism.
New pair of salivary glands discovered in Human Body
A new pair of salivary glands called the tubarial glands was discovered in humans. Researchers at the Netherlands Cancer Institute found the glands, which are located between the nasal cavity and throat, in prostate cancer patients using PET/CT scans. The tubarial glands are approximately 3.9 centimeters in length and are highly sensitive to radiation therapy.
Coronavirus
Coronaviruses can cause respiratory infections in humans and are named for their crown-like appearance under electron microscopy. Common human coronaviruses include HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, and MERS-CoV. In December 2019, a new coronavirus emerged in Wuhan, China causing pneumonia and was subsequently named 2019-nCoV. It is genetically similar to SARS-CoV and can be transmitted between animals and people through air droplets. Symptoms include fever, cough, breathing difficulties, and pneumonia.
How to treat snake bite person
If a person is bitten by a snake, it's important that he or she remains calm, immobilises the bite area and removes jewellery or tight clothing. Emergency medical care should be obtained as soon as possible.
Ebola virus
Ebola virus causes Ebola hemorrhagic fever, which was first discovered near the Ebola River in Africa. The virus is transmitted through contact with infected wildlife like bats or non-human primates, or through human-to-human transmission via bodily fluids. Symptoms start with fever and fatigue and progress to vomiting, diarrhea and internal/external bleeding. There is no proven treatment, but an experimental vaccine is being tested.
About Gum acacia
Gum arabic is collected from the Acacia nilotica tree. It is a complex mixture of glycoproteins and polysaccharides that is soluble in water, edible, and non-toxic. Gum arabic has a variety of industrial applications as a binder and emulsifying agent in pharmaceuticals, cosmetics, food, textiles, paint, beverages, and other industries due to its ability to slow drug absorption rates and act as a stabilizer. It is composed of arabinogalactan, arabinose, galactose, and 8-5' non cyclic diferulic acid.
How Jackfruit is important for us
Jackfruit is a large exotic fruit native to South India that can weigh up to 80 pounds. It contains flavors of apples, pineapples, mangoes and bananas. Jackfruit is highly nutritious as it provides vitamins, minerals, protein, carbohydrates, fiber and antioxidants like vitamin C, carotenoids and flavanones. Its antioxidants may help regulate blood sugar levels.
Basic Introduction of Apoptosis or Cell death
This document discusses several topics related to cell death processes including the hallmarks of apoptosis and necrosis, molecular mechanisms of apoptosis signaling pathways, regulation of apoptosis by the Bcl-2 family of proteins, and regulation of survival and cell death by the p53 network.
Best Collections of Rangolies preapared in India
Sushil Patel sent a thank you note expressing gratitude. The note thanked the recipient for their time and acknowledged their discussion. Patel closed by wishing the recipient well.
Raw264.7 Cell line
-Cell line used for checking the expression of TNF-alpha
-Also used for Inflammatory Studies
-This cell line is easy to propagate, high efficiency for DNA transfection
-Sensitivity to RNA interference, and supports replication of murine noroviruses.
Wide spectrum applications of Bacterial and Fungal pigments
Bacteria and Fungi have capability to produce wide variety of pigments which have wide spectrum applications
More Related Content
Similar to DRDO's 2-DG drug for treatment of Covid 19 patients
Cadila healthcare ltd
The best stock broker and share broker in India, Rudra Shares & Stock Brokers Ltd. is member of all the leading Equity & commodity exchanges in India, dealing in stocks, shares, commodity & currency serving clientele in 18 states through 225 business partners. Rudra Shares Fundamental Call Report which will brief about Fundamental coverage of CADILA Healthcare Ltd
Strategies for ensuring a Medical Device released under EUA will stay on the ...
1) Strategies for ensuring a medical device released under an Emergency Use Authorization (EUA) stays on the market after the EUA expires include pursuing a premarket submission such as a De Novo or 510(k).
2) Key considerations in preparing a premarket submission for a device released under an EUA include leveraging any clinical data collected under the EUA if possible, conducting a gap analysis against regulations and standards, and seeking funding assistance from organizations like BARDA or the CDC.
3) Recommended strategies include having pre-submission meetings with the FDA, leveraging available EUA clinical data for the premarket submission, conducting a gap analysis of applicable quality and regulatory requirements, and seeking support from
Global submission of ind, nda, anda
The document discusses Investigational New Drug Applications (INDs), New Drug Applications (NDAs), and Abbreviated New Drug Applications (ANDAs). It provides information on the purpose and requirements for submitting each type of application to regulatory agencies like the FDA.
An IND is required to get approval to conduct clinical trials of an investigational drug in humans. It must contain preclinical and manufacturing data as well as details on the proposed clinical trial protocol. An NDA is submitted to seek marketing approval for a new drug after Phase III trials. It contains extensive data from nonclinical studies, clinical trials, and information on manufacturing. An ANDA can be submitted for a generic drug to demonstrate equivalence to an approved brand name
vaccination
This document summarizes India's strategy for COVID-19 vaccination, which aims to vaccinate its entire population of over 1.3 billion people. It discusses the four main vaccines approved or undergoing clinical trials in India - Covishield, Covaxin, ZyCoV-D, and an unnamed vaccine by Biological E. Limited. The Indian government and manufacturers are working to rapidly increase vaccine production capacity to meet domestic demand and assist other countries.
Usfda generic drug user fee act a complete review
This document provides a review of the Generic Drug User Fee Act (GDUFA) implemented by the US Food and Drug Administration (USFDA). It discusses:
1) The increasing backlog of generic drug applications and inspections that GDUFA aims to address by providing additional funds to the USFDA.
2) The key goals of GDUFA are to ensure safety, efficacy, and access by prioritizing application review, increasing facility inspections, and expediting approval processes.
3) GDUFA fees are paid by generic drug manufacturers and facility owners and are split between application fees and facility fees, with the total revenue expected to be $299 million annually from 2013-
final semiar ppt
The document provides information for filing an Investigational New Drug (IND) application in electronic Common Technical Document (eCTD) format with the US FDA. It discusses the objectives of filing an IND for the drug Riociguat to treat pulmonary hypertension. It provides background on CTD and eCTD submission formats. It also includes details on the chemistry, manufacturing, and controls of Riociguat, preclinical and clinical studies, labeling, and stability data required for the IND application in eCTD format.
Posterior Segment Company Showcase - Graybug Vision
Posterior Segment Company Showcase - Graybug Vision at OIS@AAO 2016.
Presenter:
Jeffrey Cleland, PhD, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Study of the Effect of Gedunin against Protein GTP Binding Protein RAD to Tre...
Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on herbal phytochemicals are considered as the most prominent for the treatments. The computational study helps in finding the structural basis analysis of the compounds by rapid screening tools with rational drug designing. This study aims to identify the natural inhibitor of Rad GTP binding protein to treat Diabetes dysfunctionality.Therefore, by searching the natural compounds against Rad GTPase binding protein with 2DPX structure, all the important data was retrieved by using online webservers followed by computing docking score in AutoDock Vina. Out of three selected compounds, Gedunin was used to dock with the protein 2DAX protein structure, as it follows the both criteria for proceeding further, one is to follow lowest binding criteria then ADME Absorption, Distribution, Metabolism and excretion . The docking score of Gedunin compound shows that, this bioactive agent can go against the Diabetes mellitus and inhibits the expression of Rad GTPase. By result Gedunin has shown its therapeutic role with 7.9 kcal mol value. It has been concluded that in future Gedunin may act as a novel drug target. Chanchal Prajapati | Varsha Prajapati | Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "Study of the Effect of Gedunin against Protein-GTP-Binding Protein RAD to Treat Diabetes: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, URL: https://www.ijtsrd.com/papers/ijtsrd43888.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43888/study-of-the-effect-of-gedunin-against-proteingtpbinding-protein-rad-to-treat-diabetes-an-insilico-approach/chanchal-prajapati
My Presentation
This document outlines the requirements for registering a new drug in India. It discusses that new drugs must be registered with the Central Drugs Standard Control Organization (CDSCO) for safety, quality, and efficacy reasons. The registration process involves filing an Investigational New Drug (IND) application with preclinical data, then conducting clinical trials in three phases before filing a New Drug Application with full clinical data. The NDA requires documentation of manufacturing methods, non-clinical and clinical studies, and evidence that the drug is safe and effective for its intended use. Approval of the NDA by the Drugs Controller General of India allows the drug to be legally marketed.
Similar to DRDO's 2-DG drug for treatment of Covid 19 patients (9)
Strategies for ensuring a Medical Device released under EUA will stay on the ...
Strategies for ensuring a Medical Device released under EUA will stay on the ...
Posterior Segment Company Showcase - Graybug Vision
Posterior Segment Company Showcase - Graybug Vision
Study of the Effect of Gedunin against Protein GTP Binding Protein RAD to Tre...
Study of the Effect of Gedunin against Protein GTP Binding Protein RAD to Tre...
More from Sushil Patel
Deadly Black Fungus In COVID-19 Patients In India
Mucormycosis, also known as black fungus, is a rare but serious fungal infection caused by a group of molds called mucormycetes. It has been occurring in COVID-19 patients in India treated with steroids, which can reduce immunity and increase blood sugar levels. Symptoms vary depending on the infected organ but may include sinus congestion, black lesions, fever and loss of vision. Those at highest risk include diabetics, severely immunocompromised individuals, and those with prolonged hospital stays. The fungus enters through inhalation or skin and spreads rapidly if not treated promptly with antifungal drugs and possibly surgery to remove infected tissue.
Rainbow code of biotechnology
This document outlines different categories of biotechnology including red, industrial, green, blue, yellow, grey, gold, brown, violet, and dark biotechnology. Red biotechnology involves medical applications like antibiotics, vaccines, and genetic engineering for disease treatment. Green biotechnology includes agricultural applications such as new crops, biofertilizers, and biopesticides. Dark biotechnology involves harmful applications like biological warfare and bioterrorism.
New pair of salivary glands discovered in Human Body
A new pair of salivary glands called the tubarial glands was discovered in humans. Researchers at the Netherlands Cancer Institute found the glands, which are located between the nasal cavity and throat, in prostate cancer patients using PET/CT scans. The tubarial glands are approximately 3.9 centimeters in length and are highly sensitive to radiation therapy.
Coronavirus
Coronaviruses can cause respiratory infections in humans and are named for their crown-like appearance under electron microscopy. Common human coronaviruses include HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, and MERS-CoV. In December 2019, a new coronavirus emerged in Wuhan, China causing pneumonia and was subsequently named 2019-nCoV. It is genetically similar to SARS-CoV and can be transmitted between animals and people through air droplets. Symptoms include fever, cough, breathing difficulties, and pneumonia.
How to treat snake bite person
If a person is bitten by a snake, it's important that he or she remains calm, immobilises the bite area and removes jewellery or tight clothing. Emergency medical care should be obtained as soon as possible.
Ebola virus
Ebola virus causes Ebola hemorrhagic fever, which was first discovered near the Ebola River in Africa. The virus is transmitted through contact with infected wildlife like bats or non-human primates, or through human-to-human transmission via bodily fluids. Symptoms start with fever and fatigue and progress to vomiting, diarrhea and internal/external bleeding. There is no proven treatment, but an experimental vaccine is being tested.
About Gum acacia
Gum arabic is collected from the Acacia nilotica tree. It is a complex mixture of glycoproteins and polysaccharides that is soluble in water, edible, and non-toxic. Gum arabic has a variety of industrial applications as a binder and emulsifying agent in pharmaceuticals, cosmetics, food, textiles, paint, beverages, and other industries due to its ability to slow drug absorption rates and act as a stabilizer. It is composed of arabinogalactan, arabinose, galactose, and 8-5' non cyclic diferulic acid.
How Jackfruit is important for us
Jackfruit is a large exotic fruit native to South India that can weigh up to 80 pounds. It contains flavors of apples, pineapples, mangoes and bananas. Jackfruit is highly nutritious as it provides vitamins, minerals, protein, carbohydrates, fiber and antioxidants like vitamin C, carotenoids and flavanones. Its antioxidants may help regulate blood sugar levels.
Basic Introduction of Apoptosis or Cell death
This document discusses several topics related to cell death processes including the hallmarks of apoptosis and necrosis, molecular mechanisms of apoptosis signaling pathways, regulation of apoptosis by the Bcl-2 family of proteins, and regulation of survival and cell death by the p53 network.
Best Collections of Rangolies preapared in India
Sushil Patel sent a thank you note expressing gratitude. The note thanked the recipient for their time and acknowledged their discussion. Patel closed by wishing the recipient well.
Raw264.7 Cell line
-Cell line used for checking the expression of TNF-alpha
-Also used for Inflammatory Studies
-This cell line is easy to propagate, high efficiency for DNA transfection
-Sensitivity to RNA interference, and supports replication of murine noroviruses.
Wide spectrum applications of Bacterial and Fungal pigments
Bacteria and Fungi have capability to produce wide variety of pigments which have wide spectrum applications
Epidemiology of Breast Cancer
This review article summarizes the epidemiology of breast cancer in Indian women. Some key points are:
- Breast cancer is the most common cancer in Indian women, surpassing cervical cancer. However, cervical cancer remains more common in rural India.
- The age-adjusted incidence of breast cancer in India is lower than countries like the UK, but the mortality rates are similar.
- Risk factors for breast cancer in India include increasing age, obesity, household activities, betel nut and tobacco chewing, higher lifetime exposure to estrogen and progesterone, and polycyclic aromatic hydrocarbons.
- Breast cancer incidence and mortality are increasing in India due to rapid urbanization and changes to diet and lifestyle. However,
More from Sushil Patel (14)
New pair of salivary glands discovered in Human Body
New pair of salivary glands discovered in Human Body
Wide spectrum applications of Bacterial and Fungal pigments
Wide spectrum applications of Bacterial and Fungal pigments
Recently uploaded
ABDOMINAL TRAUMA in pediatrics part one.
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
share - Lions, tigers, AI and health misinformation, oh my!.pptx
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Adhd Medication Shortage Uk - trinexpharmacy.com
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
STIs may cause PID. For the both disease, herbal medicine Fuyan Pill can be a solution.
Journal Article Review on Rasamanikya
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Top 10 Best Ayurvedic Kidney Stone Syrups in India
we have mentioned the best 10 ayurvedic Kidney Stone Syrups. You can check all these products and choose the best one for yourself.
Light House Retreats: Plant Medicine Retreat Europe
Our aim is to organise conscious gatherings and retreats for open and inquisitive minds and souls, with and without the assistance of sacred plants.
Recently uploaded (20)
Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
share - Lions, tigers, AI and health misinformation, oh my!.pptx
share - Lions, tigers, AI and health misinformation, oh my!.pptx
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptx
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Muscles of Mastication by Dr. Rabia Inam Gandapore.pptx
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
DRDO's 2-DG drug for treatment of Covid 19 patients
- 1. Sushil Kumar Cancer Biology and MSB Division CSIR-CDRI Lucknow, India 1/11 2DG Anti COVID 19 Drug Live COVID19 Virus Dead COVID 19 Virus
- 2. CSIR-CDRI 2-Deoxy-D-glucose(2DG) is a analog of D-Glucose • 2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen • Institute of Nuclear Medicine & Allied Sciences (INMAS) New Delhi, is a laboratory of DRDO India that developed 2DG as a medicine for COVID19 2/11
- 3. CSIR-CDRI Approval of 2DG as Anti COVID19 drug in India • Drugs Controller General of India approved an anti-COVID oral drug: May 8, 2021 • 2DG as an anti Covid drug developed by DRDO(Defence Research and Development Organisation (DRDO)India • Large scale production of 2DG by Dr. Reddy's Laboratories Hyderabad, India Who's better fit to take 2DG as adjunct therapy Moderate Covid 19 patients Severe coronavirus patients 2DG Faster recovery from Covid 19 Reduce supplemental oxygen dependence 03/11
- 4. CSIR-CDRI Which form of 2-Deoxy-D-glucose(2DG) used as Anti-Covid 19 drug 2DG as a powder Water 2DG + Water Take orally twice a day First dose Second dose Before Breakfast Before Dinner Fasting increase the working efficacy of 2DG in Covid 19 Patients 04/11
- 5. CSIR-CDRI Experimental results which proved 2DG is effective against COVID 19 Image from Press Information Bureau (PIB) India 05/11
- 6. CSIR-CDRI Graphic showing how 2-DG drug reacts when used to treat SARS-CoV-2 infection Image from Press Information Bureau (PIB) India 06/11
- 7. CSIR-CDRI Expected molecular mechanism of 2DG to kill COVID19 Virus 2DG (GLUT)Glucose transporters 2DG (Inside of the viral infected cells) 2DG(Out side of the cell) Oral intake Inhibit Glycolysis Inhibit ATP Production ROS generation Results Blocked synthesis of Viral structural components such as envelop & neucleocapsid Directly destroy structural components 07/11
- 8. CSIR-CDRI Clinical trials of 2DG as an Anti COVID19 Medicine Permission from DCGI, India (May2020) for Clinical trial of 2DG in India Phase II Clinical trials Phase III clinical trails 6 Hospitals of India 11 Hospitals of India From May 2020 to October 2020 From December 2020 to March 2021 DRDO, India CCMB, India April 2020 First trial of 2DG against COVID 19 Virus 08/11
- 9. CSIR-CDRI Side effect of 2DG • No side effects were found in Covid 19 patients during clinical trials • Its safe medicine for Covid 19 09/11
- 10. CSIR-CDRI Biomedical applications of 2DG 2DG Anticancer Drug Antiviral drug Imaging agent PET CT Anti-COVID oral drug To treat Neurological disorders Epilepsy Breast Cancer 10/11
- 11. CSIR-CDRI 11/11