Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 28th publication IJMOR 1st name
Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 28th publication IJMOR 1st name
Caudal Anaesthesia for CTEV with Post-Op Analgesia in Paediatric Patient- A C...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Caudal Anaesthesia for CTEV with Post-Op Analgesia in Paediatric Patient- A C...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
It remains the responsibility of all clinicians using LA
to understand their potential
for severe systemic toxicity and to be prepared to respond immediately to these events when they occur.
Ropivacaine is a recently launched local anesthetic in Iran. Because of its more safety profile, it would be an appropriate substitution for routinely used LA, Bupivacaine.
Sahu S, Patley A, Kharsan V, Madan RS, Manjula V, Tiwari RVC. Comparative evaluation of efficacy and latency of twin mix vs 2% lignocaine HCL with 1:80000 epinephrine in surgical removal of impacted mandibular third molar. J Family Med Prim Care. 2020 Feb;9(2):904-908. doi: 10.4103/jfmpc.jfmpc_998_19. eCollection 2020 Feb. PubMed PMID: 32318443; PubMed Central PMCID: PMC7113948.
Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A.
Material and Methods:
Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfactants Tween 80, benzalkonium chloride and Pluronic and evaluated for pH, particle size, entrapment efficiency, differential scanning calorimetry (DSC), stability and drug release. Also, Draize test was used to evaluate the irritation of rabbit eye by formulations.
Results:
All formulations showed a small mean size that is well suited for ocular application. Also it was observed that the particle size decreased with increase in the amount of surfactant. Drug entrapment increased with increasing amount of surfactant. It was shown that initial and final drug release can be controlled by the ratio and the total amount of surfactants, respectively.
Conclusion:
It was concluded that the use of Tween 80 and Pluronic in the formualtions with a proper ratio does not show eye irritation and could be useful to achieve a suitable nanosuspension of vitamin A as a novel ocular delivery system.
Effectiveness of intra-articular dexmedetomidine as postoperative analgesia i...iosrphr_editor
Background And Objectives: To study the effect of inj.Ropivacaine (0.25%) 2mg/kg with and without Inj.Dexmedetomidine (1-2μg/kg) intraarticularly for postoperative analgesia in arthroscopic knee surgery.1:To Evaluate Onset, Duration and analgesic efficacy of Intraarticular Dexmedetomidine2: To monitor the safety of Dexmedetomidine and Ropivacaine.
Methods: A prospective randomized double blind study, was conducted in 50 patients undergoing elective arthroscopy of knee joint under spinal anaesthesia. At the completion of the surgery, all patients were divied into two groups;GroupP(n=25):received Inj. Ropivacaine 0.25% and GroupD(n=25):received Inj.Ropivacaine(0.25%)+Inj. Dexmedetomidine(1μg/kg) total volume 20 ml was deposited intra-articularly.Patients were monitored in the postoperative ward for the hemodynamic parameters and their Sedation score was assessed.. The efficacy of the drug was determined by improvement in VAS score, duration of analgesia and total number of rescue analgesics during 24 hr in post operative period.
Results: There was no statistically significant differences observed in heart rate except changes at 6 and 8 hr. At 6 and 8 hr in group P pulse (82.48 ± 7.49, 81.44 ± 8.78) as compared to group D (75.38 ± 6.52, 74.96 ± 5.70),because of duration of action of ropivacaine with or without dexmedetomidine.There was no statistically significant difference in blood pressure was found, except at 12 hour and 24 hour (p=0.018), because of longer duration of action of intrarticular dexmedetomidine with ropivacaine in group D.At 6 hrs patients in Group P had a mean VAS score of 3.2 as compared to VAS score values of 1.8 in Group D which is statistically significant..At 2 , 4, 6 and 8 hour VAS score in P group was 1.64, 2.44, 3.24, 2.84 respectively. As compared to group P, in group D VAS score at 2, 4, 6 and 8 hour was 0.92, 1.04, 1.79 and 2.08 respectively. So VAS score lower in group D as compared to group P at 2, 4, 6 and 8 hrs.
Analgesic Effect of Lidocaine in Orofacial Pain Of RatsQUESTJOURNAL
ABSTRACT: In dental treatment, lidocaine is currently used as local anesthetic, but studies on the control of orofacial pain are limited. The aim of this study was to investigate whether pre-treatment with lidocaine would involved in pain modulation in inflammatory orofacial pain.Male Sprague-Dawley white rats (240-280g) were used. The experimental group were divided into 3 groups(n=5); formalin (5 %, 50 μL), Administer 0.2%, 2% lidocaine, after administration, formalin (s.c). To induced orofacial pain, 5% formalin (50 μL) was injected under the skin on the right region of the whiskers of the experimental animals (n=5), and the act of rubbing or scratching the facial area in which the drug was injected was considered pain index. The administration of lidocaine at 2% concentration was found that the formalin-induced pain behavioral reaction was effectively reduced. The level of Nrf2 protein expression increased by formalin noticeably decreased in the medulla oblongata after lidocaine administration. Nuclear factor erythroid 2–related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor. Both ginsengs significantly down-regulated the increased Nrf2 level in formalin group. These results indicate that lidocaine could be a promising regulated in the treatment of inflammatory orofacial pain
The administration of Local anesthesia is the greatest fear a child would encounter in the dental office. Hence it is important that dentists obtain pain control with minimum discomfort to the child. This Review VEDIO provides an overview about the various local anesthetic agents used in pediatric dental practice, dosage, complications and the recent advances
Similar to Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 28th publication IJMOR 1st name
It remains the responsibility of all clinicians using LA
to understand their potential
for severe systemic toxicity and to be prepared to respond immediately to these events when they occur.
Ropivacaine is a recently launched local anesthetic in Iran. Because of its more safety profile, it would be an appropriate substitution for routinely used LA, Bupivacaine.
Sahu S, Patley A, Kharsan V, Madan RS, Manjula V, Tiwari RVC. Comparative evaluation of efficacy and latency of twin mix vs 2% lignocaine HCL with 1:80000 epinephrine in surgical removal of impacted mandibular third molar. J Family Med Prim Care. 2020 Feb;9(2):904-908. doi: 10.4103/jfmpc.jfmpc_998_19. eCollection 2020 Feb. PubMed PMID: 32318443; PubMed Central PMCID: PMC7113948.
Preparation and evaluation of vitamin A nanosuspension as a novel ocular drug...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
The aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A.
Material and Methods:
Formulations were designed based on full factorial design. A high pressure homogenization technique was used to produce nanosuspensions. Fifteen formulations were prepared by the use of different combinations of surfactants Tween 80, benzalkonium chloride and Pluronic and evaluated for pH, particle size, entrapment efficiency, differential scanning calorimetry (DSC), stability and drug release. Also, Draize test was used to evaluate the irritation of rabbit eye by formulations.
Results:
All formulations showed a small mean size that is well suited for ocular application. Also it was observed that the particle size decreased with increase in the amount of surfactant. Drug entrapment increased with increasing amount of surfactant. It was shown that initial and final drug release can be controlled by the ratio and the total amount of surfactants, respectively.
Conclusion:
It was concluded that the use of Tween 80 and Pluronic in the formualtions with a proper ratio does not show eye irritation and could be useful to achieve a suitable nanosuspension of vitamin A as a novel ocular delivery system.
Effectiveness of intra-articular dexmedetomidine as postoperative analgesia i...iosrphr_editor
Background And Objectives: To study the effect of inj.Ropivacaine (0.25%) 2mg/kg with and without Inj.Dexmedetomidine (1-2μg/kg) intraarticularly for postoperative analgesia in arthroscopic knee surgery.1:To Evaluate Onset, Duration and analgesic efficacy of Intraarticular Dexmedetomidine2: To monitor the safety of Dexmedetomidine and Ropivacaine.
Methods: A prospective randomized double blind study, was conducted in 50 patients undergoing elective arthroscopy of knee joint under spinal anaesthesia. At the completion of the surgery, all patients were divied into two groups;GroupP(n=25):received Inj. Ropivacaine 0.25% and GroupD(n=25):received Inj.Ropivacaine(0.25%)+Inj. Dexmedetomidine(1μg/kg) total volume 20 ml was deposited intra-articularly.Patients were monitored in the postoperative ward for the hemodynamic parameters and their Sedation score was assessed.. The efficacy of the drug was determined by improvement in VAS score, duration of analgesia and total number of rescue analgesics during 24 hr in post operative period.
Results: There was no statistically significant differences observed in heart rate except changes at 6 and 8 hr. At 6 and 8 hr in group P pulse (82.48 ± 7.49, 81.44 ± 8.78) as compared to group D (75.38 ± 6.52, 74.96 ± 5.70),because of duration of action of ropivacaine with or without dexmedetomidine.There was no statistically significant difference in blood pressure was found, except at 12 hour and 24 hour (p=0.018), because of longer duration of action of intrarticular dexmedetomidine with ropivacaine in group D.At 6 hrs patients in Group P had a mean VAS score of 3.2 as compared to VAS score values of 1.8 in Group D which is statistically significant..At 2 , 4, 6 and 8 hour VAS score in P group was 1.64, 2.44, 3.24, 2.84 respectively. As compared to group P, in group D VAS score at 2, 4, 6 and 8 hour was 0.92, 1.04, 1.79 and 2.08 respectively. So VAS score lower in group D as compared to group P at 2, 4, 6 and 8 hrs.
Analgesic Effect of Lidocaine in Orofacial Pain Of RatsQUESTJOURNAL
ABSTRACT: In dental treatment, lidocaine is currently used as local anesthetic, but studies on the control of orofacial pain are limited. The aim of this study was to investigate whether pre-treatment with lidocaine would involved in pain modulation in inflammatory orofacial pain.Male Sprague-Dawley white rats (240-280g) were used. The experimental group were divided into 3 groups(n=5); formalin (5 %, 50 μL), Administer 0.2%, 2% lidocaine, after administration, formalin (s.c). To induced orofacial pain, 5% formalin (50 μL) was injected under the skin on the right region of the whiskers of the experimental animals (n=5), and the act of rubbing or scratching the facial area in which the drug was injected was considered pain index. The administration of lidocaine at 2% concentration was found that the formalin-induced pain behavioral reaction was effectively reduced. The level of Nrf2 protein expression increased by formalin noticeably decreased in the medulla oblongata after lidocaine administration. Nuclear factor erythroid 2–related factor 2 (Nrf2) is an oxidative stress-mediated transcription factor. Both ginsengs significantly down-regulated the increased Nrf2 level in formalin group. These results indicate that lidocaine could be a promising regulated in the treatment of inflammatory orofacial pain
The administration of Local anesthesia is the greatest fear a child would encounter in the dental office. Hence it is important that dentists obtain pain control with minimum discomfort to the child. This Review VEDIO provides an overview about the various local anesthetic agents used in pediatric dental practice, dosage, complications and the recent advances
Similar to Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 28th publication IJMOR 1st name (20)
60.Srinivasan S, Velusamy G, Munshi MAI, Radhakrishnan K, Tiwari RVC. Comparative Study of Antifungal Efficacy of Various Endodontic Irrigants with and without Clotrimazole in Extracted Teeth Inoculated with Candida albicans. J Contemp Dent Pract. 2020 Dec 1;21(12):1325-1330. PubMed PMID: 33893253.
Mathew P, Kattimani VS, Tiwari RV, Iqbal MS, Tabassum A, Syed KG. New Classification System for Cleft Alveolus: A Computed Tomography-based Appraisal. J Contemp Dent Pract. 2020 Aug 1;21(8):942-948. PubMed PMID: 33568619
65.Izna, Sasank Kuntamukkula VK, Khanna SS, Salokhe O, Chandra Tiwari RV, Tiwari H. Knowledge and Apprehension of Dental Health Professionals Pertaining to COVID in Southern India: A Questionnaire Study. J Pharm Bioallied Sci. 2021 Jun;13(Suppl 1):S448-S451. doi: 10.4103/jpbs.JPBS_551_20. Epub 2021 Jun 5. PubMed PMID: 34447131; PubMed Central PMCID: PMC8375944.
Vohra P, Belkhode V, Nimonkar S, Potdar S, Bhanot R, Izna, Tiwari RVC. Evaluation and diagnostic usefulness of saliva for detection of HIV antibodies: A cross-sectional study. J Family Med Prim Care. 2020 May;9(5):2437-2441. doi: 10.4103/jfmpc.jfmpc_138_20. eCollection 2020 May. PubMed PMID: 32754516; PubMed Central PMCID: PMC7380795
Mittal S, Hussain SA, Tiwari RVC, Poovathingal AB, Priya BP, Bhanot R, Tiwari H. Extensive pelvic and abdominal lymphadenopathy with hepatosplenomegaly treated with radiotherapy-A case report. J Family Med Prim Care. 2020 Feb;9(2):1215-1218. doi: 10.4103/jfmpc.jfmpc_1125_19. eCollection 2020 Feb. PubMed PMID: 32318498; PubMed Central PMCID: PMC7113973.
36.Kesharwani P, Hussain SA, Sharma N, Karpathak S, Bhanot R, Kothari S, Tiwari RVC. Massive radicular cyst involving multiple teeth in pediatric mandible- A case report. J Family Med Prim Care. 2020 Feb;9(2):1253-1256. doi: 10.4103/jfmpc.jfmpc_1059_19. eCollection 2020 Feb. PubMed PMID: 32318508; PubMed Central PMCID: PMC7113959.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
CDSCO and Phamacovigilance {Regulatory body in India}
Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 28th publication IJMOR 1st name
1. Original Article
COMPARISON OF EFFICACY OF 2% LIDOCAINE AND 0.75% ROPIVACAINE ACTIVITY IN
ACHIEVING QUALITATIVE AND QUANTITATIVE ANALGESIA DURING SURGICAL
REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS
Raj Kumar Tiwari * , Sreekumar R *, Rahul Tiwari *, M Faiza *, Rahul Anand *
* Department of Oral and Maxillofacial Surgery, Meenakshi Ammal Dental College, Chennai, Tamil Nadu,
India.
* Department of Oral and Maxillofacial Surgery , Meenakshi Ammal Dental College, Chennai, Tamil Nadu,
India.
** Department of Oral and Maxillofacial Surgery , Jubilee Mission Medical College Hospital, Thrissur,
Kerala, India.
* Department of Oral and Maxillofacial Surgery , Meenakshi Ammal Dental College, Chennai, Tamil Nadu,
India.
* Department of Oral and Maxillofacial Surgery , Meenakshi Ammal Dental College, Chennai, Tamil Nadu,
India.
ABSTRACT
Background: Ropivacaine has been successfully
used in surgery, gynaecology and obstetrics, but
is not currently available for dentists. Reports
support the use of Ropivacaine as a long acting
local anaesthetic in oral and maxillofacial surgical
procedures requiring surgical anaesthesia and
post-operative analgesia.
Aim: The aim of the study was to compare the
anaesthetic efficacy of 0.75% Ropivacaine with
that of 2% Lidocaine Hydrochloride during the
surgical removal of impacted mandibular third
molars.
Material and Methods: A prospective
randomized double-blind clinical trial was
conducted on 28 subjects who required surgical
extracted of one or both of their impacted
mandibular third molars. A single operator
performed the extractions following injection of
either 0.75% Ropivacaine or 2% Lidocaine
Hydrochloride + 1: 80,000 conc. adrenaline,
randomly in a double-blind manner. Pain during
the surgery was assessed using a Visual Analog
Scale. Other parameters that were considered,
included the time of onset of anaesthesia, duration
of anaesthesia and the need for re-anaesthesia
during the procedure.
Results: The results showed that differences in
time of onset for 0.75% Ropivacaine (92.27 ±
34.85 secs) and 2% lidocaine (79.14 ± 11.065
secs), duration of action for 0.75% Ropivacaine
(5.03 ± 0.41 hrs) and 2% Lidocaine (3.27 ± 056
hrs) and intraoperative pain for 0.75%
Ropivacaine (1.27) and 2% Lidocaine (0.00) were
statistically significant. Also, 2% of subjects
required a re-anaesthesia using 0.75%
Ropivacaine whereas none of the subjects which
were given 2% Lidocaine, required re-
anaesthesia.
Conclusion: The study concludes that the clinical
effects of 2% Lidocaine with 1: 80,000 conc.
Adrenaline in terms of latency, intraoperative
pain control and depth of anaesthesia are superior
to 0.75% Ropivacaine, though the latter gives a
prolonged duration of anaesthesia.
KEYWORDS:
Lidocaine , Ropivacaine, Impacted Molars
INTRODUCTION
Pain is defined as an unpleasant emotional or
sensory experience associated with actual or
potential tissue damage or described in terms of
Received : 20‑03‑17
Review completed : 03‑04‑17
Accepted : 14‑05‑17
IJMOR
International Journal of Medical and Oral Research July-December 2017; 2(2):1-5
1
2. such damage (Burkit). Effective control of pain
during dental treatment has been one of the most
important prerequisite for practice of painless
dentistry. The discovery of anaesthesia has been a
great boon to the field of dentistry and surgery in
general. Local anaesthesia forms the back bone of
pain control techniques in dentistry. Their
advantage to block the perception of pain only in
limited portion of body and no need of circulation
as an intermediate carrier made it more popular as
compared to general anaesthetics for local
procedures. Lidocaine, an intermediate acting
local anaesthetic, still remains the most
commonly used agent in a dental setup, owing to
its safety and effectiveness. In a quest to discover
a more effective anaesthetic, Lidocaine has
become a pattern for comparison among newer
agents. First used in the Royal Hospital for
Women, Sydney in 1992, Ropivacaine is a new
amide long-acting local anaesthetic with chemical
similarity to Bupivacaine and Mepivacaine.
Chemically, Ropivacaine is a monohydrate of the
hydrochloride salt of 1-propyl-20,60-
pipecoloxylidide. It is less lipophilic than
bupivacaine and less liable to penetrate large
myelinated motor fibres, therefore has a selective
action on the pain transmitting Aδ and C nerves
rather than Aδ fibres alone, which are involved in
motor function. It is metabolised extensively in
the liver, predominantly by aromatic
hydroxylation, and excreted through the kidneys.
Ropivacaine has been successfully used in
surgery, gynaecology and obstetrics, but is not
currently available for dentists. Reports support
the use of Ropivacaine as a long acting local
anaesthetic in oral and maxillofacial surgical
procedures requiring surgical anaesthesia and
post-operative analgesia10
. One report also
assessed the anaesthetic efficacy of different
Ropivacaine concentrations for inferior alveolar
nerve block9.
The anaesthetic efficacy of
Ropivacaine, to our knowledge has not been
compared with that of the most commonly used
Lidocaine. Our study, thus aims at comparing the
efficacy of plain 0.75% Ropivacaine with
conventional 2% Lidocaine + 1: 80,000 conc.
Adrenaline in terms of latency, duration of
anaesthesia, pain and need for re-anaesthesia
during the surgical removal of impacted
mandibular third molars.
METHODOLOGY
A prospective randomized double-blind clinical
trial was conducted on 28 subjects over a period
of 2 months. Subjects were divided into two
groups. The first group comprised 15 patients
who received 0.75% Ropivacaine (Ropin,Neon)
while the second group of 14 patients received
2% Lidocaine with 1: 80,000 conc. Adrenaline
(Lignospan special, Septodant1:80000
adrenaline). Informed written consent was
obtained and surgical extraction of impacted
mandibular third molar was carried out by a
single operator. All injections were administered
using a self-aspirating syringe (Septodont) fitted
with a long 30-gauge needle (Septodont) for
Lidocaine and 3 ml Dora-One syringe with long
needle for Ropivacaine. Inferior Alveolar Nerve
block was given by administering 1.8 ml of
solution (1ml Inferior alveolar nerve, 0.5ml
Lingual nerve, 0.3ml Long buccal nerve) at the
rate of 1 ml/min. After injection of the anaesthetic
solution, the time of onset of anaesthesia was
recorded as the time elapsed from full needle
withdrawal until the onset of subjective signs of
anaesthesia. The duration of anaesthesia was then
recorded as the time from initial patient
perception of the anaesthetic effect to the moment
when the effect began to fade. The need to re-
anaesthetize the surgical site was also recorded.
The anaesthetic techniques used to re-anesthetize
the surgical site comprised intraligamentous and
intrapulpal approaches. Also, a Visual Analogue
Scale (VAS) was used to subjectively assess the
overall pain intensity during surgery. Data was
statistically analysed using Windows SPSS
Version 16.0. Student’s T-test was used to derive
the significance in the collected data.
RESULTS
The study comprised a total of 28 patients, of
which 11 were males and 17 were females
between the age group of 17-40 years, with a
mean age of 26.2 years. All patients who had
undergone surgical removal of impacted
mandibular third molar were evaluated
preoperatively. The study group comprised 14
subjects who received 0.75% Ropivicaine
whereas the control group consisted of 13
subjects that received 2% Lidocaine with 1:80000
epinephrine. Of the 28 subjects, only one patient
underwent surgical extraction of bilateral
Raj Kumar Tiwari et al IJMOR
2
3. impacted mandibular third molars where 0.75%
Ropivacaine was given on one side and 2%
Table No 1
Gender
LA used
Total
Ropivacaine Lignocaine
N % N % N %
Male 5 33.3 6 42.8 11 39.2
Female 10 66.6 8 57.1 17 60.7
Total 15 100.0 14 100.0 28 100.0
Table No.2
Table No.3
GroupStatistics
15 92.27 34.850 8.998
14 79.14 11.065 2.957
GROUP
0.75% ROPIVACAINE
2% LIDOCAINE
ONSETOFANESTHESIA
N Mean Std.Deviation
Std.Error
Mean
Table No.4
Group Statistics
15 302.13 24.816 6.407
14 196.43 33.936 9.070
GROUP
0.75 % ROPIVACAINE
2% LIDOCAINE
DURATION OF
ANESTHESIA
N Mean Std. Deviation
Std. Error
Mean
Table No 5
NEED FOR RE - ANESTHESIA
2 6.9 6.9 6.9
27 93.1 93.1 100.0
29 100.0 100.0
YES
NO
Total
Valid
Frequency Percent Valid Percent
Cumulative
Percent
Table No. 6
Group Statistics
15 1.27 1.387 .358
14 .00 .000 .000
GROUP
0.75 % ROPIVACAINE
2% LIDOCAINE
VAS - INTRAOPERATIVE
N Mean Std. Deviation
Std. Error
Mean
Lidocaine was administered on the contralateral
side. Thus a total of 29 interventions were
included in the study. (Table No.1 & 2) The time
of onset of anaesthesia, need for reinjection,
duration of action and VAS scores for pain
preoperatively, intraoperatively & postoperatively
were recorded and the results were tabulated in
the tables and depicted in the graphs. The mean
time for onset of anaesthesia for 0.75%
Ropivicaine was 92.27+34.85 secs and for 2%
Lidocaine was 79.14+11.065 secs, being
statistically significant (p value<0.002). (Table
No.3) The mean duration of anaesthesia was 5.03
± 0.41 hrs for 2% Lidocaine and that for 0.75%
Ropivacaine was 3.27 ± 056 hrs which was
statistically significant (p value<0.001). (Table
No.4) In 2 of the 14 patients receiving 0.75%
Ropivacaine, a second injection was required
whereas none of the patients receiving 2%
Lidocaine required re-injection. (Table No.5)
Subjective intraoperative pain scorings by the
patients showed statistical significance (p
value<0.01), with a mean VAS scores of 1.27 and
0 for 0.75% Ropivacaine and 2% Lidocaine
respectively, on a scale of 1-10. (Table No.6).
DISCUSSION
Ropivacaine is a long-acting amide local
anaesthetic with chemical similarity to
bupivacaine and mepivacaine1
. Ropivacaine
belongs to pipecoloxylidide group of local
anaesthetics2
. It is available as an
enantiomerically pure form (S-enantiomer),
contrasting to bupivacaine which is a racemic
mixture of (R)- and (S)-enantiomers1,3
. Because
of its favourable qualities such as low toxicity,
long duration of action and affinity for
nociceptive nerve fibres, Ropivacaine is being
used in various fields of surgery. Despite many
positive observations and wide use in surgical
anaesthesia and obstetrics, there are only a few
articles about the use of Ropivacaine in dentistry.
Kennedy et al. (2001) reported the first study on
the anaesthetic effect of Ropivacaine. The author
found that maxillary lateral incisor infiltration
anaesthesia for a concentration of 0.5%
Ropivacaine was only 68% effective when used
without a vasoconstrictor and 75% effective for
the same concentration when administered with
epinephrine, which was proved using an electrical
pulp tester7
. The low efficacy of Ropivacaine
encouraged Ernberg & Koop (2002) to conduct a
dose–dependent study of Ropivacaine as a local
anaesthetic in dentistry. The anaesthetic effects of
plain Ropivacaine, when used in concentrations
of 0.2%, 0.5% and 0.75% respectively, was
LA used N mean
AGE
Ropivacaine 15 27.6
Lignocaine 14 24.9
Lidocaine and Ropivacaine
IJMOR
International Journal of Medical and Oral Research July-December 2017; 2(2):1-5
3
4. investigated in a group of 30 patients using an
electrical pulp tester. The authors concluded that
the administration of Ropivacaine even in the
highest concentration did not assure satisfactory
anaesthesia4
. As a consequence, subsequent
studies were conducted, which showed a more
profound pulpal anaesthesia with 0.75%
concentration of Ropivacaine5,10
. El-Sharrawy &
Yagiela (2006) conducted a similar study
comparing four concentrations of Ropivacaine
(0.25%, 0.375%, 0.5% and 0.75%) for the
administration of Inferior Alveolar nerve block,
achieving successful anaesthesia with the use
0.5% and 0.75% concentrations6
. As per an article
published by Akerman et al, the onset of action
for Ropivacaine was found to be faster because of
its lack of binding to extraneural fat and tissues
and to its greater availability for transfer to the
nerve site. However, other studies suggest
otherwise. The dissociation constant (pKa) of
local anesthetics directly affects the latency
period. Thus, greater the pKa value, greater will
be the latency, thereby longer onset time.
Reviewing the pKa values of 0.75% Ropivacaine
and 2% Lidocaine, 0.75% Ropivacaine (pKa =
8.1) should have a greater latency than 2%
Lidocaine (pKa = 7.9)19
. In this study similar
results were obtained with the latency of
Ropivacaine being 1.16 times greater than
Lidocaine. Buric N in his paper described the
application of Ropivacaine in oral surgery. The
achieved anaesthesia in all patients enabled
analgesia in the course of the operation, and the
expected intraoperative and postoperative
bleeding, whereas postoperative analgesia lasted
long enough (up to 380 minutes) to prevent the
intake of analgesics18
. Decreased blood flow at
the site of local anaesthetic injection not only
provides a bloodless field of surgery, but also
considerably decreases the rate of absorption,
reduces the incidence of systemic toxicity and
prolongs the duration of action of anasthesia17
.
All local anaesthetics currently available for
dental use have vasodilating activity10
.
Ropivacaine has a biphasic vascular effect, which
could be useful in dentistry. At low
concentrations (0.063–0.5%), it shows
vasoconstriction per se, whereas at higher
concentrations of 1%, it produces a vasodilatory
effect8,9
. The vasoconstriction induced by the
local anaesthetic at low doses mainly depends on
the calcium influx through voltage-operated
calcium channels and lipid solubility15,16
. In this
study the duration of the anaesthetic effect of
Ropivacaine varied from 270 to 360 minutes
(mean 302.13 minutes) while for Lidocaine it
varied from 160 to 210 minutes (mean 196.43
minutes). Although performing an electric pulp
test for the objective assessment of anesthetic
efficacy is the gold standard, it could not be
adhered to in the given clinical situation for
obvious reasons. Hence the need for re-injection
was considered one of the parameters to evaluate
the efficacy of the test solution. In 2 interventions
(6.9% of cases), a second dose of anesthetic
solution had to be administered (intrapulpal /
intraligamentous) in the group that received
0.75% Ropivacaine. Postoperative pain after third
molar surgery usually reaches its maximum
intensity within 6–8 h of operation as a result of
the release of chemical mediators13
. Ropivacaine
was effective in reducing immediate
postoperative pain because of its residual
analgesic property which extends for 6 h
postoperatively, thereby reducing the need for
analgesics in the immediate postoperative period.
Thus in our study, we found that postoperative
pain was considerably reduced when 0.75%
Ropivacaine was administered. However,
Ropivacaine is said to have a selective action on
the pain-transmitting Aδ and C nerves due of its
relatively less lipophilic nature14
. This was
probably why we found lesser intraoperative pain
control with the use of 0.75% Ropivacaine (Mean
VAS score-1.27) when compared to 2%
Lidocaine (Mean VAS score-0.00) which was
statistically significant. The efficacy of the
solution in infected and inflamed tissue is still
questionable. Postoperative paraesthesia or
altered nerve sensations was not detected in any
of the patients participating in the study.
CONCLUSION
The results obtained suggest that 2% lidocaine
with adrenaline offers better clinical effect than
0.75% Ropivacaine in terms of latency in surgical
removal of impacted 3rd
molars, whereas 0.75%
Ropivacaine had a longer duration of action,
thereby reducing postoperative pain, compared to
2% lidocaine. However, a multi-centric study
with a larger sample size is essential to validate
the findings.
Raj Kumar Tiwari et al
IJMOR
4
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