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DNA replication is semi-conservative. Based on this principle if the original parent dsDNA is
radioactively labeled, what is the final ratio of labeled strands to unlabeled strands after 4 rounds
of division?
Solution
After 4 rounds of replication there will be 2^4 ds-DNA = 16 ds-strands.
Out of 16 , 14 will be labelled strands and 2 will be unlabelled strands.
So, final ratio of labeled strands to unlabeled strands after 4 rounds of division will be 14:2
Explanation :As per the semi-conservative method of DNA replication, the two original strands
of the parental ds-DNA will be present in 2 cells after 1 st generation,each having one parental
DNA strand.Accodingly after 4 generation that will come to 14 labelled ds-DNA and 2
unlabelled DNA.

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  • 1. DNA replication is semi-conservative. Based on this principle if the original parent dsDNA is radioactively labeled, what is the final ratio of labeled strands to unlabeled strands after 4 rounds of division? Solution After 4 rounds of replication there will be 2^4 ds-DNA = 16 ds-strands. Out of 16 , 14 will be labelled strands and 2 will be unlabelled strands. So, final ratio of labeled strands to unlabeled strands after 4 rounds of division will be 14:2 Explanation :As per the semi-conservative method of DNA replication, the two original strands of the parental ds-DNA will be present in 2 cells after 1 st generation,each having one parental DNA strand.Accodingly after 4 generation that will come to 14 labelled ds-DNA and 2 unlabelled DNA.