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Dissecting Heart Failure Through the 
Multiscale Approach of Systems 
Medicine 
Heart failure (HF) is a complex syndrome which can be the exit of different etiologies which 
lead to a common clinical picture. Treatment outcome is modest and new insights into 
pathophysiology are needed to improve effectively diagnosis, prognosis, and therapy. As a 
complex disease, it can really benefit from the new approach provided by molecular 
medicine where information about the cell program can deeply change the patient 
management. The comprehension of molecular mechanisms relies on new technologies 
which are able to provide data at the different levels of the cell workflow. A proper 
processing of these data is as essential as the generation of data itself, together with an 
integrative approach able to exploit observations at different scales, starting from the 
molecular levels up to an effective assessment of phenotype with cardiovascular and 
systemic parameters. In this paper, evidences concerning current understanding of HF, 
passing from one scale to another, are reported, to underline how functional genomics and 
systems biology perspective, fostered by the combination of biotechnologies and 
bioinformatic methods, may transform the concepts of diagnosis and, consequently, of 
treatment, toward the fulfillment of the invoked patient-specific medicine.

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Dissecting heart failure through the multiscale approach of systems medicine

  • 1. Dissecting Heart Failure Through the Multiscale Approach of Systems Medicine Heart failure (HF) is a complex syndrome which can be the exit of different etiologies which lead to a common clinical picture. Treatment outcome is modest and new insights into pathophysiology are needed to improve effectively diagnosis, prognosis, and therapy. As a complex disease, it can really benefit from the new approach provided by molecular medicine where information about the cell program can deeply change the patient management. The comprehension of molecular mechanisms relies on new technologies which are able to provide data at the different levels of the cell workflow. A proper processing of these data is as essential as the generation of data itself, together with an integrative approach able to exploit observations at different scales, starting from the molecular levels up to an effective assessment of phenotype with cardiovascular and systemic parameters. In this paper, evidences concerning current understanding of HF, passing from one scale to another, are reported, to underline how functional genomics and systems biology perspective, fostered by the combination of biotechnologies and bioinformatic methods, may transform the concepts of diagnosis and, consequently, of treatment, toward the fulfillment of the invoked patient-specific medicine.