As a venture company professionally researching and developing common rail service apparatus, is constantly expanding its business to the overseas market as well as to the local market, through the continuous development of brand new products and quality management. Under the highly competitive business environment in the 21st century, promised to do our best to satisfy the customers' various demands and to provide perfect system through inventive technologies.
We endeavors for study and product development to be constant by drastic investment for fast generalization of LED, and reduces the cost that is an issue largest of a LED generalization, and will supply it to customers with reasonable prices.
As a venture company professionally researching and developing common rail service apparatus, is constantly expanding its business to the overseas market as well as to the local market, through the continuous development of brand new products and quality management. Under the highly competitive business environment in the 21st century, promised to do our best to satisfy the customers' various demands and to provide perfect system through inventive technologies.
We endeavors for study and product development to be constant by drastic investment for fast generalization of LED, and reduces the cost that is an issue largest of a LED generalization, and will supply it to customers with reasonable prices.
BLAZQUEZ, María. Nuevas soluciones para la evaluación de los riesgos de los nanomateriales sectores tradicionales Proyecto LIFE SIRENA. Burjassot: INVASSAT. 04.12.2014. 44 p. 10,54 MB.
The chemical resistance and barrier of TOPAS COC make it an excellent replacement for Barex in many packaging applications, including nicotine patch sealants and more. See our data.
Passive Samplers for Vapor Intrusion Monitoring: Update of EPA’s Technical S...Chris Lutes
Lutes, C., R. Truesdale, H. Hayes, T. McAlary, H. Dawson, B. Cosky , D. Grossee, B. Schumacher and J. Zimmerman Passive Samplers for Vapor Intrusion Monitoring: Update of EPA’s Technical Support Document and Research Results, Presented at Third International Symposium on Bioremediation and Sustainable Environmental Technologies (Battelle Symposium); Miami Florida 2015
Waters analytical technologies enable laboratories to generate more information, complete analyses more rapidly and reduce overall costs throughout key steps in the agrochemical development workflow - including Synthetic Chemistry, Purification, Formulation, Trace Detection, Metabolite ID.
SETAC Rome Non-Target Screening For Chemical DiscoveryEmma Schymanski
SETAC Special Session: Solutions for emerging pollutants – Towards a holistic chemical quality status assessment in European freshwater resources
Non-target Screening for Holistic Chemical Monitoring and Compound Discovery: Open Science, Real-time and Retrospective Approaches
Emma L. Schymanski [1*], Reza Aalizadeh [2], Nikiforos Alygizakis [3], Juliane Hollender [4], Martin Krauss [5], Tobias Schulze [5], Jaroslav Slobodnik [3], Nikolaos S. Thomaidis [2] and Antony J. Williams [6]
[1] Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg
[2] National and Kapodistrian University of Athens, Department of Chemistry, Athens, Greece.
[3] Environmental Institute, Koš, Slovak Republic
[4] Eawag: Swiss Federal Institute for Aquatic Science and Technology, Dübendorf, Switzerland
[5] UFZ – Helmholtz Centre for Environmental Research, Leipzig, Germany
[6] National Centre for Computational Toxicity, US EPA, Research Triangle Park, Durham, NC, USA
*presenting author: emma.schymanski@uni.lu
Keywords: Non-target screening, Open Science, Mass Spectrometry, Monitoring
Non-target screening (NTS) with high resolution mass spectrometry (HR-MS) provides opportunities to discover chemicals, their dynamics and effects on the environment far beyond the current 45 “priority pollutants” or even “known” chemicals. Open science and the exchange of information (between for example scientists and regulatory authorities) has a critical role to play in the continuing evolution of NTS. Using a variety of case studies from Europe, this talk will highlight how open science activities such as MassBank.EU (https://massbank.eu), the NORMAN Suspect Exchange (http://www.norman-network.com/?q=node/236) and NORMAN Digital Sample Freezing Platform (http://norman-data.eu) as well as the US EPA CompTox Chemistry Dashboard (https://comptox.epa.gov/dashboard/) can support NTS. Further, it will show how initiatives such as near “real time” monitoring of the River Rhine and retrospective screening via so-called “digital freezing” platforms have opened up new potential for exploring the dynamics and distribution even of as-yet-unidentified chemicals. Collaborative European and international activities facilitate data exchange amongst analytical data scientists and enable quick, effective and reproducible provisional compound identification in digitally archived HR-MS data. This is leading to new ways of assessing and prioritizing the next generation of “emerging pollutants” in the environment, enabling a pro-active approach to environmental assessment unthinkable only a few years ago. Note: This abstract does not reflect US EPA policy.
BLAZQUEZ, María. Nuevas soluciones para la evaluación de los riesgos de los nanomateriales sectores tradicionales Proyecto LIFE SIRENA. Burjassot: INVASSAT. 04.12.2014. 44 p. 10,54 MB.
The chemical resistance and barrier of TOPAS COC make it an excellent replacement for Barex in many packaging applications, including nicotine patch sealants and more. See our data.
Passive Samplers for Vapor Intrusion Monitoring: Update of EPA’s Technical S...Chris Lutes
Lutes, C., R. Truesdale, H. Hayes, T. McAlary, H. Dawson, B. Cosky , D. Grossee, B. Schumacher and J. Zimmerman Passive Samplers for Vapor Intrusion Monitoring: Update of EPA’s Technical Support Document and Research Results, Presented at Third International Symposium on Bioremediation and Sustainable Environmental Technologies (Battelle Symposium); Miami Florida 2015
Waters analytical technologies enable laboratories to generate more information, complete analyses more rapidly and reduce overall costs throughout key steps in the agrochemical development workflow - including Synthetic Chemistry, Purification, Formulation, Trace Detection, Metabolite ID.
SETAC Rome Non-Target Screening For Chemical DiscoveryEmma Schymanski
SETAC Special Session: Solutions for emerging pollutants – Towards a holistic chemical quality status assessment in European freshwater resources
Non-target Screening for Holistic Chemical Monitoring and Compound Discovery: Open Science, Real-time and Retrospective Approaches
Emma L. Schymanski [1*], Reza Aalizadeh [2], Nikiforos Alygizakis [3], Juliane Hollender [4], Martin Krauss [5], Tobias Schulze [5], Jaroslav Slobodnik [3], Nikolaos S. Thomaidis [2] and Antony J. Williams [6]
[1] Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg
[2] National and Kapodistrian University of Athens, Department of Chemistry, Athens, Greece.
[3] Environmental Institute, Koš, Slovak Republic
[4] Eawag: Swiss Federal Institute for Aquatic Science and Technology, Dübendorf, Switzerland
[5] UFZ – Helmholtz Centre for Environmental Research, Leipzig, Germany
[6] National Centre for Computational Toxicity, US EPA, Research Triangle Park, Durham, NC, USA
*presenting author: emma.schymanski@uni.lu
Keywords: Non-target screening, Open Science, Mass Spectrometry, Monitoring
Non-target screening (NTS) with high resolution mass spectrometry (HR-MS) provides opportunities to discover chemicals, their dynamics and effects on the environment far beyond the current 45 “priority pollutants” or even “known” chemicals. Open science and the exchange of information (between for example scientists and regulatory authorities) has a critical role to play in the continuing evolution of NTS. Using a variety of case studies from Europe, this talk will highlight how open science activities such as MassBank.EU (https://massbank.eu), the NORMAN Suspect Exchange (http://www.norman-network.com/?q=node/236) and NORMAN Digital Sample Freezing Platform (http://norman-data.eu) as well as the US EPA CompTox Chemistry Dashboard (https://comptox.epa.gov/dashboard/) can support NTS. Further, it will show how initiatives such as near “real time” monitoring of the River Rhine and retrospective screening via so-called “digital freezing” platforms have opened up new potential for exploring the dynamics and distribution even of as-yet-unidentified chemicals. Collaborative European and international activities facilitate data exchange amongst analytical data scientists and enable quick, effective and reproducible provisional compound identification in digitally archived HR-MS data. This is leading to new ways of assessing and prioritizing the next generation of “emerging pollutants” in the environment, enabling a pro-active approach to environmental assessment unthinkable only a few years ago. Note: This abstract does not reflect US EPA policy.
This presentation was a plenary talk on environmental forensics delivered at the 2011 Dioxin Conference in Brussels (www.dioxin2011.org). The presentation focused on the topic of environmental forensics investigations and techniques and their application to the field of persistent organic pollutants (POPs).
The presentation of LQtest was made at Aviation Security Panel (AVSECP) of International Civil Aviation Organization (Montreal, 30 March to 3 April 2009). The Russian effective screening technology was considered as perspective to integrate into universal security system for civil aviation and was strongly supported by the Panel.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
2. Considerations for Selecting
HME Detection Tests
Are budgetary issues imposing serious limitations?
Instrument versus Field Test Kit
What is the technical knowledge of the end users?
First responders or EOD unit
How much time for training can be set aside?
What are the environmental conditions?
Rural area, limited access to power supplies etc.
Detection of bulk versus trace?
2
A.Roxana Nicolaescu MKT 16-36 WebSlides
3. Requirements for HME Field Tests
Easy to use with minimal training
Short time on target
Small in size and weight
Long shelf-life under normal environmental
conditions
Low cost
No power requirements
A.Roxana Nicolaescu MKT 16-36 WebSlides 3
4. Scenario for Use of HME Detection
Colorimetric detection products are able to identify/confirm
the presence of homemade explosive materials in the field in
the fastest and easiest way possible.
4
A.Roxana Nicolaescu MKT 16-36 WebSlides
5. Scenario for Use of HME Detection
Testing for explosive residue as part of a route clearance
and demolitions.
5
Testing for explosive
residue helps combat
engineers identify
roadside bomb makers.
A.Roxana Nicolaescu MKT 16-36 WebSlides
6. Scenario for Use of HME Detection
Stopping the supply
chain of HME’s and
precursors such as
Calcium Ammonium
Nitrate Fertilizer.
6
A.Roxana Nicolaescu MKT 16-36 WebSlides
7. Scenario for Use of HME Detection
Quick assessment of the situation possible with simple tools.
7
A.Roxana Nicolaescu MKT 16-36 WebSlides
CNN.com 2010
8. Scenario for Use of HME Detection
Quick screening of assumed HME use in post blast investigation.
8
A.Roxana Nicolaescu MKT 16-36 WebSlides
10. Colorimetric HME Field Detection Products
10
Detection or identification of the explosives
is made by observing a specific color change
when chemical reagents come in contact
with the suspect sample.
When treated by an appropriate reagent, a
color that is characteristic of the sample
compound is produced.
A.Roxana Nicolaescu MKT 16-36 WebSlides
11. Applications for
Colorimetric HME Field Detection Products
11
Detection of explosive compounds in
combat theaters
Testing of suspicious packages or objects at
Check Points
Support EOD operations
Assessing abandoned soils and facilities for
explosive compounds and residues
Confirming K-9 Alerts
Screening in post-blast explosions
A.Roxana Nicolaescu MKT 16-36 WebSlides
12. The instructions must be followed precisely,
with timed steps.
Liquid reagents have to be mixed/applied in a
specific sequence to obtain correct results.
Often, require multiple steps/samples for one
identification, e.g., Ammonium Nitrate.
Performance/shelf life is affected by prolonged
exposure to dramatic swings in temperature
and humidity.
Liquid Chemistry
Colorimetric HME Field Detection Products
A.Roxana Nicolaescu MKT 16-36 WebSlides
12
13. Liquid Chemistry
Colorimetric HME Field Detection Products
Use strong acids, concentrated bases and
flammable organic solvents encapsulated in
glass ampoules or in dropper bottles.
There is a high possibility for VIOLENT
reactions occurring upon contact with
unknown substances.
May expose the user to dangerous
chemicals, even in the absence of explosives.
Watch for disclosures: contact with skin,
disposal, etc.
Short shelf life, especially after opened.
A.Roxana Nicolaescu MKT 16-36 WebSlides 13
14. Most commercially available colorimetric kits rely on
liquid chemistry.
Liquid Chemistry
Colorimetric HME Field Detection Products
14
DropEx – Mistral Security, Inc. – Expray®
A.Roxana Nicolaescu MKT 16-36 WebSlides
Nitrates +
15. Liquid Chemistry
Colorimetric HME Field Detection Products
15
Pocket-ETK™ NC – Lindon Defense Trace X® – Morphix® Technologies
A.Roxana Nicolaescu MKT 16-36 WebSlides
In some kits liquids come in glass ampules encased in plastic
to protect user from harsh chemicals.
16. Dry Reagent Chemistry
Colorimetric HME Field Detection Products
This technology addresses many difficulties
encountered in the liquid based colorimetric
chemistry.
Chemical reagents are in dry format
Chemical reactions are contained within the
indicator pad.
Sample wetting with non-hazardous liquids
helps desensitization.
The user exposure to hazards is minimized.
Longer shelf life under harsh environmental
conditions.
Test Strip
Indicator
Pads
A.Roxana Nicolaescu MKT 16-36 WebSlides 16
17. 17
Dry Reagent Chemistry
Colorimetric HME Field Detection Products
Serim® Discern® HME Detection Kit
5189B
American Innovations
Bulk HME Precursor Test Kit
AI-HME-001
A.Roxana Nicolaescu MKT 16-36 WebSlides
18. Dry Reagent Chemistry
Colorimetric HME Field Detection Products
18
AI-HME-001 detects
Nitrates and Chlorates
with one sample
A.Roxana Nicolaescu MKT 16-36 WebSlides
Discern detects and identifies up to five
separate threats using one sample for
the bulk detection of HMEs.
19. Case Studies: Unknown Substance
19A.Roxana Nicolaescu MKT 16-36 WebSlides
White powder or prills of unknown substances is the most common scenario
encountered when entering suspected terrorist compounds.
20. Case Study #1. Fertilizer?
20A.Roxana Nicolaescu MKT 16-36 WebSlides
TEST RESULTS: Not a Fertilizer - sample contained Urea Nitrate. All colorimetric tests detected
Nitrates, but DropEx and Serim Discern tests distinguished the sample as Urea Nitrate.
21. Case Study #2. Peroxides
TATP
21A.Roxana Nicolaescu MKT 16-36 WebSlides
TEST RESULTS: Some colorimetric tests lack specificity to distinguish between oxidizers. Discern®
HME and DropEx can distinguish between Chlorates and Peroxides using a 2-step test procedure.
22. Case Study #3. Flashpowder
22A.Roxana Nicolaescu MKT 16-36 WebSlides
TEST RESULTS: Some test kits cannot be used with Flashpowder or Blackpowder, as the dark
powdered samples mask any color reaction. The Discern HME I.D. test uses a filter sampling
method that minimizes color interferences.
23. Identification of Ammonium Nitrate –
Liquid vs Dry Reagent Chemistry
23
Kit
Take sample
then:
Test Sequence Result
LIQUID
DropEx,
ETK
Sample #1:
Step 1
Break ampule or open
bottle 1, add reagent
Sample #1:
Step 2
Break ampule or open
bottle 2, add reagent
Sample #1:
Step 3
Break ampule or open
bottle 3, add reagent
Inorganic
Nitrates
Sample #2:
Step 4
Break ampule or open
bottle 4 (not available in
all kits), add reagent
Ammonium
A.Roxana Nicolaescu MKT 16-36 WebSlides
24. 24A.Roxana Nicolaescu MKT 16-36 WebSlides
Kit
Take sample
then:
Test Sequence Result
LIQUID
TraceX
Sample #1:
Steps 1
through 10
Break ampule, wet swab, take
sample, apply sample, break
reagent ampules, shake.
Inorganic
Nitrates
DRY
AI-HME -
001
Sample #1:
Step 1
Dissolve sample, insert strip
Inorganic
Nitrates
DRY
Discern
HME I.D.
Sample #1:
Step 1
Wet sample, swab and apply
to strip
Ammonium
Nitrate
Identification of Ammonium Nitrate –
Liquid vs Dry Reagent Chemistry (con’t)
25. Test results are obtained in one minute or less
Uses less steps to obtain results
Dry chemistry test strips have a shelf-life of 18
months or more under harsh conditions
No hazardous/corrosive liquids are required
Samples are desensitized with water
Advantages of Dry Reagent Chemistry
Colorimetric HME Field Detection Tests
A.Roxana Nicolaescu MKT 16-36 WebSlides 25
26. Very inexpensive
Can detect and identify threats quickly
Are easy to use and suitable for first responders
Samples can be collected for further forensic
testing
Advantages of Dry Reagent Chemistry
Colorimetric HME Field Detection Tests
A.Roxana Nicolaescu MKT 16-36 WebSlides 26
27. Limitations of Colorimetric HME Tests –
Liquid or Dry Reagent Chemistry
27
Specificity limited to groups of explosives
Low specificity for certain Oxidizers; cannot distinguish
between Peroxides such as TATP and HMTD or Chlorates and
Bromates
Color reactions can also occur with non-explosive samples.
React to Nitrites (used to preserve meat) the same as for
Nitrates (Fertilizer use)
Although detection limit varies for each product, generally
not suitable for trace detection.
For forensic evidence, sample has to be confirmed by
laboratory tests
A.Roxana Nicolaescu MKT 16-36 WebSlides
28. Discern® HME I.D. Detection Test –
EASE OF USE IN THE FIELD
28
NEW Discern App
A.Roxana Nicolaescu MKT 16-36 WebSlides
29. Discern® HME Detection Kit
The Discern® HME Detection Kit is
available from:
Serim Research
Elkhart, IN 4651 4
www.DiscernHME.com
800-542-4670
A.Roxana Nicolaescu MKT 16-36 WebSlides 29
