1. Web based simulations of the
Postprandial Glucose Response
With the Dalla Man et al
(2007) model

2. References
1.
Meal Simulation Model of the Glucose-Insulin System. C. Dalla
Man, R.A. Rizza, and C. Cobelli. IEEE Transactions on Biomedical
Engineering (2007) 54(10), 1740-1749.
2.
A System Model of Oral Glucose Absorption: Validation on Gold
Standard Data. C. Dalla Man, M. Camilleri, and C. Cobelli. IEEE
Transactions on Biomedical Engineering (2006) 53(12), 2472-2478

3. Glucose homeostasis – Dalla Man et al (2007)
Compartments involved in glucose metabolism
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blood plasma
pancreas (beta-cells)
liver
muscle and adipose tissue
gastrointestinal tract

4. Glucose homeostasis – Dalla Man et al (2007)
Core processes in glucose metabolism:
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glucose utilization
endogenous glucose production (EGP)
exogenous glucose uptake (food digestion) = oral glucose absorption
insulin synthesis and secretion
renal excretion

5. Glucose homeostasis – Dalla Man et al (2007)
BioModels database: dallaman2007_mealmodel
Following the selection of the modle in the GeneXplain platform, the model
equations can be viewed under “Overview” as Rules (scroll down)

6. Simulations
Before we start, we will make the following changes
1.
Completion time (Simulation tab) -> 360 minutes
2.
Initial condition of Qsto1 (Variables) -> 106000
3.
Value of D (Parameters) -> 106000
4.
Turn of “Show in plot” for all variables (Variables Tab) and instead tick the
entities you would like plotted – e.g. G (plasma glucose) and I (plasma insulin)

7. Simulation
Now run the simulation (in the simulation tab)

8. Reduced Beta-cell activity
beta (parameters) from 0.11 -> 0.05
Note the change of y-axis in these plots

9. Reduced peripheral insulin sensitivity
V_mX from 0.047 -> 0.02

10. The GeneXplain platform can also be used to
invetigate the underlying change of insulin
secretion and glucose uptake.

11. cbio.bmt.tue.nl/resolve