This study examines the interactions between runners and the urban physical environment of Groningen, the Netherlands and how these interactions influence runners' perception, behavior, and route choices. A mixed methods approach was used, including a survey of 157 runners, GPS tracking of routes from 35 runners, and 3 run-along interviews. The GPS data showed varied routes throughout the city and landscape, with home location and intended distance determining the scope of routes. Runners reported both positive and negative experiences, with women and those in central neighborhoods reporting less positive experiences due to feelings of insecurity and more nuisances. Running routes were determined by criteria like presence of greenery, path quality, lighting, and safety, with insufficient lighting and safety concerns limiting