PlacentaCon v2

Lucine Health Sciences, Inc. | Hormones Matter I Heal with Friends
Not your Grandmother’s
Nutrition Class
Navigating Maternal Health in the 21st Century
Chandler Marrs, PhD
Lucine Health Sciences
Hormones Matter
Heal with Friends

Who am I?
• Mom, wife, jock, researcher, writer, women’s health
advocate
• Background in maternal health and hormones
• More recently, medication adverse reactions, nutrition and
mitochondrial damage
I am you

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Lucine Health Sciences
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Hormonesmatter.com

Social Health
Social health
A place for conversations
about health and healing

Websites
o LucineHealthSciences.com I Business
o HormonesMatter.com I online journal, medication adverse
events surveys
o HealwithFriends.com I Social health
Social Media
o Facebook pages: Hormones Matter, Lucine Women
Community
o Twitter: @chanatlucine, @lucinewoman, @hormonesmatter,
@healwithfriends
o Email: chandler@lucinehealthsciences.com or
chandler@hormonesmatter.com
How to find me

Not your grandmother’s
nutrition class

Not even your mother’s nutrition
class

Through the wisdom of previous
generations we have…

Environmental Toxicants
o 2000 environmental
chemicals (EPA 2004)
o In food, air, every
product on the market
o Up to 99% adults
tested have chemicals
in blood, urine, serum
o Placenta, breast
milk, cord blood
o Infants and
children
Certain polychlorinated biphenyls, organochlorine
pesticides, PFCs, phenols, PBDEs, phthalates, polycyclic
aromatic hydrocarbons, and perchlorate were detected
in 99–100% of pregnant women. The median number of
detected chemicals by chemical class ranged from 4 of
12 PFCs to 9 of 13 phthalates. Across chemical classes,
median number ranged from 8 of 17 chemical analytes
to 50 of 71 chemical analytes (NHANES 2003-2004).
BPA and tOP were detected in 92.6% and 57.4% of the
persons, respectively...Females had statistically higher
BPA LSGM concentrations than males (p = 0.043).
Children had higher concentrations than adolescents (p <
0.001), who in turn had higher concentrations than
adults (p = 0.003). LSGM concentrations were lowest for
participants in the high household income category (>
$45,000/year).

Endocrine Disruptors
Endocrine disruptors are
synthetic chemicals that when
absorbed into the body either
mimic or block hormones and
disrupt the body's normal
functions.
Most of the endocrine disruptors
on the market are estrogenic or
anti-androgenic.
For generations to come

Nutrient Stripped Food
o Highly processed food-like
products
o Sugar, carbs, fats and chemicals
o Genetically culled produce
o 70% reduced nutrient content
o With no genetic variation ( 96%)
o Glyphosate, toxic adjuvants and
more
o 8 of the 9 formulations tested were
1000X more toxic than their active
principles
o Chemically laden meats
o Heavy antibiotics, antibiotic resistant
bacteria, growth and other
hormones

Even what appears healthy
May not be

Through the wisdom of previous
generations
We are dying
younger

Living Sick and Dying Young

Medication nation
Mayo Clinic Reports
o 70% adults take prescription
medications chronically
o 50% take 2 or more meds
o 20% take 5 or more meds
“Before the SSRIs, drugs were poisons that came
with risks. Now they are fertilizers to be used as
widely as possible, being given in ever larger
amounts to children and the elderly - the only risks
the authorities can see it would seem stem from not
using enough of them.” David Healy

During Pregnancy
o 80% of women take at least one
medication during pregnancy
o ~30% take 4 or more medications
during pregnancy
60% increase in medication use
during pregnancy in 30 years

A long, inglorious history
Diethylstilbestrol (DES) – to prevent
miscarriage
At least 3 generations affected, sons, daughters and
grandchildren
Thalidomide -prescribed for morning
sickness

Of medicating women

More recently
And yes, Flu vaccines still contain thimerosal (Johns Hopkins Inst. Vaccine Safety)

We are drowning in a sea of
toxins

Medications & Toxicants
Transgenerational Effects

Infants and toddlers
Psychotropics prescribed in
the US
o 274,000 infants (0-1 year olds)
o 370,000 toddlers (1-3 year olds)
“Prescriptions of powerful
antipsychotics such as
Risperdal for infants and very
young children have also
sharply risen. Office visits for
childhood bipolar disorder
have risen 40-fold over the
past decade in the U.S.”

We wonder why
o 1-68 children develop autism
o Kids are largest growing market for
psychotropics
o 14% teens
o 4-12% polypharmacy
o 7X increase in antipsychotics ages 0-13
years, from 1998-2009
o 1 in 6 children are obese
o 70% to 80% have NAFLD
o ~30% increase in pediatric type 2
diabetes 2001-2009

We have a perfect storm
Of over-medication,
environmental hazards
and dietary deficiencies.

We all want to be healthy
Or at least that’s what we tell ourselves
What is health?

Is it about weight?
Who is healthier?

Or BMI
Maybe not

Or diet?

Is it enough?
Sure, avoiding junk food matters

Especially when it is no longer
food
“Everything nature can do, man can
do so much better and more
profitably.”
o ‘Natural’ cheese that matures in 72
hours.
o Preservatives prevent produce
browning
And if we can’t, then re-define
o ‘Clean labeling’ removes the most
glaring industrial ingredients and
replaces them with substitutes that
sound natural and benign.
“For the salesman, this preparation was
a technical triumph, a boon to caterers
who would otherwise waste unsold
food. There was a further benefit:
NatureSeal is classed as a processing aid,
not an ingredient, so there’s no need to
declare it on the label, no obligation to
tell consumers that their “fresh” fruit
salad is weeks old.”

Or when healthy food
Is doused in chemicals and stripped
of nutrients
• Over last 100 years
(1999)
• Top soil mineral
content depleted by
>70%
• Fruit and vegetable
vitamin and mineral
content diminished
~40%

What is health?

What Medication Adverse
Reactions Tell Us about
Nutrition
A ticking time bomb

It’s all about the
biochemistry

Medications & Vaccines
o Modify biochemistry in some manner or
another
o Each med has a specific
o Job to do
o Set of side-effects based on its particular mechanism of
action
o We believe there is no overlap
o But that is not true

Meds I study
o Fluoroquinolone antibiotics
o (Cipro, Levaquin, Avelox, etc.)
o Lupron
o Oral Contraceptives
o HPV Vaccine
o (Gardasil, Cervarix)

Primary Side Effects
o Fluoroquinolones
o Tendon rupture, neuropathy, psychosis, CNS disturbances
o Lupron
o Osteoporosis, psychosis, gallbladder disease, and more
o Oral Contraceptives
o Blood clots, stroke, heart attack, weight gain, depression/anxiety
o HPV Vaccine
o Death, vasculitis, CNS disturbances, autoimmune diseases and more

Digging deeper
o Patterns emerge
o Thyroid disease
o Central nervous system effects
o Neuromuscular
o Autoimmune
o Psychosis
o And many more

How can different drugs share
similar side effects?
Convergence point
Deplete nutrients and/or exacerbate existing
nutrient deficiencies.

At the most basic level
o Consume O2 to
produce energy from
nutrients
o Mitochondria take
electrons from food to
produce ATP
o ATP = cellular
energy/cell survival
o ROS is a by-product of
energy production
o Too much or too little
ROS impaired function
o Food supplies
mitochondria vitamins,
minerals necessary to
produce cellular
energy
o Without nutrients
functional
mitochondrial deficits
and cell death
Mitochondria produce ATP.
ATP is the universal
energy currency of
life.

Mitochondria: Cellular
Powerhouses
oControl dozens of cell processes
o Energetics, steroidogenesis, cell death, CA2+ management
oBidirectional hormone regulation
o Highly susceptible to endocrine disruptors
oInteract significantly with nDNA
o 90% of factors required for mitochondrial function encoded by nDNA
o Bidirectional cross talk critical for cell homeostasis
o Lack protective histones – susceptible to epigenetic alterations
o Oxidative damage 10X higher than nDNA
oSit at the center of host immune function
o Sensing and sending danger signals via multiple mechanisms

Mitochondria are important
o Energy
o Mitochondria feed the cells
o W/o healthy mitochondria, cells die
o When cells die, tissues die, organs die, we die (sometimes
slowly and painfully, sometimes quickly)
o Control hormones
o Regulate inflammatory pathways
o Nexus of health and illness
Damage at your own risk.

Mitochondria are the drivers of
health or disease
“…mitochondria are located at
the hub of the wheel of
metabolism and play a central
role in non-infectious cellular
stress, innate immunity,
inflammasome activation, and
the stereotyped antiviral
response, we searched for a
signaling system that was both
traceable to mitochondria and
critical for innate immunity.”
Robert Naviaux, UCSD

Technical stuff
o Inherited maternally
o 37 genes that code for 13 proteins, 22 RNAs, 2 rRNAs
o Interact significantly with nDNA
o 90% of factors required for mitochondrial function encoded by nDNA
o Silenced or activated genes in mom and dad can evoke mitochondrial
damage and mutations
o Interact significantly with extracellular (host)
environment
o Sense and send danger signals
o Medical and environmental exposures matter

Mitochondrial DNA comes from
Mom
o Mom’s nutrient status
matters and determines
o Pregnancy/postpartum
health
o Fetal/infant/child (and
grandchildren’s health)

Dad’s health matters too!
o mDNA passed from mom-child,
but mitochondria rely on
nuclear DNA to function
(~90%)
o If Dad is unhealthy and
nutrient deficient,
dysfunctional mitochondria
are possible in the
offspring, even if mom is
healthy
Dad’s health matters

Mitochondria Need Vitamins &
Minerals
o >20 vitamins and minerals to process ATP
o Those nutrients come from food
o Without nutrients, ATP declines and
cascade ill health begins
o Most of us don’t get the appropriate
nutrients
o Devastating for maternal/fetal health

Maternal Nutrient Deficiency
Oxidative stress caused by free radicals has been implicated in
many studies of the etiology of preeclampsia (38). Because
ascorbic acid and vitamin E inhibit free radical formation, a
double-blind randomized trial was conducted in 283 women
who had either a previous history of pregnancy complications or
an abnormal ultrasound (39). The supplement provided 1000
mg ascorbic acid and 400 IU vitamin E daily from week 16–22
of pregnancy, and resulted in a 76% reduction in preeclampsia,
and a 21% reduction in indicators of endothelial activation
and placental dysfunction.
Evidence from experimental animals supports the concept that in addition to primary
deficiencies, secondary embryonic and fetal nutritional deficiencies can be caused by diverse
factors including genetics, maternal disease, toxicant insults and physiological stressors that
can trigger a maternal acute phase response. These secondary responses may be significant
contributors to the occurrence of birth defects. An implication of the above is that the
frequency and severity of pregnancy complications may be reduced through an
improvement in the micronutrient status of the mother.
Micronutrient status in fetal and early life may alter
metabolism, vasculature, and organ growth and
function, leading to increased risk of cardiometabolic
disorders, adiposity, altered kidney function, and,
ultimately, to type 2 diabetes and cardiovascular
diseases.

Poor nutrition, high toxic load
Foundation from
which most parents-
to-be approach
reproduction
With the cascade of ill-
health already in progress.

Environmentally induced
mitochondrial dysfunction
mtDNA
damage
Functional
deficits
mtDNA
mutations
Altered ETC
Decreased
ATP
Mito damage
Increased
ROS
Oxidative
stress
Toxic Exposures
Medications, Vaccines, Environmental
Direct
 Induce mitochondrial
membrane permeability
changes
 Alter channel open times
 Activate death pathways
Indirect
 Block critical nutrient co-
factors for ATP
 Alters hormone activity
(endocrine disruptors)
 Activate/deactivate critical
transcription and repair
proteins (epigenetics)
Cell death & disease

Mitochondria are targets
Sensors of cell danger

How prevalent is mito disease?
“Disorders of the mitochondrial respiratory chain affect at least 1 in 8000 of the population,
making them among the most common genetically determined diseases.”
Patrick Chinnery, Medical School, Newcastle upon Tyne.
Prevalence is likely underestimated because
functional mitochondrial damage is often
overlooked and most mitochondrial
deficits, especially those emerging later in
life, remain undiagnosed.
Not widely recognized
1 in 500

What mitochondrial dysfunction
does
“These are partial defects. Mitochondrial dysfunction doesn’t really cause anything, what it does
is predisposes towards seemingly everything. It’s one of many risk factors in multifactorial
disease. It can predispose towards epilepsy, chronic fatigue, and even autism, but it doesn’t do it
alone. It does it in combination with other factors, which is why in a family with a single
mutation going through the family, everyone in the family is affected in a different way. Because
it predisposes for disease throughout the entire system.”
Dr. Richard Boles, Director of the Metabolic and Mitochondrial Disorders Clinic at Children’s
Hospital Los Angeles

First signs of mitochondrial
distress
As Hans Selye observed many decades ago, one of the first,
and most consistent of the sickness behaviors, no matter the
disease, is lethargy, fatigue and sleepiness.
Excessive sleeping,
fatigue, anorexia

What does it look like?
oManifests broadly and variably
o Fatigue, hypersomnia
o Migraines, seizures
o Muscle weakness, neuropathies
o Hair loss
o Cognitive & psychiatric symptoms
o Gait, balance and tremors
o GI disturbances
o Food intolerances
o Gastroparesis, dysmotility, cyclic vomiting,
anorexia
o Autonomic dysregulation
o Temperature
o Cardiovascular – Cardiometabolic
o Salt/potassium balance
o Thyroid damage
o Likely other endocrine disruptions

Mitochondrial dysfunction

Cascade of ill health

All comes back to
nutrients

NAVIGATING
MATERNAL HEALTH

Avoid the toxins
Clean up the diet
Feed the deficiencies

Counterbalance

Nutrients are key

Exercise helps too!

Feed your body what it
needs to survive and thrive

Whole food
• Eat only or mostly
• Organic, non-GMO
• Embrace variety, dark richly colored fruits and vegetables
• Minimize or eliminate processed food
• Avoid sugar, corn syrup, additives, artificial colors
• Gluten, breads and pastas, if necessary
• Avoid ‘gluten-free’ marketed foods

Supplement Deficiencies
• We’re all deficient in something
• Medications leach nutrients
• Agro chemicals leach nutrients
• Exercise uses nutrients
• Begin with the basics and work from there
• Mitochondria need
• B vitamins, magnesium, coQ10, L-carnitine, fatty acids,
cholesterol, vitamin C, lipoic acid, glutathione and more
• Everyone needs vitamin D

You did then what you
knew how to do,
And when you knew better,
You did better.
Maya Angelou

PlacentaCon v2

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