DCD-working-slide MC2018

•

0 likes•413 views

2018年のMC研究会で発表（梅沢侑実さん筆頭）したASD者の発達性協調運動障害（BOT-2アセスメントで評価）と脳の運動野・補足運動野のGABA濃度との関連についての、進行中のデータ（現在は参加者を増やし、基本的な結果は維持しながらもやや結果は[より頑強な方向で]変化）。This slide is a working data presented at The Japanese Society for Motor Control 2018 regarding our study investigating motor disabilities of ASD and GABA concentration in the motor related brain regions.

Science

研究仮説
一次運動野のGABA増加と
自閉スペクトラム症者の粗大運動障害との関連
梅沢侑実1，松島佳苗2，渥美剛史1，加藤寿宏2，深津玲子1，和田真1，井手正和1
1. 国立障害者リハビリテーションセンター研究所脳機能系障害研究部 2.京都大学大学院医学研究科人間健康科学系専攻
自閉症者の脳の
GABAの過剰・過少
自閉症者の8割が
運動に困難をもつ
（仮説2）運動野でGABA増
（Green et al., Developmental Medicine & Child Neurology, 2009）
（Gaetz et al., NeuroImage, 2014）
神経活動の過度な抑制により，
大きな筋収縮が困難になる
脳の運動領域のGABA変容が、運動障害を引き起こす？
抑制系の神経伝達物質
 運動障害のアセスメント
微細運動粗大運動
（仮説１）運動野でGABA減
側抑制機能が阻害され、
細かな筋制御が困難になる
微細運動の障害？
粗大運動の障害？
 研究背景
④筋力と機敏性
①正確な運動制御 ②手先の協調
③全身の協調
(色塗り, はさみ…) (コイン運び, ボール投げ…)
(バランス歩行,片足立ち…) (片足立ちジャンプ, 腹筋…)
 総合スコアと4つの下位尺度のスコアを算出
特に、粗大運動（③全身の協調・④筋力と機敏性）で
自閉症者のスコアの低下が顕著にみられた（p<0.01）

一次運動野のGABA増加が自閉症者の粗大運動障害と関連する（仮説2を支持）
 MRSectroscopyによるGABA計測
 運動障害の程度とＧＡＢＡ濃度の関連
④筋力と機敏性③全身の協調
GABA/Cr GABA/Cr
r = - 0.44
p = 0.069
r = - 0.59
p = 0.011
r = - 0.53
p = 0.023
総合スコアとGABAの関連
M1
SMA
SMA+PMCM1+S1
下位尺度とM1GABAとの関係
M1+S1 SMA+PMC
(M1)
(SMA)
SMA+PMCM1+S1
得られたスペクトルから
GABA/Crを算出
GABA平均値は
ASD・TDで
違いがなかった
MEGA-PRESSシーケンス
で計測
※Gannet2.0を利用
GABA/Cr
ASD TD
n.s.
ASD TD
n.s.
r = 0.22
p = 0.38
GABA/Cr GABA/Cr

Featured

How to Prepare For a Successful Job Search for 2024

Albert Qian

A report by thenetworkone and Kurio. The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).

Social Media Marketing Trends 2024 // The Global Indie Insights

Kurio // The Social Media Age(ncy)

The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands. It’s important that you’re ready to implement new strategies in 2024. Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024. You’ll learn: - The latest trends in AI and automation, and what this means for an evolving paid search ecosystem. - New developments in privacy and data regulation. - Emerging ad formats that are expected to make an impact next year. Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape. If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.

Trends In Paid Search: Navigating The Digital Landscape In 2024

Search Engine Journal

From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world. With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively. The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage. Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience. See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers See the original article on Forbes here: http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b

5 Public speaking tips from TED - Visualized summary

SpeakerHub

Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world. Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance. For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age. Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.

ChatGPT and the Future of Work - Clark Boyd

Clark Boyd

Getting into the tech field. what next

Tessa Mero

Google's Just Not That Into You: Understanding Core Updates & Search Intent

Lily Ray

How to have difficult conversations

Rajiv Jayarajah, MAppComm, ACC

Introduction to Data Science

Christy Abraham Joy

Time Management & Productivity - Best Practices

Vit Horky

The six step guide to practical project management If you think managing projects is too difficult, think again. We’ve stripped back project management processes to the basics – to make it quicker and easier, without sacrificing the vital ingredients for success. “If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.” Dr Andrew Makar, Tactical Project Management

The six step guide to practical project management

MindGenius

Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...

RachelPearson36

During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59 Key takeaways: • Learn how to use ChatGPT to add AI power to your testing and test automation • Understand the limitations of the technology and where human expertise is crucial • Gain insight into different AI-based tools • Adopt AI-based tools to stay relevant and optimize work for developers and testers * ChatGPT and OpenAI belong to OpenAI, L.L.C.

Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...

Applitools

12 Ways to Increase Your Influence at Work

GetSmarter

ChatGPT webinar slides

Alireza Esmikhani

More than Just Lines on a Map: Best Practices for U.S Bike Routes

Project for Public Spaces & National Center for Biking and Walking

Has your project been caught in a storm of deadlines, clashing requirements, and the need to change course halfway through? If yes, then check out how the administration team navigated through all of this, relocating 160 people from 3 countries and opening 2 offices during the most turbulent time in the last 20 years. Belka Games’ Chief Administrative Officer, Katerina Rudko, will share universal approaches and life hacks that can help your project survive unstable periods when there seem to be too many tasks and a lack of time and people.

Ride the Storm: Navigating Through Unstable Periods / Katerina Rudko (Belka G...

DevGAMM Conference

Barbie - Brand Strategy Presentation

Erica Santiago

According to the latest State of the American Manager report from Gallup, employees who have regular meetings with their managers are almost three times as likely to be engaged as those who don’t. These regular check-ins keep managers and employees in sync and aligned. Want to see better manager/employee relationships in your organisation? Then make an all-in commitment to 1:1 meetings. Not sure how? You’ve come to the right place. In this webinar with Jamie Resker, Founder and Practice Leader for Employee Performance Solutions (EPS), and Teala Wilson, Talent Management Consultant at Saba Software, you’ll get the inside track on how to hold effective 1:1 meetings, including tips for getting managers on board. • Go beyond discussing the status of everyday work to higher level topics, including recognition, performance, development, and career aspirations • Learn how to decide meeting frequency, what to cover, as well as roles and responsibilities of the manager and employee • Understand how managers can build trust and make it comfortable for employees to provide upward feedback • Unite your organisation with a unified approach to 1:1 meetings Join us for this 1-hour webinar to get practical tips for building better manager-employee relationships with intention and purpose. About the Speakers Jamie Resker - Founder and Practice Leader for Employee Performance Solutions (EPS) Jamie Resker, Practice Leader and Founder of Employee Performance Solutions, is a recognized innovator in performance management. She is the originator of the-the Performance Continuum Feedback Method® and Conversations to Optimize Employee Performance training program; tools and training that reshape communications between managers and employees to drive and align performance. Jamie is on the faculty for the Northeast Human Resources Association, is a contributor to Halogen Software's Talent Space Blog, and is an editorial advisory board member for HR Examiner. Teala Wilson - Senior Consultant, Strategic Services, Saba Software Teala is a Talent Management Consultant at Halogen Software, now a part of Saba Software. She has worked with teams on a national and global level supporting human resources in areas such as performance management, recruitment, employee benefit programs, training and talent development, workforce planning and internal communications. Teala also has a personal passion for visual arts and design. Want to learn more? Join us for an upcoming Product Tour! http://bit.ly/2yitfqu

Good Stuff Happens in 1:1 Meetings: Why you need them and how to do them well

Saba Software

This video by Simplilearn will explain to you Introduction to C Programming Language. Introduction to C Programming Language Tutorial For Beginners will explain to you the C language's history, C's importance, its features, real-world applications, and some of its advantages and disadvantages. 00:00 Introduction to C 1:42-History of C language Dennis Ritchie, a computer scientist, could identify the gaps and tap out the best features from both B and BCPL languages to invent a new hybrid. Hence, C was born in 1972 at Bell Laboratories. A remarkably simple and highly readable programming language resulted in groundbreaking advancements in the IT industry. 2:48-Importance and unraveling the powerful capabilities of C, The widespread use of C started to take over the IT industry. Unraveling the potential of C, the designers began to discover new possibilities that led them to focus on the big picture. 3:56-C's cutting-edge features The designers at Bell Laboratories ensured that their programming language solved the issues with B and BCPL and the ones they had foreseen. 6:35-The popular real-world applications of C -UNIX operating system -google file system -Mozilla -Graphical user interface 8:30-The advantages and disadvantages of C 10:34-The popular IT companies and their domains that employ C · MasterCard · IBM · Flipkart · Dell · Twitter · GitHub and twitch 11:09-First c program. 🔥 Explore our FREE courses with completion certificates: https://www.simplilearn.com/skillup-f... ✅Subscribe to our Channel to learn more about the top Technologies: https://bit.ly/2VT4WtH ⏩ Check out the C++ Programming training videos: https://www.youtube.com/playlist?list... #IntroductiontoCProgrammingLanguage #CLanguage #CProgramming #CProgram #CProgrammingLanguage #LearnCProgramming #HowToCodeInCForBeginners #CTutorialForBeginners #LearnCProgramming #Simplilearn Dennis Ritchie, a computer scientist, was able to identify the gaps and tap out the best features from both B and BCPL languages to invent a new hybrid. Hence, C was born in 1972 at Bell Laboratories. A remarkably simple and highly readable programming language resulted in groundbreaking advancements in the IT industry. ✅What is C++ Programming? C++ is an enhanced and extended version of C programming language, developed by Bjarne Stroustrup in 1979 as part of his Ph.D. project. Bjarne developed what he called ‘C with Classes’ (later renamed C++) because he felt limited by the existing programming languages that were not ideal for large scale projects. He used C to build what he wanted because C was already a general-purpose language that was efficient and fast in its operations. ✅C++ Career Prospects: With just C++ programming expertise, you will have excellent job opportunities, salaries, and career prospects. However, for a career based on programming languages such as Java and Python (which are in more demand than C++) or for careers based on front-end, back-end, and full-stack

Introduction to C Programming Language

Simplilearn

Featured (20)