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Investigating
the local dependencies
of network data,
the Bayesian way
Alberto Caimo 

acaimo.github.io
New Relic

October 3, 2018
Network graph
Network data
Network graph Adjacency matrix
Network data
Whole-brain network
Modelling brain networks
Identify how local network
structures are evolving across
the lifespan, and how
sensitive these are to
random / targeted lesions
Whole-brain network Research objective
Modelling brain networks
Identify how local network
structures are evolving across
the lifespan, and how
sensitive these are to
random / targeted lesions
Whole-brain network Research objective
Statistical network
analysis
Modelling brain networks
Graph changes across lifespan
ng percentages of nodes with the highest betweenness centrality.
uated the consequences of random-node and hub-node damage
ocal structure parameters (e.g. edges, GWESP, GWNSP, and hemi-
nodematch). The effect of simulated damage between percentages
ated nodes was quantified with 95% credibility intervals obtained
difference between the posterior distributions.
3. Results
3.1. Network matrices and model parameters
We generated group-based networks for each age category
are depicted in Fig. 3 as network graph representations (for
Age 20-34 Age 20-34 vs Age 35-50
lost connections
new connections
Probabilistic: describe the probability of 

the network structure
Generative: try to explain how the network 

structure might have been generated
Assumption: links formation depend on 

the relative presence / absence of some
local network structures
Exponential random graphs
Density
Multiple
Closure
Multiple
Connectivity
ERGMWhole-brain network
Exponential random graphs
Density
Multiple
Closure
Multiple
Connectivity
ERGM
… the Bayesian way…
Sparsity
Transitivity
Prior
—
—
—
+
Density
Multiple
Closure
Multiple
Connectivity
ERGM
… the Bayesian way…
Sparsity
Transitivity
Prior
Posterior
—
—
—
+
Density
Multiple
Closure
ERGM
… the Bayesian way…
Multiple
Connectivity
Sparsity
Transitivity
Prior
Posterior
computationally
doubly-intractable!
—
—
—
+
Simulation-based
computation
Density
Multiple
Closure
ERGM
… the Bayesian way…
Multiple
Connectivity
The Bergm package for
On CRAN: CRAN.R-project.org/package=Bergm

Website: acaimo.github.io/Bergm
Bayesian
Analysis
Exponential
Random
Graph
Models
Missing Data
Imputation
Parameter
InferenceBergm
Model
Selection
Model
Assessment
Results
Fig. 5. Network parameters across lifespan. Edges, GWESP, GWNSP, and hemispheric nodematch for age categories 20–34, 35–50, 51–70, and N70 years of age.
86 M.R.T. Sinke et al. / NeuroImage 135 (2016) 79–91
Density Multiple Closure
Multiple Connectivity Hemispheric Density
Age groups Age groups
Structural
networks remain
stable across the
lifespan
Results
organization (Bullmore and Sporns,
dematch values indicate a tendency
(Dennis et al., 2013; Gong et al., 2009; Hagmann et al., 201
Montembeault et al., 2012; Otte et al., 2015; Wu et al., 2012; Z
Density Multiple Closure
Multiple Connectivity Hemispheric Density
Age groups Age groups
Hub-node
damage has
stronger effects
in people above
70 years of age
BERGM: many applications!
Knowledge transfer in
organisations
Foreign direct investment 

flow dynamics
Sustainable energy 

district planning
More info:
acaimo.github.io

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