B-Trees and B+ Trees are data structures used to store large amounts of data on disks when it cannot all fit in main memory. They allow for efficient multilevel indexing and reduce disk access times compared to other balanced trees like AVL trees by keeping the tree height low. B-Trees have multiple keys in each node and store data pointers in internal and leaf nodes, while B+ Trees only store data pointers in leaf nodes. B+ Trees provide faster searches and easier insertion/deletion compared to B-Trees. Both are commonly used in database systems and file systems to efficiently organize and retrieve large blocks of indexed data from secondary storage.