CV_OConnor_Jan2017

Curriculum vitae, Peter B. O'Connor (PBO)
http://www2.warwick.ac.uk/fac/sci/chemistry/research/oconnor/oconnorgroup/
Education:
University of North Texas, Denton, TX, USA B.S. 1991 Chemistry
Cornell University, Ithaca, NY, USA M.S. 1993 Analytical Chemistry
Cornell University, Ithaca, NY, USA Ph.D. 1995 Mass Spectrometry
FOM Inst. for Atomic & Molecular Physics Postdoc 1997 Mass Spectrometry
Professional Experience:
1997 - 1999 Staff Scientist, IonSpec Corporation, Irvine, CA
08/99 - 02/01 Sr. Research Associate, Boston University School of Medicine
02/01 - 07/06 Assistant Professor, Boston University School of Medicine
07/06 – 11/08 Associate Professor, Boston University School of Medicine
11/08 – 12/08 Professor, Boston University School of Medicine
02/01 - 12/08 Assistant Director, BUSM Mass Spectrometry Resource
09/02 - 12/08 CryoFTMS Project Director, BUSM Cardiovascular Proteomics Center
01/09 – now Professor, University of Warwick, Department of Chemistry
Research interests:
PBO develops advanced mass spectrometry instrumentation and methods that can be used to more fully
characterise biomedical samples, and collaborating with biomedical researchers to form a solid understanding
of the molecular basis of various biological activities, including diseases. As such, most of his research
involves improving mass spectrometry instrumentation capabilities in terms of resolution, accuracy, sensitivity,
etc for analysis of protein sequence and modifications.
Prior publicly funded research grants:
EPSRC CASE award ‘Using advanced mass spectrometry methods to characterise block copolymers’, with
Aztra-Zeneca, £100k.
Warwick Impact Fund, ‘Building a prototype 2DMS in a linear ion trap’, £50k
Warwick Impact Fund, ‘Proof of concept: 2DMS in a linear ion trap’, £30k
EPSRC N033191, ‘Nanoscale metallomics and mineralization: advanced spectro-microscopy determination of
the role of iron and calcium in Alzheimer's disease’, £514k (with J. Collingwood)
EPSRC N021630, ‘Preliminary design study for a benchtop, cryogen-free FTICR mass spectrometer’ £130k
EPSRC J000302, 2012-2015 ‘Is a NOESY-like 2 dimensional experiment possible in mass spectrometry?’
£525k
NIH 2008-2012, ‘Defining the Isoaspartome’ $1.2M
NIH 2002-206 ‘Cardiovascular Proteomics Center’ $12M (with C. Costello)
NIH 2008-2013 ‘BUSM Mass Spectrometry Resource’ $8.5M (with C. Costello)
NIH 2003-2008 ‘BUSM Mass Spectrometry Resource ‘$8M (with C. Costello)
NIH 1998-2003 ‘BUSM Mass Spectrometry Resource ‘$7.5M (with C. Costello)
Committees and service:
Elected to the BMSS Executive committee (paper secretary – in charge of the scientific programme of the
annual meeting 2015-2017). Warwick Chemistry Department final year exam board secretary. Editorial board
for the Journal of the American Society for Mass Spectrometry (2007-present), Reviews about 50-100
manuscripts/year for JASMS, AC, IJMS, JMS, JACS, RCMS, etc. NIH Instrument and Systems Development
study section (2003-2009), NIH shared instrument grant study section member 2002, 2004, 2006 (chair), 2004-
2007 ASMS Sanibel Committee member. PhD thesis committee member for 16 students and external
examiner on 7 PhD theses to date. Boston University Physics Department Scientific Instrument Facility
advisory committee member (2003-2007). Warwick final year exam board (2009-present)
Supervision: 16 PhD students have obtained PhD awards and 14 PDRAs have been trained. Current group
is 7 PhD students, two PDRAs, one research scientist, 3 MSc students, and 1 undergraduate summer student.
Patents
1. O'Connor, P. B. Apparatus and Method for Ion Cyclotron Resonance Mass Spectrometry USA 2003
10/338423
2. Mathur, R; O'Connor, P. B. Low-Noise Wideband Preamplifier for Fourier Transform Mass Spectrometry
USA WO2008US54815 20080223
3. Peter B. O'Connor, C. A. W., Haytham Hussein, Manying Wong Ionising Molecules and Electrospray
Ionisation Apparatus UK Patent Pending GB1605613.7. 1 April, 2016.

4. Maria van Agthoven, P. B. O. C. 2 Dimensional Mass Spectrometry in a Linear Ion Trap UK Patent Pending
GB1615469. September, 2016.
Publications (>138 publications, >5k citations, h-index = 38)
https://scholar.google.co.uk/citations?hl=en&user=oVnU6OsAAAAJ
138. Maria A. van Agthoven, P. B. O. C., Two-Dimensional Mass Spectrometry in a Linear Ion Trap: an In
Silico Model. Rapid Comm Mass Spectrom 2017, submitted.
137. Alessandro Del Grosso, L.-D. G., Cookson K. C. Chiu, Guy C. Clarkson, Peter B. O'Connor, Martin Wills,
A Class of Strained Alkyne Derived from 2,2'-Dihydroxy-1,1'Biaryls; Synthesis and Copper-Free Cycloaddition
with Azides. J Am Chem Soc 2017, submitted.
136. Wootton, C. A.; Lam, Y. P. Y.; Willetts, M.; Agthoven, M. A. v.; Barrow, M. P.; Sadler, P. J.; O'Connor, P.
B., Automatic Assignment of Metal-containing Peptides in Proteomic LC-MS and MS/MS Datasets. Analyst
2016, submitted.
135. Floris, F.; Agthoven, M. A. v.; Chiron, L.; Soulby, A.; Wootton, C. A.; Barrow, M. P.; Delsuc, M.-A.;
Rolando, C.; O'Connor, P. B., 2-Dimensional IRMPD/FTICR MS of Calmodulin: A Top-Down and Bottom-Up
Approach. J Am Soc Mass Spectrom 2016, 27 (9), 1531-1538.
134. Wei, J.; O'Connor, P. B., Extensive fragmentation of pheophytin-a by infrared multiphoton dissociation
tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29 (24), 2411-2418.
133. Wei, J., et al.,Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State
NMR and Ultra-High Resolution FTICR-MS. Biochemistry 2016, 55, 2065.
132. Simon, H. J., et al.,Uncoiling collagen: a multidimensional mass spectrometry study. Analyst 2016, 141,
157.
131. Agthoven, M. A. v., et al.,Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with
Cytochrome c. Anal Chem 2016, 88, 4409.
130. Wootton, C. A.; Sanchez-Cano, C.; Liu, H.-K.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B. Binding of an
organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based
dissociations in high resolution Top-Down FT-ICR mass spectrometry Dalton Transactions 2015, 44, 3624-
3632.
129. Wei, J.; Bristow, A. W. T.; O'Connor, P. B. The Competitive Influence of Li+, Na+, K+, Ag+, and H+ on the
Fragmentation of a PEGylated Polymeric Excipient J Am Soc Mass Spectrom 2015, 26, 166-173.
128. Soulby, A. J.; Heal, J. W.; Barrow, M. P.; Roemer, R. A.; O'Connor, P. B. Does deamidation cause protein
unfolding? A top-down tandem mass spectrometry study Protein Science 2015, 24, 850-860.
127. Simon, H. J.; Agthoven, M. A. v.; Lam, P. Y.; Floris, F.; Chiron, L.; Coutouly, M.-A.; Delsuc, M.-A.;
Rolando, C.; Barrow, M. P.; O'Connor, P. B., Uncoiling Collagen: A Multidimensional Mass Spectrometry
Study. Analyst 2015, 141 (1), 157-165.
126. Floris, F.; Agthoven, M. A. v.; Chiron, L.; Soulby, A.; Wootton, C. A.; Barrow, M. P.; Delsuc, M.-A.;
Rolando, C.; O'Connor, P. B. 2-Dimensional IRMPD/FTICR MS of Calmodulin: A Top-Down and Bottom-Up
Approach J Am Soc Mass Spectrom 2015, submitted.
125. Agthoven, M. A. v.; Chiron, L.; Coutouly, M.-A.; Wootton, C. A.; Soulby, A.; Wei, J.; Barrow, M. P.; Delsuc,
M.-A.; Rolando, C.; O'Connor, P. B. Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass
Spectrometry Characterization of Cytochrome C Tryptic Digest Anal Chem 2015, submitted.
124. van Agthoven, M.; Barrow, M.; Chiron, L.; Coutouly, M.-A.; Kilgour, D.; Wootton, C.; Wei, J.; Soulby, A.;
Delsuc, M.-A.; Rolando, C.; O’Connor, P., Differentiating Fragmentation Pathways of Cholesterol by Two-
Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J Am Soc Mass Spectrom 2015,
1-10.
123. Wills, R. H.; O'Connor, P. B. Structural Characterization of Actinomycin D Using Multiple Ion Isolation and
Electron Induced Dissociation J Am Soc Mass Spectrom 2014, 25, 186-195.
122. Wills, R. H.; Habtemariam, A.; Lopez-Clavijo, A. F.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B. Insights
into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High
Resolution Mass Spectrometry J Am Soc Mass Spectrom 2014, 25, 662-672.
121. Wei, J.; Bristow, A.; McBride, E.; Kilgour, D.; O'Connor, P. B. D-alpha-tocopheryl Polyethylene Glycol
1000 Succinate: A View from FTICR MS and Tandem MS Anal Chem 2014, 86, 1567-1574.
120. Qi, Y.; O'Connor, P. B. Data processing in Fourier transform ion cyclotron resonance mass spectrometry
Mass Spectrometry Reviews 2014, 33, 333-352.
119. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; Soulby, A.; Canelon, I. R.; Barrow, M.; O'Connor, P. B.
Unexpected Crosslinking and Diglycation as Advanced Glycation End-Products from Glyoxal J Am Soc Mass
Spectrom 2014, 25, 2125-2133.

118. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; O'Connor, P. B. Tandem mass spectrometry for the study of
glyoxal-derived advanced glycation end-products (AGEs) in peptides Rapid Communications in Mass
Spectrometry 2014, 28, 25-32.
117. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; Canelon, I. R.; Barrow, M. P.; Kilgour, D.; Rabbani, N.;
Thornalley, P. J.; O'Connor, P. B. Study of an Unusual Advanced Glycation End-Product (AGE) Derived from
Glyoxal Using Mass Spectrometry J Am Soc Mass Spectrom 2014, 25, 673-683.
116. Li, H.; Snelling, J. R.; Barrow, M. P.; Scrivens, J. H.; Sadler, P. J.; O'Connor, P. B. Mass Spectrometric
Strategies to Improve the Identification of Pt(II)-Modification Sites on Peptides and Proteins J Am Soc Mass
Spectrom 2014, 25, 1217-1227.
115. Griffiths, M. T.; Da Campo, R.; O'Connor, P. B.; Barrow, M. P. Throwing Light on Petroleum: Simulated
Exposure of Crude Oil to Sunlight and Characterization Using Atmospheric Pressure Photoionization Fourier
Transform Ion Cyclotron Resonance Mass Spectrometry Anal Chem 2014, 86, 527-534.
114. Cho, Y.; Qi, Y.; O'Connor, P. B.; Barrow, M. P.; Kim, S. Application of Phase Correction to Improve the
Interpretation of Crude Oil Spectra Obtained Using 7 T Fourier Transform Ion Cyclotron Resonance Mass
Spectrometry J Am Soc Mass Spectrom 2014, 25, 154-157.
113. Wei, J.; Li, H.; Barrow, M. P.; O'Connor, P. B. Structural Characterization of Chlorophyll-a by High
Resolution Tandem Mass Spectrometry J Am Soc Mass Spectrom 2013, 24, 753-760.
112. Smith, D. F.; Kilgour, D. P. A.; Konijnenburg, M.; O'Connor, P. B.; Heeren, R. M. A. Absorption Mode
FTICR Mass Spectrometry Imaging Anal Chem 2013, 85, 11180-11184.
111. Qi, Y.; Liu, Z.; Li, H.; Sadler, P. J.; O'Connor, P. B. Mapping the protein-binding sites for novel iridium(III)
anticancer complexes using electron capture dissociation Rapid Communications in Mass Spectrometry 2013,
27, 2028-2032.
110. Qi, Y.; Li, H.; Wills, R. H.; Perez-Hurtado, P.; Yu, X.; Kilgour, D. P. A.; Barrow, M. P.; Lin, C.; O'Connor, P.
B. Absorption-Mode Fourier Transform Mass Spectrometry: The Effects of Apodization and Phasing on
Modified Protein Spectra J Am Soc Mass Spectrom 2013, 24, 828-834.
109. Kilgour, D. P. A.; Wills, R.; Qi, Y.; O'Connor, P. B. Autophaser: An Algorithm for Automated Generation of
Absorption Mode Spectra for FT-ICR MS Anal Chem 2013, 85, 3903-3911.
108. Kilgour, D. P. A.; Neal, M. J.; Soulby, A. J.; O'Connor, P. B. Improved optimization of the Fourier
transform ion cyclotron resonance mass spectrometry phase correction function using a genetic algorithm
Rapid Communications in Mass Spectrometry 2013, 27, 1977-1982.
107. Wills, R. H.; Tosin, M.; O'Connor, P. B. Structural Characterization of Polyketides Using High Mass
Accuracy Tandem Mass Spectrometry Anal Chem 2012, 84, 8863-8870.
106. Wills, R.; Habtemariam, A.; Sadler, P. J.; O'Connor, P. B. Mapping the Binding Sites of Organometallic
Ruthenium Anticancer Compounds on Peptides using FTICR Mass Spectrometry J Am Soc Mass Spectrom
2012, submitted.
105. Qi, Y.; Witt, M.; Jertz, R.; Baykut, G.; Barrow, M. P.; Nikolaev, E. N.; O'Connor, P. B. Absorption-mode
spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell Rapid Communications
in Mass Spectrometry 2012, 26, 2021-2026.
104. Qi, Y.; Barrow, M. P.; Li, H.; Meier, J. E.; Van Orden, S. L.; Thompson, C. J.; O'Connor, P. B. Absorption-
Mode: The Next Generation of Fourier Transform Mass Spectra Anal Chem 2012, 84, 2923-2929.
103. Lopez-Clavijo, A. F.; Barrow, M. P.; Rabbani, N.; Thornalley, P. J.; O'Connor, P. B. Determination of
Types and Binding Sites of Advanced Glycation End Products for Substance P Anal Chem 2012, 84, 10568-
10575.
102. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. A low noise single-transistor transimpedance preamplifier for
Fourier-transform mass spectrometry using a T feedback network Rev Sci Instrum 2012, 83.
101. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. United Kingdom, 2012; Vol. WO2008103970.
100. Lin, C.; O'Connor, P. B. In Protein and Peptide Mass Spectrometry in Drug Discovery; Gross, M. L.,
Chen, G., Pramanik, B. N., Eds.; John Wiley & Sons, Inc: Hoboken, New Jerssey, 2012.
99. Li, X.; Yu, X.; Costello, C. E.; Lin, C.; O'Connor, P. B. Top-Down Study of beta(2)-Microglobulin
Deamidation Anal Chem 2012, 84, 6150-6157.
98. Li, H.; Wells, S. A.; Jimenez-Roldan, J. E.; Roemer, R. A.; Zhao, Y.; Sadler, P. J.; O'Connor, P. B. Protein
flexibility is key to cisplatin crosslinking in calmodulin Protein Science 2012, 21, 1269-1279.
97. Li, H.; O'Connor, P. B. Electron Capture Dissociation of Disulfide, Sulfur-Selenium, and Diselenide Bound
Peptides J Am Soc Mass Spectrom 2012, 23, 2001-2010.

96. Leach, F. E., III; Kharchenko, A.; Vladimirov, G.; Aizikov, K.; O'Connor, P. B.; Nikolaev, E.; Heeren, R. M.
A.; Amster, I. J. Analysis of phase dependent frequency shifts in simulated FTMS transients using the filter
diagonalization method International Journal of Mass Spectrometry 2012, 325, 19-24.
95. Kilgour, D. P. A.; Mackay, C. L.; Langridge-Smith, P. R. R.; O'Connor, P. B. Use of an Artificial Immune
System Derived Method for the Charge State Assignment of Small-Molecule Mass Spectra Anal Chem 2012,
84, 7436-7439.
94. Kilgour, D. P. A.; Mackay, C. L.; Langridge-Smith, P. R. R.; O'Connor, P. B. Appropriate Degree of Trust:
Deriving Confidence Metrics for Automatic Peak Assignment in High-Resolution Mass Spectrometry Anal
Chem 2012, 84, 7431-7435.
93. Hurtado, P. P.; O'Connor, P. B. Differentiation of isomeric amino acid residues in proteins and peptides
using mass spectrometry Mass Spectrometry Reviews 2012, 31, 609-625.
92. Hurtado, P. P.; Lam, P. Y.; Kilgour, D.; Bristow, A.; McBride, E.; O'Connor, P. B. Use of High Resolution
Mass Spectrometry for Analysis of Polymeric Excipients in Drug Delivery Formulations Anal Chem 2012, 84,
8579-8586.
91. Smith, D. F.; Aizikov, K.; Duursma, M. C.; Giskes, F.; Spaanderman, D.-J.; McDonnell, L. A.; O'Connor, P.
B.; Heeren, R. M. A. An External Matrix-Assisted Laser Desorption Ionization Source for Flexible FT-ICR Mass
Spectrometry Imaging with Internal Calibration on Adjacent Samples J Am Soc Mass Spectrom 2011, 22, 130-
137.
90. R. Wills, M. Tosin, P. B. O'Connor, The Use of Electron Induced Dissociation for the Structural
Characterisation of Polyketides. Anal. Chem. 2011, PBO is editing the first draft.
89. P. Perez-Hurtado, P. B. O'Connor, Deamidation of Collagen. Anal. Chem. 2011, in press.
88. A. F. Lopez-Clavijo, M. P. Barrow, N. Rabbani, P. J. Thornalley, P. B. O'Connor, Binding site identification
of glyoxal in substance P by mass spectrometry. Anal. Chem. 2011, Third draft being edited by PBO.
87. T.-Y. Lin, R. J. Green, P. B. O'Connor, A gain and bandwidth enhanced transimpedance preamplifier for
Fourier-transform ion cyclotron resonance mass spectrometry. Rev. Sci. Inst. 2011, 82.
86. R. Wills, A. Habtemariam, P. J. Sadler, P. B. O'Connor, Mapping the Binding Sites of Organometallic
Ruthenium Anticancer Compounds on Peptides using FTICR Mass Spectrometry. J. Am. Soc. Mass Spectrom.
2012, submitted.
85. Y. Qi, M. P. Barrow, J. E. Meier, H. Li, S. L. V. Orden, C. J. Thompson, P. B. O'Connor, Absorption-mode:
The Next Generation of Fourier Transform Mass Spectra. Anal. Chem. 2012, submitted.
84. D. F. Smith, K. Aizikov, M. C. Duursma, F. Giskes, D.-J. Spaanderman, L. A. McDonnell, P. B. O'Connor,
R. M. A. Heeren, An External Matrix-Assisted Laser Desorption Ionization Source for Flexible FT-ICR Mass
Spectrometry Imaging with Internal Calibration on Adjacent Samples. J. Am. Soc. Mass Spectrom. 2011, 22,
130-137.
83. N. P. Sargaeva, C. Lin, P. B. O'Connor, Unusual Fragmentation of beta-Linked Peptides by ExD Tandem
Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22, 480-491.
82. N. P. Sargaeva, C. Lin, P. B. O'Connor, Differentiating N-Terminal Aspartic and Isoaspartic Acid Residues
in Peptides. Anal. Chem. 2011, 83, 6675-6682.
81. N. P. Sargaeva, A. A. Goloborodko, P. B. O'connor, E. Moskovets, M. V. Gorshkov, Sequence-specific
predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate
isomerization in peptides. Electrophoresis 2011, 32, 1962-69.
80. Y. Qi, C. J. Thompson, S. L. Van Orden, P. B. O'Connor, Phase Correction of Fourier Transform Ion
Cyclotron Resonance Mass Spectra Using MatLab. J. Am. Soc. Mass Spectrom. 2011, 22, 138-147.
79. Y. Qi, M. Barrow, S. L. VanOrden, C. J. Thompson, H. Li, P. Perez-Hurtado, P. B. O'connor, Variation of
the Fourier transform mass spectral phase function with experimental parameters. Anal. Chem. 2011, 83,
8477-8483.
78. X. J. Li, C. Lin, P. B. O'Connor, Glutamine Deamidation: Differentiation of Glutamic Acid and gamma-
Glutamic Acid in Peptides by Electron Capture Dissociation. Anal. Chem. 2010, 82, 3606-3615.
77. X. J. Li, C. Lin, L. Han, C. E. Costello, P. B. O'Connor, Charge Remote Fragmentation in Electron Capture
and Electron Transfer Dissociation. J. Am. Soc. Mass Spectrom. 2010, 21, 646-656.
76. X. Li, Y. Huang, P. B. O'Connor, C. Lin, Structural Heterogeneity of Doubly-Charged Peptide b-Ions. J.
Am. Soc. Mass Spectrom. 2011, 22, 245-254.
75. X. Li, C. Lin, W. Cui, P. B. O'Connor, Top-Down Analysis of Deamidation products in Proteins. Anal.
Chem. 2010, manuscript in preparation.
74. W. Y. K. Chan, T. W. D. Chan, P. B. O'Connor, Electron Transfer Dissociation with Supplemental
Activation to Differentiate Aspartic and Isoaspartic Residues in Doubly Charged Peptide Cations. J. Am. Soc.
Mass Spectrom. 2010, 21, 1012-1015.

73. R. Yamin, C. Zhao, P. B. O'Connor, A. C. McKee, C. R. Abraham, Acyl peptide hydrolase degrades
monomeric and oligomeric amyloid-beta peptide. Molecular Neurodegeneration 2009, 4.
72. I. Van Rhijn, D. C. Young, A. De Jong, J. Vazquez, T. Y. Cheng, R. Talekar, D. C. Barral, L. Leon, M. B.
Brenner, J. T. Katz, R. Riese, R. M. Ruprecht, P. B. O'Connor, C. E. Costello, S. A. Porcelli, V. Briken, D. B.
Moody, CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids (vol 206, pg 1409,
2009). J. Exp. Med. 2009, 206, 1831-1831.
71. N. P. Sargaeva, C. Lin, P. B. O'Connor, Identification of Aspartic and Isoaspartic Acid Residues in Amyloid
beta Peptides, Including A beta 1-42, Using Electron-Ion Reactions. Anal. Chem. 2009, 81, 9778-9786.
70. R. Mathur, P. B. O'Connor, Artifacts in Fourier transform mass spectrometry. Rapid Commun. Mass
Spectrom. 2009, 23, 523-529.
69. K. Aizikov, R. Mathur, P. B. O'Connor, The Spontaneous Loss of Coherence Catastrophe in Fourier
Transform Ion Cyclotron Resonance Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2009, 20, 247-256.
68. R. S. Zee, D. R. Pimentel, X. Hou, M. Zang, C. X. Yao, P. B. O'Connor, M. M. Bachschmid, R. A. Cohen,
Sirtuin-1 Zinc Thiolate Center Is a Direct Molecular Target of Oxidants. Free Radic. Biol. Med. 2008, 45, S76-
S76.
67. R. Mathur, P. B. O'Connor, Artifacts in Fourier transform mass spectrometry. Rapid Commun Mass
Spectrom 2008, 523-529.
66. R. Mathur, R. W. Knepper, P. B. O'Connor, A Low-Noise Broadband Cryogenic Preamplifier Operated in a
High-Field Superconducting Magnet. Ieee Transactions on Applied Superconductivity 2008, 18, 1781-1789.
65. C. Lin, J. C. Cournoyer, P. B. O'Connor, Probing the gas phase folding kinetics of peptide ions by IR-
Activated DR-ECD. J. Am. Soc. Mass Spectrom. 2008, 19, 870-879.
64. X. J. Li, J. J. Cournoyer, C. Lin, P. B. O'Connor, The Effect of Fixed Charge Modifications on Electron
Capture Dissociation. J. Am. Soc. Mass Spectrom. 2008, 19, 1514-1526.
63. Lin, C.; Cournoyer, J. C.; O'Connor, P. B. Probing the gas phase folding kinetics of peptide ions by IR-
activated DR-ECD J. Am. Soc. Mass Spectrom. 2008, 19, 780-789.
62. Xie, B.; Luo, X.; Zhao, C.; Priest, C. M.; Chan, S.-Y.; O'Connor, P. B.; Kirschner, D. A.; Costello, C. E.
Molecular characterization of myelin protein zero in xenopus laevis peripheral nerve: Equilibrium between non-
covalently associated dimer and monomer Int. J. Mass Spectrom. Ion Processes 2007, 268, 304-315.
61. Lin, C.; Mathur, R.; Aizikov, K.; O'Connor, P. B. First signal on the cryogenic Fourier-transform ion
cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2090-2093.
60. Mathur, R.; Knepper, R. W.; O'Connor, P. B. A low-noise, wideband preamplifier for a Fourier-transform ion
cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2233-2241.
59. Zhao, C.; Cournoyer, J.; Xie, B.; Zaia, J.; Costello, C. E.; O'Connor, P. B. Structural analysis of milk
oligosaccharides and N-linked branched glycans by electron detachment dissociation 2007, in revision.
58. Zhao, C.; Xie, B.; Chan, S.-Y.; Costello, C. E.; O'Connor, P. B. Collisionally activated dissociation and
electron capture dissociation provide complementary structural information for permethylated oligosaccharides
J. Am. Soc. Mass Spectrom. 2007, 19, 138-150.
57. Zhao, C.; O'Connor, P. B. Removal of polyethylene glycols from protein samples using titanium dioxide
Anal. Biochem. 2007, 365, 283-285 .
56. Cournoyer, J. J.; O'Connor, P. B. Analysis of deamidation in proteins in Protein Mass Spectrometry;
Whitelegge, J. P., Ed., 2008, Elsevier, Amsterdam.
55. O'Connor, P. B. The development of Matrix-assisted laser desorption ion sources In Electrospray ionization
mass spectrometry; Cole, R. B., Ed.; 2007 Wiley Interscience, San Francisco.
54. O'Connor, P. B.; Hillenkamp, F. MALDI mass spectrometry insturmentation In MALDI-MS: a practical guide
to instrumentation, methods and applications; Hillenkamp, F., Peter-Katalinic, J., Eds.; 2007, Wiley-VCH
Weinheim, Germany.
53. Kaur, P.; O'Connor, P. B. Quantitative determination of isotope ratios from experimental isotopic
distributions Anal. Chem. 2007, 79, 1198-1204.
52. Mathur, R.; O'Connor, P. B. Design and implementation of a high power RF oscillator on a printed circuit
board for multipole ion guides Rev. Sci. Instrum. 2006, 77, 114101.
51. Kaur, P.; O'Connor, P. B. Comparison of charge state determination methods for high resolution mass
spectra IEEE Int. Conf. on Granular Computing May 10, 2006, 550-553 .
50. Cournoyer, J. C.; Lin, C.; Bowman, M. J.; O'Connor, P. B. Quantitating the relative abundance of
isoaspartyl residues in deamidated proteins by electron capture dissociation J. Am. Soc. Mass Spectrom.
2007, 18, 48-56.
49. Belyayev, M. A.; Cournoyer, J. J.; Lin, C.; O'Connor, P. B. The effect of radical trap moieties on electron
capture dissociation spectra of substance P J. Am. Soc. Mass Spectrom. 2006, 17, 1428-1436.
48. Lin, C.; Cournoyer, J. J.; O'Connor, P. B. Use of a double resonance electron capture dissociation
experiment to probe fragment intermediate lifetimes J. Am. Soc. Mass Spectrom. 2006, 17, 1605-1615.
47. Zhao, C.; Sethuraman, M.; Clavreul, N.; Kaur, P.; Cohen, R. A.; O'Connor, P. B. A detailed map of
oxidative post-translational modifications of human p21ras using Fourier transform mass spectrometry Anal.
Chem. 2006, 78, 5134-5142.

46. Aizikov, K.; O'Connor, P. B. Use of the filter diagonalization method in the study of space charge related
frequency modulation in FTMS J. Am. Soc. Mass Spectrom. 2006, 17, 836-843.
45. O'Connor, P. B.; Cournoyer, J. J.; Pitteri, S. J.; Chrisman, P. A.; McLuckey, S. A. Differentiation of aspartic
and isoaspartic acids using electron transfer dissociation J. Am. Soc. Mass Spectrom. 2006, 17, 15-19.
44. Perlman, D. H.; Berg, E. A.; O'Connor, P. B.; Costello, C. E.; Hu, J. Reverse transcription-associated
dephosphorylation of hepadnavirus nucleocapsids Proc. Nat. Acad. Sci. USA 2005, 102, 9020-9025.
43. O'Connor, P. B.; Lin, C.; Cournoyer, J. J.; Pittman, J. L.; Belyayev, M.; Budnik, B. A. Long-lived electron
capture dissociation product ions experience radical migration via hydrogen abstraction J. Am. Soc. Mass
Spectrom. 2006, 17, 576-585.
42. Kaur, P.; O'Connor, P. B. Algorithms for automatic interpretation of high resolution mass spectra J. Am.
Soc. Mass Spectrom. 2006, 17, 459-468.
41. Cournoyer, J. J.; Lin, C.; O'Connor, P. B. Detecting deamidation products in proteins by electron capture
dissociation Anal. Chem. 2006, 78, 1264-1271 ..
40. O'Connor, P. B.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Cournoyer, J. C.; Jebanathirajah, J.; Lin, C.;
Moyer, S.; Zhao, C. A new hybrid electrospray Fourier transform mass spectrometer: Design and performance
characteristics Rapid Commun Mass Spectrom 2006, 20, 259-266.
39. Jebanathirajah, J. A.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Kaur, P.; Rape, M.; Kirschner, M.;
Costello, C. E.; O'Connor, P. B. Characterization of a new qQq-FTICR mass spectrometer for post-
translational modification analysis and top-down tandem mass spectrometry of whole proteins J. Am. Soc.
Mass Spectrom. 2005, 16, 1985-1999.
38. Ivleva, V. B.; Sapp, L. M.; O'Connor, P. B.; Costello, C. E. Ganglioside analysis by thin-layer
chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry J. Am.
Soc. Mass Spectrom. 2005, 16, 1552-1560.
37. Cournoyer, J. J.; Pittman, J. L.; Ivleva, V. B.; Fallows, E.; Waskell, L.; Costello, C. E.; O'Connor, P. B.
Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation
Protein Science 2005, 14, 452-463.
36. Pittman, J. L.; O'Connor, P. B. A minimum thickness gate valve with integrated ion optics for mass
spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 441-445.
35. Moody, D. B.; Young, D. C.; Cheng, T.-Y.; Rostat, J.-P.; Roura-mir, C.; O'Connor, P. B.; Zajonc, D. M.;
Walz, A.; Miller, M. J.; Levery, S. B.; Wilson, I. A.; Costello, C. E.; Brenner, M. B. T-cell activation by
lipopeptide antigens Science 2004, 203, 527-531.
34. Kaur, P.; O'Connor, P. B. Use of statistical methods for quantitative determination of the number of trapped
ions Anal. Chem. 2003, 76, 2756-2762.
33. Budnik, B. A.; Moyer, S. C.; Pittman, J. L.; Ivleva, V. B.; Sommer, U.; Costello, C. E.; O'Connor, P. B. High
pressure MALDI-FTMS: Implications for proteomics Int. J. Mass Spectrom. Ion Processes 2004, 234, 203-212.
32. Ivleva, V. B.; Elkin, Y. N.; Budnik, B. A.; Moyer, S. C.; O'Connor, P. B.; Costello, C. E. Coupling thin layer
chromatography with high pressure matrix assisted laser desorption/ionization Fourier transform mass
spectrometry for the analysis of ganglioside mixtures Anal. Chem. 2004, 76, 6484-6491.
31. O'Connor, P. B.; Budnik, B. A.; Ivleva, V. B.; Kaur, P.; Moyer, S. C.; Pittman, J. L.; Costello, C. E. A High
pressure matrix-assisted laser desorption Fourier-transform mass spectrometry ion source designed to
accommodate large targets with diverse surfaces J Am Soc Mass Spectrom 2003, 15, 128-132.
30. Moyer, S. C.; Budnik, B. A.; Pittman, J. L.; Costello, C. E.; O'Connor, P. B. Attomole peptide analysis by
high-pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry Anal. Chem.
2003, 75, 6449-6454.
29. Leymarie, N.; Costello, C. E.; O'Connor, P. B. Electron capture dissociation initiates a free radical reaction
cascade J. Am. Chem. Soc. 2002, 125, 8949-8958.
28. O'Connor, P. B.; Costello, C. A.; Earle, W. E. A high voltage RF oscillator for driving multipole ion guides J.
27. Leymarie, N.; Berg, E. A.; McComb, M. E.; O'Connor, P. B.; Grogan, J.; Oppenheim, F. G.; Costello, C. E.
Tandem Mass spectrometry for structural characterization of proline-rich proteins: application to salivary PRP-3
Anal. Chem. 2002, 74, 4124-4132.
26. Hopkins, C. E.; O'Connor P, B.; Allen, K. N.; Costello, C. E.; Tolan, D. R. Chemical-modification rescue
assessed by mass spectrometry demonstrates that γ-thia-lysine yields the same activity as lysine in aldolase
Protein Sci 2002, 11, 1591-1599.
25. McClellan, J. E.; Costello, C. E.; O'Connor, P. B.; Zaia, J. Influence of charge state on product ion mass
spectra and the determination of 4s/6s sulfation sequence of chondroitin sulfate oligosaccharides Anal. Chem.
2002, 74, 3760-3771.
24. O'Connor, P. B. Considerations for the design of a Fourier-transform mass spectrometer in the 4.2K cold
bore of a superconducting magnet Rapid Commun Mass Spectrom 2002, 16, 1160-1167.
23. Mirgorodskaya, E.; O'Connor, P. B.; Costello, C. E. A general method for precalculation of parameters for
sustained off resonance irradiation/collision-induced dissociation J. Am. Soc. Mass Spectrom. 2002, 13, 318-
324.

22. O'Connor, P. B.; Mirgorodskaya, E.; Costello, C. E. High pressure matrix-assisted laser
desorption/ionization Fourier-transform mass spectrometry for minimization of ganglioside fragmentation J.
21. Lim, A.; Prokaeva, T.; McComb, M. E.; O'Connor, P. B.; Theberge, R.; Connors, L. H.; Skinner, M.;
Costello, C. E. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass
spectrometric peptide mapping and DNA sequence analysis Anal. Chem. 2002, 74, 741-751.
20. Costello, C. E.; Lim, A.; O'Connor, P. B.; Prokaeva, T.; Connors, L. H.; Skinner, M. Identification of novel
transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping Amyloid
2001, 8, 104-105.
19. O'Connor, P. B.; Costello, C. E. A High pressure matrix-assisted laser desorption/ionization Fourier-
transform mass spectrometry ion source for thermal sabilization of labile biomolecules Rapid Commun. Mass
Spectrom. 2001, 15, 1862-1868.
18. van den Brink, O. F.; Boon, J. J.; O'Connor, P. B.; Duursma, M. C.; Heeren, R. M. A. Matrix-assisted laser
desorption/ionization Fourier-transform mass spectrometric analysis of oxygenated triglycerides and
phosphatidylcholines in egg tempera paint dosimeters used for environmental monitoring of museum display
conditions J. Mass Spectrom. 2001, 36, 479-492.
17. O'Connor, P. B.; Costello, C. E. Application of multishot acquisition in Fourier-transform mass spectrometry
Anal. Chem. 2000, 72, 5125-5130.
16. O'Connor, P. B.; Costello, C. E. Internal calibration on adjacent samples (INCAS) with Fourier-transform
mass spectrometry Anal. Chem. 2000, 72, 5881-5885.
15. O'Connor, P. B.; Duursma, M. C.; Rooij, G. J. v.; Heeren, R. M. A.; Boon, J. J. Correction of time of flight
shifted polymeric molecular weight distributions in MALDI-FTMS Anal. Chem. 1997, 69, 2751-2755.
14. Guan, Z.; Kelleher, N. L.; O'Connor, P. B.; Aaserud, D. J.; Little, D. P.; McLafferty, F. W. 193 nm
photodissociation of larger multiply charged biomolecules Int. J. Mass Spectrom. Ion Processes 1996,
157/158, 357-364.
13. Moertz, E.; O'Connor, P. B.; Roepstorff, P.; Kelleher, N. L.; Wood, T. D.; McLafferty, F. W.; Mann, M.
Sequence tag identification of intact proteins by matching tandem mass spectral data against sequence
databases Proc. Nat. Acad. Sci. USA 1996, 93, 8264-8267.
12. O'Connor, P. B.; McLafferty, F. W. Oligomer characterization of 4-22 kDa polymers by electrospray
Fourier-transform mass spectrometry J. Am. Chem. Soc. 1995, 117, 12826-12831.
11. O'Connor, P. B.; Speir, J. P.; Wood, T. D.; Chorush, R. A.; Guan, Z.; McLafferty, F. W. Quadrupolar
axialization of large multiply charged ions J. Mass Spectrom. 1996, 31, 555-559.
10. Aaserud, D. J.; Little, D. P.; O'Connor, P. B.; McLafferty, F. W. Distinguishing N- and C- terminus ions for
mass spectrometry sequencing of proteins without prior degradation Rapid Commun. Mass Spectrom. 1995, 9,
871-876.
9. Kelleher, N. L.; Senko, M. W.; Little, D. P.; O'Connor, P. B.; McLafferty, F. W. Complete large-molecule high-
resolution mass spectra from 50-femtomole microvolume injection J. Am. Soc. Mass Spectrom. 1995, 6, 220-
221.
8. McLafferty, F. W.; Senko, M. W.; Little, D. P.; Wood, T. D.; O'Connor, P. B.; Speir, J. P.; Chorush, R. A.;
Kelleher, N. L. Electrospray ionization and Fourier-transfrom mass spectrometry in biomedical research Adv.
Mass Spectrom. 1995, 13, 115-128.
7. O'Connor, P. B.; Little, D. P.; McLafferty, F. W. Isotopic assignment in large molecule mass spectra by
fragmentation of a selected isotopic peak Anal. Chem. 1996, 68, 542-545.
6. O'Connor, P. B.; McLafferty, F. W. High resolution ion isolation with the capacitively coupled open cell J.
5. O'Connor, P. B.; Speir, J. P.; Senko, M. W.; Little, D. P.; McLafferty, F. W. Tandem mass spectrometry of
carbonic anhydrase (29 kDa) J. Mass Spectrom. 1995, 30, 88-93.
4. Wood, T. D.; Chorush, R. A.; Wampler, F. M. I.; Little, D. P.; O'Connor, P. B.; McLafferty, F. W. Gas phase
folding and unfolding of cytochrome-c cations Proc. Nat. Acad. Sci. USA 1995, 92, 2451.
3. Little, D. P.; Speir, J. P.; Senko, M. W.; O'Connor, P. B.; McLafferty, F. W. Infrared multiphoton dissociation
of large multiply-charged ions for biomolecule sequencing Anal. Chem. 1994, 66, 2809-2815.
2. Marshall, P.; O'Connor, P. B.; Chan, W.-T.; Kristof, P. B.; Goddard, J. D. Reactions of Boron and Aluminum
Atoms with Small Molecules In Gas Phase Metal Reactions; Fontijn, A., Ed.; 1992, Elsevier: Amsterdam.
1. Cioslowski, J.; O'Connor, P. B.; Fleischmann, E. D. Is superbenzene superaromatic? J. Am. Chem. Soc.
1991, 113, 1086.

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