CTO case of the month: winner of the competition
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The document announces the best CTO case of the month, which was nominated by a committee and selected from cases involving: a retrograde wire escalation and rota technique to treat an LAD CTO; a retrograde PCI through an SVG to treat an ostial RCA CTO; and the use of dedicated guidewires to perform an AWE procedure. The document also lists the names of the nominating committee and the doctors who presented the selected cases.
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John Davies (Basildon - UK),
Marco Hautmann (Essen - D),
Aravinda Nanjundappa (Cleveland - USA)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
If you want to know all the details of the event, click on the image below to download the final program, where you will be able to orient yourself on the day, time and place of a specific video recorded at 15th Experts Live CTO.
Kambis Mashayekhi: Keynote: My essential tipps & tricks for success in compli...
14th Experts Live CTO
September 2nd - 3rd, 2022 - Mainz, Germany
AGIK Parallel Session - Session 5:
Essential tools for complication management
Keynote: My essential tipps & tricks for success in complication management
Kambis Mashayekhi, Lahr, Germany
Room:
West Foyer - Saturday 12:30
Chairmen:
Dimitrios Karmpaliotis, Morristown, USA;
Kambis Mashayekhi, Lahr, Germany;
Andrea Gagnor, Turin, Italy
Mohamed Ayoub: LIAB post CABG mit Impella
14th Experts Live CTO
September 2nd - 3rd, 2022 - Mainz, Germany
AGIK Parallel Session - Session 5:
Essential tools for complication management
LIAB post CABG mit Impella
Mohamed Ayoub, Bad Oeynhausen, Germany
Room:
West Foyer - Saturday 12:00
Chairmen:
Dimitrios Karmpaliotis, Morristown, USA;
Kambis Mashayekhi, Lahr, Germany;
Andrea Gagnor, Turin, Italy
Sylvia Otto: Impulse: How to evaluate and adress the risks of CTO PCI
14th Experts Live CTO
September 2nd - 3rd, 2022 - Mainz, Germany
AGIK Parallel Session - Session 5:
Essential tools for complication management
Impulse: How to evaluate and adress the risks of CTO PCI
Sylvia Otto, Jena, Germany
Room:
West Foyer - Saturday 11:30
Chairmen:
Dimitrios Karmpaliotis, Morristown, USA;
Kambis Mashayekhi, Lahr, Germany;
Andrea Gagnor, Turin, Italy
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
More Related Content
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15th Experts Live CTO - Claudia Cosgrove: Calcium and CTO
10:14
Calcium and CTO
Claudia Cosgrove (London - UK)
___________________________________________
PARALLEL SESSION
Challenges And Opportunities In Cto Recanalization
Auditorium Zubin Mehta - Saturday 10:00 - 11:10
Chairperson:
Jonathan Hill (London - UK)
Discussants:
Lesnek Bryniarski (Krakow - PL),
Ugo Fabrizio (Vercelli),
Paul Knaapen (Amsterdam - NL),
Eugenio La Scala (Ollioiouls - F)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Gregor Leibundgut Update on microcatheter options and selection
Live Cases from Florence and Rome
From Tor Vergata Hospital, Rome
Operators:
Andrea Gagnor (Turin),
Mohaned Egred (Newcastle - UK),
Daniela Benedetto (Rome)
From Careggi University Hospital, Florence
Operators:
Masahisa Yamane (Tokyo - J),
Stelios Pyxaras (Furth - D),
Carlo Di Mario (Florence)
Flash Highlights
8:30
Update on microcatheter options and selection
Gregor Leibundgut (Basel - CH)
___________________________________________
PLENARY SESSION
Live Cases from Florence and Rome + Flash Highlights
Auditorium Zubin Mehta - Saturday 8:30 - 10:00
Coordinator:
Roberto Garbo (Turin)
Chairpersons:
Heinz Joachim Büttner (Bad Krozingen - D),
Roberto Diletti (Rotterdam - NL)
Discussants:
Michael Behnes (Mannheim - D),
Giacomo Boccuzzi (Turin),
Alexander Bufe (Krefeld - D),
Salvatore Colangelo (Turin)
Challengers:
Paul Knaapen (Amsterdam - NL),
Gioel Gabrio Secco (Alessandria)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Francesco Burzotta: Tips & tricks on radial CTO-PCI
Live Cases from Florence and Rome
From Tor Vergata Hospital, Rome
Operators:
Andrea Gagnor (Turin),
Mohaned Egred (Newcastle - UK),
Daniela Benedetto (Rome)
From Careggi University Hospital, Florence
Operators:
Masahisa Yamane (Tokyo - J),
Stelios Pyxaras (Furth - D),
Carlo Di Mario (Florence)
Flash Highlights
8:30
Tips & tricks on radial CTO-PCI
Francesco Burzotta (Rome)
___________________________________________
PLENARY SESSION
Live Cases from Florence and Rome + Flash Highlights
Auditorium Zubin Mehta - Saturday 8:30 - 10:00
Coordinator:
Roberto Garbo (Turin)
Chairpersons:
Heinz Joachim Büttner (Bad Krozingen - D),
Roberto Diletti (Rotterdam - NL)
Discussants:
Michael Behnes (Mannheim - D),
Giacomo Boccuzzi (Turin),
Alexander Bufe (Krefeld - D),
Salvatore Colangelo (Turin)
Challengers:
Paul Knaapen (Amsterdam - NL),
Gioel Gabrio Secco (Alessandria)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Kambis Mashayekhi: EuroCTO Consensus on treatment of Calcified CTO lesion Eur...
AUDITORIUM ZUBIN MEHTA
08/09/2023 04:30 - 05:20
PLENARY SESSION - INTERVENTIONAL CTO & CHIP RESEARCH Best CTO Publications 2022-23 (selected by the Editors of the Cardiology Interventional journals)
Emmanouil S. Brilakis - CTO PCI Outcome associated with poor quality of the d...
16:53
CTO PCI Outcome associated with poor quality of the distal target vessel
Emmanouil Brilakis (Minneapolis - USA)
_____________________________________________
PARALLEL SESSION
Interventional CTO & Chip Research
Best CTO Publications 2022-23 (selected by the Editors of the Cardiology Interventional journals)
Auditorium Zubin Mehta - Friday 16:30 - 17:16
Chairpersons:
Davide Capodanno (Catania),
Carlo Di Mario (Florence),
Giuseppe Tarantini (Padua)
Panelist:
Roberto Diletti (Rotterdam - NL),
Giovanni Esposito (Naples),
Paul Knaapen (Amsterdam - NL),
Maksymilian Opolski (Warsaw - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Mario Iannaccone - 2 EuroCTO Consensus on Guide Catheter Extensions JACC Card...
16:33
EuroCTO Consensus on Guide Catheter Extensions JACC Cardiovasc Interventions
Mario Iannaccone (Turin)
_____________________________________________
PARALLEL SESSION
Interventional CTO & Chip Research
Best CTO Publications 2022-23 (selected by the Editors of the Cardiology Interventional journals)
Auditorium Zubin Mehta - Friday 16:30 - 17:16
Chairpersons:
Davide Capodanno (Catania),
Carlo Di Mario (Florence),
Giuseppe Tarantini (Padua)
Panelist:
Roberto Diletti (Rotterdam - NL),
Giovanni Esposito (Naples),
Paul Knaapen (Amsterdam - NL),
Maksymilian Opolski (Warsaw - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Javier Escaned: 3 Low contrast complex and CTO PCI
Flash Highlights
15:00
3 Low contrast complex and CTO PCI
Javier Escaned (Madrid - Spain)
___________________________________________
PARALLEL SESSION
Live Cases from Rome + Flash Highlights
Auditorium Zubin Mehta - Friday 15:00 - 16:30
Coordinator:
Andrea Gagnor (Turin)
Chairpersons:
Roberto Diletti (Rotterdam - NL),
Bernward Lauer (Jena - D)
Discussants:
Alessio Gaetano La Manna (Catania),
Eugenio Stabile (Potenza)
Challengers:
Paul Knaapen (Amsterdam - NL),
Alessio Mattesini (Florence)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Giuseppe Tarantini: Protect IV and PROTECT-Europe trial
11:35
Protect IV and PROTECT-Europe trial
Giuseppe Tarantini (Padua)
_____________________________________________
PARALLEL SESSION
Cto & Chip Regitries & Trials
Auditorium Zubin Mehta - Friday 11:00 - 12:00
Chairpersons:
Paul Knaapen (Amsterdam - NL),
Gennaro Sardella (Rome)
Discussants:
Björn Billmann (Wolfenbuettel - D),
Laurent Drogul (Nice - F),
Sergey Furkalo (Kiev - UA),
Maciej Lesiak (Poznan - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Paul Knaapen: The PROCTOR randomized trial
11:28
The PROCTOR randomized trial
Paul Knaapen (Amsterdam - NL)
_____________________________________________
PARALLEL SESSION
Cto & Chip Regitries & Trials
Auditorium Zubin Mehta - Friday 11:00 - 12:00
Chairpersons:
Paul Knaapen (Amsterdam - NL),
Gennaro Sardella (Rome)
Discussants:
Björn Billmann (Wolfenbuettel - D),
Laurent Drogul (Nice - F),
Sergey Furkalo (Kiev - UA),
Maciej Lesiak (Poznan - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
John Davies: Update on the ORBITA - CTO trial
11:21
Update on the ORBITA - CTO trial
John Davies (Basildon - UK)
_____________________________________________
PARALLEL SESSION
Cto & Chip Regitries & Trials
Auditorium Zubin Mehta - Friday 11:00 - 12:00
Chairpersons:
Paul Knaapen (Amsterdam - NL),
Gennaro Sardella (Rome)
Discussants:
Björn Billmann (Wolfenbuettel - D),
Laurent Drogul (Nice - F),
Sergey Furkalo (Kiev - UA),
Maciej Lesiak (Poznan - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Masahisa Yamane: The Complex CTO Japanese Registry
11:14
The Complex CTO Japanese Registry
Masahisa Yamane (Tokyo - J)
_____________________________________________
PARALLEL SESSION
Cto & Chip Regitries & Trials
Auditorium Zubin Mehta - Friday 11:00 - 12:00
Chairpersons:
Paul Knaapen (Amsterdam - NL),
Gennaro Sardella (Rome)
Discussants:
Björn Billmann (Wolfenbuettel - D),
Laurent Drogul (Nice - F),
Sergey Furkalo (Kiev - UA),
Maciej Lesiak (Poznan - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Kambis Mashayekhi: Trends and spin-offs from the EuroCTO Registry
11:00
Trends and spin-offs from the EuroCTO Registry
Kambis Mashayekhi (Lahr - D)
_____________________________________________
PARALLEL SESSION
Cto & Chip Regitries & Trials
Auditorium Zubin Mehta - Friday 11:00 - 12:00
Chairpersons:
Paul Knaapen (Amsterdam - NL),
Gennaro Sardella (Rome)
Discussants:
Björn Billmann (Wolfenbuettel - D),
Laurent Drogul (Nice - F),
Sergey Furkalo (Kiev - UA),
Maciej Lesiak (Poznan - PL)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
Emmanouil Brilakis: Update on the PROGRESS Registry
11:07
Update on the PROGRESS Registry
Emmanouil Brilakis (Minneapolis - USA)
_____________________________________________
PARALLEL SESSION
Cto & Chip Regitries & Trials
Auditorium Zubin Mehta - Friday 11:00 - 12:00
Chairpersons:
Paul Knaapen (Amsterdam - NL),
Gennaro Sardella (Rome)
Discussants:
Björn Billmann (Wolfenbuettel - D),
Laurent Drogul (Nice - F),
Sergey Furkalo (Kiev - UA),
Maciej Lesiak (Poznan - PL)
___________________________________________
15th Experts Live CTO
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
15th Experts "Live" CTO: Masahisa Yamane - New wires in CTO recanalization
Live Cases from San Camillo Hospital, Rome
Operators:Alexander Avran (Valenciennes - F), Nicolas Boudou (Bordeaux - F),
Francesco De Felice (Rome)
Live Cases from Catholic University, Rome
Operators: Alfredo Ruggero Galassi (Palermo), Sevket Gorgulu (Istanbul - TR), Francesco Burzotta (Rome)
Flash Highlights
New wires in CTO recanalization
Masahisa Yamane (Tokyo - J)
________________________________________
PARALLEL SESSION
Live Cases from Rome + Flash Highlights
Auditorium Zubin Mehta - Friday 9:00 - 10:30
Chairpersons: Omer Goktekin (Istanbul - TR),
Gabriele Gasparini (Milan)
Coordinator:
Roberto Garbo (Turin)
Discussants:
Zisis Dimitriadis (Wiesbaden - D),
Kadriye Orta Kilickesmez (Istanbul - TR),
Stylianos Pyxaras (Furth - D)
Challengers:
Claudia Cosgrove (London - UK),
Juan Luis Gutierrez Chico (Marbella - E)
_______________________
15th Experts Live CTO: Emmanouil S. Brilakis - The Year in CTO research & pra...
15th Experts "Live" CTO: Auditorium Zubin Mehta - Friday 08:00
15th Experts Live CTO: Opening Session
PLENARY - OPENING SESSION
08:29
The Year in CTO research & practice
Emmanouil Brilakis (Minneapolis - USA)
___________________________________________
PLENARY - OPENING SESSION
Auditorium Zubin Mehta - Friday 8:00 - 9:00
Chairpersons:
Antonio Colombo (Milan),
Giovanni Esposito (Naples)
Discussants:
John Davies (Basildon - UK),
Marco Hautmann (Essen - D),
Aravinda Nanjundappa (Cleveland - USA)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
If you want to know all the details of the event, click on the image below to download the final program, where you will be able to orient yourself on the day, time and place of a specific video recorded at 15th Experts Live CTO.
15th Experts Live CTO: Opening Session - Emanuele Barbato
15th Experts "Live" CTO: Auditorium Zubin Mehta - Friday 08:00
15th Experts Live CTO: Opening Session
PLENARY - OPENING SESSION
08:05
CTO in the Revascularization Guidelines
Emanuele Barbato (Rome)
___________________________________________
PLENARY - OPENING SESSION
Auditorium Zubin Mehta - Friday 8:00 - 9:00
Chairpersons:
Antonio Colombo (Milan),
Giovanni Esposito (Naples)
Discussants:
John Davies (Basildon - UK),
Marco Hautmann (Essen - D),
Aravinda Nanjundappa (Cleveland - USA)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
If you want to know all the details of the event, click on the image below to download the final program, where you will be able to orient yourself on the day, time and place of a specific video recorded at 15th Experts Live CTO.
15th Experts Live CTO: Opening Session - Carlo Di Mario
15th Experts "Live" CTO: Auditorium Zubin Mehta - Friday 08:00
15th Experts Live CTO: Opening Session
PLENARY - OPENING SESSION
08:00
Introduction
Carlo Di Mario (Florence)
___________________________________________
PLENARY - OPENING SESSION
Auditorium Zubin Mehta - Friday 8:00 - 9:00
Chairpersons:
Antonio Colombo (Milan),
Giovanni Esposito (Naples)
Discussants:
John Davies (Basildon - UK),
Marco Hautmann (Essen - D),
Aravinda Nanjundappa (Cleveland - USA)
___________________________________________
15th Experts Live CTO,
EUROCTO Club meeting in partnership with the GISE CTO meeting.
September 8th - 9th, 2023
Florence, Italy
If you want to know all the details of the event, click on the image below to download the final program, where you will be able to orient yourself on the day, time and place of a specific video recorded at 15th Experts Live CTO.
Kambis Mashayekhi: Keynote: My essential tipps & tricks for success in compli...
14th Experts Live CTO
September 2nd - 3rd, 2022 - Mainz, Germany
AGIK Parallel Session - Session 5:
Essential tools for complication management
Keynote: My essential tipps & tricks for success in complication management
Kambis Mashayekhi, Lahr, Germany
Room:
West Foyer - Saturday 12:30
Chairmen:
Dimitrios Karmpaliotis, Morristown, USA;
Kambis Mashayekhi, Lahr, Germany;
Andrea Gagnor, Turin, Italy
Mohamed Ayoub: LIAB post CABG mit Impella
14th Experts Live CTO
September 2nd - 3rd, 2022 - Mainz, Germany
AGIK Parallel Session - Session 5:
Essential tools for complication management
LIAB post CABG mit Impella
Mohamed Ayoub, Bad Oeynhausen, Germany
Room:
West Foyer - Saturday 12:00
Chairmen:
Dimitrios Karmpaliotis, Morristown, USA;
Kambis Mashayekhi, Lahr, Germany;
Andrea Gagnor, Turin, Italy
Sylvia Otto: Impulse: How to evaluate and adress the risks of CTO PCI
14th Experts Live CTO
September 2nd - 3rd, 2022 - Mainz, Germany
AGIK Parallel Session - Session 5:
Essential tools for complication management
Impulse: How to evaluate and adress the risks of CTO PCI
Sylvia Otto, Jena, Germany
Room:
West Foyer - Saturday 11:30
Chairmen:
Dimitrios Karmpaliotis, Morristown, USA;
Kambis Mashayekhi, Lahr, Germany;
Andrea Gagnor, Turin, Italy
More from Euro CTO Club (20)
15th Experts Live CTO - Claudia Cosgrove: Calcium and CTO
15th Experts Live CTO - Claudia Cosgrove: Calcium and CTO
Gregor Leibundgut Update on microcatheter options and selection
Gregor Leibundgut Update on microcatheter options and selection
Francesco Burzotta: Tips & tricks on radial CTO-PCI
Francesco Burzotta: Tips & tricks on radial CTO-PCI
Kambis Mashayekhi: EuroCTO Consensus on treatment of Calcified CTO lesion Eur...
Kambis Mashayekhi: EuroCTO Consensus on treatment of Calcified CTO lesion Eur...
Emmanouil S. Brilakis - CTO PCI Outcome associated with poor quality of the d...
Emmanouil S. Brilakis - CTO PCI Outcome associated with poor quality of the d...
Mario Iannaccone - 2 EuroCTO Consensus on Guide Catheter Extensions JACC Card...
Mario Iannaccone - 2 EuroCTO Consensus on Guide Catheter Extensions JACC Card...
Javier Escaned: 3 Low contrast complex and CTO PCI
Javier Escaned: 3 Low contrast complex and CTO PCI
Giuseppe Tarantini: Protect IV and PROTECT-Europe trial
Giuseppe Tarantini: Protect IV and PROTECT-Europe trial
Masahisa Yamane: The Complex CTO Japanese Registry
Masahisa Yamane: The Complex CTO Japanese Registry
Kambis Mashayekhi: Trends and spin-offs from the EuroCTO Registry
Kambis Mashayekhi: Trends and spin-offs from the EuroCTO Registry
Emmanouil Brilakis: Update on the PROGRESS Registry
Emmanouil Brilakis: Update on the PROGRESS Registry
15th Experts "Live" CTO: Masahisa Yamane - New wires in CTO recanalization
15th Experts "Live" CTO: Masahisa Yamane - New wires in CTO recanalization
15th Experts Live CTO: Emmanouil S. Brilakis - The Year in CTO research & pra...
15th Experts Live CTO: Emmanouil S. Brilakis - The Year in CTO research & pra...
15th Experts Live CTO: Opening Session - Emanuele Barbato
15th Experts Live CTO: Opening Session - Emanuele Barbato
15th Experts Live CTO: Opening Session - Carlo Di Mario
15th Experts Live CTO: Opening Session - Carlo Di Mario
Kambis Mashayekhi: Keynote: My essential tipps & tricks for success in compli...
Kambis Mashayekhi: Keynote: My essential tipps & tricks for success in compli...
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Sylvia Otto: Impulse: How to evaluate and adress the risks of CTO PCI
Recently uploaded
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Non-respiratory Functions of the Lungs.pdf
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Hemodialysis: Chapter 4, Dialysate Circuit - Dr.Gawad
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
ANATOMY AND PHYSIOLOGY OF URINARY SYSTEM.pptx
Valuable Content of Human Anatomy and Physiology of Urinary system as per PCI Syllabus for Pharmacy and PharmD Students.
CDSCO and Phamacovigilance {Regulatory body in India}
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Physiology of Special Chemical Sensation of Taste
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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