1. Outcomes of the Queensland Accelerated Chest pain Risk
Evaluation (ACRE) Project
Skoien W, Cullen L, Ashover S, Sippel J, Bettens V, Parsonage W
Statewide ACRE Project, Queensland Department of Health, Australia
Background: Possible cardiac chest pain presents a constant challenge to
Emergency Department (ED) physicians, who must balance the potential for
hazardous outcomes with the clinical realities of assessing this high volume patient
group.
Aims: To replicate the success of a single-site pilot trial 4 by implementing the ADP
in all eligible Queensland public hospitals, and to demonstrate improved efficiency
by reporting:
• Uptake of the ADP, as proportion of ‘low risk’ chest pain patients managed;
• ED length of stay (LOS), hospital admissions rates, and total hospital LOS for
patients with chest pain .
Methods: Twenty-two target sites were identified from the QLD DoH defined
‘Reporting Hospitals’ for the Emergency Department Information Systems (EDIS)
database.
Relevant clinical stakeholders were approached directly by the project team. Site
visits to discuss implementation with stakeholders and information sessions for the
broader staff followed. Sites were encouraged to nominate a local project
champion to facilitate implementation. Implementation was supported by adaption
of local clinical pathways.
Data were extracted from the EDIS database with eligible patients ‘flagged’ by
treating clinicians within the EDIS case record. Post-implementation data were
compared with 12 months of pre-implementation data at recruited sites.
ADP Uptake: There were 19,283 post-implementation presentations of which 4543 (24%)
were assessed using the ADP (Figure 3).
Discussion: The comparatively short stay of ADP eligible patients and a reduction
in admission rates has reduced the median hospital LOS for all cardiac chest pain
presentations. Total hospital LOS and admission rates were not reported in the pilot
study, which targeted ED LOS only. The 11% reduction in median ED LOS reported
here is less than seen in the pilot study, probably due to hospital-specific factors or
more likely, the influence of global improvements in ED LOS across Queensland
since the pilot study was undertaken. This has reduced the margin for improvement,
but the widespread influence of the ACRE Project means that seemingly small gains
in ED LOS equate to a significant impact in EDs across the state.
Limitations: Data reported are dependent on the accuracy of EDIS database input.
The ACRE Project is a clinical redesign as opposed to clinical trial and results
should be interpreted as such. Clinical outcome data were not collected but the ADP
is based on the large, widely cited ADAPT trial.
Conclusion: The ADAPT ADP is widely applicable to routine clinical practice and
leads to improvement in total hospital LOS, ED LOS, and hospital admissions for
patients presenting to ED with possible cardiac chest pain. Its continued use in QLD
hospitals will have an ongoing impact.
References:
1. Australian Institute of Health and Welfare 2012. Australian hospital statistics 2011–12: emergency
department care. Health services series no. 45. Cat. no. HSE 126. Canberra: AIHW
2. Goodacre S, Cross E, Arnold J, Angelini K, Capewell S, Nicholl J. The health care burden of acute chest pain. Heart.
2005; 91 (2): 229-30.
Email: ACRE_Project@health.qld.gov.au
Mail: C/- Healthcare Improvement Unit
Level 2, 15 Butterfield St, Herston
QLD 4006, AUSTRALIA
Phone: +61 7 3646 5891
Results: Of the 22 target sites,
three sites elected not to implement
due respectively to: limited
pathology laboratory access, a well
matured alternate process in place,
and local stakeholder decision.
One site was not targeted due to
absence of an onsite pathology
laboratory.
As at July 2015 15 sites (68.2% of
target) had implemented the project
(Figure 2).
Post-implementation data to June
2015 are presented, derived from
12 hospital sites that implemented
the ADP between October 2013
and May 2015.
Comparative pre-implementation
data is pooled from the specific 12
months immediately prior to
implementation for each site.
Linked (total hospital LOS) data is
reported to February 2015.
Length of Stay: Median ED LOS for
possible cardiac chest pain patients fell
by 11% from 236 to 210 minutes (figure
4). Total hospital LOS reduced by 34%,
from 1218 minutes to 801 minutes
(figure 5). Post-implementation data
are broken down to patients assessed
using the ACRE pathway and those
assessed as per usual care.
Hospital Admissions: Overall
admission rates reduced with
implementation of the ADP, dropping
from 69% to 57% following
implementation (figure 6).
Risk stratification guidelines
incorporate justifiably prolonged
assessment processes, but up to 85%
of the estimated 500,000 chest pain
presentations per annum in Australia
are eventually diagnosed with non-
cardiac causes 1,2.
The ACRE project involves clinical
redesign to implement an accelerated
diagnostic protocol (ADP). The
ADAPT3 trial described an ADP that
identified ~20% of ED patients
presenting with chest pain as low risk
for short-term major adverse cardiac
events (Figure 1).
Figure 4: Combined pre and post-implementation
ED LOS for all sites
Figure 5: Combined pre and post-implementation
total hospital LOS for all sites
Figure 1: ADP derived from the ADAPT study
Figure 2: Distribution of ACRE Project Sites
Figure 6: Combined pre and post-
implementation admission rates for all sites
3. Than M, Cullen L, Aldous S, Parsonage WA, Reid CM, Greenslade J, et al. 2-Hour
Accelerated Diagnostic Protocol to Assess Patients With Chest Pain Symptoms Using
Contemporary Troponins as the Only Biomarker: The ADAPT Trial. J Am Coll Cardiol. 2012; 59
(23):2091-8.
4. George T, Ashover S, Cullen L, Gibson J, Bilesky J, Coverdale S, Parsonage W. Introduction
of an accelerated diagnostic protocol in the assessment of emergency department patients with
possible acute coronary syndrome: The Nambour Short Low-Intermediate Chest pain project.
Emerg. Med. Australas. 2013; 25: 340-344.
Funding was granted by the Queensland Department of Health (QLD DoH) Health Innovation Fund, and
supported by the QLD DoH Healthcare Improvement Unit (formerly known as the Clinical Access and
Redesign Unit) and Metro North Hospital and Health Service.
Figure 3: Monthly cardiac chest pain presentations at implemented sites