(En el relato bíblico, Dios creó el universo de la nada; durante cinco días puso
orden en lo creado, el sexto día creó al hombre, el único ser de la creación
hecho “a su imagen y semejanza” y destinado a “dominar” el resto de la
creación; al séptimo descansó. A la mujer, la creó después de la costilla de
Adán y fue ella la que tentó a Adán para que actuara en contra de la palabra
de Dios. Por esto fueron expulsados del paraíso. Es decir, la mujer es el origen
del pecado y el mal en el mundo
Autores: Carmelo Martines
Localización: DavarLogos,
ISSN 1666-7832,
Vol. 10, Nº. 1,
2011, págs. 1-12
Idioma: español
With growing interest among the educational community in the adoption of Open Educational Resources (OER) in learning and teaching, there is increasing concern and some anxiety on whether the use of OER poses different or additional challenges to the design of effective, efficient and engaging learning and teaching experiences? If so, what are they? What are their pedagogical implications? How might course developers and teachers approach and address these challenges? The stories in this book offer critical insights into these challenges, approaches and to their resolution. They comprise the lived experiences of current members of the Faculty of Education at the OUSL. These are the stories of a group of trail blazers bent on bringing about transformational and lasting change in their learning and teaching practices with the integration of OER.
Shironica Karunanayaka & Som Naidu (Editors)
With growing interest among the educational community in the adoption of Open Educational Resources (OER) in learning and teaching, there is increasing concern and some anxiety on whether the use of OER poses different or additional challenges to the design of effective, efficient and engaging learning and teaching experiences? If so, what are they? What are their pedagogical implications? How might course developers and teachers approach and address these challenges? The stories in this book offer critical insights into these challenges, approaches and to their resolution. They comprise the lived experiences of current members of the Faculty of Education at the OUSL. These are the stories of a group of trail blazers bent on bringing about transformational and lasting change in their learning and teaching practices with the integration of OER.
Shironica Karunanayaka & Som Naidu (Editors)
Using Social Media to Enhance Civic Participation: Executive Summary and Guid...Yasmin Fodil
This document is an abridged version of our full report Using Social Media to Enhance Civic Engagement in U.S. Federal Agencies, and includes our executive summary of findings and recommendations as well as a set of tools that agencies can use to help with implementation.
História da administração faculdade shalomPUC Minas
Trabalho interdisciplinar elaborado pelos acadêmicos do 1o. período do curso de Gestão de RH da Faculdade Shalom e apresentado na IX Semana Científica.
Est ce que la mise au point d'un vaccin changerait les stratégies de lutte contre le paludisme en Afrique - Présentation de la 3e édition du Cours international « Atelier Paludisme » -RATSARAVOLANA Eric - PSI Madagascar - Immeuble FIARO. Escalier D. 2ème étage . 101-Antananarivo - Coordinateur de marque PaluStop (chloroquine préemballée et prédosée) - ericr@psi.mg
Using Social Media to Enhance Civic Participation: Executive Summary and Guid...Yasmin Fodil
This document is an abridged version of our full report Using Social Media to Enhance Civic Engagement in U.S. Federal Agencies, and includes our executive summary of findings and recommendations as well as a set of tools that agencies can use to help with implementation.
História da administração faculdade shalomPUC Minas
Trabalho interdisciplinar elaborado pelos acadêmicos do 1o. período do curso de Gestão de RH da Faculdade Shalom e apresentado na IX Semana Científica.
Est ce que la mise au point d'un vaccin changerait les stratégies de lutte contre le paludisme en Afrique - Présentation de la 3e édition du Cours international « Atelier Paludisme » -RATSARAVOLANA Eric - PSI Madagascar - Immeuble FIARO. Escalier D. 2ème étage . 101-Antananarivo - Coordinateur de marque PaluStop (chloroquine préemballée et prédosée) - ericr@psi.mg
El metamorfismo es el conjunto de procesos que, esencialmente, se desarrollan en estado sólido y que afecta a las rocas provocando cambios en su composición
El Huascarán
El Huascarán o Mataraju —orónimo en quechua; traducido respectivamente al español como ‘Nevado sobre el pueblo de Huashco’ o ‘Nevados gemelos’— es la montaña nevada granítica culminante de los Andes peruanos, con una altitud oficial de 6757 m s.n.m. (metros sobre el nivel del mar) según la última medición de 2017.56 Se localiza en el límite de las provincias de Yungay y Carhuaz, región Áncash, en el sector orográfico denominado como Cordillera Blanca, en el corazón del parque nacional Huascarán.
en-el-principio-creacion-biblica-y-ciencia-nathan-aviezer-
El autor en el libro sostiene en base al capítulo uno del libro de Génesis, su creencia es que el tiempo de creación no se da en un cuadro de tiempo de 24 horas, si no que el termino en donde usa una termino que nos explica un determinado de lapso de tiempo que concuerda con lo descrito en la biblia son dividirlo en 24 horas.
A su ves nos habla de que todo lo que a lo largo de la historia se ha descubierto y encontrado, ya se encuentro descrito a la luz de la palabra.
Los Servicios Ambientales son los aspectos de los ecosistemas
que, activa o pasivamente, producen bienestar a los seres
humanos. Incluyen la formación de suelos, la provisión de agua
dulce, la producción de cultivos, la regulación del clima y las
oportunidades de recreación.
El Aire de Medellin
Fenómenos Ambientales
Geografía Urbana
Valle del Aburrá
Calidad del aire
Contaminación Urbana
Industrialización
Expansión Urbana
Algunas características del valle y sus colinas que la enmarcan, Hacen de Medellín un fenómeno ambiental que se relaciona directamente con la calidad de aire.
morfometria_cuenca.pdf
Cuenca hidrográfica
Para el concepto de cuenca hidrográfica se tienen varias definiciones. Según Heras (1972), se entiende
por cuenca vertiente, o cuenca de drenaje de un río, considerado en un punto dado de su curso, al área
limitada por el contorno en el interior del cual el agua precipitada corre por su superficie, se encuentra y
pasa por el punto determinado del cauce.
Aforo Cuenca Hidrográfica
El conocimiento de la cantidad de agua disponible en un predio, es de fundamental
importancia para decidir el establecimiento de un sistema de riego. En las áreas de
secano el agua es escasa, pero existen pequeñas fuentes que pueden ser utilizadas
para el riego de cultivos agrícolas como vertientes, puqios, pozos noria o pozos
profundos.
Biodivercities
Biodiversidad una mirada urbana
Un mensaje central de esta publicación es que, especialmente para las ciudades en el Sur Global, abordar los los retos del desarrollo sostenible requiere un nuevo enfoque de la política que vaya más allá de la "optimización de los sistemas" a través de enfoques tecnocráticos de arriba abajo. Las transformaciones implican cambios radicales en los sistemas sociotécnicos y socio-ecológicos y la forma en que se relacionan, cómo se relacionan. El término "radical" se refiere al alcance del cambio más que a su velocidad (Grin et al., 2010).
Instituto de Investigación de Recursos Biológicos
Alexander von Humboldt
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!