CR Bard: MD&M East 2013
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PANEL: Ground breaking technology brought to you by the MDEA nominees Jay Muse, Senior R&D Engineer, CR Bard Jay Muse is a Product Development Director for BARD Access Systems, the market leader in peripherally inserted central line catheters. His team is committed to delivering best-in-class products to patients and clinicians.
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Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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- 1. *PowerGlide trademark CR Bard, Inc
- 2. Toughened Skin Deep veins Power Injection Small Veins PICC Nurse Availability Infiltration
- 3. IV – like insertion
- 4. Proto 1 Proto 8 Evolution “eye test”
- 7. Lie Distance Distance from needle heal to catheter taper
- 8. Barium Stripes • 6 barium stripes allow for radiographic visualization and blood visualization
- 9. Blood control with Safety
- 10. Strain Relief
Editor's Notes
- The secret is having an in house machine shop and analytical labPrototype materialsStack up of materialsMaterial selectionModularize the design for reuse
- Guidewire coupler molding: required shrink rate studies, and applying two different shrink rates to the front and back portion of the guidewire coupler to achieve the correct dimensions. The two different shrink rates were required due to the long thin part with varying thicknesses.
- Achieving accurate needle bevel location to achieve lie distance tolerance. The Needle hub design with glue port through hole allows for accurate axial positioning of the needle in a fixture, with end of the needle protruding from the proximal end of the glue hole. The adhesive is then applied into the through hole and wicks all around the needle. This accomplishes accurate bevel positioning to achieve appropriate lie distance, and facilitates a robust gluing procedure that achieves good adhesion without needing to texture proximal end of the needle, and has no issues with occluded needles.
- Branching
- Blood control valve coupled with protrusion of safety can so there is no drag from the valve during placement and catheter advancement,
- Strain Relief molding: Due to the soft durometer of polyurethane and thin wall of the extrusion, we needed to use a molding machine with precise control for filling the part to avoid “wrinkling” the catheter. Need 95-98% fill before entering pack phase, or else wrinkling would occur.