1. CORRELATIONS BETWEEN
CLINICAL AND
MICROSCOPIC FEATURES
OF PREMALIGNANT
LESIONS
Done by : Ahmed Ali Al-Asmari

2. Idiopathic Leukoplakia :
 Clinical features :
Asymptomatic white patch; cannot be wiped off;
males affected more than females
- Age
Usually over 40 years
- High-Risk Sites for Malignant Transformation
Floor > tongue > lip > palate > buccal > vestibule
> retromolar

3.  Microscopic Diagnoses At First Diagnosis
Hyperkeratosis—80%
Dysplasia—12%
In situ carcinoma—3%
Squamous cell carcinoma—5%

7. Erythroplakia :
 Clinical features :
Asymptomatic red velvety patch; red lesions
may have foci or white hyperkeratosis
(speckled erythroplakia)
- Age
typically between 50 and 70 years
- High-risk sites
floor of mouth, tongue, retromolar mucosa,
soft palate

8.  Histopathology
Squamous cell carcinoma (50%)
Severe dysplasia or in situ carcinoma (40%)
Mild-to-moderate dysplasia (10%)

11. Lichen planus :
 Clinical features :
asymptomatic except when erosions are present;
occasionally present and are purple pruritic
papules; forearm and lower leg most common skin
areas
- Age
seen in middle age
- High-risk sites
buccal mucosa most commonly affected, with
lesions occasionally on tongue, gingiva, and palate;
skin lesions

12.  Possible Risk of Carcinoma Transformation
May be slightly increased with erosive form
(0.4%–2.5% of cases)

15. Reference :
 Oral Pathology : Clinical Pathologic
Correlations by Joseph A. Regezi , James J.
Sciubba , and Richard C.K. Jordan , 5th ed
2007 , Saunders Company , Chapter 4 , Page
100-130