CONFERENCE POSTER PHARMACOGNOSY.pdf
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This document studies the effects of sporamin, a protein from sweet potatoes, on human gut cancer cell lines. It finds that sporamin exerts significant anti-proliferative and anti-metastatic effects by inducing apoptosis in human pancreatic, esophageal, and colorectal cancer cell lines. Specifically, sporamin treatment was found to suppress tumor growth through influencing expression of Bcl-2 family proteins and inhibiting the NF-κB pathway. Figures 1-3 show results of experiments demonstrating sporamin's dose-dependent inhibition of cancer cell proliferation and induction of apoptosis.
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![Finding phytoproteins that suppress tumour growth on
gut micro environment
Sporamin from Ipomoea batatas
(sweet potato) provide the first clue
RESULTS
METHODOLOGY
AIM
FINDINGS
Fig.1. Effects of sporamin
treatment on the expressionof
Bcl-2, Bcl-XL, and Bax in
human pancreatic cancer cell
lines, PANC-1 and BxPC-3
(western blot)
BACKGROUND
Fig. 2. Effects of sporamin
treatment on the expression
levels of Bcl-2, Bcl-XL and Bax in
esophageal squamous cell
carcinoma cell lines , EC9706 and
EC109 (western blot)
Fig. 3. Effect of sweet potatoprotein
on human colorectal cancer SW480
cells.
A: Effects of various concentrations
of sweet potatoprotein (SPP) on
SW480 cell proliferation.Observed
dose-dependent inhibition.
B: Effect of various treatment times
with 40 μmol/L SPP on SW480 cell
proliferation.Time-dependent
inhibitionobserved.
C: Hoechst 33258 nuclear staining.
SW480 cells were incubated in the
absence or presence of various
concentrationsof SPP for 48 h,
stained with Hoechst 33258 dye.
Sporamin exerts
significant anti-
proliferative and anti-
metastatic effects by
inducing apoptosis of
human gut cancer cell
lines.
ETHNOBOTANY
The sweet potato (Ipomoea
batatas) is a dicotyledonous
plant, Family-Convolvulaceae.
✓anti-cancer
✓Anti-diabetic
✓Anti-inflammatory
To study whether sporamin, a
storage protein from sweet potato,
suppresses the growth of tumour
cells of human GI tract in vitro.
Electronic databases
searching:
PubMed, Google scholar, and
ScienceDirect
Reference:
1. Qian C, Chen X, Qi Y, et al. Sporamin induces apoptosis and inhibits NF-κB activation in human pancreatic cancer cells. Tumor Biology. 2017;39(7).
doi:10.1177/1010428317706917
2. Qian, C., Qi, Y., Chen, X., Zeng, J., & Yao, J. (2017). Sporamin suppresses growth of human esophageal squamous cell carcinoma cells by inhibition of
NF-κB via an AKT-independent pathway. Molecular Medicine Reports, 16, 9620-9626. https://doi.org/10.3892/mmr.2017.7772
3. Li PG, Mu TH, Deng L. Anticancer effects of sweet potato protein on human colorectal cancer cells. World J Gastroenterol 2013; 19(21): 3300-3308
[PMID: 23745032 DOI: 10.3748/wjg.v19.i21.3300]
Induction of cell apoptosis in
human cancer cell lines in vitro](https://image.slidesharecdn.com/meenaloshinieposter-230220131738-29aeec8c/85/CONFERENCE-POSTER-PHARMACOGNOSY-pdf-1-320.jpg)
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apoptosis in cancer cells and this apoptosis was considered
to be caspase-dependent, since the pan-caspase inhibitor
Z-VAD-FMK reduced the number of Annexin V-positive cells.
In murine subcutaneous xenograft models using Caki-1 cells, a
10-day treatment with the combination of ritonavir and pano-
binostat significantly inhibited tumor growth. Panobinostat
alone increased histone acetylation in a dose-dependent
manner and the co-administration of ritonavir synergistically
enhanced this acetylation. Furthermore, this combination
inhibited the expression of HDACs, which may also play a role
in the enhancement of histone acetylation. Thus, the present
study may provide a basis for testing the combination of rito-
navir and panobinostat for patients with advanced renal cancer.
Introduction
A novel approach to the treatment of advanced renal cancer
is needed, as, despite the wide use of kinase inhibitors or
mammalian target of rapamycin inhibitors, there is currently
no curative treatment. Increasing histone acetylation is an
attractive epigenetic approach to cancer treatment and panobi-
nostat is a novel histone deacetylase (HDAC) inhibitor that has
been shown to exert beneficial antitumor effects in phase II
trials in patients with hematological malignancies (1,2).
Panobinostat was also clinically tested in patients with solid
tumors (3,4), but no complete or partial response was observed
in those studies. Ritonavir is a human immunodeficiency virus
protease inhibitor widely used for the treatment of acquired
immune deficiency syndrome, which is also a potent CYP3A4
inhibitor (5). As panobinostat is one of the substrates of
CYP3A4 (6), we hypothesized that ritonavir may enhance the
activity of panobinostat by increasing its intracellular accumu-
lation through inhibiting its degradation.
In the present study, we aimed to evaluate the combined
effect of ritonavir and panobinostat on renal cancer cells
in vitro and in vivo and investigate their mechanism of action.
Materials and methods
Cell lines. The Caki‑1, ACHN, 769‑P and 786‑O renal canc ...
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1) Breast cancer stem cells (BCSCs) are responsible for tumor development and maintenance due to their self-renewal and survival abilities, and they have high resistance to treatments like chemotherapy.
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power point presentatio in biochemistry 2024
The document discusses how cancer cells evade apoptosis or programmed cell death. It describes the two main pathways of apoptosis - intrinsic and extrinsic - and how they activate caspase proteases to kill cells. Cancer cells resist apoptosis through several mechanisms: 1) Overexpressing anti-apoptotic proteins like Bcl-2, 2) Suppressing or destroying pro-apoptotic proteins, 3) Altering protein functions through phosphorylation, and 4) Modulating gene and protein expression transcriptionally or translationally. The most common way is disabling the p53 tumor suppressor gene in over half of cancers.
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- 1. Finding phytoproteins that suppress tumour growth on gut micro environment Sporamin from Ipomoea batatas (sweet potato) provide the first clue RESULTS METHODOLOGY AIM FINDINGS Fig.1. Effects of sporamin treatment on the expressionof Bcl-2, Bcl-XL, and Bax in human pancreatic cancer cell lines, PANC-1 and BxPC-3 (western blot) BACKGROUND Fig. 2. Effects of sporamin treatment on the expression levels of Bcl-2, Bcl-XL and Bax in esophageal squamous cell carcinoma cell lines , EC9706 and EC109 (western blot) Fig. 3. Effect of sweet potatoprotein on human colorectal cancer SW480 cells. A: Effects of various concentrations of sweet potatoprotein (SPP) on SW480 cell proliferation.Observed dose-dependent inhibition. B: Effect of various treatment times with 40 μmol/L SPP on SW480 cell proliferation.Time-dependent inhibitionobserved. C: Hoechst 33258 nuclear staining. SW480 cells were incubated in the absence or presence of various concentrationsof SPP for 48 h, stained with Hoechst 33258 dye. Sporamin exerts significant anti- proliferative and anti- metastatic effects by inducing apoptosis of human gut cancer cell lines. ETHNOBOTANY The sweet potato (Ipomoea batatas) is a dicotyledonous plant, Family-Convolvulaceae. ✓anti-cancer ✓Anti-diabetic ✓Anti-inflammatory To study whether sporamin, a storage protein from sweet potato, suppresses the growth of tumour cells of human GI tract in vitro. Electronic databases searching: PubMed, Google scholar, and ScienceDirect Reference: 1. Qian C, Chen X, Qi Y, et al. Sporamin induces apoptosis and inhibits NF-κB activation in human pancreatic cancer cells. Tumor Biology. 2017;39(7). doi:10.1177/1010428317706917 2. Qian, C., Qi, Y., Chen, X., Zeng, J., & Yao, J. (2017). Sporamin suppresses growth of human esophageal squamous cell carcinoma cells by inhibition of NF-κB via an AKT-independent pathway. Molecular Medicine Reports, 16, 9620-9626. https://doi.org/10.3892/mmr.2017.7772 3. Li PG, Mu TH, Deng L. Anticancer effects of sweet potato protein on human colorectal cancer cells. World J Gastroenterol 2013; 19(21): 3300-3308 [PMID: 23745032 DOI: 10.3748/wjg.v19.i21.3300] Induction of cell apoptosis in human cancer cell lines in vitro