Compare the advantage of double circulation in vertebrates to that of single circulation in vertebrates. Solution Double circulation: Double circulation in vertebrates represents the advanced network of circulation in which oxygenated and deoxygenated blood is pumped by a 4-chambered heart simultaneously to the body and the lungs, respectively. Advantage: The advantage of double circulation can be addressed as below: Thus, in 4-chambered animals, double circulation possesses multiple benefits and makes it possible for them to survive in harsh conditions and synchronize circulation along with ventilation..