Combined effect of drugs
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This document discusses the combined effects of drugs, including synergism and antagonism. It provides examples of different types of synergism such as additive, supradditive, and potentiation. It also describes various types of antagonism including physical, chemical, physiological, dispositional, receptor, competitive, non-competitive, and irreversible antagonism. Competitive antagonism can be overcome by increasing the agonist concentration while non-competitive antagonism suppresses the maximum response through binding to an allosteric site.
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一比一原版(EUR毕业证)鹿特丹伊拉斯姆斯大学毕业证如何办理
EUR毕业证offer【微信95270640】《鹿特丹伊拉斯姆斯大学毕业证书原版制作EUR成绩单》【Q微信95270640】《仿制EUR毕业证成绩单鹿特丹伊拉斯姆斯大学学位证书pdf电子图》，A.为什么留学生需要操作留信认证?
留信认证全称全国留学生信息服务网认证,隶属于北京中科院。①留信认证门槛条件更低,费用更美丽,并且包过,完单周期短,效率高②留信认证虽然不能去国企,但是一般的公司都没有问题,因为国内很多公司连基本的留学生学历认证都不了解。这对于留学生来说,这就比自己光拿一个证书更有说服力,因为留学学历可以在留信网站上进行查询!
B.为什么我们提供的毕业证成绩单具有使用价值？
查询留服认证是国内鉴别留学生海外学历的唯一途径，但认证只是个体行为，不是所有留学生都操作，所以没有办理认证的留学生的学历在国内也是查询不到的，他们也仅仅只有一张文凭。所以这时候我们提供的和学校颁发的一模一样的毕业证成绩单，就有了使用价值。
实体公司，专业可靠，办理加拿大毕业证|办美国成绩单|做德国文凭学历认证|办新西兰学位证，办澳洲文凭认证，办留信网认证（网上可查，实体公司，专业可靠）铸就十年品质！信誉！实体公司！
办理国外鹿特丹伊拉斯姆斯大学毕业证书 #成绩单改成绩 #教育部学历学位认证 #毕业证认证 #留服认证 #使馆认证（留学回国人员证明） #（证）等
真实教育部认证教育部存档中国教育部留学服务中心认证（即教育部留服认证）网站100%可查.
真实使馆认证（即留学人员回国证明）使馆存档可通过大使馆查询确认.
留信网认证国家专业人才认证中心颁发入库证书留信网永久存档可查.
鹿特丹伊拉斯姆斯大学鹿特丹伊拉斯姆斯大学毕业证假文凭毕业证 #成绩单等全套材料从防伪到印刷从水印到钢印烫金跟学校原版100%相同.
国际留学归国服务中心：实体公司注册经营行业标杆精益求精！
国外毕业证学位证成绩单办理流程：
1客户提供办理鹿特丹伊拉斯姆斯大学鹿特丹伊拉斯姆斯大学毕业证假文凭信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询）；
2开始安排制作鹿特丹伊拉斯姆斯大学毕业证成绩单电子图；
3鹿特丹伊拉斯姆斯大学毕业证成绩单电子版做好以后发送给您确认；
4鹿特丹伊拉斯姆斯大学毕业证成绩单电子版您确认信息无误之后安排制作成品；
5鹿特丹伊拉斯姆斯大学成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快递邮寄鹿特丹伊拉斯姆斯大学鹿特丹伊拉斯姆斯大学毕业证假文凭）。地跟着父亲昼夜兼程第二天凌晨就辗转到了父亲的城哇父亲的城真的好大好美哟走出广州火车东站的那一刻山娃感受到了一种从未有过的激动和震撼太美了可爱的广州父亲的城山娃惊喜得几乎叫出声来山娃觉得父亲太伟大了居然能单匹马地跑到这么远这么大这么美的地方赚大钱高楼大厦鳞次栉比大街小巷人潮涌动山娃一路张望一路惊叹他发现城里的桥居然层层叠叠扭来扭去桥下没水却有着水一般的车水马龙山娃惊诧于城里的公交车那么大那么美不的
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CHAPTER 1 SEMESTER V COMMUNICATION TECHNIQUES FOR CHILDREN.pdf
Here are some key objectives of communication with children:
Build Trust and Security:
Establish a safe and supportive environment where children feel comfortable expressing themselves.
Encourage Expression:
Enable children to articulate their thoughts, feelings, and experiences.
Promote Emotional Understanding:
Help children identify and understand their own emotions and the emotions of others.
Enhance Listening Skills:
Develop children’s ability to listen attentively and respond appropriately.
Foster Positive Relationships:
Strengthen the bond between children and caregivers, peers, and other adults.
Support Learning and Development:
Aid cognitive and language development through engaging and meaningful conversations.
Teach Social Skills:
Encourage polite, respectful, and empathetic interactions with others.
Resolve Conflicts:
Provide tools and guidance for children to handle disagreements constructively.
Encourage Independence:
Support children in making decisions and solving problems on their own.
Provide Reassurance and Comfort:
Offer comfort and understanding during times of distress or uncertainty.
Reinforce Positive Behavior:
Acknowledge and encourage positive actions and behaviors.
Guide and Educate:
Offer clear instructions and explanations to help children understand expectations and learn new concepts.
By focusing on these objectives, communication with children can be both effective and nurturing, supporting their overall growth and well-being.
Fit to Fly PCR Covid Testing at our Clinic Near You
A Fit-to-Fly PCR Test is a crucial service for travelers needing to meet the entry requirements of various countries or airlines. This test involves a polymerase chain reaction (PCR) test for COVID-19, which is considered the gold standard for detecting active infections. At our travel clinic in Leeds, we offer fast and reliable Fit to Fly PCR testing, providing you with an official certificate verifying your negative COVID-19 status. Our process is designed for convenience and accuracy, with quick turnaround times to ensure you receive your results and certificate in time for your departure. Trust our professional and experienced medical team to help you travel safely and compliantly, giving you peace of mind for your journey.www.nxhealthcare.co.uk
AI Trends in Creative Operations 2024 by Artwork Flow.pdf
Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Skeleton Culture Code
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
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一比一原版(UoA毕业证)昆士兰科技大学毕业证如何办理
UoA毕业证学历书【微信95270640】办文凭{昆士兰科技大学毕业证}Q微Q微信95270640UoA毕业证书成绩单/学历认证UoA Diploma未毕业、挂科怎么办？+QQ微信：Q微信95270640-大学Offer（申请大学）、成绩单（申请考研）、语言证书、在读证明、使馆公证、办真实留信网认证、真实大使馆认证、学历认证
办理国外昆士兰科技大学毕业证书 #成绩单改成绩 #教育部学历学位认证 #毕业证认证 #留服认证 #使馆认证（留学回国人员证明） #（证）等
真实教育部认证教育部存档中国教育部留学服务中心认证（即教育部留服认证）网站100%可查.
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留信网认证国家专业人才认证中心颁发入库证书留信网永久存档可查.
昆士兰科技大学昆士兰科技大学毕业证文凭证书毕业证 #成绩单等全套材料从防伪到印刷从水印到钢印烫金跟学校原版100%相同.
国际留学归国服务中心：实体公司注册经营行业标杆精益求精！
国外毕业证学位证成绩单办理流程：
1客户提供办理昆士兰科技大学昆士兰科技大学毕业证文凭证书信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询）；
2开始安排制作昆士兰科技大学毕业证成绩单电子图；
3昆士兰科技大学毕业证成绩单电子版做好以后发送给您确认；
4昆士兰科技大学毕业证成绩单电子版您确认信息无误之后安排制作成品；
5昆士兰科技大学成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快递邮寄昆士兰科技大学昆士兰科技大学毕业证文凭证书）。闷不乐的样子父亲特意带山娃去找三楼房东家的儿子小伍玩小伍比山娃小一岁虎头虎脑的很霸气父亲让山娃跟小伍去夏令营听课山娃很高兴夏令营就设在附近一所小学山娃发现那所小学比自己的学校更大更美操场上还铺有塑胶跑道呢里面很多小朋友一班一班的快快乐乐原来城里娃都藏这儿来了怪不得平时见不到他们山娃恍然大悟起来吹拉弹唱琴棋书画山娃都不懂却什么都想学山娃怨自己太笨什么都不会斟酌再三山娃终于选定了学美术当听说每月要交感
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1比1制作(uofm毕业证书)美国密歇根大学毕业证学位证书原版一模一样
原版定制【微信:bwp0011】《(uofm毕业证书)美国密歇根大学毕业证学位证书》【微信:bwp0011】成绩单 、雅思、外壳、留信学历认证永久存档查询，采用学校原版纸张、特殊工艺完全按照原版一比一制作（包括：隐形水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠，文字图案浮雕，激光镭射，紫外荧光，温感，复印防伪）行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备，十五年致力于帮助留学生解决难题，业务范围有加拿大、英国、澳洲、韩国、美国、新加坡，新西兰等学历材料，包您满意。
【业务选择办理准则】
一、工作未确定，回国需先给父母、亲戚朋友看下文凭的情况，办理一份就读学校的毕业证【微信bwp0011】文凭即可
二、回国进私企、外企、自己做生意的情况，这些单位是不查询毕业证真伪的，而且国内没有渠道去查询国外文凭的真假，也不需要提供真实教育部认证。鉴于此，办理一份毕业证【微信bwp0011】即可
三、进国企，银行，事业单位，考公务员等等，这些单位是必需要提供真实教育部认证的，办理教育部认证所需资料众多且烦琐，所有材料您都必须提供原件，我们凭借丰富的经验，快捷的绿色通道帮您快速整合材料，让您少走弯路。
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
【关于价格问题（保证一手价格）】
我们所定的价格是非常合理的，而且我们现在做得单子大多数都是代理和回头客户介绍的所以一般现在有新的单子 我给客户的都是第一手的代理价格，因为我想坦诚对待大家 不想跟大家在价格方面浪费时间
对于老客户或者被老客户介绍过来的朋友，我们都会适当给一些优惠。
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一比一原版(USF毕业证)旧金山大学毕业证如何办理
USF毕业证offer【微信95270640】《旧金山大学毕业证购买》《如何办理USF毕业证旧金山大学文凭学历》Q微信95270640实体公司，专业可靠，办理毕业证办美国成绩单,做加拿大文凭学历认证,办新西兰学位证，学位证书是什么?《制作旧金山大学毕业证多少钱》《USF学历证书丢了怎么办理》办澳洲文凭认证，办留信网认证（网上可查，实体公司，专业可靠）
专业为留学生办理旧金山大学旧金山大学硕士学位证成绩单【100%存档可查】留学全套申请材料办理。本公司承诺所有毕业证成绩单成品全部按照学校原版工艺对照一比一制作和学校一样的羊皮纸张保证您证书的质量！
如果你回国在学历认证方面有以下难题请联系我们我们将竭诚为你解决认证瓶颈
1所有材料真实但资料不全无法提供完全齐整的原件。【如：成绩单丶毕业证丶回国证明等材料中有遗失的。】
2获得真实的国外最终学历学位但国外本科学历就读经历存在问题或缺陷。【如：国外本科是教育部不承认的或者是联合办学项目教育部没有备案的或者外本科没有正常毕业的。】
3学分转移联合办学等情况复杂不知道怎么整理材料的。时间紧迫自己不清楚递交流程的。
如果你是以上情况之一请联系我们我们将在第一时间内给你免费咨询相关信息。我们将帮助你整理认证所需的各种材料.帮你解决国外学历认证难题。
国外旧金山大学旧金山大学硕士学位证成绩单办理方法：
1客户提供办理信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询旧金山大学旧金山大学硕士学位证成绩单）；
2开始安排制作旧金山大学毕业证成绩单电子图；
3旧金山大学毕业证成绩单电子版做好以后发送给您确认；
4旧金山大学毕业证成绩单电子版您确认信息无误之后安排制作成品；
5旧金山大学成品做好拍照或者视频给您确认；
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一比一原版(EUR毕业证)鹿特丹伊拉斯姆斯大学毕业证如何办理
EUR毕业证offer【微信95270640】《鹿特丹伊拉斯姆斯大学毕业证书原版制作EUR成绩单》【Q微信95270640】《仿制EUR毕业证成绩单鹿特丹伊拉斯姆斯大学学位证书pdf电子图》，A.为什么留学生需要操作留信认证?
留信认证全称全国留学生信息服务网认证,隶属于北京中科院。①留信认证门槛条件更低,费用更美丽,并且包过,完单周期短,效率高②留信认证虽然不能去国企,但是一般的公司都没有问题,因为国内很多公司连基本的留学生学历认证都不了解。这对于留学生来说,这就比自己光拿一个证书更有说服力,因为留学学历可以在留信网站上进行查询!
B.为什么我们提供的毕业证成绩单具有使用价值？
查询留服认证是国内鉴别留学生海外学历的唯一途径，但认证只是个体行为，不是所有留学生都操作，所以没有办理认证的留学生的学历在国内也是查询不到的，他们也仅仅只有一张文凭。所以这时候我们提供的和学校颁发的一模一样的毕业证成绩单，就有了使用价值。
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国际留学归国服务中心：实体公司注册经营行业标杆精益求精！
国外毕业证学位证成绩单办理流程：
1客户提供办理鹿特丹伊拉斯姆斯大学鹿特丹伊拉斯姆斯大学毕业证假文凭信息：姓名生日专业学位毕业时间等（如信息不确定可以咨询顾问：我们有专业老师帮你查询）；
2开始安排制作鹿特丹伊拉斯姆斯大学毕业证成绩单电子图；
3鹿特丹伊拉斯姆斯大学毕业证成绩单电子版做好以后发送给您确认；
4鹿特丹伊拉斯姆斯大学毕业证成绩单电子版您确认信息无误之后安排制作成品；
5鹿特丹伊拉斯姆斯大学成品做好拍照或者视频给您确认；
6快递给客户（国内顺丰国外DHLUPS等快递邮寄鹿特丹伊拉斯姆斯大学鹿特丹伊拉斯姆斯大学毕业证假文凭）。地跟着父亲昼夜兼程第二天凌晨就辗转到了父亲的城哇父亲的城真的好大好美哟走出广州火车东站的那一刻山娃感受到了一种从未有过的激动和震撼太美了可爱的广州父亲的城山娃惊喜得几乎叫出声来山娃觉得父亲太伟大了居然能单匹马地跑到这么远这么大这么美的地方赚大钱高楼大厦鳞次栉比大街小巷人潮涌动山娃一路张望一路惊叹他发现城里的桥居然层层叠叠扭来扭去桥下没水却有着水一般的车水马龙山娃惊诧于城里的公交车那么大那么美不的
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Here are some key objectives of communication with children:
Build Trust and Security:
Establish a safe and supportive environment where children feel comfortable expressing themselves.
Encourage Expression:
Enable children to articulate their thoughts, feelings, and experiences.
Promote Emotional Understanding:
Help children identify and understand their own emotions and the emotions of others.
Enhance Listening Skills:
Develop children’s ability to listen attentively and respond appropriately.
Foster Positive Relationships:
Strengthen the bond between children and caregivers, peers, and other adults.
Support Learning and Development:
Aid cognitive and language development through engaging and meaningful conversations.
Teach Social Skills:
Encourage polite, respectful, and empathetic interactions with others.
Resolve Conflicts:
Provide tools and guidance for children to handle disagreements constructively.
Encourage Independence:
Support children in making decisions and solving problems on their own.
Provide Reassurance and Comfort:
Offer comfort and understanding during times of distress or uncertainty.
Reinforce Positive Behavior:
Acknowledge and encourage positive actions and behaviors.
Guide and Educate:
Offer clear instructions and explanations to help children understand expectations and learn new concepts.
By focusing on these objectives, communication with children can be both effective and nurturing, supporting their overall growth and well-being.
Fit to Fly PCR Covid Testing at our Clinic Near You
A Fit-to-Fly PCR Test is a crucial service for travelers needing to meet the entry requirements of various countries or airlines. This test involves a polymerase chain reaction (PCR) test for COVID-19, which is considered the gold standard for detecting active infections. At our travel clinic in Leeds, we offer fast and reliable Fit to Fly PCR testing, providing you with an official certificate verifying your negative COVID-19 status. Our process is designed for convenience and accuracy, with quick turnaround times to ensure you receive your results and certificate in time for your departure. Trust our professional and experienced medical team to help you travel safely and compliantly, giving you peace of mind for your journey.www.nxhealthcare.co.uk
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See the original article on Forbes here:
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Combined effect of drugs
- 1. COMBINED EFFECT OF DRUGS Dr S P Dhanya
- 3. Combined effect of drugs Synergism Antagonism
- 5. + =Effect of drug A Effect of drug B Effect of drug A+B
- 6. Additive synergism + = 1 1 2
- 8. + <Effect of drug A Effect of drug B Effect of drug A+B
- 9. Supradditive synergism + =1 1 3
- 11. Cotrimoxazole
- 12. Only very small % reaches the brain Dopa decarboxylase Dopa decarboxylase Potentiation
- 13. + >Effect of drug A Effect of drug B Effect of drug A+B
- 14. Antagonism + =Effect of drug A Effect of drug B No effect
- 16. Physical antagonism Activated charcoal and alkaloids
- 19. Physiological antagonism Adrenaline 0.5ml of 1:1000- ******Anaphylaxis*****
- 21. Dispositional antagonisn Affecting A D M E ↓concentration at target site
- 22. Digoxin(inotropic agent) Decreased efficacy of digoxin
- 24. For an acidic drug (salicylate) poisoning what should we do?
- 26. Receptor Interactions Agonist Receptor Agonist -Receptor Complex EFFECT
- 27. Receptor Interactions Antagonist Receptor Antagonist-Receptor Complex DENIED! Atropine NO EFFECT
- 28. i) Competitive Antagonism Competition between agonist & antagonist for specific site or receptor Antagonism can be overcome by concentration of agonist Surmontable antagonism
- 29. COMPETITIVE ANTAGONISM Agonist - maximal response in higher concentration Shifts to Log DRC to? Which means?
- 31. Morphine
- 33. iii) Non-competitive (non-surmountable) Antagonism Antagonist binds to allosteric site of receptor Unrelated to agonist
- 35. Non-competitive Antagonist What is decreased? DRC is flattened and maximum response is
- 36. II) Irreversible Antagonist Antagonist binds to receptor with covalent bond-irreversible Slow dissociation-pseudo-irreversibe max. response
- 38. COMPETITIVE NON COMPETITIVE Surmountable Unsurmountable Antagonist resembles chemically with the agonist Does not resemble Bind with the same site Binds with another site Maximum response obtained by increasing the dose Maximum response suppressed Parallel rightward shift of DRC Flattening of DRC Eg. Atropine on muscarinic receptors Eg. Bicuculine on benzodiazepine receptors