This document describes an automated procedure for running multiple simulations of the Coastal Modeling System's wave model (CMS-Wave). The procedure uses MATLAB scripts to generate input files, run CMS-Wave on a PC, post-process output, and plot results. It allows efficient setup and evaluation of CMS-Wave for resource-intensive projects and research requiring numerous simulations. Two examples are provided to demonstrate the procedure: 1) validating CMS-Wave against laboratory wave experiments testing different breaking formulas, and 2) performing a field application with model-data comparison.