July 21-24, 2019; Mexico City, Mexico
Download slide highlights of key studies addressing current issues in HIV care, as reported at this important annual conference.
Key Slides on ART for HIV : Evolving Concepts and Innovative Strategies.2020hivlifeinfo
Expert-authored slides on evolving ART concepts, including simplification to 2-drug therapy, ART safety during pregnancy, weight gain, and long-acting injectable ART.
File Size: 580 KB
Released: October 20, 2020
Clinical Impact of New HIV Data From CROI 2019hivlifeinfo
March 4-7, 2019; Seattle, Washington
In this downloadable slideset, expert faculty members summarize key studies from this important annual conference.
Format: Microsoft PowerPoint (.ppt)
File Size: 576 KB
Released: March 22, 2019
Clinical Impact of New Data From AIDS 2020hivlifeinfo
current ART in principal populations, including older patients and women who become pregnant; metabolic outcomes during ART; HIV and COVID-19; investigational ART strategies; and HIV prevention.
FLAIR: Switch to Long-Acting CAB + RPV Following Oral Induction in ART-Naive ...hivlifeinfo
March 4-7, 2019; Seattle, Washington
Higher patient-reported satisfaction with monthly injectable dual regimen compared with daily oral tablets.
Released: March 11, 2019
Confronting the Challenges of HIV Care in an Aging Population.2019hivlifeinfo
Еxpert faculty use case-based examples to examine considerations for aging patients with HIV. Topics include ART modification, bone loss, renal impairment, cardiovascular risk, and cognitive decline.
Слайдсет о новом в лечении ВИЧ.Key Slides on What’s Hot in HIV Treatment.2020 hivlifeinfo
Expert-authored slides on the latest issues relating to HIV care, featuring patient cases and considerations for optimal treatment approaches. Topics include integrating newer ARVs, individualizing ART for women of childbearing potential and during pregnancy, adverse events during ART, and anticipated roles of emerging ART strategies.
In this downloadable slideset, expert faculty members Andrew Carr, MBBS, MD, FRACP, FRCPA; Daniel R. Kuritzkes, MD; and Ian M. Sanne, MBBCH, FCP(SA), review key studies presented at the 2016 International AIDS Conference.
Format: Microsoft PowerPoint (.ppt)
File size: 1.28 MB
Date posted: 8/5/2016
Современное лечение ВИЧ: новые подходы к оптимизации АРТ/Contemporary Managem...hivlifeinfo
Вопросы, связанные с АРТ первого ряда, смена арв-стратегии для пациентов с вирусной супрессией, акцентом на возрастающую роль новыхантиретровирусных стратегий.
Key Slides on ART for HIV : Evolving Concepts and Innovative Strategies.2020hivlifeinfo
Expert-authored slides on evolving ART concepts, including simplification to 2-drug therapy, ART safety during pregnancy, weight gain, and long-acting injectable ART.
File Size: 580 KB
Released: October 20, 2020
Clinical Impact of New HIV Data From CROI 2019hivlifeinfo
March 4-7, 2019; Seattle, Washington
In this downloadable slideset, expert faculty members summarize key studies from this important annual conference.
Format: Microsoft PowerPoint (.ppt)
File Size: 576 KB
Released: March 22, 2019
Clinical Impact of New Data From AIDS 2020hivlifeinfo
current ART in principal populations, including older patients and women who become pregnant; metabolic outcomes during ART; HIV and COVID-19; investigational ART strategies; and HIV prevention.
FLAIR: Switch to Long-Acting CAB + RPV Following Oral Induction in ART-Naive ...hivlifeinfo
March 4-7, 2019; Seattle, Washington
Higher patient-reported satisfaction with monthly injectable dual regimen compared with daily oral tablets.
Released: March 11, 2019
Confronting the Challenges of HIV Care in an Aging Population.2019hivlifeinfo
Еxpert faculty use case-based examples to examine considerations for aging patients with HIV. Topics include ART modification, bone loss, renal impairment, cardiovascular risk, and cognitive decline.
Слайдсет о новом в лечении ВИЧ.Key Slides on What’s Hot in HIV Treatment.2020 hivlifeinfo
Expert-authored slides on the latest issues relating to HIV care, featuring patient cases and considerations for optimal treatment approaches. Topics include integrating newer ARVs, individualizing ART for women of childbearing potential and during pregnancy, adverse events during ART, and anticipated roles of emerging ART strategies.
In this downloadable slideset, expert faculty members Andrew Carr, MBBS, MD, FRACP, FRCPA; Daniel R. Kuritzkes, MD; and Ian M. Sanne, MBBCH, FCP(SA), review key studies presented at the 2016 International AIDS Conference.
Format: Microsoft PowerPoint (.ppt)
File size: 1.28 MB
Date posted: 8/5/2016
Современное лечение ВИЧ: новые подходы к оптимизации АРТ/Contemporary Managem...hivlifeinfo
Вопросы, связанные с АРТ первого ряда, смена арв-стратегии для пациентов с вирусной супрессией, акцентом на возрастающую роль новыхантиретровирусных стратегий.
Ключевые слайды по индивидуальному выбору АРТ / Key Slides on Individualized ...hivlifeinfo
Слайды с последними данные и рекомендациями по выбору АРТ, как для пациентов, ранее не получавших лечения, так и пациентов с вирусологической супрессией. Оценки разных вариантов лечения, индивидуализация АРТ для женщин детородного возраста и во время беременности, пациентов с опортунистическими инфекциями и новые данные об исследовательских стратегиях АРТ.
Key Slides on Individualizing ART Management Based on Treatment Safety and To...hivlifeinfo
Обзор последних рекомендаций DHHS , индивидуализация лечения в отдельных группах пациентов, минимизация побочных эффектов и межлекарственных взаимодействий
Современное лечение ВИЧ: новые парадигмы в АРТ / Contemporary Management of H...hivlifeinfo
Набор слайдов c рассмотрением важных вопросов об АРТ первого ряда, арв-препаратами пролонгированного действия и схемами АРТ с двумя препаратами, акцент в публикации на роль новых стратегий.
In this downloadable slideset, Joel E. Gallant, MD, MPH, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at upcoming agents currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 3.00 MB
Date posted: 6/15/2015
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусологической супре...hivlifeinfo
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусологической супрессией (2021) / Contemporary Management of HIV: Modifying ART in Virologically Suppressed Patients 2021
Contemporary Management of HIV.How Aging Affects ART Management.2018hivlifeinfo
In this downloadable slideset, Expert Faculty review key data on managing aging patients with HIV.
Format: Microsoft PowerPoint (.ppt)
File size: 720 KB
Date posted: 3/7/2018
Сравнение режимов лечения ВИЧ в разрезе различных клинических сценариев.ART...hivlifeinfo
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
Современное лечение ВИЧ.Усилить или не усилить : преимущества и недостатки бу...hivlifeinfo
Современное лечение ВИЧ.Усилить или не усилить : преимущества и недостатки бустированных режимов АРТ / Contemporary Management of HIV.To Boost or Not to Boost-Advantages and Disadvantages of Boosted ART.2017
In this downloadable slideset, Eric S. Daar, MD, and Program Director Joseph J. Eron, Jr., MD, review advantages and disadvantages of boosted ART regimens for managing patients with HIV.
Format: Microsoft PowerPoint (.ppt)
File size: 514 KB
Date posted: 6/16/2017
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусной супрессией и ...hivlifeinfo
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусной супрессией и у пациентов с вирусологической неудачей. /Contemporary Management of HIV. Modifying Antiretroviral Therapy in Virologically Suppressed Patients and Those With Treatment Failure.2016
In this downloadable slideset, W. David Hardy, MD, and Program Director Eric S. Daar, MD review key data and optimal approaches for modifying ART in patients who are virologically suppressed or have experienced treatment failure.
Format: Microsoft PowerPoint (.ppt)
File size: 2.07 MB
Модификация схем АРТ у пациентов с вирусной супрессией и после вирусологичес...hivlifeinfo
Best Practices in Antiretroviral Therapy: Switching ART in Virologically Suppressed Patients and After Virologic Failure
In this downloadable slideset, Joseph J. Eron, Jr., MD, discusses data on changing antiretroviral therapy in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 2.06 MB
HIV Alert:ART Considerations for Aging Patients.2018hivlifeinfo
In this downloadable slideset, Eric S. Daar, MD, and David A. Wohl, MD, provide expert recommendations for older patients with HIV, both in terms of ART selection and general management.
Format: Microsoft PowerPoint (.ppt)
File size: 545 KB
Date posted: 2/12/2018
Should Integrase Inhibitors Be Your First Choice When Starting HIV Therapy- E...Hivlife Info
In this downloadable slideset, Joseph J. Eron, Jr., MD, and Daniel Kuritzkes, MD, review key data on the evolving use of INSTIs in patients beginning HIV therapy.
Format: Microsoft PowerPoint (.ppt)
File size: 2.29 MB
In this downloadable slideset, Joseph J. Eron, Jr., MD, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at potential future agents and strategies currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 2.06 MB
Date posted: 6/1/2016
Новые данные с конференции по ВИЧ-инфекции CROI 2017/Clinical Impact of New D...hivlifeinfo
Clinical Impact of New Data From CROI 2017
Expert faculty members Joel E. Gallant, MD, MPH, and Charles B. Hicks, MD, summarize key studies from this important annual conference.
Format: Microsoft PowerPoint (.ppt)
File size: 1.25 MB
Date posted: 3/3/2017
Начало АРТ впервые.Наилучшая практика.Best Practices in Antiretroviral Therap...hivlifeinfo
Best Practices in Antiretroviral Therapy: Initiating First-line Therapy
In this downloadable slideset, Charles B. Hicks, MD, discusses data on initiating antiretroviral therapy in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 2.16 MB
Современное лечение ВИЧ : АРТ как профилактика.Contemporary Management of HIV...hivlifeinfo
Contemporary Management of HIV. Antiretroviral Therapy As Prevention.2016
In this downloadable slideset, Kenneth Mayer, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for pre- and post-exposure prophylaxis in patients at risk for HIV infection.
Format: Microsoft PowerPoint (.ppt)
File size: 2.13 MB
Современное лечение ВИЧ.Объединенные данные с конференции IAS 2019 / Contemp...hivlifeinfo
Review key HIV data from IAS 2019 on the updated NTD risk in women receiving ART at conception, PrEP, first-line and switch options, and early-phase investigational strategies.
Ключевые слайды по индивидуальному выбору АРТ / Key Slides on Individualized ...hivlifeinfo
Слайды с последними данные и рекомендациями по выбору АРТ, как для пациентов, ранее не получавших лечения, так и пациентов с вирусологической супрессией. Оценки разных вариантов лечения, индивидуализация АРТ для женщин детородного возраста и во время беременности, пациентов с опортунистическими инфекциями и новые данные об исследовательских стратегиях АРТ.
Key Slides on Individualizing ART Management Based on Treatment Safety and To...hivlifeinfo
Обзор последних рекомендаций DHHS , индивидуализация лечения в отдельных группах пациентов, минимизация побочных эффектов и межлекарственных взаимодействий
Современное лечение ВИЧ: новые парадигмы в АРТ / Contemporary Management of H...hivlifeinfo
Набор слайдов c рассмотрением важных вопросов об АРТ первого ряда, арв-препаратами пролонгированного действия и схемами АРТ с двумя препаратами, акцент в публикации на роль новых стратегий.
In this downloadable slideset, Joel E. Gallant, MD, MPH, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at upcoming agents currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 3.00 MB
Date posted: 6/15/2015
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусологической супре...hivlifeinfo
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусологической супрессией (2021) / Contemporary Management of HIV: Modifying ART in Virologically Suppressed Patients 2021
Contemporary Management of HIV.How Aging Affects ART Management.2018hivlifeinfo
In this downloadable slideset, Expert Faculty review key data on managing aging patients with HIV.
Format: Microsoft PowerPoint (.ppt)
File size: 720 KB
Date posted: 3/7/2018
Сравнение режимов лечения ВИЧ в разрезе различных клинических сценариев.ART...hivlifeinfo
This downloadable slideset summarizes optimal evidence-based antiretroviral therapy management strategies for a series of challenging clinical cases and is based on a satellite symposium presented at HIV Glasgow 2016.
Format: Microsoft PowerPoint (.ppt)
File size: 1.32 MB
Date posted: 11/11/2016
Современное лечение ВИЧ.Усилить или не усилить : преимущества и недостатки бу...hivlifeinfo
Современное лечение ВИЧ.Усилить или не усилить : преимущества и недостатки бустированных режимов АРТ / Contemporary Management of HIV.To Boost or Not to Boost-Advantages and Disadvantages of Boosted ART.2017
In this downloadable slideset, Eric S. Daar, MD, and Program Director Joseph J. Eron, Jr., MD, review advantages and disadvantages of boosted ART regimens for managing patients with HIV.
Format: Microsoft PowerPoint (.ppt)
File size: 514 KB
Date posted: 6/16/2017
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусной супрессией и ...hivlifeinfo
Современное лечение ВИЧ: модификация АРТ у пациентов с вирусной супрессией и у пациентов с вирусологической неудачей. /Contemporary Management of HIV. Modifying Antiretroviral Therapy in Virologically Suppressed Patients and Those With Treatment Failure.2016
In this downloadable slideset, W. David Hardy, MD, and Program Director Eric S. Daar, MD review key data and optimal approaches for modifying ART in patients who are virologically suppressed or have experienced treatment failure.
Format: Microsoft PowerPoint (.ppt)
File size: 2.07 MB
Модификация схем АРТ у пациентов с вирусной супрессией и после вирусологичес...hivlifeinfo
Best Practices in Antiretroviral Therapy: Switching ART in Virologically Suppressed Patients and After Virologic Failure
In this downloadable slideset, Joseph J. Eron, Jr., MD, discusses data on changing antiretroviral therapy in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 2.06 MB
HIV Alert:ART Considerations for Aging Patients.2018hivlifeinfo
In this downloadable slideset, Eric S. Daar, MD, and David A. Wohl, MD, provide expert recommendations for older patients with HIV, both in terms of ART selection and general management.
Format: Microsoft PowerPoint (.ppt)
File size: 545 KB
Date posted: 2/12/2018
Should Integrase Inhibitors Be Your First Choice When Starting HIV Therapy- E...Hivlife Info
In this downloadable slideset, Joseph J. Eron, Jr., MD, and Daniel Kuritzkes, MD, review key data on the evolving use of INSTIs in patients beginning HIV therapy.
Format: Microsoft PowerPoint (.ppt)
File size: 2.29 MB
In this downloadable slideset, Joseph J. Eron, Jr., MD, reviews the evidence behind the latest antiretroviral guidelines and offers a glimpse at potential future agents and strategies currently under investigation.
Format: Microsoft PowerPoint (.ppt)
File size: 2.06 MB
Date posted: 6/1/2016
Новые данные с конференции по ВИЧ-инфекции CROI 2017/Clinical Impact of New D...hivlifeinfo
Clinical Impact of New Data From CROI 2017
Expert faculty members Joel E. Gallant, MD, MPH, and Charles B. Hicks, MD, summarize key studies from this important annual conference.
Format: Microsoft PowerPoint (.ppt)
File size: 1.25 MB
Date posted: 3/3/2017
Начало АРТ впервые.Наилучшая практика.Best Practices in Antiretroviral Therap...hivlifeinfo
Best Practices in Antiretroviral Therapy: Initiating First-line Therapy
In this downloadable slideset, Charles B. Hicks, MD, discusses data on initiating antiretroviral therapy in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt)
File size: 2.16 MB
Современное лечение ВИЧ : АРТ как профилактика.Contemporary Management of HIV...hivlifeinfo
Contemporary Management of HIV. Antiretroviral Therapy As Prevention.2016
In this downloadable slideset, Kenneth Mayer, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for pre- and post-exposure prophylaxis in patients at risk for HIV infection.
Format: Microsoft PowerPoint (.ppt)
File size: 2.13 MB
Современное лечение ВИЧ.Объединенные данные с конференции IAS 2019 / Contemp...hivlifeinfo
Review key HIV data from IAS 2019 on the updated NTD risk in women receiving ART at conception, PrEP, first-line and switch options, and early-phase investigational strategies.
Washington Global Health Alliance Discovery Series
Catherine Wilfert, MD [
December 1, 2008
'Global Prevention of Mother to Child Transmission of HIV-1'
Случаи и разногласия по ВИЧ в 2019 году: европейские перспективы / Cases and...hivlifeinfo
Learn unique perspectives across Europe on PrEP, rapid ART initiation, ART in women, and options for switching ART.
Format: Microsoft PowerPoint (.ppt)
File Size: 1.33 MB
Released: July 10, 2019
Contemporary Management of HIV. New Data From IDWeek 2018 and Other Fall 2018...hivlifeinfo
Contemporary Management of HIV. New Data From IDWeek 2018 and Other Fall 2018 HIV Conferences
Format: Microsoft PowerPoint (.ppt)
File Size: 690 KB
Released: December 5, 2018
Clinical Impact of New Data From AIDS 2018hivlifeinfo
Clinical Impact of New Data From AIDS 2018
July 23-27, 2018; Amsterdam, The Netherlands
Expert faculty members summarize key studies from this important annual conference.
AIDSTAR-One Implementation of WHO's 2008 Pediatric HIV Treatment GuidelinesAIDSTAROne
In April 2008, the WHO Technical Reference Group for Pediatric HIV/ART and Care released a series of nine updated recommendations for diagnostic testing, initiation of treatment, and appropriate treatment regimens for HIV-exposed and infected infants. This technical brief outlines practical implementation considerations for program planners and policymakers working to incorporate these recommendations into their local efforts.
http://www.aidstar-one.com/implementation_whos_2008_pediatric_hiv_treatment_guidelines
Pre and Post Exposure Prophylaxis and HIV Prevention presented by Dr. Ken Mayer, Research Director of the Fenway Health Center at the Fenway Health Center community education conference: An End To AIDS - How A State Bill Can Change Everything hosted by SearchForACure.org, the Fenway Health Center, and the MA Dept. of Public Health
DIAGNOSIS OF PEDIATRIC INFECTIOUS DISEASES - Slideset by professor Susanna Esposito, president WAidid, presented at the 7th International Congress of Laboratory and Clinic, held in Tehran (Iran) from 12 to 14 February 2015
Ομιλία-Παρουσίαση: Γιώτα Τουλούμη, Καθηγήτρια Βιοστατιστικής και Επιδημιολογίας, Εργαστήριο Υγιεινής, Επιδημιολογίας και Ιατρικής Στατιστικής, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Дискуссии о здоровом старении с ВИЧ /Key Slides on Healthy Aging With HIV.2022hivlifeinfo
Дискуссии о здоровом старении с ВИЧ
Узнайте о медицинских и немедицинских проблемах, с которыми сталкиваются стареющие пациенты с ВИЧ, включая дополнительные проблемы, с которыми сталкиваются пожилые женщины и пожилые люди, живущие в условиях ограниченных ресурсов.
Основы ведения АРТ у многократно леченных пациентов 2022 / Foundations of ART...hivlifeinfo
Основы ведения АРТ у многократно леченных пациентов (2022)
Тактики ведения пациентов с большим опытом лечения, включая анализ резистентности, последние рекомендации и данные по новым схемам АРТ
Современное лечение и профилактика ВИЧ : передовые стратегии лечения у пациен...hivlifeinfo
Стратегии смены АРТ у пациентов с вирусной супрессией, включая смену АРТ при резистентности, рекомендации по инъекционным препаратам длительного действия , смена АРТ до или во время беременности
Гиперлипопротеидемия(а) как опасное генетически обусловленное нарушение липид...hivlifeinfo
Гиперлипопротеидемия(а) как опасное генетически обусловленное нарушение липидного обмена и фактор риска атеротромбоза и сердечно-сосудистых заболеваний
Липопротеид(а) [Лп(а)] представляет собой сложный надмолекулярный комплекс, принадлежащий к апоВ100 содержащим липопротеидам. Лп(а) состоит из ЛНП-подобной частицы, в которой молекула апобелка В100 ковалентно связана дисульфидной связью с уникальной полиморфной молекулой апобелка(а). Концентрация Лп(а) генетически контролируется, при этом варьирует в очень широком диапазоне. Повышенный уровень Лп(а) является независимым фактором риска атеросклероза коронарных, сонных и периферических артерий, ИБС и стеноза аортального клапана, сопутствующих сердечно-сосудистых осложнений, а также осложнений после операций реваскуляризации миокарда. Несмотря на это, уровень Лп(а) по-прежнему не учитывается в стратификации риска сердечно-сосудистых заболеваний. Отчасти, это может быть связано с тем, что ни современная лекарственная терапия, ни новые поколения биологических гиполипидемических препаратовтерапия практически не влияют на концентрацию Лп(а), за исключением 20-30% снижения Лп(а) никотиновой кислотой и ингибиторами пропротеиновой конвертазы субтилизин-кексин 9 типа (PCSK9).
Лекция освящает современные представления о Лп(а), как факторе риска сердечно-сосудистых заболеваний, возможности и целесообразности его определения, а также посвящена современным возможностям коррекции гиперлипопротеидемии(а).
Физическая активность и физические тренировки как метод профилактики сердечно...hivlifeinfo
Чушкин М.И., Мандрыкин С.Ю., Карпина Н.Л., Попова Л.А. Физическая активность и физические тренировки как метод профилактики сердечно-сосудистых заболеваний. Кардиология. 2018;58(9S):10-18
Большое число данных свидетельствует, что функциональные возможности кардиореспираторной системы являются не менее важным фактором прогноза летальности, чем курение, артериальная гипертензия, ожирение, гиперхолестеринемия, СД. Пациенты с большей физической активностью имеют значительно меньший риск ССЗ, чем пациенты, ведущие неактивный образ жизни. В данном обзоре авторы показали возможности оценки физической активности и основные положения назначения физических тренировок для сохранения и повышения функциональных возможностей кардиореспираторной системы.
Современное лечение ВИЧ.Обобщённые данные с конференции CROI 2020 / Contempor...hivlifeinfo
Современное лечение ВИЧ.Обобощенные данные с конференции CROI 2020 / Contemporary Management of HIV.Integrating New Data From CROI 2020
Широкий спектр вопросов, включая стратегии АРТ на поздних стадихя заболевания, менеджмент ожирения, метаболические исходы АРТ, данные по АРТ во время беременности и пр
Format: Microsoft PowerPoint (.ppt)
File Size: 554 KB
Released: April 14, 2020
Свобода интернета 2018: делегирование репрессий.Доклад Международной Агорыhivlifeinfo
«Настоящий доклад посвящен обзору вмешательства в свободу интернета в России в 2018 году и основан на данных постоянного мониторинга ситуации, который мы ведем более 10 лет.
Как обычно, доклад состоит из двух основных разделов, первый из которых посвящен описанию результатов мониторинга с приведением наиболее показательных примеров, а второй – авторской оценке состояния свободы интернета. В приложении даны сводные результаты мониторинга в виде таблицы со ссылкой на дату, источник, регион и вид ограничения по каждому известному эпизоду, а также карта нарушений, на которой цветом обозначен уровень относительной свободы интернета в отдельных субъектах Федерации.»
https://guides.files.bbci.co.uk/bbc-russian/AGORA_Freedom-of-the-Internet-2018.pdf
Предиабет-определение, риски, подходы к диагностике и профилактике сахарного ...hivlifeinfo
Предиабет-определение, риски, подходы к диагностике и профилактике сахарного диабета 2 типа и сердечно-сосудистых осложнений.Консенсус экспертов РКО.2019
"Результаты международного эпидемиологического проекта HAPIEЕ показали, что распространенность преддиабета в Российской Федерации (РФ), определяемого по нарушенной гликемии натощак, может быть еще выше — от 28,1% при отрезной точке по уровню глюкозы плазмы ≥6,1 ммоль/л (критерий Российской ассоциации эндокринологов) до 54.8 % при при отрезной точке по уровню глюкозы плазмы ≥5,6 ммоль/л (критерий ADA), соответственно."
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
1. In partnership with
Clinical Impact of New Data From IAS 2019
This activity is supported by independent educational grants from
Gilead Sciences and ViiV Healthcare
CCO Official Conference Coverage
of the 10th IAS Conference on HIV Science,
July 21-24, 2019; Mexico City, Mexico
2. About These Slides
Please feel free to use, update, and share some or all of these slides in
your noncommercial presentations to colleagues or patients
When using our slides, please retain the source attribution:
These slides may not be published, posted online, or used in
commercial presentations without permission. Please contact
permissions@clinicaloptions.com for details
Slide credit: clinicaloptions.com
3. Faculty
Brenda E. Crabtree Ramírez, MD
IAS 2019 Local Scientific Co-Chair
Assistant Professor, HIV Program
Department of Infectious Diseases
Instituto Nacional de Ciencias
Médicas y Nutrición, Salvador Zubirán
Mexico City, Mexico
Anton L. Pozniak, MD, FRCP
IAS 2019 International Scientific
Co-Chair
Consultant Physician
Department of HIV and
Genitourinary Medicine
Chelsea and Westminster Hospital
NHS Foundation Trust
London, United Kingdom
4. Faculty Disclosures
The faculty reported the following financial relationships or relationships
to products or devices they or their spouse/life partner have with
commercial interests related to the content of this CME/CE activity:
Brenda E. Crabtree Ramírez, MD, has disclosed that she has received
consulting fees from Merck Sharp & Dohme and ViiV Healthcare and
funds for research support from Merck Sharp & Dohme.
Anton L. Pozniak, MD, FRCP, has disclosed that he has received
consulting fees from Cipla, Gilead Sciences, Janssen, Merck, and ViiV
Healthcare.
6. Tsepamo: Neural Tube Defects and DTG Exposure
Birth outcomes surveillance study among Botswanan women ± HIV infection
‒ Initial findings in May 2018 found apparent increase in NTD incidence among women
who conceived while receiving DTG[1]
‒ Warnings issued from WHO, EMA, FDA regarding use of DTG at time of conception[2-4]
and some countries halted plans to use DTG-based ART as preferred first-line therapy
Current analysis reports updated birth outcomes as of March 2019[5,6]
‒ From July to September 2018, surveillance area expanded to capture ~ 72% of all births
in Botswana; data abstracted from obstetric cards of all in-hospital deliveries
‒ Government midwives trained to assess congenital abnormalities performed infant
surface exams; abnormalities photographed with maternal consent and reviewed by
external medical geneticist (blinded to drug exposure history)
Slide credit: clinicaloptions.com
1. Zash. NEJM. 2018;379:979. 2. WHO Statement. May 2018. 3. EMA Statement. May 2018.
4. FDA. Sep 2018. 5. Zash. IAS 2019. Abstr MOAX0105LB. 6. Zash. NEJM. 2019;[Epub].
7. 0.09
0.080.030.04
Tsepamo: NTD Prevalence by ARV Exposure
As of March 2019, rate of NTDs with DTG at
conception lower than initially signaled[1,2]
No significant difference in major external
structural malformations with DTG vs non-DTG
ART[1,2]
WHO released updated recommendations
reconfirming use of DTG-based ART as preferred
first-line and second-line therapy[3]
Slide credit: clinicaloptions.com
Outcome
At Conception DTG in
Pregnancy
(n = 3840)
HIV Negative
(n = 89,372)
DTG
(n = 1683)
Non-DTG
(n = 14,792)
EFV
(n = 7959)
NTDs per exposures, n/N 5/1683 15/14792 3/7959 1/3840 70/89372
Prevalence difference, % (95% CI) Reference
0.20
(0.01-0.59)
0.26
(0.07-0.66)
0.27
(0.06-0.67)
0.22
(0.05-0.62)
NTDs per exposures since May 2018, n/N 1/1275 1/3492 0/2172 1/1028 9/23,315
1. Zash. IAS 2019. Abstr MOAX0105LB. 2. Zash. NEJM. 2019;[Epub]. 3. WHO ARV Policy Update. July 2019.
Pre-May 2018
Current analysis
DTG Any Non-
DTG ART
EFV HIV
Negative
Pregnancy
NTDs,%(95%CI)
DTG
Conception
0.30
0.10 0.05
0.00
0.5
1
0
0.94
0.12
8. Tsepamo: Additional Adverse Birth Outcomes
No difference between DTG and EFV for any single adverse birth
outcome, including preterm/very preterm birth (< 37/< 32 wks), small
gestational age, stillbirth, in-hospital neonatal death
Analysis included single births since October 2016
Zash. IAS 2019. Abstr MOAX0105LB. Slide credit: clinicaloptions.com
Birth Outcome, n (%)
DTG at Conception
(n = 1271)
EFV at Conception
(n = 4430)
Adjusted RR
(95% CI)*
Any adverse 422 (33.2) 1550 (35.0) 0.94 (0.86-1.02)
Any severe (SB, NND, vPTB, vSGA) 151 (11.9) 568 (12.8) 0.89 (0.74-1.05)
*Adjusted for maternal age, education, gravida.
9. Additional NTD Data From Botswana and Brazil
Prospective birth outcomes surveillance study among Botswanan women commissioned by
Botswana Ministry of Health and Wellness in response to May 2018 Tsepamo findings[1]
‒ Surveillance area included 22 facilities not covered by Tsepamo (October 2018 to March 2019);
potential NTDs evaluated by trained midwives prior to discharge with suspected NTDs reviewed
by blinded geneticist
Slide credit: clinicaloptions.com
Outcome
HIV Positive
HIV Negative
(n = 2328)
DTG
(n = 152)
Any Non-DTG ART
(n = 381)
EFV
(n = 261)
NTDs, n (%) [95% CI]
1 (0.66)
[0.02 to 3.69]
0 (0)
[0 to 0.79]
0 (0)
[0 to 1.15]
2 (0.09)
[0.01 to 0.31]
Prevalence difference,
% (95% CI)
Reference
0.66
(-0.73 to 4.16)
0.66
(-1.25 to 4.16)
0.58
(-0.10 to 4.10)
1. Raesima. IAS 2019. Abstr MOAX0106LB. 2. Pereira. IAS 2019. Abstr MOAX0104LB.
Retrospective cohort of Brazilian women with HIV found no NTDs among births to women
with possible exposure to DTG at conception from 2017-2018 (n = 384)[2]
11. ImPREP: Same-Day PrEP With TDF/FTC for High-Risk
MSM and TGW in Brazil, Mexico, and Peru
Prospective, open-label demonstration study of same-day PrEP in MSM and TGW
at high risk of HIV infection (≥ 1 risk criteria)
Eligible participants were screened and enrolled on the same day to receive a
30-day supply of TDF/FTC
‒ Study enrolled 5019 MSM (94%) and 335 TGW (6%)
Primary outcomes
‒ PrEP early continuation: attendance to the first 2 follow-up visits within 120 days of
PrEP initiation
‒ PrEP adherence: ≥ 16 days of PrEP medication filled per 30-day period (medication
possession ratio ≥ 0.53)
Veloso. IAS 2019. Abstr TUAC0404LB. Slide credit: clinicaloptions.com
12. ImPREP: Levels of Early Continuation and Adherence
Veloso. IAS 2019. Abstr TUAC0404LB. Slide credit: clinicaloptions.com
Population
Early
Continuation, %
Medication
Possession Ratio
≥ 0.53, %
Follow-up, PY
HIV Incidence per
100 PY (95% CI)
Brazil 85.4 98.7 1438.6 0.2 (0.1-0.6)
Mexico 84.0 98.0 344.0 0.6 (0.2-2.3)
Peru 52.7 91.0 286.4 2.4 (1.2-5.1)
Overall
TGW
79.6
55.7
97.2
88.7
2069.0
--
0.6 (0.3-1.0)
--
13. ANRS Prevenir: Daily vs On-Demand PrEP With FTC/TDF
Multicenter, open-label, prospective cohort study mainly in MSM (98.6%) from Paris
HIV-negative adults at high risk of
HIV infection with inconsistent
condom use; eGFR ≥ 50 mL/min;
HBsAg negative in on-demand arm
(N = 3045)*
Daily FTC/TDF PrEP†
(n = 1546)
On-Demand FTC/TDF PrEP†
(n = 1499)
*Participants enrolled on arm of their choice with ability to switch. †Plus condoms, gels, risk reduction and adherence counseling, questionnaire on
sexual behavior. Follow-up every 3 mos with STI and/or HIV testing, plasma creatinine measurement.
End of Study
May 31, 2020
Current Analysis
May 2, 2019
Slide credit: clinicaloptions.com
Beginning of Study
May 3, 2017
Molina. IAS 2019. Abstr TUAC0202.
Primary endpoint: ≥ 15% reduction in new HIV diagnoses among MSM in Paris vs rate
reported by National Surveillance network in 2016
Secondary endpoints: PrEP adherence, sexual behavior, safety
14. ANRS Prevenir: HIV Incidence
Global HIV incidence: 0.09/100 PY (n = 2)
‒ PrEP stopped 7-10 wks before infection in both cases
Mean follow-up: 8.7 mos
Overall HIV infections averted: n = 143
‒ Assuming incidence of 6.6/100 PY as reported for placebo arm in ANRS IPERGAY study
Rate of study discontinuation: 8.9/100 PY (n = 196)
Molina. IAS 2019. Abstr TUAC0202. Slide credit: clinicaloptions.com
mITT Analysis
Daily PrEP
(1072.9 PYFU)
On-Demand PrEP*
(1132.7 PYFU)
P Value
HIV incidence/100 PY (95% CI) 0 (0-0.3) 0.2 (0-0.6) .132
*On-demand PrEP strategy not FDA or EMA approved.
15. Incidence/100 PY
(95% CI)
Daily PrEP
(1072.9 PYFU)
On-Demand PrEP
(1132.7 PYFU)
Drug-related AEs†
Leading to d/c
11.4 (9.4-13.6)
0 (0-0.3)
13.2 (11.2-15.5)
0.3 (0-0.8)‡
Grade 3/4 AEs 5.3 (4.0-6.9) 4.4 (3.3-5.8)
Viral hepatitis 0.9 (0.5-1.7) 1.2 (0.6-2.0)
ALT abnormality
Grade 3/4
13.0 (10.9-15.3)
0.8 (0.4-1.6)
10.3 (8.5-12.4)
0.6 (0.3-1.3)
Grade 1 creatinine 15.4 (13.1-17.9) 15.6 (13.4-18.1)
CrCl
50-70 mL/min
< 50 mL/min
17.7 (15.3-20.4)
0.8 (0.4-1.6)
18.5 (16.1-21.2)
0.8 (0.4-1.5)
ANRS Prevenir: PrEP Adherence, Sexual Behavior, Safety
Daily PrEP users had:
‒ More sexual partners
‒ More frequent condomless sex
‒ Higher incidence of bacterial STIs
Slide credit: clinicaloptions.com
At Last Sexual
Encounter, n (%)
Daily PrEP
(3806 Acts)
On-Demand PrEP
(3879 Acts)
PrEP use
Correct*
3705 (97.3)
3613 (97.5)
3188 (82.2)
3072 (96.4)
Condom use 716 (18.8) 851 (21.9)
Participants with adherence data, n = 2134.
*Per protocol, or at least 1 pill before and after within 24 hrs.
†Most were gastrointestinal. ‡Grade 3 vomiting, grade 1 diarrhea,
grade 1 nausea/headache/dizziness; each n = 1.
Molina. IAS 2019. Abstr TUAC0202.
16. DISCOVER: FTC/TAF vs FTC/TDF as PrEP in MSM, TGW
International, randomized, double-blind, active-controlled phase III trial
Slide credit: clinicaloptions.com
Adult cis-MSM or TGW at
high risk of HIV infection,*
no HBV infection, previous
PrEP use permitted
(N = 5387)
Primary analysis of HIV incidence/100 PY:
Conducted when 100% of patients completed
Wk 48 and 50% completed Wk 96
FTC/TAF 200/25 mg QD
(n = 2694)
FTC/TDF 200/300 mg QD
(n = 2693)
Wk 96Wk 48
0.16
0.34
IRR: 0.47 (95% CI: 0.19-1.15)
Noninferiority established
because upper bound of
95% CI < 1.62
*Defined as ≥ 2 episodes of condomless anal sex within past 12 wks or rectal gonorrhea, chlamydia, or syphilis within past 24 wks.
Spinner. IAS 2019. Abstr TUAC0403LB. Hare. CROI 2019. Abstr 104LB.
Current analysis assessed whether adherence, PK, sexual behavior, or STI incidence
could account for observed differences in HIV infection rates
17. DISCOVER: Onset and Duration of Protection With
FTC/TAF vs FTC/TDF as PrEP
Adherence comparable between arms
by self-report over time, pill count
(median adherence: 98% in each arm),
and TFV-DP levels in DBS
Steady-state PBMC TFV-DP levels
were 6.3-fold higher with FTC/TAF vs
FTC/TDF
Modeling found that concentrations
> EC90 would last for 16 days after
final dose of FTC/TAF vs 10 days after
FTC/TDF
FTC/TAF
(n = 158)
FTC/TDF
(n = 151)
PBMCTFV-DPLevels(fmol/106cells)
EC90 = 40 fmol/106 cells
(associated with 90%
HIV risk reduction)
PBMC TFV-DP Levels at 20-28 h Postdose
100,000
10,000
1000
100
10
1
404
61
98% of
participants
> EC90
68% of
participants
> EC90
Spinner. IAS 2019. Abstr TUAC0403LB. Reproduced with permission. Slide credit: clinicaloptions.com
18. DISCOVER: Sexual Behaviors and STI Incidence
Sexual behavior and STI incidence comparable between arms
‒ AE-based incidence of chlamydia, gonorrhea, and syphilis: 145/100 PY with FTC/TAF,
139/100 PY with FTC/TDF
Spinner. IAS 2019. Abstr TUAC0403LB. Reproduced with permission. Slide credit: clinicaloptions.com
Wk
Number of Condomless
Receptive Anal Sex Partners Lab-Based Rectal Gonorrhea/Chlamydia
10
8
6
4
2
0
MeanNo.ofPartners(SD)
0 12 24 36 48 60 72 84 96
FTC/TAF
FTC/TDF
Wk
20
15
10
5
0
Participants(%)
0 12 24 36 48 60 72 84 96
19. DISCOVER: Adherence by DBS at HIV Diagnosis Visit in
Nested Case-Control Study
Low adherence (< 2 doses/wk) associated with significantly increased risk of HIV
infection in both arms (both P < .001)
Spinner. IAS 2019. Abstr TUAC0403LB. Reproduced with permission. Slide credit: clinicaloptions.com
HIV Cases
(n = 7)
FTC/TAF FTC/TDF
HIV-Negative
Controls
(n = 35)
HIV Cases
(n = 15)
HIV-Negative
Controls
(n = 75)
P < .001
P < .001
MedianTFV-DPConcentration,
fmol/punch(es)(Q1,Q3)
2500
2000
1500
900
450
0
≥ 4 doses/wk
2-3 doses/wk
< 2 doses/wk
Adherence
2000
1500
1000
700
350
0
20. DISCOVER: Rapidity in Achieving EC90
In a phase I study in healthy volunteers, median PBMC TFV-DP concentration > EC90 reached
within 1-2 hrs (all within 4 hrs) of dosing with FTC/TAF vs 3 days of dosing with FTC/TDF
Spinner. IAS 2019. Abstr TUAC0403LB. Reproduced with permission. Slide credit: clinicaloptions.com
MedianTFV-DPConcentration,
fmol/106cells(Range)
10000
1000
100
10
1
0.1
FTC/TAF
FTC/TDF
0 2 4 8 24
Hours
EC90
First Dose
22. ANRS 12300 Reflate TB2: (RAL vs EFV) + 3TC/TDF
in ART-Naive Patients With HIV and Tuberculosis
International, randomized, open-label phase III noninferiority trial
Primary endpoint: HIV-1 RNA < 50 copies/mL at Wk 48 by FDA
Snapshot algorithm in ITT population
‒ Noninferiority margin: -12%
Slide credit: clinicaloptions.com
RAL 400 mg BID + 3TC/TDF QD
(n = 228)
EFV 600 mg QD + 3TC/TDF QD
(n = 227)
Wk 48
ART-naive patients with HIV infection,
confirmed or probable TB, and ≤ 8 wks
of standard rifampin-based TB
treatment; no TB meningitis
(N = 455)
Stratified by country
De Castro. IAS 2019. Abstr MOAB0101.
23. ANRS 12300 Reflate TB2: Primary Endpoint at Wk 48
RAL 400 mg BID + 3TC/TDF did not meet criteria for noninferior efficacy
vs EFV 600 mg QD + 3TC/TDF
Slide credit: clinicaloptions.com
Virologic Outcomes (FDA Snapshot) RAL-EFV Treatment Difference (95% CI)
-13.9 3.7
-5.1
-12% NI margin
-12 -8 -4 0 4 8
RAL + 3TC/TDFEFV + 3TC/TDF
12-16 -14Virologic
Nonresponse
HIV-1 RNA
< 50 c/mL
No Virologic
Data
Patients(%)
60
100
80
20
40
0
66
61
22
29
1210
RAL + 3TC/TDF
EFV + 3TC/TDF
De Castro. IAS 2019. Abstr MOAB0101. Reproduced with permission.
24. AE, n (%)
RAL +
3TC/TDF
(n = 229)
EFV +
3TC/TDF
(n = 230)
Any AE 207 (90) 208 (90)
Grade 3/4 AEs
Grade 3
Grade 4
Drug related
•Leading to ART d/c
IRIS
Hepatotoxicity
Hypersensitivity
Renal failure
62 (27)
42 (18)
20 (9)
25 (11)
1 (< 1)
10 (4)
9 (4)
1 (< 1)
0 (0)
68 (30)
41 (18)
27 (12)
22 (10)
3 (< 1)
13 (6)
9 (4)
1 (1)
4 (2)
Endpoint
RAL +
3TC/TDF
(n = 228)
EFV +
3TC/TDF
(n = 227)
HIV-1 RNA < 50 c/mL, n (%) 139 (61) 150 (66)
Virologic nonresponse, n (%)
HIV-1 RNA ≥ 50 c/mL, n
D/c for lack of efficacy, n
D/c for other reasons with
last HIV-1 RNA ≥ 50 c/mL, n
66 (29)
45
13
8
50 (22)
31
9
10
No data in window, n (%)
D/c for AE or death, n
D/c for other reason, n
On study but missing data, n
23 (10)
12
11
0
27 (12)
18
7
2
ANRS 12300 Reflate TB2: Efficacy and Safety at Wk 48
Slide credit: clinicaloptions.comDe Castro. IAS 2019. Abstr MOAB0101.
25. ADVANCE: First-line DTG/FTC/TAF vs DTG/FTC/TDF vs
EFV/FTC/TDF
Multicenter, randomized, open-label phase III trial conducted in South Africa
Primary endpoint: HIV-1 RNA < 50 c/mL, d/c, or missing data at Wk 48 (FDA Snapshot in ITT)
‒ Noninferiority margin: -10%
Secondary endpoints: safety
Venter. IAS 2019. Abstr WEAB0405LB. Venter. NEJM. 2019;[Epub]. Slide credit: clinicaloptions.com
ART-naive patients age ≥ 12 yrs
with HIV-1 RNA ≥ 500 copies/mL,
no ART in prior 6 mos,
no TB or pregnancy,
no BL genotype, and
CrCl > 60 mL/min
(N = 1053)
DTG 50 mg QD + FTC/TAF QD
(n = 351)
DTG 50 mg QD + FTC/TDF QD
(n = 351)
EFV/FTC/TDF QD
(n = 351)
Wk 48
Primary Endpoint Wk 96
27. ADVANCE: Primary Efficacy and Resistance at Wk 48
Emergent NRTI resistance:
0 DTG + FTC/TAF vs 1 (0.3%) DTG +
FTC/TDF vs 4 (1.0%) EFV/FTC/TDF
Emergent NNRTI resistance:
0 DTG + FTC/TAF vs 0 DTG +
FTC/TDF vs 3 (1%) EFV/FTC/TDF
No emergent INSTI resistance
Among patients with HIV-1 RNA > 50
c/mL at Wk 48, DTG arm had n = 14
with resuppression after adherence
counseling, n = 3 without, n = 2 with
no f/u or early termination; EFV arm
had n = 7 with resuppression after
adherence counselling, n = 7
without, n = 2 with no f/u
Slide credit: clinicaloptions.com
Difference in HIV-1 RNA < 50 c/mL (98.3% CI)
-12-10 -8 -6 -4 -2 0 12108642 14
DTG + FTC/TAF
vs DTG + FTC/TDF (P = .68)
DTG + FTC/TDF
vs EFV/FTC/TDF (P = .03)
DTG + FTC/TAF
vs EFV/FTC/TDF (P = .08)
-1.1
-7.7 5.4
6.3
-0.7 13.2
-1.9
5.1
12.2
Venter. IAS 2019. Abstr WEAB0405LB. Reproduced with permission.
-10% NI margin
29. NAMSAL and ADVANCE: Study Design
Multicenter, randomized, open-label phase III trials[1-3]
Slide credit: clinicaloptions.com
DTG 50 mg + 3TC/TDF QD
(n = 310)
EFV 400 mg + 3TC/TDF QD
(n = 303)
ART-naive patients (≥ 12 yrs)
with HIV-1 RNA ≥ 500 c/mL
(N = 1053)
ADVANCE: South Africa
Wk 96
DTG 50 mg + FTC/TAF QD
(n = 351)
DTG 50 mg + FTC/TDF QD
(n = 351)
EFV 600 mg/FTC/TDF QD
(n = 351)
1. Hill. IAS 2019. Abstr MOAX0102LB. 2. NCT02777229. 3. NCT03122262.
4. NAMSAL ANRS 12313 Study Group. NEJM. 2019:[Epub]. 5. Venter. NEJM. 2019:[Epub].
ART-naive adults with
HIV-1 RNA > 1000 c/mL
(N = 613)
NAMSAL: Cameroon
Primary Endpoint (Both Trials)
HIV-1 RNA < 50 c/mL at Wk 48 by
FDA Snapshot in ITT population
(noninferiority margin: -10%)[4,5]
30. NAMSAL and ADVANCE: Progressive Weight Gain and
Clinical Obesity
Slide credit: clinicaloptions.com
Outcome
NAMSAL ADVANCE
DTG +
3TC/TDF
(n = 293)
EFV +
3TC/TDF
(n = 278)
P Value
DTG +
FTC/TAF
DTG +
FTC/TDF
EFV/
FTC/TDF
P Value
Mean Δ in weight, kg
Wk 48
Wk 96
+5
NA
+3
NA
< .001 +6
+8
+3
+5
+1
+2
< .001
Mean Δ in BMI at Wk 48 +1.7 +1.2 < .001 NR NR NR
Treatment-emergent
overweight (BMI 25-29.9), %
Wk 48
Wk 96
16
NA
17
NA
NS 23
25
14
13
9
11
NS
Treatment-emergent obesity
(BMI ≥ 30), %
Wk 48
Wk 96
12
NA
5
NA
< .01 14
19
7
8
6
4
< .01
Hill. IAS 2019. Abstr MOAX0102LB.
31. Significantly greater weight increase* with DTG vs EFV, with TAF vs TDF; plateauing
in weight gain after Wk 48 observed in men but not in women
ADVANCE: Mean Change in Weight to Wk 96 by Sex
Slide credit: clinicaloptions.com
Wk
Women
Hill. IAS 2019. Abstr MOAX0102LB. Reproduced with permission.
MeanWeightChange(kg)
Men
4
2
0
0 4 12 24 36
10
8
6
12
48 60 72 84 96
14
n = 430 418 402 387 376 374 366 292 232 140
+5 kg
+4 kg
+1 kg
NS
*Wilcoxon rank-sum comparison at Wk 96.
WkMeanWeightChange(kg)
4
2
0
0 4 12 24 36
10
8
6
12
48 60 72 84 96
DTG + FTC/TAF
DTG + FTC/TDF
EFV + FTC/TDF
14
n = 549 531 514 488 474 459 441 359 276 175
+10 kg
+5 kg
+3 kg
P<.05P<.001
P<.01
P<.001
P<.01
32. GEMINI-1 and -2: DTG + 3TC in ART-Naive Adults
Parallel, international, randomized, double-blind phase III noninferiority studies
Secondary endpoints at Wk 96: HIV-1 RNA < 50 copies/mL (FDA Snapshot and TRDF
analyses); AEs; resistance; changes from BL in bone, renal, and lipid parameters
Slide credit: clinicaloptions.com
ART-naive adults with
HIV-1 RNA 1000-500,000 copies/mL,
≤ 10 days on previous ART, no major
RT or PI resistance mutations, no HBV
infection or HCV requiring therapy
(N = 1433)
DTG + 3TC PO QD
(n = 716)
DTG + FTC/TDF PO QD
(n = 717)
Wk 144
Primary Endpoint
Wk 48
Stratified by HIV-1 RNA (≤ vs > 100,000 copies/mL),
CD4+ cell count (≤ vs > 200 cells/mm³)
Screening within 28 days of study start; studies double-blinded until Wk 96, open-label until Wk 144.
Continuation of
DTG + 3TC
permitted
Current Analysis
Wk 96
Cahn. IAS 2019. Abstr WEAB0404LB. NCT02831673. NCT02831764.
33. GEMINI-1 and -2: Virologic Response
DTG + 3TC met criteria for noninferior efficacy vs DTG + FTC/TDF at Wk 96
Slide credit: clinicaloptions.com
*Adjusted for BL HIV-1 RNA, BL CD4+ cell count, and study.
Endpoint, % (n)
DTG + 3TC
(n = 716)
DTG + FTC/TDF
(n = 717)
Difference,* %
(95% CI)
Responders 86.0 (616) 89.5 (642) -3.4 (-6.7 to 0)
HIV-1RNA<50copies/mL,
%(95%CI)
100
80
60
40
20
0
0 4 8 12 16 24 36 48 60 72 84 96
Wk
87.0
93.2 91.5 87.2 86.0
89.589.4
93.393.4
84.4
Cahn. IAS 2019. Abstr WEAB0404LB. Reproduced with permission.
Rates of HIV-1 RNA ≥ 50 copies/mL unchanged from Wk 48 to 96.
D/c for reasons other than AEs or death higher with DTG + 3TC at Wk 96 (8% vs 5% with 3-drug ART).
39. TANGO: Switch to DTG/3TC vs Continuing TAF-Based ART
International, randomized, open-label phase III noninferiority study
Slide credit: clinicaloptions.com
Adults with HIV-1 RNA < 50 c/mL for
> 6 mos on stable TAF-based ART*;
no prior VF, NRTI or INSTI resistance,
HBV infection or HCV requiring tx
(N = 741)
Switch to DTG/3TC
(n = 369)
Continue TAF-Based Regimen
(n = 372)
Wk 196
Primary Analysis
Wk 48
Stratified by BL third agent class
Continuation
of DTG/3TC
permitted
Wk 148
*Initial regimen of FTC/TAF + PI, NNRTI, or INSTI, or TDF switched to TAF ≥ 3 mos prior to screening with no other regimen changes.
DTG/3TC
Van Wyk. IAS 2019. Abstr WEAB0403LB. NCT03446573.
Primary endpoint: virologic failure at Wk 48 by FDA Snapshot analysis (ITT-E)
‒ Noninferiority margin: 4%
Secondary endpoint: safety
40. 0.5
Difference (%)
-3.4
0.2
-8 -6 -4 -2 0 2 4 6 8
3.9
Key Secondary Endpoint
(HIV-1 RNA < 50 c/mL)
DTG/3TC noninferior to
continued TAF-based ART
-8% NI
margin
TANGO: Virologic Outcomes by FDA Snapshot at Wk 48
Slide credit: clinicaloptions.com
TAF-Based ARTDTG/3TC
TAF-Based ART DTG/3TC
-1.2 0.7
-0.3
-8 -6 -4 -2 0 2 4 6 8
Patients(%)
100
80
40
60
20
0
HIV-1 RNA
≥ 50 c/mL
HIV-1 RNA
< 50 c/mL
No Virologic
Data
0.3
93.2 93.0
6.5 6.5
Switch to DTG/3TC
(n = 369)
Continue TAF-based ART
(n = 372)
Virologic Outcomes (ITT-E) Adjusted Treatment Difference (95% CI)*
Primary Endpoint
(HIV-1 RNA ≥ 50 c/mL)
DTG/3TC noninferior to
continued TAF-based ART
4% NI
margin
*Adjusted for baseline third agent class.
van Wyk. IAS 2019. Abstr WEAB0403LB.
No CVW in DTG/3TC arm, CVW in 1 (< 1%) patient in
TAF-based ART arm; no resistance detected at failure
All 7 patients (4 in DTG/3TC group, 3 in TAF-based ART
group) with proviral M184V/I mutation at baseline
maintained HIV-1 RNA < 50 c/mL at Wk 48
41. TANGO: Safety at Wk 48
Mean weight gain and frequency of weight gain
comparable between arms
Significantly higher elevation in some bone and
renal markers with DTG/3TC
Van Wyk J. IAS 2019. Abstr WEAB0403LB. Slide credit: clinicaloptions.com
AE, n (%)
DTG + 3TC
(n = 369)
TAF-Based
ART
(n = 371)
Any AE
Nasopharyngitis
Upper RTI
Diarrhea
Headache
Syphilis
Back pain
Fatigue
Bronchitis
295 (80)
43 (12)
31 (8)
30 (8)
24 (7)
24 (7)
21 (6)
20 (5)
8 (2)
292 (79)
41 (11)
32 (9)
26 (7)
17 (5)
13 (4)
28 (8)
3 (1)
20 (5)
AE, n (%)
DTG + 3TC
(n = 369)
TAF-Based
ART
(n = 371)
Drug-related grade 2-5 AE 17 (6) 3 (< 1)
Drug-related grade 2-5 AE
occurring in ≥ 0.5%*
Insomnia
Constipation
Flatulence
Headache
4 (1)
2 (1)
2 (1)
2 (1)
0
1 (< 1)
0
0
AEs leading to withdrawal
Drug-related AEs
leading to withdrawal
13 (4)†
9 (2)
2 (1)
1 (< 1)
Any serious AE‡ 21 (6) 16 (4)
*All drug-related AEs were grade 2 severity. †Includes 1 fatal AE due
to homicide. ‡None was drug related.
42. Study 380-4030: Switch to BIC/FTC/TAF From
DTG + FTC/(TAF or TDF)
Randomized, double-blind, active-controlled phase III noninferiority trial
Sax. IAS 2019. Abstr MOAB0105. Slide credit: clinicaloptions.com
Adults receiving DTG + FTC/(TAF or TDF) with
HIV-1 RNA < 50 copies/mL for ≥ 3-6 mos,* no known
INSTI resistance,† and no previous VF on INSTI
(N = 565)
BIC/FTC/TAF QD
(n = 284)
DTG + FTC/TAF QD
(n = 281)
Wk 48
*3 mos if no known NRTI resistance mutations, 6 mos with known/suspected resistance.
†Documented or suspected NRTI, NNRTI, or PI resistance permitted.
Stratified by known/suspected NRTI resistance at BL
(K65R or ≥ 3 TAMs vs other NRTI RAMs vs none)
Primary endpoint: HIV-1 RNA ≥ 50 c/mL at Wk 48 by FDA Snapshot algorithm
‒ Noninferiority margin: 4%
43. Switch to BIC/FTC/TAF noninferior to remaining on DTG-based ART; HIV-1 RNA
≥ 50 copies/mL not observed in any patient with preexisting NRTI resistance
HIV-1 RNA
< 50 c/mL
HIV-1 RNA
≥ 50 c/mL
No Virologic
Data
1/
284
3/
281
265/
284
256/
281
22/
281
18/
284
Study 380-4030: Virologic Outcomes at Wk 48
Sax. IAS 2019. Abstr MOAB0105. Reproduced with permission. Slide credit: clinicaloptions.com
Virologic Outcomes (FDA Snapshot)
BIC/FTC/TAF
(n = 284)
DTG + FTC/TAF
(n = 281)
Patients(%)
n/N =
100
80
40
60
20
0
< 1 1
93 91
6 8
-4 -2 0 2 4
Favors DTG + FTC/TAFFavors BIC/FTC/TAF
-0.7
1.0-2.8
HIV-1 RNA ≥ 50 copies/mL
Treatment Difference, % (95% CI)
44. Study 380-4030: Resistance Analyses
Among patients with virologic rebound (n = 3 in DTG + FTC/TAF arm),
no treatment-emergent resistance through Wk 48
Predictor of Preexisting
NRTI Resistance
Any NRTI Mutation Present M184V/I Present*
OR (95% CI) P Value OR (95% CI) P Value
Time since ART start (per yr) 1.1 (1.1-1.2) < .0001 1.1 (1.1-1.1) < .0001
Prior PI-containing regimen 2.0 (1.2-3.5) .0116 2.2 (1.1-4.2) .0189
Black race (vs nonblack) 2.1 (1.2-3.6) .0106 2.5 (1.4-4.6) .0026
History of PI resistance 3.0 (1.3-6.9) .0123 2.6 (1.1-6.0) .0295
History of NNRTI resistance 2.4 (1.4-4.0) .0014 2.7 (1.5-4.7) .0007
Sax. IAS 2019. Abstr MOAB0105. Slide credit: clinicaloptions.com
*Preexisting M184V/I mutation present in 42% with PI resistance, 35% with NNRTI resistance.
45. Study 380-4030: Safety
Adverse Events
BIC/FTC/TAF
(n = 284)
DTG + FTC/TAF
(n = 281)
AE leading to study drug discontinuation, n (%) 6 (2.1) 6 (2.1)
Deaths,* n (%) 2 (< 1) 1 (< 1)
All grade AEs, %
Any AE
AEs in ≥ 10% of patients in either group
– Nasopharyngitis
– Diarrhea
– Upper respiratory tract infection
83
11
8
7
86
10
11
11
Any drug-related AE, %
AEs in ≥ 2% of patients in either group
– Diarrhea
– Headache
14
1
1
10
2
2
Sax. IAS 2019. Abstr MOAB0105. Slide credit: clinicaloptions.com
*Included cardiopulmonary arrest (treatment emergent) and acute cerebral infarction (not treatment emergent) in the BIC/FTC/TAF group and
suspected myocardial infarction (treatment emergent) in the DTG + FTC/TAF group.
No difference between arms in changes in fasting lipids or weight from BL to Wk 48
46. ATLAS and FLAIR Pooled Analysis: Long-Acting
Injectable CAB + RPV vs Daily Oral Three-Drug ART
Multicenter, randomized, open-label phase III noninferiority trials
Primary endpoint for both trials: HIV-1 RNA ≥ 50 copies/mL at Wk 48 by FDA Snapshot in ITT-E
Slide credit: clinicaloptions.com
LA CAB 400 mg + RPV 600 mg IM Q4W
(n = 303)
Continue Baseline ART PO
(n = 308)
Adults on stable ART (either first
or second regimen) with
HIV-1 RNA < 50 copies/mL for
≥ 6 mos with no previous VF
(N = 616)
Comparator arm
patients eligible to
receive CAB + RPV
in extension phase
after Wk 52
(ATLAS-2M study)
Wk 48 Primary Endpoint
ATLAS
LA CAB 400 mg +
RPV 600 mg IM Q4W
(n = 278)
Continue DTG/ABC/3TC PO QD
(n = 283)
ART-naive patients with
HIV-1 RNA ≥ 1000 copies/mL,
HBsAg negative, no NNRTI RAMs
but K103N permitted
(N = 629)
CAB 30 mg +
RPV 25 mg PO QD
(n = 283)
Wk 48 Primary EndpointWk 4
DTG/ABC/3TC PO QD
Wk 96Day 0
Wk 20FLAIR
Overton. IAS 2019. Abstr MOPEB257.
CAB 30 mg +
RPV 25 mg PO QD
(n = 308)
Wk 4Day 0
47. ATLAS and FLAIR Pooled Analysis:
Efficacy at Wk 48 in ITT-E Population
Overton. IAS 2019. Abstr MOPEB257. Reproduced with permission.
Participants(%)
100
80
40
60
20
0
Virologic
Nonresponse
(≥ 50 c/mL)
Virologic
Success
(< 50 c/mL)
No Virologic
Data
1.9 1.7
93.1 94.4
5.1 3.9
LA CAB + RPV
(n = 591)
Continue oral ART
(n = 591)
Slide credit: clinicaloptions.com
Oral ARTLA CAB + RPV
Difference (%)
Oral ART LA CAB + RPV
-4.1
-1.4
-10 -8 -6 -4 -2 0 2 4 6 8 10
1.4
-1.4 1.7
0.2
-10 -8 -6 -4 -2 0 2 4 6 8 10
4% NI
margin
-10% NI
margin
*Adjusted for sex and
BL third agent class.
Key Secondary Endpoint
(HIV-1 RNA < 50 copies/mL)
LA CAB + RPV noninferior to
continued BL ART
Primary Endpoint
(HIV-1 RNA ≥ 50 copies/mL)
LA CAB + RPV noninferior to
continued BL ART
48. ATLAS: Health Status and Treatment Acceptance of
Long-Acting CAB + RPV
Health status scores by SF-12 (mental and
physical) statistically similar between
arms at baseline, Wks 24 and 48
Treatment acceptance by ACCEPT
questionnaire significantly higher with LA
CAB + RPV switch vs continued BL oral
ART at Wks 8, 24, and 48
Slide credit: clinicaloptions.com
*LOFC analysis adjusted for sex, age, race (white vs nonwhite), and
third agent class (INSTI vs PI vs NNRTI).
Mean Score* (± SD) LA CAB + RPV Oral ART
Mental component
Baseline
Wk 24
Wk 48
53.13 (8.19)
53.49 (8.59)
53.8 (8.84)
53.68 (7.34)
53.43 (8.58)
53.57 (8.04)
Physical component
Baseline
Wk 24
Wk 48
55.24 (5.74)
55.75 (5.55)
55.80 (5.51)
54.61 (5.76)
54.66 (5.96)
54.79 (6.23)
Adjusted Mean Δ
From BL in General
Acceptance
Domain*
LA CAB
+ RPV
Oral
ART
Difference
(95% CI)†
Wk 8 8.9 1.0 7.9 (4.1-11.7)
Wk 24 12.3 5.5 6.9 (3.3-10.4)
Wk 48 13.7 3.0 10.7 (7.1-14.4)
Murray. IAS 2019. Abstr MOAB0103.
†P < .001 for all listed differences.
49. ATLAS: Patient Views on Long-Acting CAB + RPV
86% to 90% of LA CAB + RPV recipients
scored ISRs and pain at Wk 48 as totally
or very acceptable in PIN questionnaire
Greater improvement in treatment
satisfaction by HIVTSQ at Wks 24, 44
with LA CAB + RPV vs daily oral ART
Slide credit: clinicaloptions.comMurray. IAS 2019. Abstr MOAB0103.
Acceptability, %
LA CAB + RPV
Wk 5 (n = 296) Wk 48 (n = 303)
ISRs
Totally
Very
Moderately
A little
Not at all
48
26
18
5
3
67
23
7
3
1
Pain
Totally
Very
Moderately
A little
Not at all
29
35
20
10
6
55
31
9
4
1
P < .001 for Δ over time in “acceptability of ISRs” domain of PIN.
Patient Preference for
ART Delivery Method
by Population, % (n/N)
Long-acting
IM
Daily
PO
ITT-E 86 (266/308) 2 (7/308)
Responding patients 97 (266/273) 3 (7/273)
Adjusted Mean Δ
From BL in Tx
Satisfaction*
LA CAB +
RPV
BL Oral
ART
Difference
(95% CI)†
Wk 24 6.43 1.05 5.39 (4.17-6.60)
Wk 44 6.12 0.44 5.68 (4.37-6.98)
*Adjusted for BL score, sex, age, race, and BL third agent class.
†P < .001 for all listed differences.
50. ANRS 170 QUATUOR: Study Design
Multicenter, randomized, open-label phase III noninferiority study
Slide credit: clinicaloptions.com
HIV-infected adults with HIV-1 RNA < 50 c/mL
for ≥ 12 mos on ART,* no genotypic resistance,
CD4+ cell count > 250 cells/mm3
(N = 640)
ART on 4 Days Out of 7 (4D/7)
(n = 320)
ART on 7 Days Out of 7 (7D/7)
(n = 320)
Primary Endpoint
Wk 48Stratified by 3rd agent
*ART regimen based on either PI, NNRTI, or INSTI with 2 NRTIs.
All participants
receive open-label
4D/7 through Wk 96
Landman. IAS 2019. Abstr WEAB0406LB.
Primary endpoint: HIV-1 RNA < 50 copies/mL and no strategy
interruption (except for pregnancy and within-class switches)
‒ Noninferiority margin: -5%
51. ITT - KM
PP - KM
ANRS 170 QUATUOR: Treatment Success at Wk 48 in ITT
Population (Primary Endpoint)
VF not associated with ARV class
Emergent resistance detected in 3 of 6
failing 4D/7 vs 1 of 4 failing 7D/7
Slide credit: clinicaloptions.comLandman. IAS 2019. Abstr WEAB0406LB. Reproduced with permission.
Therapeutic Success
Patients(%)
100
80
40
60
20
0
Therapeutic
Success
No Virologic
Data
1.9 1.3
95.6 97.2
2.5 1.6
4D/7 (n = 318)
7D/7 (n = 318)
Virologic
Failure
4D/77D/7
-1.3
-1.6
-5 -4 -3 -2 -1 0 1 2 3 4 5
NI margin -1.6
ITT - KM
PP - KM
ITT - Snapshot
Virologic Failure
0.6
-5 -4 -3 -2 -1 0 1 2 3 4 5
0.6
Difference (95% CI)
NI margin
52. ANRS 170 QUATUOR: Treatment Failure by Third Agent
Slide credit: clinicaloptions.comLandman. IAS 2019. Abstr WEAB0406LB. Reproduced with permission.
Virologic Failure
by Third Agent, n/N
4D/7 7D/7
INSTI 3/152 1/152
NNRTI 3/148 3/148
PI 0/18 0/18
Virologic Failure
Difference (95% CI) of Proportion
4D/77D/7
0.0
1.4
-5 -4 -3 -2 -1 0 1 2 3 4 5
0.0
INSTI
NNRTI
PI
Third Agent
53. ANRS 170 QUATUOR: Safety at Wk 48
Slide credit: clinicaloptions.com
Median Change in Laboratory Parameters and
Weight Between BL and Wk 48
P < .05
Landman. IAS 2019. Abstr WEAB0406LB. Reproduced with permission.
15
5
10
0
-5
4D/7
7D/7
No difference in overall safety
between strategies
Significantly greater eGFR elevation
with 4D/7 vs 7D/7 from BL to Wk 48
(P < .05)
AEs
4D/7
(n = 318)
7D/7
(n = 318)
P Value
All AEs, % 72.3 73.9 .721
Grade 3/4 AEs, % 7.9 9.4 .594
Death, n 2 0 .499
D/c due to AE, n 1 0 1.000
54. BRIGHTE: Fostemsavir in Heavily Treatment–
Experienced Adults With Multidrug Resistant HIV
Wk 96 analysis of randomized, double-blind phase III trial in heavily treatment–experienced adults
failing current ART with confirmed HIV-1 RNA ≥ 400 c/mL
‒ At BL: median HIV-1 RNA, 4.6 log10 c/mL; median CD4+ cell count, 80 cells/mm3; AIDS history, 86%
Slide credit: clinicaloptions.com
Randomized Cohort
1-2 remaining ARV classes
(≥ 1 fully active§ approved agent/class),
cannot construct viable regimen with
remaining agents
(n = 272)
*Blinded. †Day 8 adjusted by Day 1. ‡Open-label. §No evidence of resistance; patient eligible for, tolerant of, willing to receive the ARV. ║Measured from start of open-label tx.
Study conducted until another option, rollover study, or approved ARV available.
Primary Endpoint
Mean Δ in HIV-1 RNA,†
log10 c/mL (95% CI)
-0.79 (-0.88 to -0.70)
-0.17 (-0.33 to -0.01)
Day 9
FTR 600 mg BID +
Failing Regimen*
(n = 203)
Placebo +
Failing Regimen*
(n = 69)
FTR 600 mg BID + OBT‡
FTR 600 mg BID + OBT‡
Treatment ∆: -0.63
Nonrandomized Cohort
No remaining ARV classes and no
fully active§ approved agents
(n = 99)
FTR 600 mg BID + OBT‡ (investigational agents allowed)
Day 1
Lataillade. IAS 2019. Abstr MOAB0102. Pialoux. IAS 2018. Abstr THPEB045.
Day 8 Wk 96‖
55. BRIGHTE: ITT-E Virologic Response Through Wk 96
Lataillade. IAS 2019. Abstr MOAB0102. Reproduced with permission.
Randomized Cohort (n = 272)
Nonrandomized Cohort (n = 99)
HIV-1RNA<40copies/mL(%)
*Snapshot analysis excluded baseline data. 1 patient had BL HIV-1 RNA < 40 copies/mL.
100
80
60
40
20
0
Baseline* Wk 24 Wk 48 Wk 72 Wk 96
53 54 53
60
37 38 35 37
Outcome at Wk 96, n (%)
Randomized
Cohort
(n = 272)
Nonrandomized
Cohort
(n = 99)
HIV-1 RNA < 40 copies/mL 163 (60) 37 (37)
HIV-1 RNA ≥ 40 copies/mL
Data in window not below
threshold
D/c for lack of efficacy
D/c for other reason while
not below threshold
Change in ART*
81 (30)
33 (12)
10 (4)
17 (6)
21 (8)
43 (43)
15 (15)
3 (3)
6 (6)
19 (19)
No virologic data
D/c due to AE or death
D/c for other reasons
Missing data during
window
28 (10)
15 (6)
8 (3)
5 (2)
19 (19)
14 (14)
4 (4)
1 (1)
Mean change from BL to Wk 96 in CD4+ count, cells/mm3: randomized cohort, 205; nonrandomized cohort, 119
In the randomized cohort, mean CD4+/CD8+ cell ratio increased from BL (0.2) to Wk 96 (0.443)
Slide credit: clinicaloptions.com
56. BRIGHTE: Safety Through Wk 96
Slide credit: clinicaloptions.comLataillade. IAS 2019. Abstr MOAB0102.
Cumulative Safety Outcomes
Through Wk 96, n (%)
Randomized Cohort
(n = 272)*
Nonrandomized Cohort
(n = 99)
All Treated Patients
(N = 371)
Any event 249 (92) 98 (99) 347 (94)
Any grade 2-4 AE 216 (79) 87 (88) 303 (82)
Drug-related grade 2-4 AEs 57 (21) 22 (22) 79 (21)
Any grade 3/4 AE 78 (29) 49 (49) 127 (34)
Any serious AE 92 (34) 48 (48) 140 (38)
Drug-related serious AE 9 (3) 3 (3) 12 (3)
Any AE leading to d/c 14 (5) 12 (12) 26 (7)
Any CDC class C event 23 (8) 15 (15) 38 (10)
Death 12 (4) 17 (17) 29 (8)†
*Includes patients initially randomized to placebo. Data are from initiation of open-label fostemsavir.
†AIDS-related events or acute infections, n = 18 (1 case of IRIS considered treatment-related); occurring after study d/c, n = 5.
57. Study 380-4449: Switch to BIC/FTC/TAF in
Adults ≥ 65 Yrs of Age
Multicenter, open-label, single-arm phase IIIb study in adults ≥ 65 yrs of age with
virologic suppression on stable ART for ≥ 3 mos (N = 86)
‒ Switch from EVG/COBI/FTC/TAF or FTC/TDF + third agent to BIC/FTC/TAF
Maggiolo. IAS 2019. Abstr MOPEB238. Slide credit: clinicaloptions.com
HIV-1 RNA ≥
50 copies/mL
HIV-1 RNA
< 50 copies/mL
(Primary Endpoint)
n/N =
Participants(%)
100
80
60
40
20
0
No Virologic Data
in Window
84/86
2
98
0/86 2/86
Virologic Outcomes at Wk 24 (FDA Snapshot)
Median change in CD4+ cell count at
Wk 24: -7 cells/mm3 (IQR: -80 to 90)
58. Study 380-4449: Safety
No grade 3/4 treatment-related
AEs
1 treatment-related AE resulted
in study drug discontinuation
Maggiolo. IAS 2019. Abstr MOPEB238. Slide credit: clinicaloptions.com
Median Δ From BL to Wk 24 BIC/FTC/TAF
Weight, kg 0
eGFR, mL/min -4.5
Lipid parameters
Total cholesterol, mg/dL
LDL cholesterol, mg/dL
HDL cholesterol, mg/dL
Triglycerides, mg/dL
Total cholesterol:HDL
-14
-7
-3
-17
0.1
Renal biomarkers, %
β2-microglobulin:creatinine
RBP:creatinine
-20.8
-15.6
60. DRIVE2Simplify Part 2: Islatravir + Doravirine vs
DOR/3TC/TDF in ART-Naive Adults
Current analysis of Part 2 for international, randomized, double-blind phase IIb trial
Slide credit: clinicaloptions.comMolina. IAS 2019. Abstr WEAB0402LB.
Primary endpoints: rate of HIV-1 RNA < 50 c/mL at Wks 24 and 48 (FDA Snapshot), AEs, AE-related d/c
Treatment-naive adults with
HIV-1 RNA ≥ 1000 c/mL,
CD4+ count ≥ 200 cells/mm3,
no ARV drug resistance,
no active HCV or HBV
coinfection
(N = 121)
Part 1:
3-Drug Dose Ranging
ISL 0.25 mg + DOR + 3TC QD*
(n = 29)
DOR/3TC/TDF QD†
(n = 31)
ISL 0.75 mg + DOR + 3TC QD*
(n = 30)
ISL 2.25 mg + DOR + 3TC QD*
(n = 31)
Stratified by screening HIV-1 RNA
(≤ vs > 100,000 c/mL)
ISL 0.25 mg + DOR QD
(n = 29)
DOR/3TC/TDF QD
(n = 28)
ISL 0.75 mg + DOR QD
(n = 30)
ISL 2.25 mg + DOR QD
(n = 27)
ISL at selected dose +
DOR QD
DOR/3TC/TDF QD
Part 2:
2-Drug Dose Ranging
Part 3:
Maintenance
If HIV-1 RNA < 50 c/mL at Wk 20
without meeting any VF criteria‡
Wk 24 Wk 48 Wk 96
*Received placebo for DOR/3TC/TDF. †Received placebo for ISL + DOR + 3TC QD.
‡If HIV-1 RNA ≥ 50 c/mL at Wk 20, continued Part 1 until HIV-1 RNA < 50 c/mL
and, if not meeting any VF criteria, transitioned to Part 2.
61. 0/28
DRIVE2Simplify Part 2: Virologic Outcomes at Wk 24
Upon Entry to Part 2 (FDA Snapshot)
HIV-1 RNA < 50 c/mL HIV-1 RNA ≥ 50 c/mL No Virologic Data in Window
Patients(%)
25/28 27/30 24/27 27/28 2/28 2/30 1/27 1/28 1/28 1/30 2/27n/N =
Slide credit: clinicaloptions.comMolina. IAS 2019. Abstr WEAB0402LB. Reproduced with permission.
Wk 24 Primary Endpoint
ISL 0.25 mg + DOR + 3TC
ISL 0.75 mg + DOR + 3TC
ISL 2.25 mg + DOR + 3TC
DOR/3TC/TDF
100
80
60
40
20
0
83.9 90 88.9
96.4
7.1 6.7 3.7 3.6 3.6 3.3
7.4
62. Patients(%)
26/29 27/30 24/31 2/29 2/30
DRIVE2Simplify Part 2: Virologic Outcomes at Wk 48
(FDA Snapshot)
Slide credit: clinicaloptions.comMolina. IAS 2019. Abstr WEAB0402LB. Reproduced with permission.
All patients with PDVF had confirmatory HIV-1 RNA < 80 c/mL;
no patients met criteria for resistance testing
HIV-1 RNA < 50 c/mL HIV-1 RNA ≥ 50 c/mL No Virologic Data in Window
26/31 4/31 2/31 1/29 1/30 3/31 3/31n/N =
Wk 48 Primary Endpoint
ISL 0.25 mg + DOR
ISL 0.75 mg + DOR
ISL 2.25 mg + DOR
DOR/3TC/TDF
100
80
60
40
20
0
89.7 90
77.4
83.9
7.1 6.7
12.9
6.5
3.4 3.3
9.7 9.7
63. DRIVE2Simplify Part 2: Adverse Events Through Wk 48
No deaths reported
Numerically greater frequency of drug-related AEs with DOR/3TC/TDF vs any dose
of ISL
Slide credit: clinicaloptions.comMolina. IAS 2019. Abstr WEAB0402LB.
Safety Outcome,
n (%)
ISL 0.25 mg
Arm
(n = 29)
ISL 0.75 mg
Arm
(n = 30)
ISL 2.25 mg
Arm
(n = 31)
All ISL
Arms
(n = 90)
DOR/3TC/TDF
Arm
(n = 31)
≥ 1 AE 21 (72.4) 26 (86.7) 19 (61.3) 66 (73.3) 24 (77.4)
Drug-related AE 0 3 (10.0) 4 (12.9) 7 (7.8) 6 (19.4)
Serious AE 1 (3.4) 2 (6.7) 0 3 (3.3) 2 (6.5)
D/c due to AE 0 0 2 (7.4)* 2 (2.2) 1 (3.2)†
*1 case each of diarrhea/nausea/vomiting with onset at Day 200 lasting ~ 2 wks and reactivated HBV with onset at Day 201.
†1 case of worsening congenital long QT syndrome.
64. Select Agents Under Early Investigation For the
Prevention and Treatment of HIV
Slide credit: clinicaloptions.com
Agent MOA Phase n Key Findings
Ad26.Mos4.HIV and either
clade C gp140 or bivalent
gp140[1]
Vaccine I/IIa 126
Both regimens induced immune responses against a broad
range of HIV-1 subtypes in healthy adults; well tolerated
Islatravir (ISL; MK-8591)[2] NRTTI I 12
Drug-eluting implants projected to provide HIV prophylaxis for
≥ 1 yr; well tolerated. ISL + DOR tx regimen in phase IIb[3]
2-hydroxypropyl--
cyclodextrin cabotegravir
nanochannel delivery
implant[4]
INSTI PK
6
(rats)
Clinically-relevant plasma CAB concentrations and drug
penetration into relevant tissues; no AEs observed
GS-6207[5] HIV-1 capsid
inhibitor
Ib 18
Single SC 50-450 mg dose provided potent antiviral activity,
well tolerated in PLWH naive to capsid and integrase inhibitors
VRC01LS and VRC07-523LS[6] HIV-1 bNAbs I 16
Decreased HIV-1 RNA following 1 IV dose in viremic PLWH;
well tolerated
Vesatolimod (GS-9620)[7] TLR 7 agonist Ib 36
Induced immune activation at doses ≥ 4 mg in virologically-
suppressed PLWH; well tolerated
1. Stieh. IAS 2019. Abstr TUAC0402LB. 2. Matthews. IAS 2019. Abstr TUAC0401LB. 3. Molina. IAS 2019. Abstr WEAB0402LB. 4. Pons-Faudoa.
IAS 2019. Abstr TUPEA106. 5. Daar. IAS 2019. Abstr LBPEB13. 6. Chen. IAS 2019. Abstr WEAA0305LB. 7. Riddler. IAS 2019. Abstr WEAA0304.
66. HPTN 078: Intervention to Engage Virologically
Unsuppressed MSM Living With HIV
Remien. IAS 2019. Abstr MOAX0101LB. Slide credit: clinicaloptions.com
MSM living with HIV infection,
detectable HIV-1 RNA
(N = 144)
Enhanced Case Management
(n = 72)
Standard of Care
(n = 72)
12 Mos
Enhanced case management: access to a case manager and referral services, counseling
using motivational interviewing, and automated adherence and motivational messaging
‒ Intervention intensity was participant driven (by choosing frequency and content of interactions)
Study population: predominantly black (84%), educated (≥ 90% had high school diploma),
low income (65% earned < $20,000 annually), and ART experienced (86%)
‒ Median HIV-1 RNA at baseline: 19,459 copies/mL
67. HPTN 078: Virologic Suppression Rates Similar With
Enhanced Case Management vs Standard of Care
Remien. IAS 2019. Abstr MOAX0101LB. Slide credit: clinicaloptions.com
At Month 12, 91% of participants were retained and 48% were virologically
suppressed
No significant difference in virologic suppression rates between enhanced case
management and standard of care (OR: 0.615; 95% CI: 0.315-1.197; P = .1526)
Enhanced case management
Standard of care
Month 3
n/N =
HIV-1RNA
<200copies/mL(%)
100
80
60
40
20
0
20/72
2928
Month 6 Month 9 Month 12
21/72 26/72
3636
26/72 28/72
3939
28/72 30/72
54
42
38/72
68. Rosuvastatin for Atherosclerotic Progression in People
With HIV at Moderate Cardiovascular Risk
Randomized, double blind, placebo-controlled, multinational trial
Study population consisted primarily of white males; mean age: 54 years
Approximately one third of participants were current smokers, and approximately one third had a family
history of heart attack
Approximately one quarter of participants were receiving abacavir
Trevillyan. IAS 2019. Abstr MOAB0201. Slide credit: clinicaloptions.com
Patients with HIV infection (> 30 yrs
of age) with moderate coronary heart
disease risk* and no indication for
initiation of statin therapy; on stable
ART for > 3 mos and HIV-1 RNA
< 200 copies/mL for ≥ 6 mos
(N = 84)
Rosuvastatin 20 mg QD†
(n = 44)
Placebo
(n = 40)
*Framingham risk score: 10-15%.
†Participants on a boosted PI or COBI received 10 mg rosuvastatin.
Wk 96
69. Rosuvastatin vs Placebo: Outcomes at Wk 96
Decreases in total and LDL cholesterol with rosuvastatin vs placebo
Greater incidence of adverse events in rosuvastatin vs placebo arm
‒ 75% vs 27% of participants experienced ≥ 1 AE
‒ 16% vs 0% experienced grade 3/4 AEs
Trevillyan. IAS 2019. Abstr MOAB0201. Slide credit: clinicaloptions.com
Mean Common Carotid IMT (SD) Rosuvastatin
(n = 44)
Placebo
(n = 40)
P Value†
Baseline 0.722 (0.032) 0.772 (0.033) .115
48 wks 0.726 (0.032) 0.771 (0.033) .158
96 wks (primary endpoint) 0.726 (0.032) 0.779 (0.033) .097
P value* .319 .115
*Baseline vs Wk 96 within each arm.
†Difference between arms at each time point.
70. BRAHMS: STIs Among MSM in Germany
Multicenter, prospective study in MSM aged 18-45 yrs at risk of HIV
infection (N = 1040)
‒ Eligibility criteria: in last 24 wks, documented syphilis, rectal gonorrhea,
or chlamydia OR condomless anal intercourse with ≥ 2 unique male
partners whose HIV status was positive or unknown
Participants screened for STIs every 3 mos by blood, urine, anal swab,
and oropharyngeal swab; also given sexual behavior questionnaires
At BL, 45% were receiving PrEP, 18% initiated PrEP after risk reduction
counseling, and 37% chose not to receive PrEP
Slide credit: clinicaloptions.comStreeck. IAS 2019. Abstr TUPDC0106.
71. BRAHMS: STI Prevalence
No difference in STI point prevalence
by PrEP status; all cases of HIV in
non-PrEP users
25% of participants had > 1 STI
Most STIs were rectal, asymptomatic
STI Point Prevalence (N = 1040) Chlamydia
(n = 155)
Mycoplasma
(n = 231)
Gonorrhea
(n = 134)
Slide credit: clinicaloptions.com
17%
15%
68%
15%
26% 59%
44%
7%
49%
Streeck. IAS 2019. Abstr TUPDC0106. Reproduced with permission.
Non-PrEP
PrEP
Cases
250
200
150
100
50
0
Point Prevalence, % 12
12.6
11.4
19
18.5
19.7
9.2
8.5
10.2
4.6
4
5.5
0.4
0.7
0.2
0.4
0.6
0.2
Overall
Non-PrEP
PrEP
Anal
Urine
Throat
72. clinicaloptions.com/hiv
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