ovarian tumor classification, tumors of ovary, who classification

1. DR NANDAKANTA MAHANTA
PGT, DEPARTMENT OF PATHOLOGY
SMCH, SILCHAR

2. WHO CLASSIFICATION

3. EPITHELIAL TUMORS
MESENCHYMAL TUMORS
MIXED EPITHELIAL AND MESENCHYMAL
TUMORS
SEX CORD-STROMAL TUMORS
MIXED SEX CORD-STROMAL TUMORS
GERM CELL TUMORS
MONOCLONAL TERATOMA AND SOMATIC TYPE
TUMORS ARISING FROM A DERMOID CYST
GERM CELL-SEX CORD-STROMAL TUMORS
MISCELLANEOUS TUMORS
MESOTHELIAL TUMORS
SOFT TISSUE TUMORS
TUMOR LIKE LESIONS
LYMPHOID AND MYELOID TUMORS
SECONDARY TUMORS

4. EPITHELIAL TUMORS
 MOST COMMON
 6O % OF OVARIAN TUMORS
 SEROUS AND MUCINOUS CYSTADENOMAS ARE
MOST COMMON EPITHELIAL TUMORS (30% )

5. EPITHELIAL TUMORS
a)SEROUS TUMORS:
FIG: SEROUS CYSTADENOMA, LINED BY
CILIATED LOW COLUMNAR CELL WITH
BLAND BASAL NUCLEI
BENIGN: Interior and exterior surface
smooth.
 Serous cystadenoma
 Serous adenofibroma (solid)
 Serous surface papilloma

6. a)SEROUS TUMORS
BORDERLINE:
large,usually multilocular cystic neoplasms that are
bilateral in 35 -40% cases
 Serous borderline tumour/ Atypical proliferative serous
tumour
 Serous borderline tumour-micropapillary variant / Non
invasive low-grade serous carcinoma

7. a) SEROUS TUMOR:
BORDERLINE:

8. a)SEROUS TUMORS
Serous carcinoma. The tumor cells cover papillae
and grow in sheets. They have large vesicular nuclei with
coarse chromatin, and some have prominent nucleoli.
 MALIGNANT: mixture of cystic,
papillary, and solid growth.
 Low-grade serous
carcinoma
 High-grade serous
carcinoma

9. b)MUCINOUS TUMORS
BENIGN: U/L, 10 cm,uni/multilocular mucin filled cysts
 Mucinous cystadenoma (cystic)
 Mucinous adenofi broma (solid)
BORDERLINE:
 Mucinous borderline tumour / Atypical proliferative
mucinous tumour
MALIGNANT: large, multilocular cystic ,15 -20 cm.Firm, fleshy, white or tan
solid areas, foci of hemorrhage Or necrosis
 Malignant Mucinous carcinoma

10. MUCINOUS TUMOR
MUCINOUS CYSTADENOMA BORDERLINE MUCINOUS TUMOR

11. MUCINOUS CARCINOMA:

12. c)ENDOMETRIOID TUMORS
BENIGN: solid fibrous tumor,
 Endometriotic cyst
 Endometrioid cystadenoma
 Endometrioid adenofibroma
BORDERLINE:
 Endometrioid borderline tumour / Atypical proliferative
endometrioid tumour
MALIGNANT: cystic and solid / completely solid
 Endometrioid carcinoma

13. ENDOMETROID TUMOR
Endometrioid adenofibroma. Glands lined by a
single layer of benign endometrial-type cells
grow in dense fibrous stroma.
Borderline endometrioid tumor,
glandular pattern seen

14. ENDOMETRIOID CARCINOMA

15. d)CLEAR CELL TUMORS
BENIGN:
 Clear cell cystadenoma
 Clear cell adenofibroma
BORDERLINE:
 Clear cell borderline tumour / Atypical proliferative
clear cell tumour
MALIGNANT: >90%
 Clear cell carcinoma

16. CLEAR CELL TUMOR
CLEAR CELL ADENOFIBROMA:
cuboidal to low columnar cell, hobnail
nuclei
CLEAR CELL CARCINOMA: cuboidal to
columnar tumor cell, nuclei are
pleomorphic

17. e)BRENNER TUMORS: a type of
adenofibroma in which nests of transitional epithelium grow in a fibrous
stroma. solid fibrous tumor
BENIGN:
 Brenner tumour
BORDERLINE:
 Borderline Brenner tumour / Atypical proliferative
Brenner tumour
MALIGNANT:
 Malignant Brenner tumour

18. BRENNER TUMOR
BENIGN BRENNER TUMOR BORDERLINE BRENNER TUMOR

19. MALIGNANT BRENNER TUMOR:when a
benign or proliferating Brenner tumor is found adjacent
to transitional cell carcinoma, the tumor is designated as a
malignant Brenner tumor.

20. f)SEROMUCINOUS TUMORS
BENIGN:
 Seromucinous cystadenoma
 Seromucinous adenofibroma
BORDERLINE:
 Seromucinous borderline tumour / Atypical
proliferative seromucinous tumour
MALIGNANT:
 Seromucinous carcinoma

21. g)
UNDIFFERENTIATED CARCINOMA:
anaplastic cells