This document classifies tetracycline antibiotics based on the functional groups (R1-R6) attached to their tetracycline core structure. It lists 10 common tetracyclines including tetracycline, chlortetracycline, oxytetracycline, and minocycline. Newer generation tetracyclines like tigecycline, eravacycline, sarecycline, omadacycline, lymecycline, and rolitetracycline are also presented.

1. CLASSIFICATION OF TETRACYCLINES
R
4
R
1
H
H
O
OH
R
6
R
5
N
CH3
C
H3
OH
O
NH2
O
OH
R
3
R
2
OH
Drugs R1 R2 R3 R4 R5 R6
Tetracycline H CH3 OH H H H
Chlortetracycline H CH3 OH Cl H H
Oxytetracycline OH CH3 OH H H H
Demeclocycline H H OH H H H
Meclocycline OH =CH2 Cl H H
Methacycline OH =CH2 H H H
Minocycline H H H N(CH3)2 H H
Doxycycline OH CH3 H H H H
Tigecycline H H H N(CH3)2 H
N
N
H
O H
Eravacycline H H H F H
N
H
O
N
Sarecycline H H H
N
O
CH3
CH3 H H
Omadacycline H H H N(CH3)2 H N
H
R
4
R
1
H
H
O
OH
R
6
R
5
N
CH3
C
H3
OH
O
NH X
O
OH
R
3
R
2
OH
Lymecycline
X =
N
OH
H
NH2
O
H CH3 OH H H H
Rolitetracycline
X =
N
H CH3 OH H H H