This document discusses strategies for improving the contribution of science and technology (S&T) to sustainable development. It proposes establishing an international research system focused on solving the most pressing sustainability problems through collaborative, interdisciplinary research between scientists, policymakers, and development stakeholders. Specific priorities include accelerating trends to reduce population growth and increase food production in Africa, doubling rates of energy and resource efficiency, enabling sustainable urban growth, and restoring ecosystems. The goal is to better organize and fund S&T efforts to meet the global challenges of ensuring freedom from want, fear, and sustaining the planet for future generations.