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Circulating blood cells that differentiate into macrophages in the tissue M cells Monocytes
Common myeloid progenitors Eosinophils
Solution
Answer: b. Monocytes
Monocytes are the circulating blood cells which after production from the bone marrow,
circulate in the bloodstream for about 8 h, during which they enlarge; and then migrate into the
tissues and differentiate into specific tissue macrophages. The differentiation of a monocyte into
a tissue macrophage involves a number of changes such as :

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