This document discusses the experience of Martine Rothblatt, Ph.D. navigating her daughter's diagnosis and treatment of pediatric pulmonary hypertension. It outlines her journey working with experts in the field like Drs. Roger Ruckman and Robyn Barst. It then details Rothblatt's efforts to research the condition at Glaxo-Wellcome and her work with Sir John Vane. The document concludes by outlining Rothblatt's efforts to develop new treatment approaches like ex vivo lung perfusion and 3D bioprinting of lung scaffolds as potential solutions to the limited supply of donor lungs.

1. Grand Rounds:
A Parent’s Experience of
Pediatric Pulmonary Hypertension
Martine Rothblatt, Ph.D.
Children’s National Medical Center

3. Roger Ruckman, MD, 1990s Head of Pediatric
Cardiology at Children’s National Medical
Breathe Curiosity

4. Robyn Barst, MD, 1990s – 2000s Head of Pediatric
Pulmonary Hypertension Program at Columbia Presbyterian

5. Glaxo-Wellcome, Research Triangle Park, 1990s
Question Authority

6. Sir John Vane, Nobel
Laureate in Medicine,
Founder of William
Harvey Research
Institute

7. Do Practically

9. Act Lovingly

10. With Sir Magdi and Lady Yacoub, World Record Holder
for Heart and Lung Transplants, and My Partner Bina

11. EVLP – 1st Step in
Manufacturing an
Unlimited Supply of Lungs

12. Patient Heather Leverington Who Received Two of UT’s EVLP Lungs &
Went On to Win Shotput Gold Medal in US Transplant Games

13. 2nd Step: Allogeneic
Recell in Bioreactors of
Porcine Decell Lungs

14. Now Up to 500 Per Year –
Available to Researchers (GMP
Scaffolds & Partial Recell)

15. Step 3: Autologous Recell of 3D Printed Scaffolds

16. 3D Lung Lobe
Printing Time
Reduced from 3
Months to 3 DaysAll From Bioink
Being Optimized for
Cellularization and,
Uses Only Human
Recombinant
Collagen from
Genetically
Modified Tobacco
Plants

18. Take Away Lessons
•Breathe Curiosity: The Library
•Question Authority: Impossible = I’m Possible
•Do Practically: Parenteral > Inhaled > Oral
•Manufacture Lungs By EVLP > Allogeneic Recell
•Manufacture Lungs By Autologous 3D Bioprint
•Act Lovingly –Make People Happier